Impact of physicochemical environment on the super disintegrant functionality of cross-linked carboxymethyl sodium starch: insight on formulation precautions.

abstract：:This study was performed to prepare and characterize the biotinylated Salmon calcitonin (sCT) for oral delivery and evaluate the hypocalcemic effect of biotinylated-sCTs in rats. Biotinylated sCTs was characterized by using high performance liquid chromatography (HPLC) and MALDITOF-MS. The effect of biotinylation on p...

journal_title：AAPS PharmSciTech

authors： Cetin M,Youn YS,Capan Y,Lee KC

更新日期：2008-01-01 00:00:00

abstract：:Next to the coating formulation, process conditions play important roles in determining coating quality. This study aims to develop an operational window that separates layering from agglomeration regimes and, furthermore, the one that leads to the best coating quality in a fluidized bed coater. The bed relative humid...

journal_title：AAPS PharmSciTech

authors： Laksmana FL,Hartman Kok PJ,Vromans H,Frijlink HW,Van der Voort Maarschalk K

更新日期：2009-01-01 00:00:00

abstract：:The objective of this study was to design a time-controlled pulsatile release (TCPR) system containing propranolol (PNH) as an active pharmaceutical ingredient. Here, the developed dosage forms were coated with hydroxypropyl-methylcellulose (HPMC) and other excipients as barrier layer using dry-coated technology. The ...

journal_title：AAPS PharmSciTech

authors： Chen K,Wang Y,Gai X,Wang H,Li Y,Wen H,Pan W,Yang X

更新日期：2017-10-01 00:00:00

abstract：:The purpose of this research was to compare the viscoelastic properties of several neutral and anionic polysaccharide polymers with their mucociliary transport rates (MTR) across explants of ciliated bovine tracheal tissue to identify rheologic parameters capable of predicting the extent of reduction in mucociliary tr...

journal_title：AAPS PharmSciTech

authors： Shah AJ,Donovan MD

更新日期：2007-04-20 00:00:00

abstract：:The objective of the present study is to investigate the effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole (MTZ). Twelve formulations (1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol in 4% concentration, 1,2-hexanediol, and 1,2-heptanediol in 1% concentr...

journal_title：AAPS PharmSciTech

authors： Li N,Jia W,Zhang Y,Zhang MC,Tan F,Zhang J

更新日期：2014-04-01 00:00:00

abstract：:Pentoxifylline (PTX), an anti-hemorrhage drug used in the treatment of intermittent claudication, is extensively metabolized by the liver resulting in a reduction of the therapeutic levels within a short duration of time. Self-nano-emulsifying drug delivery system (SNEDDS) is well reported to enhance the bio-absorptio...

journal_title：AAPS PharmSciTech

authors： Shailendrakumar AM,Ghate VM,Kinra M,Lewis SA

更新日期：2020-04-21 00:00:00

abstract：:Hard capsules are made from gelatin, an organic polymer obtained through the hydrolysis of collagen present in animal tissues. Gelatin can be degraded by microorganisms and some strategies can be used to control contaminating micro-organisms. Gamma irradiation is considered as an effective sterilization method; howeve...

journal_title：AAPS PharmSciTech

authors： Rodrigues JT,Neto FNS,Ferreira MF,Naves PLF,Guilherme LR

更新日期：2019-05-20 00:00:00

abstract：:Our aim was to investigate the cellular uptake, in vitro cytotoxicity and bioavailability of ginsenoside-modified nanostructured lipid carrier loaded with curcumin (G-NLC). The formulation was prepared by melt emulsification technique, in which water was added to the melted lipids and homogenized to give a uniform sus...

journal_title：AAPS PharmSciTech

authors： Vijayakumar A,Baskaran R,Baek JH,Sundaramoorthy P,Yoo BK

更新日期：2019-01-23 00:00:00

abstract：:A number of synthesized chemical molecules suffer from low aqueous solubility problems. Enhancement of aqueous solubility, dissolution rate, and bioavailability of drug is a very challenging task in drug development. In the present study, solubility and dissolution of poorly aqueous soluble drug simvastatin (SIM) was ...

