Abstract:
OBJECTIVE:To examine the social and behavioural correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum. DESIGN:Cross-sectional study of a random population sample. PARTICIPANTS:A total of 718 community-dwelling adults (57% female), aged 18-92 years from a regional South Australian city. MEASUREMENTS:Total body fat and lean mass and abdominal fat mass were assessed by dual energy x-ray absorptiometry. Fasting venous blood was collected in the morning for assessment of glycated haemoglobin, plasma glucose, serum triglycerides, cholesterol lipoproteins and insulin. Seated blood pressure (BP) was measured. Physical activity and smoking, alcohol and diet (96-item food frequency), sleep duration and frequency of sleep disordered breathing (SDB) symptoms, and family history of cardiometabolic disease, education, lifetime occupation and household income were assessed by questionnaire. Current medications were determined by clinical inventory. RESULTS:36.5% were pharmacologically managed for a metabolic risk factor or had known diabetes ('cases'), otherwise were classified as the 'at-risk' population. In both 'at-risk' and 'cases', four major metabolic phenotypes were identified using principal components analysis that explained over 77% of the metabolic variance between people: fat mass/insulinemia (FMI); BP; lipidaemia/lean mass (LLM) and glycaemia (GLY). The BP phenotype was uncorrelated with other phenotypes in 'cases', whereas all phenotypes were inter-correlated in the 'at-risk'. Over and above other socioeconomic and behavioural factors, medications were the dominant correlates of all phenotypes in 'cases' and SDB symptom frequency was most strongly associated with FMI, LLM and GLY phenotypes in the 'at-risk'. CONCLUSION:Previous research has shown FMI, LLM and GLY phenotypes to be most strongly predictive of diabetes development. Reducing SDB symptom frequency and optimising the duration of sleep may be important concomitant interventions to standard diabetes risk reduction interventions. Prospective studies are required to examine this hypothesis.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Haren MT,Misan G,Grant JF,Buckley JD,Howe PR,Taylor AW,Newbury J,McDermott RAdoi
10.1038/nutd.2011.20subject
Has Abstractpub_date
2012-01-16 00:00:00pages
e24issn
2044-4052pii
nutd201120journal_volume
2pub_type
杂志文章abstract:BACKGROUND:Aerobic exercise training is known to have beneficial effects on whole-body glucose metabolism in people with type 2 diabetes (T2D). The responses of the liver to such training are less well understood. The purpose of this study was to determine the effect of aerobic exercise training on splanchnic glucose u...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0090-0
更新日期:2019-09-02 00:00:00
abstract:OBJECTIVE:Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.39
更新日期:2013-12-23 00:00:00
abstract:OBJECTIVE:Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripheral mechanisms. In the hypothalamus, the two systems were suggested to interact. To investigate such interplay also in non-hypothalamic tissues, we evaluated endocannabinoid levels in obese OE-NPY(DβH) mice, which overexpr...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.1
更新日期:2015-04-27 00:00:00
abstract:BACKGROUND:The global prevalence of diabetes is high and rapidly increasing. Some previous studies have found that vegetarians might have a lower risk of diabetes than non-vegetarians. OBJECTIVE:We examined the association between vegetarianism and risk of hospitalisation or death with diabetes in a large, prospective...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0074-0
更新日期:2019-02-25 00:00:00
abstract:BACKGROUND/OBJECTIVES:High dietary fibre intakes may protect against obesity by influencing colonic fermentation and the colonic microbiota. Though, recent studies suggest that increased colonic fermentation contributes to adiposity. Diet influences the composition of the gut microbiota. Previous research has not evalu...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.23
更新日期:2014-06-30 00:00:00
abstract:OBJECTIVES:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (G...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.28
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND AND DESIGN:Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin levels induced by obesity are associated with insulin resistance and ty...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.18
更新日期:2012-09-10 00:00:00
abstract:BACKGROUND:The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evid...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,meta分析
doi:10.1038/s41387-019-0086-9
更新日期:2019-06-05 00:00:00
abstract::Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-020-0127-4
更新日期:2020-07-02 00:00:00
abstract::Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly. ...
