Abstract：
:The purpose of this study was to prepare monodisperse gelatin microcapsules containing an active agent using microchannel (MC) emulsification, a novel technique for preparing water-in-oil (W/O) and oil-in-water (O/W) emulsions. As the first step in applying MC emulsification to the preparation of monodisperse gelatin microcapsules, simple gelatin microbeads were prepared using this technique. A W/O emulsion with a narrow size distribution containing gelatin in the aqueous phase was created as follows. First, the aqueous disperse phase was fed into the continuous phase through the MCs at 40 degrees C (operating pressure: 3.9 kPa). The emulsion droplets had an average particle diameter of 40.7 microm and a relative standard deviation of 5.1%. The temperature of the collected emulsion was reduced and maintained at 25 degrees C overnight. The gelatin microbeads had a smooth surface after overnight gelation; the average particle diameter was calculated to be 31.6 microm, and the relative standard deviation, 7.3%. The temperature was then lowered to 5 degrees C by rapid air cooling and finally dried. The gelatin beads were dried and could be resuspended well in iso-octane. They had an average particle diameter of 15.6 microm, and a relative standard deviation of 5.9%. Using MC emulsification, we were able to prepare gelatin microbeads with a narrow size distribution. Since this emulsification technique requires only a low-energy input, it may create desirable experimental conditions for microencapsulation of unstable substances such as peptides and proteins. This method is promising for making monodisperse microbeads.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Iwamoto S,Nakagawa K,Sugiura S,Nakajima Mdoi
10.1208/pt030325keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
E25issue
3issn
1530-9932journal_volume
3pub_type
杂志文章abstract：:The objective of this paper is to assess the number of drug particles or droplets contained in metered dose inhaler (MDI) aerosols. Equations were developed to estimate this. The number of drug particles was estimated to be as high as about 300 million for QVAR solution MDIs and as low as 670,000 for Beclovent MDIs. T...
journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-017-0853-7
更新日期：2018-01-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-008-9091-3
更新日期：2008-01-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-020-01851-5
更新日期：2020-11-12 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-019-1458-0
更新日期：2019-06-27 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-013-9935-3
更新日期：2013-06-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章,评审
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更新日期：2018-11-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-010-9534-5
更新日期：2011-03-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-020-01741-w
更新日期：2020-07-14 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-017-0787-0
更新日期：2017-11-01 00:00:00
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journal_title：AAPS PharmSciTech
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更新日期：2017-08-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-019-1420-1
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-010-9430-z
更新日期：2010-06-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-018-1215-9
更新日期：2019-01-02 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-020-01682-4
更新日期：2020-06-04 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-010-9490-0
更新日期：2010-09-01 00:00:00
