Abstract:
BACKGROUND:The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evidence about the issue. METHODS:We searched in MEDLINE and PUBMED for studies that were published before November 2018. Meta-analysis of diabetics and nondiabetics trials were performed by use of a random-effects model. RESULTS:A total of 13 case-control studies that included 428 subjects with body mass index ≥25 were identified. RS supplementation reduced fasting insulin in overall and stratified (diabetics and nondiabetics trials) analysis (SMD = -0.72; 95% CI: -1.13 to -0.31; SMD = -1.26; 95% CI: -1.66 to -0.86 and SMD = -0.64; 95% CI: -1.10 to -0.18, respectively), and reduced fasting glucose in overall and stratified analysis for diabetic trials (SMD = -0.26; 95% CI: -0.5 to -0.02 and SMD = -0.28; 95% CI: -0.54 to -0.01, respectively). RS supplementation increased HOMA-S% (SMD = 1.19; 95% CI: 0.59-1.78) and reduced HOMA-B (SMD =-1.2; 95% CI: -1.64 to -0.77), LDL-c concentration (SMD =-0.35; 95% CI: -0.61 to -0.09), and HbA1c (SMD = -0.43; 95% CI: -0.74 to -0.13) in overall analysis. CONCLUSIONS:This meta-analysis has provided evidence that RS supplementation can improve fasting glucose, fasting insulin, insulin resistance and sensitivity, especially for diabetic with overweight or obesity. However, owing to potential sophistication, individual difference and composition of intestinal microbiota, this result should be carefully taken into account.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Wang Y,Chen J,Song YH,Zhao R,Xia L,Chen Y,Cui YP,Rao ZY,Zhou Y,Zhuang W,Wu XTdoi
10.1038/s41387-019-0086-9subject
Has Abstractpub_date
2019-06-05 00:00:00pages
19issue
1issn
2044-4052pii
10.1038/s41387-019-0086-9journal_volume
9pub_type
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journal_title:Nutrition & diabetes
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journal_title:Nutrition & diabetes
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更新日期:2014-06-30 00:00:00
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更新日期:2017-05-15 00:00:00
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journal_title:Nutrition & diabetes
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