A proposed potential role for increasing atmospheric CO2 as a promoter of weight gain and obesity.

Abstract:

:Human obesity has evolved into a global epidemic. Interestingly, a similar trend has been observed in many animal species, although diet composition, food availability and physical activity have essentially remained unchanged. This suggests a common factor-potentially an environmental factor affecting all species. Coinciding with the increase in obesity, atmospheric CO2 concentration has increased more than 40%. Furthermore, in modern societies, we spend more time indoors, where CO2 often reaches even higher concentrations. Increased CO2 concentration in inhaled air decreases the pH of blood, which in turn spills over to cerebrospinal fluids. Nerve cells in the hypothalamus that regulate appetite and wakefulness have been shown to be extremely sensitive to pH, doubling their activity if pH decreases by 0.1 units. We hypothesize that an increased acidic load from atmospheric CO2 may potentially lead to increased appetite and energy intake, and decreased energy expenditure, and thereby contribute to the current obesity epidemic.

journal_name

Nutr Diabetes

journal_title

Nutrition & diabetes

authors

Hersoug LG,Sjödin A,Astrup A

doi

10.1038/nutd.2012.2

subject

Has Abstract

pub_date

2012-03-05 00:00:00

pages

e31

issn

2044-4052

pii

nutd20122

journal_volume

2

pub_type

杂志文章
  • Associations between cognitive performance and Mediterranean dietary pattern in patients with type 1 or type 2 diabetes mellitus.

    abstract::Diabetes mellitus has been associated with impaired cognitive performance, particularly in verbal memory. Mediterranean diets (MedD) may lead to improvements in overall and single cognitive functions. We hypothesised that adherence to MedD associates with better performance in verbal memory in patients with type 1 or ...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-020-0111-z

    authors: Kössler T,Weber KS,Wölwer W,Hoyer A,Strassburger K,Burkart V,Szendroedi J,Roden M,Müssig K,GDS Group.

    更新日期:2020-04-01 00:00:00

  • The metabolic activity of gut microbiota in obese children is increased compared with normal-weight children and exhibits more exhaustive substrate utilization.

    abstract:OBJECTIVE:The gut microbiota contribute otherwise impossible metabolic functions to the human host. Shifts in the relative proportions of gut microbial communities in adults have been correlated with intestinal disease and have been associated with obesity. The aim of this study was to elucidate differences in gut micr...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2011.8

    authors: Payne AN,Chassard C,Zimmermann M,Müller P,Stinca S,Lacroix C

    更新日期:2011-07-18 00:00:00

  • Acute effects of whey protein on energy intake, appetite and gastric emptying in younger and older, obese men.

    abstract:BACKGROUND:Obesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, older individuals. Obesity may be associated with diminished sensitivity to nutrients. We have repor...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-020-00139-8

    authors: Oberoi A,Giezenaar C,Jensen C,Lange K,Hausken T,Jones KL,Horowitz M,Chapman I,Soenen S

    更新日期:2020-10-02 00:00:00

  • Comparative effectiveness of a portion-controlled meal replacement program for weight loss in adults with and without diabetes/high blood sugar.

    abstract:BACKGROUND:Individuals with type 2 diabetes (DM2) may be less successful at achieving therapeutic weight loss than their counterparts without diabetes. This study compares weight loss in a cohort of adults with DM2 or high blood sugar (D/HBS) to a cohort of adults without D/HBS. All were overweight/obese and following ...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2017.32

    authors: Coleman CD,Kiel JR,Mitola AH,Arterburn LM

    更新日期:2017-07-10 00:00:00

  • Randomized trial of nutrition education added to internet-based information and exercise at the work place for weight loss in a racially diverse population of overweight women.

    abstract:OBJECTIVE:Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2013.39

    authors: Carnie A,Lin J,Aicher B,Leon B,Courville AB,Sebring NG,de Jesus J,Dellavalle DM,Fitzpatrick BD,Zalos G,Powell-Wiley TM,Chen KY,Cannon RO 3rd

    更新日期:2013-12-23 00:00:00

  • The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations.

    abstract:OBJECTIVES:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (G...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2017.28

    authors: Wang T,Ma X,Tang T,Higuchi K,Peng D,Zhang R,Chen M,Yan J,Wang S,Yan D,He Z,Jiang F,Bao Y,Jia W,Ishida K,Hu C

    更新日期:2017-05-22 00:00:00

  • Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction.

    abstract::The sympathetic nervous system (SNS) regulates energy homeostasis in part by governing fatty acid liberation from adipose tissue. We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in ti...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2017.13

    authors: Sipe LM,Yang C,Ephrem J,Garren E,Hirsh J,Deppmann CD

    更新日期:2017-04-10 00:00:00

  • The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation.

    abstract:BACKGROUND:Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have shown that despite the presence of overt obesity and dyslipidemia in the...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-020-0112-y

    authors: Cirera S,Taşöz E,Juul Jacobsen M,Schumacher-Petersen C,Østergaard Christoffersen B,Kaae Kirk R,Pagh Ludvigsen T,Hvid H,Duelund Pedersen H,Høier Olsen L,Fredholm M

