Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates.

abstract：:The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed based on the ternary phase diagram of the MO-PG-water system,...

journal_title：AAPS PharmSciTech

authors： Peng X,Wen X,Pan X,Wang R,Chen B,Wu C

更新日期：2010-09-01 00:00:00

abstract：:The use of amorphous solid dispersions to improve the bioavailability of active ingredients from the BCS II and IV classifications continues to gain interest in the pharmaceutical industry. Over the last decade, methods for generating amorphous solid dispersions have been well established in commercially available pro...

journal_title：AAPS PharmSciTech

authors： Huang S,Williams RO 3rd

更新日期：2018-07-01 00:00:00

abstract：:A transdermal drug delivery system (TDDS) is generally designed to deliver an active pharmaceutical ingredient (API) through the skin for systemic action. Permeation of an API through the skin is controlled by adjusting drug concentration, formulation composition, and patch design. A bilayer, drug-in-adhesive TDDS des...

journal_title：AAPS PharmSciTech

authors： Davis DA,Martins PP,Zamloot MS,Kucera SA,Williams RO 3rd,Smyth HDC,Warnken ZN

更新日期：2020-06-04 00:00:00

abstract：:A large number of pharmaceuticals exhibit polymorphism; 23% steroids, 60% sulfonamides, and 70% of barbiturates have shown this property. In this study, we have investigated and compared a new technique termed as melt sonocrystallization (MSC) with melt and sonocrystallization (SC) for induction of polymorphism in pro...

journal_title：AAPS PharmSciTech

authors： Tripathi R,Biradar SV,Mishra B,Paradkar AR

更新日期：2010-09-01 00:00:00

abstract：:The purpose of the present investigation is to formulate and evaluate proniosomal transdermal carrier systems for flurbiprofen. Proniosomes were prepared using various non-ionic surfactants, namely span 20 (Sp 20), span 40 (Sp 40), span 60 (Sp 60) and span 80 (Sp 80) without and with cholesterol at percentages ranging...

journal_title：AAPS PharmSciTech

authors： Ibrahim MM,Sammour OA,Hammad MA,Megrab NA

更新日期：2008-01-01 00:00:00

abstract：:The present study demonstrates a preparative medium-pressure liquid chromatography (MPLC) method for isolation of Morin besides evaluating its efficacy in comparison with its self-nanoemulsifying drug delivery (SNEDD) and nanoemulsion (NE) systems against in-vivo HgCl2-induced lung toxicity in rats. Morin was isolated...

journal_title：AAPS PharmSciTech

authors： El-Haddad AE,Sheta NM,Boshra SA

更新日期：2018-07-01 00:00:00

abstract：:The purpose of this article is to report final results of the evaluation of a chi-square ratio test proposed by the US Food and Drug Administration (FDA) for demonstrating equivalence of aerodynamic particle size distribution (APSD) profiles of nasal and orally inhaled drug products. A working group of the Product Qua...

journal_title：AAPS PharmSciTech

authors： Christopher D,Adams W,Amann A,Bertha C,Byron PR,Doub W,Dunbar C,Hauck W,Lyapustina S,Mitchell J,Morgan B,Nichols S,Pan Z,Singh GJ,Tougas T,Tsong Y,Wolff R,Wyka B

更新日期：2007-11-02 00:00:00

abstract：:The aim of this study was to identify trends in deficiencies raised during the EU evaluation of the quality part of dossiers for marketing authorisation applications of biosimilar medicinal products. All adopted day 120 list of questions on the quality module of 22 marketing authorisation applications for biosimilars ...

journal_title：AAPS PharmSciTech

authors： Cilia M,Ruiz S,Richardson P,Salmonson T,Serracino-Inglott A,Wirth F,Borg JJ

更新日期：2018-02-01 00:00:00

abstract：:Our objective was to prepare nanoparticulate system using a simple yet attractive innovated method as an ophthalmic delivery system for fluocinolone acetonide to improve its ocular bioavailability. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by adopting thin film hydration method using PLGA/poloxa...

journal_title：AAPS PharmSciTech

authors： Salama AH,Mahmoud AA,Kamel R

更新日期：2016-10-01 00:00:00

abstract：: ...

journal_title：AAPS PharmSciTech

authors： Williams ROB 3rd

更新日期：2018-08-01 00:00:00

abstract：:In this study, the resveratrol spray-dried emulsions were developed using a quality-by-design approach. Further, the product and process factors that affected the quality of the spray-dried emulsions were analyzed and illustrated using an Ishikawa diagram. The product and process risks were prioritized using a risk-ra...

journal_title：AAPS PharmSciTech

authors： Benjasirimongkol P,Piriyaprasarth S,Moribe K,Sriamornsak P

更新日期：2018-12-18 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this research was to evaluate the relation between preferential direction of pores and mechanical strength of cubic starch compacts. The preferential pore direction was quantified in SEM images of cross sections of starch compacts using a previously described algorithm for determination of the quotient ...

journal_title：AAPS PharmSciTech

authors： Wu YS,van Vliet LJ,Frijlink HW,Stokroos I,van der Voort Maarschalk K

更新日期：2008-01-01 00:00:00

abstract：:An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded ther...

journal_title：AAPS PharmSciTech

authors： Priprem A,Janpim K,Nualkaew S,Mahakunakorn P

更新日期：2016-06-01 00:00:00

abstract：:The purpose of this research was to improve the solubility and therefore dissolution and bioavailability of triamterene, a poorly water soluble diuretic, by complexation with beta-cyclodextrin. Triamterene has been reported to show low bioavailability after oral administration, with wide intersubject variation. This s...