journal_title:Nutrition & diabetes
pub_type: 已发布勘误
doi:10.1038/s41387-020-00137-w
更新日期:2020-09-23 00:00:00
abstract::Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and d...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.19
更新日期:2016-06-06 00:00:00
abstract::For convenience, health practitioners and clinicians are inclined to classify people/patients as overweight or obese based on body mass index (BMI) cutoff points of 25 and 30 kg m(-2) respectively, irrespective of age and gender. The purpose of the current study was to identity whether, for the same levels of adiposit...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.36
更新日期:2015-11-30 00:00:00
abstract:OBJECTIVES:The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and the underlying mechanism. METHODS:Information about the chemical compositions of GD was obtained from extensive literature reports. Potential target genes were predicted using PharmMapper and analyzed using Kyoto Encyclopedia...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00134-z
更新日期:2020-08-14 00:00:00
abstract:OBJECTIVE:Along with the increasing prevalence of obesity and related diseases, particularly atherosclerotic diseases, metabolic syndrome (MetS) is now a common and major public health issue in many countries around the world. Adiponectin, a protein secreted by the adipose tissue, has become recognized as a key player ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.13
更新日期:2011-10-10 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Delivery of nutrients directly to the small intestine, either via enteral feeding tube or by gastric bypass surgery, is associated with increased levels of appetite-suppressing and glucoregulatory hormones, including GLP-1, and reduced appetite. Achieving these changes non-invasively using for...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41387-019-0088-7
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND/OBJECTIVES:Aging is associated with many physiological alterations such as changes in metabolism, food intake and brain dysfunction. Possible ways to correct age-related brain dysfunction using dietary treatments still remains undeveloped. The aim of our research was to investigate whether long-term dietary ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.13
更新日期:2015-06-15 00:00:00
abstract:BACKGROUND:Individuals with type 2 diabetes (DM2) may be less successful at achieving therapeutic weight loss than their counterparts without diabetes. This study compares weight loss in a cohort of adults with DM2 or high blood sugar (D/HBS) to a cohort of adults without D/HBS. All were overweight/obese and following ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.32
更新日期:2017-07-10 00:00:00
abstract::Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially oth...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/nutd.2017.16
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigated its effects in die...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.9
更新日期:2013-05-27 00:00:00
abstract:OBJECTIVE:In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has dem...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.49
更新日期:2016-12-12 00:00:00
abstract:BACKGROUND:Obesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, older individuals. Obesity may be associated with diminished sensitivity to nutrients. We have repor...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00139-8
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND/OBJECTIVES:Sleep duration influences weight change in children and young adults, but there is less evidence in middle-aged, and, in particular, older adults. We assessed associations between sleep duration, daytime napping and sleep disturbances, respectively, with change of weight and waist circumference in...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.32
更新日期:2016-08-15 00:00:00
abstract:OBJECTIVE:Microfibrillar-associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, which is colocalized with microfibrils in elastin networks. Its function in adipose tissue (AT) is not known. We have recently shown that the expression of MFAP5 is downregulated in AT along with weight reduction (WR) i...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.10
更新日期:2011-08-29 00:00:00
abstract:BACKGROUND/OBJECTIVES:Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal pre-pregnancy overweight (body mass index (BMI) ≥ 25 kg/m2) or GDM are associated with dietary quality or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00129-w
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVE:The gut microbiota contribute otherwise impossible metabolic functions to the human host. Shifts in the relative proportions of gut microbial communities in adults have been correlated with intestinal disease and have been associated with obesity. The aim of this study was to elucidate differences in gut micr...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.8
更新日期:2011-07-18 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vegetarian diets are inversely associated with diabetes in Westerners but their impact on Asians-whose pathophysiology differ from Westerners-is unknown. We aim to investigate the association between a vegetarian diet, change in dietary patterns and diabetes risk in a Taiwanese Buddhist population...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-018-0022-4
更新日期:2018-03-09 00:00:00
abstract:OBJECTIVE:There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.7
更新日期:2016-03-07 00:00:00
abstract::Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in patients experiencing end-stage renal disease (ESRD). It includes abnormalities in bone and mineral metabolism and vascular calcification. Hyperphosphatemia is a major risk factor leading to morbidity and mortality in patients with ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-019-0080-2
更新日期:2019-04-03 00:00:00
abstract::The sympathetic nervous system (SNS) regulates energy homeostasis in part by governing fatty acid liberation from adipose tissue. We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in ti...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.13
更新日期:2017-04-10 00:00:00
abstract:OBJECTIVES:The prevalence of obesity and diabetes in the Middle East is among the highest in the world. Valid measures of abdominal adiposity are essential to understanding the metabolic consequences of obesity. Dual-energy X-ray absorptiometry (DXA) is increasingly being utilised to assess body composition in populati...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.38
更新日期:2017-01-09 00:00:00