Abstract:
OBJECTIVE:Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is recommended. We determined the proportion of individuals with elevated CRP in whom statin therapy was not indicated, and examined predictors for elevated CRP in a multi-ethnic Asian population. DESIGN:We studied 3404 participants (Chinese, Malays and Asian-Indians) without a history of hypercholesterolemia living in Singapore (mean age±s.d.: 48.9±11.2 years). Eligibility for statin therapy was determined based on the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III (ATPIII)) guideline. CRP was measured by high-sensitivity enzyme-linked immunosorbent assay method. CRP level greater than 2 mg l(-1) was considered as elevated. RESULTS:Elevated CRP was found in 29.3% participants who were not eligible for statin therapy (n=2974). Elevated CRP was more common in females and amongst those of Malay or Asian-Indian ethnicity. Compared with participants with low CRP, those with elevated CRP were shown to have higher levels of obesity, blood pressure, triglyceride and insulin resistance (IR), but lower high-density lipoprotein cholesterol levels (all Ps<0.001). After multivariate analysis, gender (odds ratio (OR) 3.34 for females), ethnicity (Malay OR 1.57, 95% confidence interval (CI) 1.25-1.96; Asian-Indian OR 1.97, 95% CI 1.55-2.50), waist circumference (OR 1.06, 95% CI 1.05-1.07), smoking (OR 1.49, 95% CI 1.08-2.05) and IR (OR 1.14, 95% CI 1.07-1.22) were significant predictors of CRP (all Ps--values<0.05). CONCLUSION:Routine measurement of CRP identifies a substantial number of Asian individuals at risk of CHD in whom statin therapy is not currently indicated, particularly in women and certain ethnic groups (Malays and Asian Indians). Weight loss and smoking cessation are important measures to reduce the proportion of individuals with elevated CRP.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Khoo CM,Tan M,Wu Y,Wai CH,Subramaniam T,Lee J,Tai ESdoi
10.1038/nutd.2011.4subject
Has Abstractpub_date
2011-05-23 00:00:00pages
e8issn
2044-4052pii
nutd20114journal_volume
1pub_type
杂志文章abstract:OBJECTIVE:The aim of dietary modification, as a cornerstone of type 2 diabetes (T2DM) management, is to optimise metabolic control and overall health. This study describes food and nutrient intake in a sample of adults with T2DM, and compares this to recommendations, and to intake in age, sex, body mass index (BMI) and...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.2
更新日期:2014-02-03 00:00:00
abstract:BACKGROUNDS:Mitochondria plays a critical role in the development and pathogenesis of nonalcoholic fatty liver disease (NAFLD). Neohesperidin (NHP) could lower blood glucose and prevent obesity in mice. However, the direct effect of NHP on hepatic steatosis has not been reported. METHODS:Mice were fed with either a ch...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00130-3
更新日期:2020-08-05 00:00:00
abstract::Obesity and related complications are major health burdens. Almost 700 million adults are currently obese globally and the prevalence is predicted to rise towards 2030. The sudden change of lifestyle with physical inactivity and excessive calorie intake undoubtedly have a major part of the epidemic development; howeve...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.9
更新日期:2012-07-30 00:00:00
abstract:BACKGROUND:Individuals who focused on calorie counting lost more weight than those who focused on increasing vegetable and fruit (V&F) intake in a weight loss program. We now present serum carotenoid data (biomarkers of V&F intake) from both groups and test whether these biomarkers correlate with changes in weight and ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.22
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding. METHODS:Forty normal to overweight men and ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.44
更新日期:2016-01-25 00:00:00
abstract:OBJECTIVE:Microfibrillar-associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, which is colocalized with microfibrils in elastin networks. Its function in adipose tissue (AT) is not known. We have recently shown that the expression of MFAP5 is downregulated in AT along with weight reduction (WR) i...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.10
更新日期:2011-08-29 00:00:00
abstract:BACKGROUND:Aerobic exercise training is known to have beneficial effects on whole-body glucose metabolism in people with type 2 diabetes (T2D). The responses of the liver to such training are less well understood. The purpose of this study was to determine the effect of aerobic exercise training on splanchnic glucose u...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0090-0
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND/OBJECTIVES:High dietary fibre intakes may protect against obesity by influencing colonic fermentation and the colonic microbiota. Though, recent studies suggest that increased colonic fermentation contributes to adiposity. Diet influences the composition of the gut microbiota. Previous research has not evalu...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.23
更新日期:2014-06-30 00:00:00
abstract::Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially oth...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/nutd.2017.16
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evid...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,meta分析
doi:10.1038/s41387-019-0086-9
更新日期:2019-06-05 00:00:00
