Excipient selection can significantly affect solid-state phase transformation in formulation during wet granulation.

abstract：:The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and Eudragit RS100 as film-forming polymers. Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in firs...

journal_title：AAPS PharmSciTech

authors： Gohel MC,Nagori SA

更新日期：2009-01-01 00:00:00

abstract：:The aim of this research was to design and evaluate a hydrophilic matrix system for sustained release of glipizide, a weakly acidic poor soluble drug. A combination of inclusion complexation and microenvironmental pH modification techniques was utilized to improve the dissolution and pH-independent release of glipizid...

journal_title：AAPS PharmSciTech

authors： Huang J,Lin H,Peng B,Huang Q,Shuai F,Xie Y

更新日期：2018-07-01 00:00:00

abstract：:Rheumatoid arthritis is an autoimmune disease that leads to cartilage destruction, synovial joint inflammation, and bacterial joint/bone infections. In the present work, methotrexate and minocycline-loaded nanoparticles (MMNPs) were developed with an aim to provide relief from inflammation and disease progression/join...

journal_title：AAPS PharmSciTech

authors： Janakiraman K,Krishnaswami V,Sethuraman V,Natesan S,Rajendran V,Kandasamy R

更新日期：2019-12-23 00:00:00

abstract：:The purpose of this research was to develop and evaluate different preparations of sustained delivery systems, using Carbopols as carriers, in the form of matrices and three-layer tablets with isosorbite mononitrate. Matrix tablets were prepared by direct compression whereas three-layer tablets were prepared by compre...

journal_title：AAPS PharmSciTech

authors： Efentakis M,Peponaki C

更新日期：2008-01-01 00:00:00

abstract：:The aim of the study is to examine thermal behavior of water within reticulated structure of bacterial cellulose (BC) films by sub-ambient differential scanning calorimetry (DSC). BC films with different carbon source, either manitol (BC (a)) or glycerol (BC (b)), were produced by Acetobacter xylinum using Hestrin and...

journal_title：AAPS PharmSciTech

authors： Kaewnopparat S,Sansernluk K,Faroongsarng D

更新日期：2008-01-01 00:00:00

abstract：:The objective of the present study was to develop fast dissolving oral film of the antipsychotic drug, flupentixol dihydrochloride, to enhance its bioavailability, optimize its therapeutic effect when used to treat depression with anxiety, and increase the convenience and compliance by the mentally ill, developmentall...

journal_title：AAPS PharmSciTech

authors： Abdelbary A,Bendas ER,Ramadan AA,Mostafa DA

更新日期：2014-12-01 00:00:00

abstract：:Drug delivery to deep-seated tissues such as bone has been a major complication till date. This preferential drug delivery is further important in targeting anti-tumour agents to bone metastasis owing to its complexity. The present study involves the formulation of PLGA nanoparticles and conjugation with zolendronic a...

journal_title：AAPS PharmSciTech

authors： Raichur V,Vemula KD,Bhadri N,Razdan R

更新日期：2017-08-01 00:00:00

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide. Its poor response to current treatment options in advanced stages and the need for efficient diagnosis in early stages call for the development of new therapeutic and diagnostic strategies. Some of them are based on the use of nanometric materials as c...

journal_title：AAPS PharmSciTech

authors： Cabeza L,Perazzoli G,Mesas C,Jiménez-Luna C,Prados J,Rama AR,Melguizo C

更新日期：2020-06-26 00:00:00

abstract：:Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT relea...

journal_title：AAPS PharmSciTech

authors： Pongjanyakul T,Kanjanabat S

更新日期：2012-06-01 00:00:00

abstract：:The present investigation was undertaken with the objective of formulating orodispersible film(s) of the antidepressant drug tianeptine sodium to enhance the convenience and compliance by the elderly and pediatric patients. The novel film former, lycoat NG73 (granular hydroxypropyl starch), along with different film-f...

journal_title：AAPS PharmSciTech

authors： El-Setouhy DA,Abd El-Malak NS

更新日期：2010-09-01 00:00:00

abstract：:In the spectrophotometric assay of multicomponent systems involved in drug degradation studies, some minor or unknown degradation products may be present. These products may interfere in the assay and thus invalidate the results due to their absorption in the range of analytical wavelengths. This interference may be e...

journal_title：AAPS PharmSciTech

authors： Ahmad I,Qadeer K,Iqbal K,Ahmed S,Sheraz MA,Ali SA,Mirza T,Hafeez A

更新日期：2013-09-01 00:00:00

abstract：:In our previously studies, we confirmed that ergosterol could ameliorate diabetic nephropathy by suppressing the proliferation of mesangial cells and the accumulation of extracellular matrix (ECM). However, the therapeutic application of ergosterol may be confined due to poor aqueous solubility and low oral bioavailab...

journal_title：AAPS PharmSciTech

authors： Dong Z,Iqbal S,Zhao Z

更新日期：2020-01-13 00:00:00

abstract：:Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC)...

journal_title：AAPS PharmSciTech

authors： Faroongsarng D,Sunpaweravong S,Raksawong A

更新日期：2019-03-18 00:00:00

abstract：:High inter- and intra-individual variability in the pH of fluids in the human gastrointestinal (GI) tract has been described in the literature. The aim of this study was to assess the influence of physiological variability in fasted pH profiles of media along the GI tract on diclofenac sodium (DF-Na) dissolution from ...

