Abstract:
BACKGROUND AND DESIGN:Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin levels induced by obesity are associated with insulin resistance and type 2 diabetes, suggesting that low adiponectin levels may contribute the pathogenesis of obesity-related insulin resistance. METHODS AND RESULTS:The objective of the present study was to investigate whether gene therapy designed to elevate circulating adiponectin levels is a viable strategy for ameliorating insulin resistance in mice fed a high-fat, high-sucrose (HFHS) diet. Electroporation-mediated gene transfer of mouse adiponectin plasmid DNA into gastrocnemius muscle resulted in elevated serum levels of globular and high-molecular weight adiponectin compared with control mice treated with empty plasmid. In comparison to HFHS-fed mice receiving empty plasmid, mice receiving adiponectin gene therapy displayed significantly decreased weight gain following 13 weeks of HFHS diet associated with reduced fat accumulation, and exhibited increased oxygen consumption and locomotor activity as measured by indirect calorimetry, suggesting increased energy expenditure in these mice. Consistent with improved whole-body metabolism, mice receiving adiponectin gene therapy also had lower blood glucose and insulin levels, improved glucose tolerance and reduced hepatic gluconeogenesis compared with control mice. Furthermore, immunoblot analysis of livers from mice receiving adiponectin gene therapy showed an increase in insulin-stimulated phosphorylation of insulin signaling proteins. CONCLUSION:Based on these data, we conclude that adiponectin gene therapy ameliorates the metabolic abnormalities caused by feeding mice a HFHS diet and may be a potential therapeutic strategy to improve obesity-mediated impairments in insulin sensitivity.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Kandasamy AD,Sung MM,Boisvenue JJ,Barr AJ,Dyck JRdoi
10.1038/nutd.2012.18subject
Has Abstractpub_date
2012-09-10 00:00:00pages
e45issn
2044-4052pii
nutd201218journal_volume
2pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:Neuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.45
更新日期:2015-01-19 00:00:00
abstract:OBJECTIVE:Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is recommended. We determined the proportion of individuals with elevated CRP in whom statin therapy was n...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.4
更新日期:2011-05-23 00:00:00
abstract:AIM:The purpose of this study was to investigate the association of dietary patterns with the risk of insulin resistance (IR), diabetes mellitus (DM), and central obesity in China. METHODS:We performed a cross-sectional study on 1432 participants, aged 40-65 years in Hangzhou, Zhejiang province, China. Dietary intake ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0120-y
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND:Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigated its effects in die...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.9
更新日期:2013-05-27 00:00:00
abstract:OBJECTIVE:In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has dem...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.49
更新日期:2016-12-12 00:00:00
abstract:BACKGROUND:A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diab...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0113-x
更新日期:2020-03-20 00:00:00
abstract:OBJECTIVE:The aim of dietary modification, as a cornerstone of type 2 diabetes (T2DM) management, is to optimise metabolic control and overall health. This study describes food and nutrient intake in a sample of adults with T2DM, and compares this to recommendations, and to intake in age, sex, body mass index (BMI) and...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.2
更新日期:2014-02-03 00:00:00
abstract::Obesity is associated with inflammatory macrophages in insulin responsive tissues and the resulting inflammatory response is a major contributor to insulin resistance. In insulin-producing pancreatic islets, the intra-islet accumulation of macrophages is observed in patients of type 2 diabetes (T2D), but such has not ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0103-z
更新日期:2019-12-02 00:00:00
abstract::Obesity and related complications are major health burdens. Almost 700 million adults are currently obese globally and the prevalence is predicted to rise towards 2030. The sudden change of lifestyle with physical inactivity and excessive calorie intake undoubtedly have a major part of the epidemic development; howeve...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.9
更新日期:2012-07-30 00:00:00
abstract:BACKGROUND:Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have shown that despite the presence of overt obesity and dyslipidemia in the...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0112-y
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding. METHODS:Forty normal to overweight men and ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.44
更新日期:2016-01-25 00:00:00
abstract:BACKGROUND:Aerobic exercise training is known to have beneficial effects on whole-body glucose metabolism in people with type 2 diabetes (T2D). The responses of the liver to such training are less well understood. The purpose of this study was to determine the effect of aerobic exercise training on splanchnic glucose u...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0090-0
