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Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?

Abstract：

:Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (HFD), and high carbohydrate-high fat diet (HCHHFD). We analyzed data from at least 35 articles per diet, from different research groups, to determine their effect on the development of the MS, aimed to aid researchers in choosing the model that better suits their research question; and also the best parameter that defines obesity, as there is no consensus to determine this condition in rats. For the HCHD we found a mild effect on body weight gain and fasting blood glucose levels (FBG), but significant increases in triglycerides, fasting insulin, insulin resistance and visceral fat accumulation. HFD had the greater increase in the parameters previously mentioned, followed by HCHHFD, which had a modest effect on FBG levels. Therefore, to study early stages of MS a HCHD is recommended, while HFD and HCHHFD better reproduce more severe stages of MS. We recommend the assessment of visceral fat accumulation as a good estimate for obesity in the rat.

journal_name

Nutr Diabetes

journal_title

Nutrition & diabetes

authors

Rodríguez-Correa E,González-Pérez I,Clavel-Pérez PI,Contreras-Vargas Y,Carvajal K

doi

10.1038/s41387-020-0127-4

subject

Has Abstract

pub_date

2020-07-02 00:00:00

pages

24

issue

1

issn

2044-4052

pii

10.1038/s41387-020-0127-4

journal_volume

10

pub_type

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