journal_title：AAPS PharmSciTech

authors： Felicijan T,Pišlar M,Vene K,Bogataj M

更新日期：2018-10-01 00:00:00

abstract：:The purpose of this study was to develop a lyotropic liquid crystalline formulation using the emulsifier vitamin E TPGS and evaluate its behavior after incorporation of a flavonoid, quercetin. The physical (macro and microscopic), chemical (determination of quercetin content by the HPLC method) and functional (determi...

journal_title：AAPS PharmSciTech

authors： Vicentini FT,Casagrande R,Verri WA Jr,Georgetti SR,Bentley MV,Fonseca MJ

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this study was to prepare monodisperse gelatin microcapsules containing an active agent using microchannel (MC) emulsification, a novel technique for preparing water-in-oil (W/O) and oil-in-water (O/W) emulsions. As the first step in applying MC emulsification to the preparation of monodisperse gelatin ...

journal_title：AAPS PharmSciTech

authors： Iwamoto S,Nakagawa K,Sugiura S,Nakajima M

更新日期：2002-01-01 00:00:00

abstract：:Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability, and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent g...

journal_title：AAPS PharmSciTech

authors： Salústio PJ,Pontes P,Conduto C,Sanches I,Carvalho C,Arrais J,Marques HM

更新日期：2011-12-01 00:00:00

abstract：:A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concent...

journal_title：AAPS PharmSciTech

authors： Mabrouk M,Mulla JA,Kumar P,Chejara DR,Badhe RV,Choonara YE,du Toit LC,Pillay V

更新日期：2016-10-01 00:00:00

abstract：:Establishing bioequivalence (BE) of drugs indicated to treat cancer poses special challenges. For ethical reasons, often, the studies need to be conducted in cancer patients rather than in healthy volunteers, especially when the drug is cytotoxic. The Biopharmaceutics Classification System (BCS) introduced by Amidon (...

journal_title：AAPS PharmSciTech

authors： Tampal N,Mandula H,Zhang H,Li BV,Nguyen H,Conner DP

更新日期：2015-02-01 00:00:00

abstract：:Pellet manufacturing by extrusion/spheronization is quite common in the pharmaceutical field because the obtained product is characterized by a high sphericity as well as a narrow particle size distribution. The established mechanisms only consider deformation of the initially fractured particles but do not account fo...

journal_title：AAPS PharmSciTech

authors： Koester M,Thommes M

更新日期：2010-12-01 00:00:00

abstract：:In a systematic effort to develop a dual-function intravaginal spermicide as well as a drug delivery vehicle against sexually transmitted pathogens, a submicron particle size (30-80 nm), lipophilic and spermicidal gel-microemulsion (viz GM-144) containing the pharmaceutical excipients propylene glycol, Captex 300, Cre...

journal_title：AAPS PharmSciTech

authors： D'Cruz OJ,Yiv SH,Uckun FM

更新日期：2001-04-09 00:00:00

abstract：:The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...

journal_title：AAPS PharmSciTech

authors： Kowapradit J,Opanasopit P,Ngawhirunpat T,Apirakaramwong A,Rojanarata T,Ruktanonchai U,Sajomsang W

更新日期：2010-06-01 00:00:00

abstract：:The solvent used for preparing the binder solution in wet granulation can affect the granulation end point and also impact the thermal, rheological, and flow properties of the granules. The present study investigates the effect of solvents and percentage relative humidity (RH) on the granules of microcrystalline cellu...

journal_title：AAPS PharmSciTech

authors： Jagia M,Trivedi M,Dave RH

更新日期：2016-08-01 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:As a synthetic clay material, laponite RDS (LR) was investigated as an effective drug carrier as a result of the special nanodisk structure together with the negative-charged surface to achieve enhanced cellular uptake and targeted delivery. In this research work, the synthesized oligomeric hyaluronic acid-aminophenyl...

journal_title：AAPS PharmSciTech

authors： Yang Y,Li J,Chen F,Qiao S,Li Y,Pan W

更新日期：2019-11-20 00:00:00

abstract：:The purpose of this research was to use our previously validated dynamic injection apparatus as a rapid method for screening pH-adjusted formulations of a new vancomycin analog, Van-An, for their potential to precipitate upon dilution. In 1 vial, Van-An was reconstituted according to the manufacturer's instructions. I...

journal_title：AAPS PharmSciTech

authors： Johnson JL,Yalkowsky SH

更新日期：2006-03-01 00:00:00

abstract：:The aim of this work was to assess the effect of 2 formulation variables, the pectin type (with different degrees of esterification [DEs]) and the amount of calcium, on drug release from pectin-based matrix tablets. Pectin matrix tablets were prepared by blending indomethacin (a model drug), pectin powder, and various...

journal_title：AAPS PharmSciTech

authors： Sungthongjeen S,Sriamornsak P,Pitaksuteepong T,Somsiri A,Puttipipatkhachorn S

更新日期：2004-02-12 00:00:00

abstract：:This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two diff...

journal_title：AAPS PharmSciTech

authors： Al-Sahaf Z,Raimi-Abraham B,Licciardi M,de Mohac LM

更新日期：2020-10-02 00:00:00

abstract：:The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Kiang YH,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00