abstract:BACKGROUND:Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have shown that despite the presence of overt obesity and dyslipidemia in the...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0112-y
更新日期:2020-03-23 00:00:00
abstract:OBJECTIVE:There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.7
更新日期:2016-03-07 00:00:00
abstract::Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-020-0127-4
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND AND DESIGN:Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin levels induced by obesity are associated with insulin resistance and ty...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.18
更新日期:2012-09-10 00:00:00
abstract:BACKGROUND/OBJECTIVES:Aging is associated with many physiological alterations such as changes in metabolism, food intake and brain dysfunction. Possible ways to correct age-related brain dysfunction using dietary treatments still remains undeveloped. The aim of our research was to investigate whether long-term dietary ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.13
更新日期:2015-06-15 00:00:00
abstract:BACKGROUND/OBJECTIVES:Neuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.45
更新日期:2015-01-19 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vegetarian diets are inversely associated with diabetes in Westerners but their impact on Asians-whose pathophysiology differ from Westerners-is unknown. We aim to investigate the association between a vegetarian diet, change in dietary patterns and diabetes risk in a Taiwanese Buddhist population...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-018-0022-4
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND/OBJECTIVE:The objective of the study was to provide current estimates of the prevalence and trends of overweight and obesity (OW+OB) in Mexican children and adolescents. SUBJECTS/METHODS:Body mass index objectively measured was analyzed for 37 147 children and adolescents aged 0-19 years obtained in 2012 as...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.52
更新日期:2017-03-13 00:00:00
abstract:BACKGROUND/OBJECTIVES:The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS:To determine if changes in the mother's diet and adip...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-018-0027-z
更新日期:2018-04-25 00:00:00
abstract:OBJECTIVES:The prevalence of obesity and diabetes in the Middle East is among the highest in the world. Valid measures of abdominal adiposity are essential to understanding the metabolic consequences of obesity. Dual-energy X-ray absorptiometry (DXA) is increasingly being utilised to assess body composition in populati...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.38
更新日期:2017-01-09 00:00:00
abstract:OBJECTIVE:Along with the increasing prevalence of obesity and related diseases, particularly atherosclerotic diseases, metabolic syndrome (MetS) is now a common and major public health issue in many countries around the world. Adiponectin, a protein secreted by the adipose tissue, has become recognized as a key player ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.13
更新日期:2011-10-10 00:00:00
abstract::Diabetes mellitus has been associated with impaired cognitive performance, particularly in verbal memory. Mediterranean diets (MedD) may lead to improvements in overall and single cognitive functions. We hypothesised that adherence to MedD associates with better performance in verbal memory in patients with type 1 or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0111-z
更新日期:2020-04-01 00:00:00
abstract::The sympathetic nervous system (SNS) regulates energy homeostasis in part by governing fatty acid liberation from adipose tissue. We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in ti...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.13
更新日期:2017-04-10 00:00:00
abstract:OBJECTIVES:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (G...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.28
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diab...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0113-x
更新日期:2020-03-20 00:00:00
abstract:AIM:The purpose of this study was to investigate the association of dietary patterns with the risk of insulin resistance (IR), diabetes mellitus (DM), and central obesity in China. METHODS:We performed a cross-sectional study on 1432 participants, aged 40-65 years in Hangzhou, Zhejiang province, China. Dietary intake ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0120-y
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND/OBJECTIVES:Pasta as a traditional component of Mediterranean diet (MeD) in Italy has not been studied in detail in the management of body weight. This study aimed at evaluating the association of pasta intake with body mass index (BMI) and waist-to-hip ratio, in two large epidemiological datasets. SUBJECTS/...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.20
更新日期:2016-07-04 00:00:00
abstract:OBJECTIVES:Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which this hyperactivation can be reversed is uncertain, and to date there has been no demonstration of cha...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.26
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocyte-secreted hormone that is important for controlling body weight, we hypothesize...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0076-y
更新日期:2019-03-18 00:00:00
abstract::Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and d...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.19
更新日期:2016-06-06 00:00:00