    更新日期:2020-03-23 00:00:00

  • Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice.

    abstract:BACKGROUND AND DESIGN:Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin levels induced by obesity are associated with insulin resistance and ty...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2012.18

    authors: Kandasamy AD,Sung MM,Boisvenue JJ,Barr AJ,Dyck JR

    更新日期:2012-09-10 00:00:00

  • Correction: The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes.

    abstract::Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly. ...

    journal_title:Nutrition & diabetes

    pub_type: 已发布勘误

    doi:10.1038/s41387-020-00137-w

    authors: Matsushita M,Muramoto A,Nomura E,Eguchi Y,Kato A,Sano Y,Kabayama M,Arakawa M,Oguma Y,Yabe D,Matsunaga M,Yatsuya H,Arima H,Tsushita K

    更新日期:2020-09-23 00:00:00

  • The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.

    abstract:BACKGROUND:Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigated its effects in die...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2013.9

    authors: Wargent ET,Zaibi MS,Silvestri C,Hislop DC,Stocker CJ,Stott CG,Guy GW,Duncan M,Di Marzo V,Cawthorne MA

    更新日期:2013-05-27 00:00:00

  • Altered functional connectivity within the central reward network in overweight and obese women.

    abstract:BACKGROUND/OBJECTIVES:Neuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2014.45

    authors: Coveleskie K,Gupta A,Kilpatrick LA,Mayer ED,Ashe-McNalley C,Stains J,Labus JS,Mayer EA

    更新日期:2015-01-19 00:00:00

  • Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons.

    abstract:OBJECTIVE:Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripheral mechanisms. In the hypothalamus, the two systems were suggested to interact. To investigate such interplay also in non-hypothalamic tissues, we evaluated endocannabinoid levels in obese OE-NPY(DβH) mice, which overexpr...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2015.1

    authors: Vähätalo LH,Ruohonen ST,Mäkelä S,Ailanen L,Penttinen AM,Stormi T,Kauko T,Piscitelli F,Silvestri C,Savontaus E,Di Marzo V

    更新日期:2015-04-27 00:00:00

  • Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction.

    abstract:BACKGROUND/OBJECTIVES:The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS:To determine if changes in the mother's diet and adip...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-018-0027-z

    authors: Monks J,Orlicky DJ,Stefanski AL,Libby AE,Bales ES,Rudolph MC,Johnson GC,Sherk VD,Jackman MR,Williamson K,Carlson NE,MacLean PS,McManaman JL

    更新日期:2018-04-25 00:00:00

  • Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes.

    abstract:BACKGROUND:Aerobic exercise training is known to have beneficial effects on whole-body glucose metabolism in people with type 2 diabetes (T2D). The responses of the liver to such training are less well understood. The purpose of this study was to determine the effect of aerobic exercise training on splanchnic glucose u...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-019-0090-0

    authors: Gregory JM,Muldowney JA,Engelhardt BG,Tyree R,Marks-Shulman P,Silver HJ,Donahue EP,Edgerton DS,Winnick JJ

    更新日期:2019-09-02 00:00:00

  • The need to redefine age- and gender-specific overweight and obese body mass index cutoff points.

    abstract::For convenience, health practitioners and clinicians are inclined to classify people/patients as overweight or obese based on body mass index (BMI) cutoff points of 25 and 30 kg m(-2) respectively, irrespective of age and gender. The purpose of the current study was to identity whether, for the same levels of adiposit...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2015.36

    authors: Nevill AM,Metsios GS

    更新日期:2015-11-30 00:00:00

  • Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway.

    abstract:OBJECTIVES:The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and the underlying mechanism. METHODS:Information about the chemical compositions of GD was obtained from extensive literature reports. Potential target genes were predicted using PharmMapper and analyzed using Kyoto Encyclopedia...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-020-00134-z

    authors: Xu W,Lu Z,Wang X,Cheung MH,Lin M,Li C,Dong Y,Liang C,Chen Y

    更新日期:2020-08-14 00:00:00

  • Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?

    abstract::Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章,评审

    doi:10.1038/s41387-020-0127-4

    authors: Rodríguez-Correa E,González-Pérez I,Clavel-Pérez PI,Contreras-Vargas Y,Carvajal K

    更新日期:2020-07-02 00:00:00

  • Microfibrillar-associated protein 5 is linked with markers of obesity-related extracellular matrix remodeling and inflammation.

    abstract:OBJECTIVE:Microfibrillar-associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, which is colocalized with microfibrils in elastin networks. Its function in adipose tissue (AT) is not known. We have recently shown that the expression of MFAP5 is downregulated in AT along with weight reduction (WR) i...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2011.10

    authors: Vaittinen M,Kolehmainen M,Schwab U,Uusitupa M,Pulkkinen L

    更新日期:2011-08-29 00:00:00

  • Diet-induced changes in brain structure and behavior in old gerbils.

