Highly Soluble Glimepiride and Irbesartan Co-amorphous Formulation with Potential Application in Combination Therapy.

abstract：:One of the current methods for cycle optimization in primary drying to is develop a graphical design space based on quality by design (QbD). In order to construct the design space, the vial heat transfer coefficient (Kv) is needed. This paper investigated experimental factors that can affect the Kv result, examined th...

journal_title：AAPS PharmSciTech

authors： Wegiel LA,Ferris SJ,Nail SL

更新日期：2018-05-01 00:00:00

abstract：:Transcutaneous immunization using a microneedle device presents a promising alternative to syringe-based injection of vaccines. The aim of this study was to investigate the effective immune response elicited after application of tetanus toxoid antigen-loaded dissolvable microneedles (TT-MN) in mice model. Dissolvable ...

journal_title：AAPS PharmSciTech

authors： Pattarabhiran SP,Saju A,Sonawane KR,Manimaran R,Bhatnagar S,Roy G,Kulkarni RB,Venuganti VVK

更新日期：2019-07-22 00:00:00

abstract：:The study was designed to build up a database for the evaluation of the self-emulsifying lipid formulations performance. A standard assessment method was constructed to evaluate the self-emulsifying efficiency of the formulations based on five parameters including excipients miscibility, spontaneity, dispersibility, h...

journal_title：AAPS PharmSciTech

authors： Shahba AA,Mohsin K,Alanazi FK

更新日期：2012-06-01 00:00:00

abstract：:MUC1 gene encodes a transmembrane mucin glycoprotein that is overexpressed in human breast cancer and colon cancer. The objective of this study was to develop an in situ gel delivery system containing paclitaxel (PTX) and mucoadhesives for sustained and targeted delivery of anticancer drugs. The delivery system consis...

journal_title：AAPS PharmSciTech

authors： Jauhari S,Dash AK

更新日期：2006-06-02 00:00:00

abstract：:Bottles and carboys are used for frozen storage and transport of biopharmaceutical formulations under a wide range of conditions. The quality of freezing and thawing in these systems has been questioned due to the formation of heterogeneous ice structures and deformation of containers. This work shows that during free...

journal_title：AAPS PharmSciTech

authors： Duarte A,Rego P,Ferreira A,Dias P,Geraldes V,Rodrigues MA

更新日期：2020-09-01 00:00:00

abstract：:A target product profile (TPP) describes how a product will be utilized by the end user. A systematically developed TPP can ensure alignment of objectives across company departments, accelerate development timelines, minimize development risks, and eventually lead to an optimal product. A TPP is particularly important...

journal_title：AAPS PharmSciTech

authors： Lambert WJ

更新日期：2010-09-01 00:00:00

abstract：:This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200). Critical quality attributes (CQAs) or associated performance indicators of the coated tablets were measured w...

journal_title：AAPS PharmSciTech

authors： Teckoe J,Mascaro T,Farrell TP,Rajabi-Siahboomi AR

更新日期：2013-06-01 00:00:00

abstract：:In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced ...

journal_title：AAPS PharmSciTech

authors： Rachid O,Simons KJ,Rawas-Qalaji M

更新日期：2018-11-01 00:00:00

abstract：:An innovative and simple methodology has been developed and used for the evaluation of mucoadhesive properties of several polymers by means of sound speed measurements using high-resolution acoustic spectroscopy. In systems made of polymers in water, variations in hydration shell of polymeric chains determine changes ...

journal_title：AAPS PharmSciTech

authors： Cespi M,Bonacucina G,Mencarelli G,Giorgioni G,Palmieri GF

更新日期：2010-09-01 00:00:00

abstract：:This work aimed to develop a fast-dissolving film made of low dextrose equivalent maltodextrins (MDX) containing nicotine hydrogen tartrate salt (NHT). Particular attention was given to the selection of the suitable taste-masking agent (TMA) and the characterisation of the ductility and flexibility under different mec...

journal_title：AAPS PharmSciTech

authors： Cilurzo F,Cupone IE,Minghetti P,Buratti S,Selmin F,Gennari CG,Montanari L

更新日期：2010-12-01 00:00:00

abstract：:To ensure consistency of clinical outcomes, orally inhaled therapies must exhibit consistent delivered dose and aerosol properties at the time of manufacturing, throughout storage, and during various patient-use conditions. Achieving consistency across these scenarios has presented a significant challenge, especially ...

journal_title：AAPS PharmSciTech

authors： Doty A,Schroeder J,Vang K,Sommerville M,Taylor M,Flynn B,Lechuga-Ballesteros D,Mack P

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to apply quality by design (QbD) for pharmaceutical development of felodipine solid mixture (FSM) containing hydrophilic carriers and/or polymeric surfactants, for easier development of controlled-release tablets of felodipine. The material attributes, the process parameters (CPP), and the cr...

journal_title：AAPS PharmSciTech

authors： Basalious EB,El-Sebaie W,El-Gazayerly O

更新日期：2011-09-01 00:00:00

abstract：:The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Kiang YH,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:Intra-periodontal pocket drug delivery systems, such as liquid crystalline systems, are widely utilized improving the drug release control and the therapy. Propolis is used in the treatment of periodontal diseases, reducing the inflammatory and infectious conditions. Iron oxide magnetic nanoparticles (MNPs) can improv...

journal_title：AAPS PharmSciTech

authors： de Alcântara Sica de Toledo L,Rosseto HC,Dos Santos RS,Spizzo F,Del Bianco L,Montanha MC,Esposito E,Kimura E,Bonfim-Mendonça PS,Svidzinski TIE,Cortesi R,Bruschi ML