journal_title：AAPS PharmSciTech

authors： Mukne AP,Nagarsenker MS

更新日期：2004-03-29 00:00:00

abstract：:Risedronate sodium (RS) is a potent inhibitor of bone resorption, having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions while keeping in an upright posture for at least 30 min to diminish common gastroesophageal injuries. To surmount suc...

journal_title：AAPS PharmSciTech

authors： Elkady OA,Tadros MI,El-Laithy HM

更新日期：2019-12-05 00:00:00

abstract：:Triple-negative breast (TNBC) cancer that is upregulated with epidermal growth factor receptor (EGFR), and devoid of both the hormonal receptors and epidermal growth factor receptor 2 (HER 2), has led to a concept of treating TNBC with EGFR-targeted therapeutics. The combination of paclitaxel (PTX) and piperine (PIP) ...

journal_title：AAPS PharmSciTech

authors： Burande AS,Viswanadh MK,Jha A,Mehata AK,Shaik A,Agrawal N,Poddar S,Mahto SK,Muthu MS

更新日期：2020-05-21 00:00:00

abstract：:Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation, where poorly soluble acidic AMG 009 molecule was intimately mixed and compressed together with a basic pH modifier (e.g., sodium carbonate) and nucleation inhibitor hydroxypropyl methylcellulose ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study was to identify the most suitable co-processed excipient to use ...

journal_title：AAPS PharmSciTech

authors： Dziemidowicz K,Lopez FL,Bowles BJ,Edwards AJ,Ernest TB,Orlu M,Tuleu C

更新日期：2018-08-01 00:00:00

abstract：:Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good ...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Shang Z,Gao C,Du M,Xu S,Song H,Liu T

更新日期：2014-08-01 00:00:00

abstract：:The study was designed to build up a database for the evaluation of the self-emulsifying lipid formulations performance. A standard assessment method was constructed to evaluate the self-emulsifying efficiency of the formulations based on five parameters including excipients miscibility, spontaneity, dispersibility, h...

journal_title：AAPS PharmSciTech

authors： Shahba AA,Mohsin K,Alanazi FK

更新日期：2012-06-01 00:00:00

abstract：:This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two diff...

journal_title：AAPS PharmSciTech

authors： Al-Sahaf Z,Raimi-Abraham B,Licciardi M,de Mohac LM

更新日期：2020-10-02 00:00:00

abstract：:The purpose of this study was to investigate physicochemical characteristics and in vitro release of zidovudine from monolithic film of Eudragit RL 100 and ethyl cellulose. Films included 2.5% or 5% (w/w) zidovudine of the dry polymer weight were prepared in various ratios of polymers by solvent evaporation method fro...

journal_title：AAPS PharmSciTech

authors： Takmaz EA,Inal O,Baykara T

更新日期：2009-01-01 00:00:00

abstract：:The effects of solvent [acetonitrile, methanol, and acetonitrile/water mixture (20:80, v/v)], buffer concentration (phosphate buffer, pH 7.5), ionic strength and commonly employed adjuvants on the photodegradation of betamethasone-17 valerate in cream and gel formulations have been studied on exposure to UV light (300...

journal_title：AAPS PharmSciTech

authors： Khattak SU,Shaikh D,Ahmad I,Usmanghani K,Sheraz MA,Ahmed S

更新日期：2013-03-01 00:00:00

abstract：:Low solubility of active pharmaceutical compounds (APIs) remains an important challenge in dosage form development process. In the manuscript, empirical models were developed and analyzed in order to predict dissolution of bicalutamide (BCL) from solid dispersion with various carriers. BCL was chosen as an example of ...

journal_title：AAPS PharmSciTech

authors： Mendyk A,Pacławski A,Szafraniec-Szczęsny J,Antosik A,Jamróz W,Paluch M,Jachowicz R

更新日期：2020-03-31 00:00:00

abstract：:A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

journal_title：AAPS PharmSciTech

authors： Bento D,Borchard G,Gonçalves T,Borges O

更新日期：2013-06-01 00:00:00

abstract：:Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...

journal_title：AAPS PharmSciTech

authors： Yu X,Sun L,Tan L,Wang M,Ren X,Pi J,Jiang M,Li N

更新日期：2020-01-29 00:00:00

abstract：:This study assessed the utility of near-infrared (NIR) spectroscopy for the real-time monitoring of content uniformity and critical quality attributes (tensile strength, Young's modulus, and relative density) of ribbed roller compacted flakes made by axially corrugated or ribbed rolls. A custom-built setup was used to...

journal_title：AAPS PharmSciTech

authors： Samanta AK,Karande AD,Ng KY,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:The ability to produce submicron particles of monoclonal antibodies of different sizes and shapes would enhance their application to pulmonary delivery. Although non-ionic surfactants are widely used as stabilizers in protein formulations, we hypothesized that non-ionic surfactants will affect the shape and size of su...

journal_title：AAPS PharmSciTech

authors： Srinivasan AR,Shoyele SA

更新日期：2013-03-01 00:00:00

abstract：:The objective of the present study was to develop fast dissolving oral film of the antipsychotic drug, flupentixol dihydrochloride, to enhance its bioavailability, optimize its therapeutic effect when used to treat depression with anxiety, and increase the convenience and compliance by the mentally ill, developmentall...

journal_title：AAPS PharmSciTech

authors： Abdelbary A,Bendas ER,Ramadan AA,Mostafa DA

更新日期：2014-12-01 00:00:00