    abstract:BACKGROUND/OBJECTIVES:Aging is associated with many physiological alterations such as changes in metabolism, food intake and brain dysfunction. Possible ways to correct age-related brain dysfunction using dietary treatments still remains undeveloped. The aim of our research was to investigate whether long-term dietary ...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2015.13

    authors: Goncharova K,Skibo G,Kovalenko T,Osadchenko I,Ushakova G,Vovchanskii M,Pierzynowski SG

    更新日期:2015-06-15 00:00:00

  • A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes.

    abstract::Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially oth...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章,评审

    doi:10.1038/nutd.2017.16

    authors: Chia JSJ,McRae JL,Kukuljan S,Woodford K,Elliott RB,Swinburn B,Dwyer KM

    更新日期:2017-05-15 00:00:00

  • Vegetarian diets and risk of hospitalisation or death with diabetes in British adults: results from the EPIC-Oxford study.

    abstract:BACKGROUND:The global prevalence of diabetes is high and rapidly increasing. Some previous studies have found that vegetarians might have a lower risk of diabetes than non-vegetarians. OBJECTIVE:We examined the association between vegetarianism and risk of hospitalisation or death with diabetes in a large, prospective...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-019-0074-0

    authors: Papier K,Appleby PN,Fensom GK,Knuppel A,Perez-Cornago A,Schmidt JA,Tong TYN,Key TJ

    更新日期:2019-02-25 00:00:00

  • Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects.

    abstract:OBJECTIVES:Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease. However, the underlying mechanism is still elusive. DESIGN:We tested the effect of EVOO, added to Mediterranean-type meal, on post-prandial glycemic and l...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2015.23

    authors: Violi F,Loffredo L,Pignatelli P,Angelico F,Bartimoccia S,Nocella C,Cangemi R,Petruccioli A,Monticolo R,Pastori D,Carnevale R

    更新日期:2015-07-20 00:00:00

  • Effects of the resistant starch on glucose, insulin, insulin resistance, and lipid parameters in overweight or obese adults: a systematic review and meta-analysis.

    abstract:BACKGROUND:The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evid...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41387-019-0086-9

    authors: Wang Y,Chen J,Song YH,Zhao R,Xia L,Chen Y,Cui YP,Rao ZY,Zhou Y,Zhuang W,Wu XT

    更新日期:2019-06-05 00:00:00

  • Adherence to a Mediterranean-style eating pattern and risk of diabetes in a U.S. prospective cohort study.

    abstract:BACKGROUND:A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diab...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/s41387-020-0113-x

    authors: O'Connor LE,Hu EA,Steffen LM,Selvin E,Rebholz CM

    更新日期:2020-03-20 00:00:00

  • Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans.

    abstract:BACKGROUND/OBJECTIVES:High dietary fibre intakes may protect against obesity by influencing colonic fermentation and the colonic microbiota. Though, recent studies suggest that increased colonic fermentation contributes to adiposity. Diet influences the composition of the gut microbiota. Previous research has not evalu...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2014.23

    authors: Fernandes J,Su W,Rahat-Rozenbloom S,Wolever TM,Comelli EM

    更新日期:2014-06-30 00:00:00

  • Central obesity and smoking are key modifiable risk factors for elevated C-reactive protein in Asian individuals who are not eligible for statin therapy.

    abstract:OBJECTIVE:Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is recommended. We determined the proportion of individuals with elevated CRP in whom statin therapy was n...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2011.4

    authors: Khoo CM,Tan M,Wu Y,Wai CH,Subramaniam T,Lee J,Tai ES

    更新日期:2011-05-23 00:00:00

  • Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years.

    abstract:OBJECTIVE:There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2016.7

    authors: DeChristopher LR,Uribarri J,Tucker KL

    更新日期:2016-03-07 00:00:00

  • Associations between sleep characteristics and weight gain in an older population: results of the Heinz Nixdorf Recall Study.

    abstract:BACKGROUND/OBJECTIVES:Sleep duration influences weight change in children and young adults, but there is less evidence in middle-aged, and, in particular, older adults. We assessed associations between sleep duration, daytime napping and sleep disturbances, respectively, with change of weight and waist circumference in...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2016.32

    authors: Kowall B,Lehnich AT,Erbel R,Moebus S,Jöckel KH,Stang A

    更新日期:2016-08-15 00:00:00

  • Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention.

    abstract:OBJECTIVES:Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which this hyperactivation can be reversed is uncertain, and to date there has been no demonstration of cha...

    journal_title:Nutrition & diabetes

    pub_type: 杂志文章

    doi:10.1038/nutd.2014.26

    authors: Deckersbach T,Das SK,Urban LE,Salinardi T,Batra P,Rodman AM,Arulpragasam AR,Dougherty DD,Roberts SB

    更新日期:2014-09-01 00:00:00