Investigating the parameters affecting the stability of superparamagnetic iron oxide-loaded nanoemulsion using artificial neural networks.

abstract：:Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree of crystallinity and melted at lower temperatures. Melting...

journal_title：AAPS PharmSciTech

authors： Bikiaris DN,Papageorgiou GZ,Papadimitriou SA,Karavas E,Avgoustakis K

更新日期：2009-01-01 00:00:00

abstract：:Risedronate sodium (RS) is a potent inhibitor of bone resorption, having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions while keeping in an upright posture for at least 30 min to diminish common gastroesophageal injuries. To surmount suc...

journal_title：AAPS PharmSciTech

authors： Elkady OA,Tadros MI,El-Laithy HM

更新日期：2019-12-05 00:00:00

abstract：:Successful pellet production has been reported in literature with cross-linked poly(vinylpyrrolidone), Polyplasdone® XL-10 and INF-10. In the present study, a quality by experimental design approach was used to assess several formulation and process parameter effects on the characteristics of Polyplasdone® XL-10 pelle...

journal_title：AAPS PharmSciTech

authors： Saripella KK,Loka NC,Mallipeddi R,Rane AM,Neau SH

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this study was to compare the effects of denaturation by microwave irradiation on release properties of 2 physically different proteins. Matrices were prepared from water-soluble bovine serum albumin loaded with metoclopramide and sorbed with adequate amount of moisture were thermally denatured in a mic...

journal_title：AAPS PharmSciTech

authors： Qasem RJ

更新日期：2006-03-01 00:00:00

abstract：:Nanoparticles, of the poorly water-soluble drug, itraconazole (ITZ), were produced by the Advanced Evaporative Precipitation into Aqueous Solution process (Advanced EPAS). This process combines emulsion templating and EPAS processing to provide improved control over the size distribution of precipitated particles. Spe...

journal_title：AAPS PharmSciTech

authors： Bosselmann S,Nagao M,Chow KT,Williams RO 3rd

更新日期：2012-09-01 00:00:00

abstract：:The present study focuses on the development and characterization of nanosuspension of a poorly soluble drug, silver sulfadiazine (SSD) incorporated in Aloe vera gel (AV-gel) for improving its therapeutic efficacy. The SSD solution in ammonia was subjected to nanoprecipitation in surfactant solution and particle size ...

journal_title：AAPS PharmSciTech

authors： Barkat MA,Harshita,Ahmad I,Ali R,Singh SP,Pottoo FH,Beg S,Ahmad FJ

更新日期：2017-11-01 00:00:00

abstract：:In a systematic effort to develop a dual-function intravaginal spermicide as well as a drug delivery vehicle against sexually transmitted pathogens, a submicron particle size (30-80 nm), lipophilic and spermicidal gel-microemulsion (viz GM-144) containing the pharmaceutical excipients propylene glycol, Captex 300, Cre...

journal_title：AAPS PharmSciTech

authors： D'Cruz OJ,Yiv SH,Uckun FM

更新日期：2001-04-09 00:00:00

abstract：:An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive ...

journal_title：AAPS PharmSciTech

authors： Shah PV,Rajput SJ

更新日期：2018-04-01 00:00:00

abstract：:Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC)...

journal_title：AAPS PharmSciTech

authors： Faroongsarng D,Sunpaweravong S,Raksawong A

更新日期：2019-03-18 00:00:00

abstract：:Posaconazole is a triazole antifungal drug that with extremely poor aqueous solubility. Up to now, this drug can be administered via intravenous injection and oral suspension. However, its oral bioavailability is greatly limited by the dissolution rate of the drug. This study aimed to improve water solubility and diss...

journal_title：AAPS PharmSciTech

authors： Tang P,Wang L,Ma X,Xu K,Xiong X,Liao X,Li H

更新日期：2017-01-01 00:00:00

abstract：:This work aimed to develop a fast-dissolving film made of low dextrose equivalent maltodextrins (MDX) containing nicotine hydrogen tartrate salt (NHT). Particular attention was given to the selection of the suitable taste-masking agent (TMA) and the characterisation of the ductility and flexibility under different mec...

journal_title：AAPS PharmSciTech

authors： Cilurzo F,Cupone IE,Minghetti P,Buratti S,Selmin F,Gennari CG,Montanari L

更新日期：2010-12-01 00:00:00

abstract：:One-third of the population of the USA suffers from metabolic syndrome (MetS). Treatment of patients with MetS regularly includes drugs prescribed simultaneously to treat diabetes and cardiovascular diseases. Therefore, the development of novel multidrug formulations is recommended. However, the main problem with thes...

journal_title：AAPS PharmSciTech

authors： Cruz-Angeles J,Videa M,Martínez LM

更新日期：2019-03-18 00:00:00

abstract：:The aim of this work was to study the effect of the type of substituent of the cellulose ethers and the molecular mass on the state and dynamics of water in the respective hydrogels to specify the quantity of adsorbed water on the polymers or, more explicitly, to calculate the average number of water molecules bound t...

journal_title：AAPS PharmSciTech

authors： Baumgartner S,Lahajnar G,Sepe A,Kristl J

更新日期：2002-01-01 00:00:00

abstract：:Two different types of derivatives of theophylline (Th-H) incorporating ethyleneoxy groups into the promoiety have been synthesized. One is a soft alkyl type where N-methyl-N-methoxyethyleneoxycarbonylaminomethyl chlorides have been used to alkylate Th-H in the 7 position. The other is in an acyl type where methoxyeth...

journal_title：AAPS PharmSciTech

authors： Majumdar S,Mueller-Spaeth M,Sloan KB

更新日期：2012-09-01 00:00:00

abstract：:The development of an oral formulation that ensures increased bioavailability of drugs is a great challenge for pharmaceutical scientists. Among many oral formulation systems, a drug delivery system employing superporous networks was developed to provide a prolonged gastro-retention time as well as improved bioavailab...