更新日期：2018-10-01 00:00:00

abstract：:Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the large armamentarium of drugs available for the management of high blood pressure, low oral availability is an ongoing challenge. Researchers are constantly developing alt...

journal_title：AAPS PharmSciTech

authors： Ita K,Ashong S

更新日期：2020-01-06 00:00:00

abstract：:The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...

journal_title：AAPS PharmSciTech

authors： Kowapradit J,Opanasopit P,Ngawhirunpat T,Apirakaramwong A,Rojanarata T,Ruktanonchai U,Sajomsang W

更新日期：2010-06-01 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:Objective of the study was to design an injectable microsphere preparation with high drug loading of bupivacaine for prolonged release and local anesthetic. PLA or PLGA was used as the biodegradable matrix material to fabricate microspheres with the o/w emulsification-solvent evaporation method. The characterization o...

journal_title：AAPS PharmSciTech

authors： Xu J,Bai Y,Li X,Wei Z,Sun L,Yu H,Xu H

更新日期：2021-01-06 00:00:00

abstract：:Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal bioadhesive films of clotrimazole for oral candidiasis. The film was designed to release the drug...

journal_title：AAPS PharmSciTech

authors： Singh S,Jain S,Muthu MS,Tiwari S,Tilak R

更新日期：2008-01-01 00:00:00

abstract：:This study examined the effect of rotor speed, amount of water sprayed, and atomizing air pressure on the geometric mean diameter and geometric standard deviation of pellets produced in a fluid-bed rotor granulator using a 23 factorial design and an optimization technique. Pellets were prepared by wet granulation. Equ...

journal_title：AAPS PharmSciTech

authors： Korakianiti ES,Rekkas DM,Dallas PP,Choulis NH

更新日期：2000-12-01 00:00:00

abstract：:Solubility challenge for a poorly water-soluble drug gets further intensified when it is weakly ionic because the most common solubility enhancement technique, salt formation, becomes less feasible. Salt screening for such drugs often concludes with either a difficult to crystalize salt or an unstable salt, leading th...

journal_title：AAPS PharmSciTech

authors： Nair R,Lamare I,Tiwari NK,Ravi PR,Pillai R

更新日期：2018-01-01 00:00:00

abstract：:The reliable in-line monitoring of pharmaceutical processes has been regarded as a key tool toward the full implementation of process analytical technology. In this study, near-infrared (NIR) spectroscopy was examined for use as an in-line monitoring method of the paracetamol cooling crystallization process. The drug ...

journal_title：AAPS PharmSciTech

authors： Wang IC,Lee MJ,Seo DY,Lee HE,Choi Y,Kim WS,Kim CS,Jeong MY,Choi GJ

更新日期：2011-06-01 00:00:00

abstract：:Hard capsules are made from gelatin, an organic polymer obtained through the hydrolysis of collagen present in animal tissues. Gelatin can be degraded by microorganisms and some strategies can be used to control contaminating micro-organisms. Gamma irradiation is considered as an effective sterilization method; howeve...

journal_title：AAPS PharmSciTech

authors： Rodrigues JT,Neto FNS,Ferreira MF,Naves PLF,Guilherme LR

更新日期：2019-05-20 00:00:00

abstract：:The purpose of this research was to compare the viscoelastic properties of several neutral and anionic polysaccharide polymers with their mucociliary transport rates (MTR) across explants of ciliated bovine tracheal tissue to identify rheologic parameters capable of predicting the extent of reduction in mucociliary tr...

journal_title：AAPS PharmSciTech

authors： Shah AJ,Donovan MD

更新日期：2007-04-20 00:00:00

abstract：:The purpose of this research was to evaluate the relation between preferential direction of pores and mechanical strength of cubic starch compacts. The preferential pore direction was quantified in SEM images of cross sections of starch compacts using a previously described algorithm for determination of the quotient ...

journal_title：AAPS PharmSciTech

authors： Wu YS,van Vliet LJ,Frijlink HW,Stokroos I,van der Voort Maarschalk K

更新日期：2008-01-01 00:00:00

abstract：:Phase transformations in formulations can lead to instability in physicochemical, biopharmaceutical, and processing properties of products. The influences of formulation design on the optimal dosage forms should be specified. The aim here was to investigate whether excipients with different water sorption behavior aff...

journal_title：AAPS PharmSciTech

authors： Airaksinen S,Karjalainen M,Kivikero N,Westermarck S,Shevchenko A,Rantanen J,Yliruusi J

更新日期：2005-10-06 00:00:00

abstract：:The purpose of this research was to use inline real-time near-infrared (NIR) to measure the moisture content of granules manufactured using a commercial production scale continuous twin-screw granulator fluid-bed dryer milling process. A central composite response surface statistical design was used to study the effec...

journal_title：AAPS PharmSciTech

authors： Chablani L,Taylor MK,Mehrotra A,Rameas P,Stagner WC

更新日期：2011-12-01 00:00:00

abstract：:The purpose of this research was to evaluate a new wireless and battery-free sensor technology for invasive product temperature measurement during freeze-drying. Product temperature is the most critical process parameter in a freeze-drying process, in particular during primary drying. The product temperature over time...

journal_title：AAPS PharmSciTech

authors： Schneid S,Gieseler H

更新日期：2008-01-01 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:The aim of the work is to develop a data fusion model using near-infrared (NIR) and process parameters for the predictions of drug dissolution from controlled release multiparticulate beads. Using a design of experiments, ciprofloxacin-coated beads were manufactured and critical process parameters such as air volume, ...

journal_title：AAPS PharmSciTech

authors： Ibrahim A,Kothari BH,Fahmy R,Hoag SW

更新日期：2019-06-18 00:00:00