更新日期:2019-09-02 00:00:00
abstract:OBJECTIVES:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (G...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.28
更新日期:2017-05-22 00:00:00
abstract::For convenience, health practitioners and clinicians are inclined to classify people/patients as overweight or obese based on body mass index (BMI) cutoff points of 25 and 30 kg m(-2) respectively, irrespective of age and gender. The purpose of the current study was to identity whether, for the same levels of adiposit...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.36
更新日期:2015-11-30 00:00:00
abstract:BACKGROUND/OBJECTIVES:High dietary fibre intakes may protect against obesity by influencing colonic fermentation and the colonic microbiota. Though, recent studies suggest that increased colonic fermentation contributes to adiposity. Diet influences the composition of the gut microbiota. Previous research has not evalu...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.23
更新日期:2014-06-30 00:00:00
abstract:OBJECTIVES:The prevalence of obesity and diabetes in the Middle East is among the highest in the world. Valid measures of abdominal adiposity are essential to understanding the metabolic consequences of obesity. Dual-energy X-ray absorptiometry (DXA) is increasingly being utilised to assess body composition in populati...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.38
更新日期:2017-01-09 00:00:00
abstract:BACKGROUND:Individuals who focused on calorie counting lost more weight than those who focused on increasing vegetable and fruit (V&F) intake in a weight loss program. We now present serum carotenoid data (biomarkers of V&F intake) from both groups and test whether these biomarkers correlate with changes in weight and ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.22
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.7
更新日期:2016-03-07 00:00:00
abstract:BACKGROUND:Individuals with type 2 diabetes (DM2) may be less successful at achieving therapeutic weight loss than their counterparts without diabetes. This study compares weight loss in a cohort of adults with DM2 or high blood sugar (D/HBS) to a cohort of adults without D/HBS. All were overweight/obese and following ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.32
更新日期:2017-07-10 00:00:00
abstract::Diabetes mellitus has been associated with impaired cognitive performance, particularly in verbal memory. Mediterranean diets (MedD) may lead to improvements in overall and single cognitive functions. We hypothesised that adherence to MedD associates with better performance in verbal memory in patients with type 1 or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0111-z
更新日期:2020-04-01 00:00:00
abstract::Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-020-0127-4
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND/OBJECTIVES:Sleep duration influences weight change in children and young adults, but there is less evidence in middle-aged, and, in particular, older adults. We assessed associations between sleep duration, daytime napping and sleep disturbances, respectively, with change of weight and waist circumference in...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.32
更新日期:2016-08-15 00:00:00
abstract:OBJECTIVE:The gut microbiota contribute otherwise impossible metabolic functions to the human host. Shifts in the relative proportions of gut microbial communities in adults have been correlated with intestinal disease and have been associated with obesity. The aim of this study was to elucidate differences in gut micr...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.8
更新日期:2011-07-18 00:00:00
abstract::Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in patients experiencing end-stage renal disease (ESRD). It includes abnormalities in bone and mineral metabolism and vascular calcification. Hyperphosphatemia is a major risk factor leading to morbidity and mortality in patients with ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-019-0080-2
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evid...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,meta分析
doi:10.1038/s41387-019-0086-9
更新日期:2019-06-05 00:00:00
abstract:BACKGROUND:Obesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, older individuals. Obesity may be associated with diminished sensitivity to nutrients. We have repor...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00139-8
更新日期:2020-10-02 00:00:00
abstract::Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly. ...
journal_title:Nutrition & diabetes
pub_type: 已发布勘误
doi:10.1038/s41387-020-00137-w
更新日期:2020-09-23 00:00:00
abstract:OBJECTIVE:To examine the social and behavioural correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum. DESIGN:Cross-sectional study of a random population sample. PARTICIPANTS:A total of 718 community-dwelling adults (57% female), aged 18-92 years from a regional Sou...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.20
更新日期:2012-01-16 00:00:00
abstract:OBJECTIVE:Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.39
更新日期:2013-12-23 00:00:00
abstract:OBJECTIVES:Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which this hyperactivation can be reversed is uncertain, and to date there has been no demonstration of cha...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.26
更新日期:2014-09-01 00:00:00