journal_title：AAPS PharmSciTech

authors： Le TN,Her J,Sim T,Jung CE,Kang JK,Oh KT

更新日期：2020-11-12 00:00:00

abstract：:The use of amorphous solid dispersions to improve the bioavailability of active ingredients from the BCS II and IV classifications continues to gain interest in the pharmaceutical industry. Over the last decade, methods for generating amorphous solid dispersions have been well established in commercially available pro...

journal_title：AAPS PharmSciTech

authors： Huang S,Williams RO 3rd

更新日期：2018-07-01 00:00:00

abstract：:The airways are verified as a relevant route to improve antibody therapeutic index with superior lung concentration but limited passage into systemic blood stream. The current research aimed to process spray-dried (SD) powder of Infliximab to assess the feasibility of respiratory delivery of antibody for local suppres...

journal_title：AAPS PharmSciTech

authors： Faghihi H,Najafabadi AR,Daman Z,Ghasemian E,Montazeri H,Vatanara A

更新日期：2019-02-26 00:00:00

abstract：:Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at ...

journal_title：AAPS PharmSciTech

authors： Terry TL,Givens BE,Rodgers VGJ,Salem AK

更新日期：2019-01-02 00:00:00

abstract：:The current investigation aimed at formulating self-microemulsifying drug delivery system (SMEDDS) to ameliorate oral bioavailability of a hydrophobic functional ingredient, limonene. Solubility test, compatibility test, and pseudo-ternary phase diagrams (PTPD) were adopted to screen the optimal compositions of limone...

journal_title：AAPS PharmSciTech

authors： Zhu Y,Xu W,Zhang J,Liao Y,Firempong CK,Adu-Frimpong M,Deng W,Zhang H,Yu J,Xu X

更新日期：2019-03-26 00:00:00

abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...

journal_title：AAPS PharmSciTech

authors： Verma S,Rudraraju VS

更新日期：2015-10-01 00:00:00

abstract：:Present investigation deals with formulation and evaluation of tamoxifen (TMX)-loaded liquid crystalline nanoparticles (TMX-LCNPs) for improving oral bioavailability and safety of the existing treatment. Hexagonal Glyceryl monooleate-based TMX-LCNPs (GLCNPs) and Phytantriol-based TMX-LCNPs (PLCNPs) were prepared by di...

journal_title：AAPS PharmSciTech

authors： Jain S,Heeralal B,Swami R,Swarnakar NK,Kushwah V

更新日期：2018-01-01 00:00:00

abstract：:Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT relea...

journal_title：AAPS PharmSciTech

authors： Pongjanyakul T,Kanjanabat S

更新日期：2012-06-01 00:00:00

abstract：:Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection ...

journal_title：AAPS PharmSciTech

authors： Li L,Li W,Sun J,Zhang H,Gao J,Guo F,Yang X,Zhang X,Li Y,Zheng A

更新日期：2018-04-01 00:00:00

abstract：:This work was aimed at evaluating the effect of a pharmaceutical cationic exchange resin (Amberlite IRP-69) on the properties of controlled release matrices using Methocel K4M (HPMC) or Ethocel 7cP (EC) as matrix formers. Diphenhydramine hydrochloride (DPH), which was cationic and water soluble, was chosen as a model ...

journal_title：AAPS PharmSciTech

authors： Akkaramongkolporn P,Ngawhirunpat T,Nunthanid J,Opanasopit P

更新日期：2008-01-01 00:00:00

abstract：:The present investigation was aimed at developing and optimizing a simple aqueous tablet-coating formulation and its process. 5-Fluorouracil (5-FU) was used to ascertain the relative lipophilic/hydrophilic behavior of the coating system. Optimization was performed by evaluating the adhesive force strength and cohesive...

journal_title：AAPS PharmSciTech

authors： Rai PR,Tiwary AK,Rana V

更新日期：2012-06-01 00:00:00

abstract：:The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and Eudragit RS100 as film-forming polymers. Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in firs...

journal_title：AAPS PharmSciTech

authors： Gohel MC,Nagori SA

更新日期：2009-01-01 00:00:00

abstract：:For the prediction of the air and product temperatures, the product moisture, and the air humidity during a coating process in a Bohle Lab-Coater, a model was developed. The purpose of this work was to determine the limit moisture, the critical moisture, and the constant for the exchange rate between both zones and to...

journal_title：AAPS PharmSciTech

authors： Page S,Baumann KH,Kleinebudde P

更新日期：2006-05-05 00:00:00

abstract：:Celecoxib (CXB) is a poorly aqueous solubility sulfonamide non-steroidal anti-inflammatory drug (NSAID). Hence, the formulation of CXB was selected for solubilization and bioavailability. To find out suitable formulation for microemulsion, the solubility of CXB in triacetin (oil phase), Tween 80 (surfactant), and Tran...

journal_title：AAPS PharmSciTech

authors： Cao M,Ren L,Chen G

更新日期：2017-08-01 00:00:00

abstract：:The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio...

journal_title：AAPS PharmSciTech

authors： Douroumis DD,Gryczke A,Schminke S

更新日期：2011-03-01 00:00:00

abstract：:Amylin is a pancreatic hormone that plays important roles in overall metabolism and in glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable for patients with diabetes who need to avoid glucose excursions. Protein conjugation with polyethylene glycol (PEG) has lon...

journal_title：AAPS PharmSciTech

authors： Guerreiro LH,Guterres MF,Melo-Ferreira B,Erthal LC,Rosa Mda S,Lourenço D,Tinoco P,Lima LM

更新日期：2013-09-01 00:00:00