Abstract:
BACKGROUND:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding. METHODS:Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days. RESULTS:Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (Pinteraction=0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52%, P=0.006, Pinteraction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol. CONCLUSION:Overfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Elshorbagy AK,Jernerén F,Samocha-Bonet D,Refsum H,Heilbronn LKdoi
10.1038/nutd.2015.44subject
Has Abstractpub_date
2016-01-25 00:00:00pages
e192issn
2044-4052pii
nutd201544journal_volume
6pub_type
杂志文章abstract:OBJECTIVE:The aim of dietary modification, as a cornerstone of type 2 diabetes (T2DM) management, is to optimise metabolic control and overall health. This study describes food and nutrient intake in a sample of adults with T2DM, and compares this to recommendations, and to intake in age, sex, body mass index (BMI) and...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.2
更新日期:2014-02-03 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocyte-secreted hormone that is important for controlling body weight, we hypothesize...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0076-y
更新日期:2019-03-18 00:00:00
abstract:OBJECTIVE:Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is recommended. We determined the proportion of individuals with elevated CRP in whom statin therapy was n...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.4
更新日期:2011-05-23 00:00:00
abstract:OBJECTIVES:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (G...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.28
更新日期:2017-05-22 00:00:00
abstract::Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and d...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.19
更新日期:2016-06-06 00:00:00
abstract:OBJECTIVE:In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has dem...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.49
更新日期:2016-12-12 00:00:00
abstract:BACKGROUND/OBJECTIVE:The objective of the study was to provide current estimates of the prevalence and trends of overweight and obesity (OW+OB) in Mexican children and adolescents. SUBJECTS/METHODS:Body mass index objectively measured was analyzed for 37 147 children and adolescents aged 0-19 years obtained in 2012 as...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.52
更新日期:2017-03-13 00:00:00
abstract:BACKGROUND/OBJECTIVES:Sleep duration influences weight change in children and young adults, but there is less evidence in middle-aged, and, in particular, older adults. We assessed associations between sleep duration, daytime napping and sleep disturbances, respectively, with change of weight and waist circumference in...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.32
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:Obesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, older individuals. Obesity may be associated with diminished sensitivity to nutrients. We have repor...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00139-8
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Delivery of nutrients directly to the small intestine, either via enteral feeding tube or by gastric bypass surgery, is associated with increased levels of appetite-suppressing and glucoregulatory hormones, including GLP-1, and reduced appetite. Achieving these changes non-invasively using for...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41387-019-0088-7
更新日期:2019-07-15 00:00:00
abstract::Obesity is associated with inflammatory macrophages in insulin responsive tissues and the resulting inflammatory response is a major contributor to insulin resistance. In insulin-producing pancreatic islets, the intra-islet accumulation of macrophages is observed in patients of type 2 diabetes (T2D), but such has not ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0103-z
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diab...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0113-x
更新日期:2020-03-20 00:00:00
abstract:BACKGROUND/OBJECTIVES:Pasta as a traditional component of Mediterranean diet (MeD) in Italy has not been studied in detail in the management of body weight. This study aimed at evaluating the association of pasta intake with body mass index (BMI) and waist-to-hip ratio, in two large epidemiological datasets. SUBJECTS/...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.20
更新日期:2016-07-04 00:00:00
abstract:OBJECTIVE:Microfibrillar-associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, which is colocalized with microfibrils in elastin networks. Its function in adipose tissue (AT) is not known. We have recently shown that the expression of MFAP5 is downregulated in AT along with weight reduction (WR) i...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.10
更新日期:2011-08-29 00:00:00
abstract:BACKGROUND/OBJECTIVES:The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS:To determine if changes in the mother's diet and adip...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-018-0027-z
更新日期:2018-04-25 00:00:00
abstract::Diabetes mellitus has been associated with impaired cognitive performance, particularly in verbal memory. Mediterranean diets (MedD) may lead to improvements in overall and single cognitive functions. We hypothesised that adherence to MedD associates with better performance in verbal memory in patients with type 1 or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0111-z
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To examine the social and behavioural correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum. DESIGN:Cross-sectional study of a random population sample. PARTICIPANTS:A total of 718 community-dwelling adults (57% female), aged 18-92 years from a regional Sou...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.20
更新日期:2012-01-16 00:00:00
abstract:OBJECTIVES:Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which this hyperactivation can be reversed is uncertain, and to date there has been no demonstration of cha...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.26
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Neuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.45
更新日期:2015-01-19 00:00:00
abstract:BACKGROUND:Individuals with type 2 diabetes (DM2) may be less successful at achieving therapeutic weight loss than their counterparts without diabetes. This study compares weight loss in a cohort of adults with DM2 or high blood sugar (D/HBS) to a cohort of adults without D/HBS. All were overweight/obese and following ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2017.32
更新日期:2017-07-10 00:00:00
abstract:BACKGROUND:Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigated its effects in die...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.9
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND/OBJECTIVES:Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal pre-pregnancy overweight (body mass index (BMI) ≥ 25 kg/m2) or GDM are associated with dietary quality or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00129-w
更新日期:2020-07-23 00:00:00
abstract::Human obesity has evolved into a global epidemic. Interestingly, a similar trend has been observed in many animal species, although diet composition, food availability and physical activity have essentially remained unchanged. This suggests a common factor-potentially an environmental factor affecting all species. Coi...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.2
更新日期:2012-03-05 00:00:00
abstract::For convenience, health practitioners and clinicians are inclined to classify people/patients as overweight or obese based on body mass index (BMI) cutoff points of 25 and 30 kg m(-2) respectively, irrespective of age and gender. The purpose of the current study was to identity whether, for the same levels of adiposit...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.36
更新日期:2015-11-30 00:00:00
abstract:BACKGROUND/OBJECTIVES:High dietary fibre intakes may protect against obesity by influencing colonic fermentation and the colonic microbiota. Though, recent studies suggest that increased colonic fermentation contributes to adiposity. Diet influences the composition of the gut microbiota. Previous research has not evalu...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.23
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:Individuals who focused on calorie counting lost more weight than those who focused on increasing vegetable and fruit (V&F) intake in a weight loss program. We now present serum carotenoid data (biomarkers of V&F intake) from both groups and test whether these biomarkers correlate with changes in weight and ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.22
更新日期:2012-10-01 00:00:00
abstract::Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-020-0127-4
更新日期:2020-07-02 00:00:00
abstract::Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially oth...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/nutd.2017.16
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND/OBJECTIVES:Aging is associated with many physiological alterations such as changes in metabolism, food intake and brain dysfunction. Possible ways to correct age-related brain dysfunction using dietary treatments still remains undeveloped. The aim of our research was to investigate whether long-term dietary ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.13
更新日期:2015-06-15 00:00:00
abstract:BACKGROUND:Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have shown that despite the presence of overt obesity and dyslipidemia in the...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0112-y
更新日期:2020-03-23 00:00:00