journal_title：AAPS PharmSciTech

authors： Pandya P,Gattani S,Jain P,Khirwal L,Surana S

更新日期：2008-01-01 00:00:00

abstract：:Anti-vascular endothelial growth factor agents have been widely used to treat several eye diseases including age-related macular degeneration (AMD). An approach to maximize the local concentration of drug at the target site and minimize systemic exposure is to be sought. Sunitinib malate, a multiple receptor tyrosine ...

journal_title：AAPS PharmSciTech

authors： Bhatt P,Narvekar P,Lalani R,Chougule MB,Pathak Y,Sutariya V

更新日期：2019-08-09 00:00:00

abstract：:This work examines the influence of various process parameters (like sodium alginate concentration, calcium chloride concentration, and hardening time) on papain entrapped in ionotropically cross-linked alginate beads for stability improvement and site-specific delivery to the small intestine using neural network mode...

journal_title：AAPS PharmSciTech

authors： Sankalia MG,Mashru RC,Sankalia JM,Sutariya VB

更新日期：2005-09-30 00:00:00

abstract：:The primary objective of this study was to evaluate the effect of drug loading on the release of leuprolide acetate from an injectable polymeric implant, formed in situ, and efficacy of the released drug in suppressing serum testosterone levels in dogs for at least 90 days. An additional objective was to compare the o...

journal_title：AAPS PharmSciTech

authors： Ravivarapu HB,Moyer KL,Dunn RL

更新日期：2000-02-28 00:00:00

abstract：:A folic acid-conjugated paclitaxel (PTX)-doxorubicin (DOX)-loaded nanostructured lipid carrier(s) (FA-PTX-DOX NLCs) were prepared by using emulsion-evaporation method and extensively characterized for particle size, polydispersity index, zeta potential, and % entrapment efficiency which were found to be 196 ± 2.5 nm, ...

journal_title：AAPS PharmSciTech

authors： Raikwar S,Vyas S,Sharma R,Mody N,Dubey S,Vyas SP

更新日期：2018-11-01 00:00:00

abstract：:The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and Eudragit RS100 as film-forming polymers. Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in firs...

journal_title：AAPS PharmSciTech

authors： Gohel MC,Nagori SA

更新日期：2009-01-01 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:Poly(vinyl alcohol) (PVA)-based formulations are used for pharmaceutical tablet coating with numerous advantages. Our objective is to study the stability of PVA-based coating films in the presence of acidic additives, alkaline additives, and various common impurities typically found in tablet formulations. Opadry® II ...

journal_title：AAPS PharmSciTech

authors： Koo OM,Fiske JD,Yang H,Nikfar F,Thakur A,Scheer B,Adams ML

更新日期：2011-06-01 00:00:00

abstract：:The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often ter...

journal_title：AAPS PharmSciTech

authors： Patil SS,Venugopal E,Bhat S,Mahadik KR,Paradkar AR

更新日期：2015-10-01 00:00:00

abstract：:Our objective was to prepare nanoparticulate system using a simple yet attractive innovated method as an ophthalmic delivery system for fluocinolone acetonide to improve its ocular bioavailability. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by adopting thin film hydration method using PLGA/poloxa...

journal_title：AAPS PharmSciTech

authors： Salama AH,Mahmoud AA,Kamel R

更新日期：2016-10-01 00:00:00

abstract：:The present work embarks upon increasing the dissolution rate and the bioavailability of model anti-diabetic drug, gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. The gliquidone nanoparticles were prepared by using anti-solvent precipitation technique in which, gliquidone solution in ...

journal_title：AAPS PharmSciTech

authors： Mohamed MS,Abdelhafez WA,Zayed G,Samy AM

更新日期：2019-12-26 00:00:00

abstract：:For the prediction of the air and product temperatures, the product moisture, and the air humidity during a coating process in a Bohle Lab-Coater, a model was developed. The purpose of this work was to determine the limit moisture, the critical moisture, and the constant for the exchange rate between both zones and to...

