Abstract:
:The sympathetic nervous system (SNS) regulates energy homeostasis in part by governing fatty acid liberation from adipose tissue. We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in timing, pattern of activation, and habituation with the most dramatic contrast between visceral and subcutaneous adipose depots. Sympathetic drive toward visceral epididymal adipose is more than doubled early in weight loss and then suppressed later in the diet when weight loss plateaued. Coincident with the decline in SNS activity toward visceral adipose is an increase in activity toward subcutaneous depots indicating a switch in lipolytic sources. In response to calorie restriction, SNS activity toward retroperitoneal and brown adipose depots is unaffected. Finally, pharmacological blockage of sympathetic activity on adipose tissue using the β3-adrenergic receptor antagonist, SR59230a, suppressed loss of visceral adipose mass in response to diet. These findings indicate that SNS activity toward discrete adipose depots is dynamic and potentially hierarchical. This pattern of sympathetic activation is required for energy liberation and loss of adipose tissue in response to calorie-restricted diet.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Sipe LM,Yang C,Ephrem J,Garren E,Hirsh J,Deppmann CDdoi
10.1038/nutd.2017.13subject
Has Abstractpub_date
2017-04-10 00:00:00pages
e260issue
4issn
2044-4052pii
nutd201713journal_volume
7pub_type
杂志文章abstract:OBJECTIVES:The prevalence of obesity and diabetes in the Middle East is among the highest in the world. Valid measures of abdominal adiposity are essential to understanding the metabolic consequences of obesity. Dual-energy X-ray absorptiometry (DXA) is increasingly being utilised to assess body composition in populati...
journal_title:Nutrition & diabetes
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journal_title:Nutrition & diabetes
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journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
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abstract:BACKGROUND/OBJECTIVES:Sleep duration influences weight change in children and young adults, but there is less evidence in middle-aged, and, in particular, older adults. We assessed associations between sleep duration, daytime napping and sleep disturbances, respectively, with change of weight and waist circumference in...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
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abstract::Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in patients experiencing end-stage renal disease (ESRD). It includes abnormalities in bone and mineral metabolism and vascular calcification. Hyperphosphatemia is a major risk factor leading to morbidity and mortality in patients with ...
journal_title:Nutrition & diabetes
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journal_title:Nutrition & diabetes
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
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更新日期:2011-07-18 00:00:00
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journal_title:Nutrition & diabetes
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更新日期:2012-10-01 00:00:00
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更新日期:2014-09-01 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
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更新日期:2020-03-23 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-07-15 00:00:00
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更新日期:2015-07-20 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
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更新日期:2019-03-18 00:00:00
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journal_title:Nutrition & diabetes
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更新日期:2020-07-02 00:00:00
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更新日期:2012-09-10 00:00:00
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journal_title:Nutrition & diabetes
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更新日期:2016-06-06 00:00:00
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更新日期:2020-08-05 00:00:00
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journal_title:Nutrition & diabetes
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更新日期:2020-03-20 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
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更新日期:2013-05-27 00:00:00
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journal_title:Nutrition & diabetes
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更新日期:2016-12-12 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
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更新日期:2014-02-03 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.44
更新日期:2016-01-25 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 已发布勘误
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更新日期:2020-09-23 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-06-05 00:00:00
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journal_title:Nutrition & diabetes
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更新日期:2015-06-15 00:00:00
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journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.9
更新日期:2012-07-30 00:00:00