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Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction.

Abstract：

BACKGROUND/OBJECTIVES:The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS:To determine if changes in the mother's diet and adiposity have long-term effects on the baby's metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering. All pups were born to lean dams fed a low fat diet but were fostered onto lean or obese dams fed a high fat diet. This study design allowed us to discern the effects of a poor diet from those of mother's adiposity and metabolism. The weaned offspring were placed on a high fat diet to test their metabolic function. RESULTS:In this feeding challenge, all male (but not female) offspring developed metabolic dysfunction. We saw increased weight gain in the pups nursed on an obesity-resistant dam fed a high fat diet, and increased pathogenesis including liver steatosis and adipose tissue inflammation, when compared to pups nursed on either obesity-prone dams on a high fat diet or lean dams on a low fat diet. CONCLUSION:Exposure to maternal over-nutrition, through the milk, is sufficient to shape offspring health outcomes in a sex- and organ-specific manner, and milk from a mother who is obesity-prone may partially protect the offspring from the insult of a poor diet.

journal_name

Nutr Diabetes

journal_title

Nutrition & diabetes

authors

Monks J,Orlicky DJ,Stefanski AL,Libby AE,Bales ES,Rudolph MC,Johnson GC,Sherk VD,Jackman MR,Williamson K,Carlson NE,MacLean PS,McManaman JL

doi

10.1038/s41387-018-0027-z

subject

Has Abstract

pub_date

2018-04-25 00:00:00

pages

18

issue

1

issn

2044-4052

pii

10.1038/s41387-018-0027-z

journal_volume

8

pub_type

杂志文章

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