journal_title：AAPS PharmSciTech

authors： Page S,Baumann KH,Kleinebudde P

更新日期：2006-05-05 00:00:00

abstract：:Although several guidelines do exist for freeze-drying process development and scale-up, there are still a number of issues that require additional attention. The objective of this review article is to discuss some emerging process development and scale-up issue with emphasis on effect of load condition and freeze-dry...

journal_title：AAPS PharmSciTech

authors： Patel SM,Pikal MJ

更新日期：2011-03-01 00:00:00

abstract：:Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the drug in the gastrointestinal tract. The study was designed to investigate the lipid formulation digestibility in the simulated gastro intestinal media. Fenofibrate was formulated in representative Type II, ...

journal_title：AAPS PharmSciTech

authors： Mohsin K

更新日期：2012-06-01 00:00:00

abstract：:Transcutaneous immunization using a microneedle device presents a promising alternative to syringe-based injection of vaccines. The aim of this study was to investigate the effective immune response elicited after application of tetanus toxoid antigen-loaded dissolvable microneedles (TT-MN) in mice model. Dissolvable ...

journal_title：AAPS PharmSciTech

authors： Pattarabhiran SP,Saju A,Sonawane KR,Manimaran R,Bhatnagar S,Roy G,Kulkarni RB,Venuganti VVK

更新日期：2019-07-22 00:00:00

abstract：:The physicochemical properties of the optimized microemulsion and the permeating ability of oxyresveratrol in microemulsion were evaluated, and the efficacy of oxyresveratrol microemulsion in cutaneous herpes simplex virus type 1 (HSV-1) infection in mice was examined. The optimized microemulsion was composed of 10% w...

journal_title：AAPS PharmSciTech

authors： Sasivimolphan P,Lipipun V,Ritthidej G,Chitphet K,Yoshida Y,Daikoku T,Sritularak B,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2012-12-01 00:00:00

abstract：:The approach documented in this article reviews data from earlier process validation lifecycle stages with a described statistical model to provide the "best estimate" on the number of process performance qualification (PPQ) batches that should generate sufficient information to make a scientific and risk-based decisi...

journal_title：AAPS PharmSciTech

authors： Pazhayattil A,Alsmeyer D,Chen S,Hye M,Ingram M,Sanghvi P

更新日期：2016-08-01 00:00:00

abstract：:Tomographic measurement techniques offer the opportunity to quantify the degree of homogeneity of particulate suspensions and other multiphase mixtures. Electrical resistance tomography is a relatively simple and inexpensive technique for measuring the distribution of electrical conductivity within multiphase systems....

journal_title：AAPS PharmSciTech

authors： Bolton GT,Primrose KM

更新日期：2005-09-30 00:00:00

abstract：:The topical application of all-trans retinoic acid (ATRA) is an effective treatment for several skin disorders, including photo-aging. Unfortunately, ATRA is susceptible to light, heat, and oxidizing agents. Thus, this study aimed to investigate the ability of polymeric micelles prepared from polyethylene glycol conju...

journal_title：AAPS PharmSciTech

authors： Wichit A,Tangsumranjit A,Pitaksuteepong T,Waranuch N

更新日期：2012-03-01 00:00:00

abstract：:Rifaximin (RFX), a semi-synthetic antibiotic belonging to BCS class IV category, has been used in the treatment of traveler's diarrhea. An attempt has been made to improve aqueous solubility of RFX in the presence of β-cyclodextrin (β-CD) and hydroxy propyl β-cyclodextrin (HP-β-CD) and control its release in the gut b...

journal_title：AAPS PharmSciTech

authors： Karanje RV,Bhavsar YV,Jahagirdar KH,Bhise KS

更新日期：2013-06-01 00:00:00

abstract：:Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection ...

journal_title：AAPS PharmSciTech

authors： Li L,Li W,Sun J,Zhang H,Gao J,Guo F,Yang X,Zhang X,Li Y,Zheng A

更新日期：2018-04-01 00:00:00

abstract：:Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT relea...

journal_title：AAPS PharmSciTech

authors： Pongjanyakul T,Kanjanabat S

更新日期：2012-06-01 00:00:00