Co-Processed Excipients for Dispersible Tablets-Part 2: Patient Acceptability.

abstract：:The purpose of this research was to develop and evaluate buccal mucoadhesive controlled release tablets of lercanidipine hydrochloride using polyethylene oxide and different viscosity grades of hydroxypropyl methylcellulose individually and in combination. Effect of polymer type, proportion and combination was studied...

journal_title：AAPS PharmSciTech

authors： Charde S,Mudgal M,Kumar L,Saha R

更新日期：2008-01-01 00:00:00

abstract：:In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the li...

journal_title：AAPS PharmSciTech

authors： Halenius A,Lakio S,Antikainen O,Hatara J,Yliruusi J

更新日期：2014-06-01 00:00:00

abstract：:This study focused on the chemical stability of the cephalosporin (6R, 7R)-7-(1-pentafluorophenoxyacetamido)-3-[2-(5-methyl-1,3,4-thiodiazolyl)thiomethyl]-Delta(3)-cephem-4-carboxylic acid, sodium salt (cephem 1) formulation after electron beam (e-beam) irradiation. The cephem 1 concentrations of samples irradiated at...

journal_title：AAPS PharmSciTech

authors： Johns PJ,Turberg M,Willard K,Matagne D,Cheesman D

更新日期：2001-11-19 00:00:00

abstract：:As of March 10, 2020, more than 100,000 novel coronavirus pneumonia cases have been confirmed globally. With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. The drugs currently being developed are not adequate to deal ...

journal_title：AAPS PharmSciTech

authors： Yan J,Liu A,Huang J,Wu J,Fan H

更新日期：2020-05-13 00:00:00

abstract：:Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...

journal_title：AAPS PharmSciTech

authors： Yu X,Sun L,Tan L,Wang M,Ren X,Pi J,Jiang M,Li N

更新日期：2020-01-29 00:00:00

abstract：:A dissolution test for tablets containing 40 mg of olmesartan medoxomil (OLM) was developed and validated using both LC-UV and UV methods. After evaluation of the sink condition, dissolution medium, and stability of the drug, the method was validated using USP apparatus 2, 50 rpm rotation speed, and 900 ml of deaerate...

journal_title：AAPS PharmSciTech

authors： Bajerski L,Rossi RC,Dias CL,Bergold AM,Fröehlich PE

更新日期：2010-06-01 00:00:00

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00

abstract：:Establishing bioequivalence (BE) of drugs indicated to treat cancer poses special challenges. For ethical reasons, often, the studies need to be conducted in cancer patients rather than in healthy volunteers, especially when the drug is cytotoxic. The Biopharmaceutics Classification System (BCS) introduced by Amidon (...

journal_title：AAPS PharmSciTech

authors： Tampal N,Mandula H,Zhang H,Li BV,Nguyen H,Conner DP

更新日期：2015-02-01 00:00:00

abstract：:To enhance the stability of coenzyme Q10 (CoQ10), Kolliphor® HS 15 (HS15) was employed as a carrier to build up a stable CoQ10-loaded micelle delivery system. The impact of micellar compositions, the preparation condition, and the preparation method on size characteristics, the solubilization efficiency, and micellar ...

journal_title：AAPS PharmSciTech

authors： Liu L,Mao K,Wang W,Pan H,Wang F,Yang M,Liu H

更新日期：2016-06-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...

journal_title：AAPS PharmSciTech

authors： Kowapradit J,Opanasopit P,Ngawhirunpat T,Apirakaramwong A,Rojanarata T,Ruktanonchai U,Sajomsang W

更新日期：2010-06-01 00:00:00

abstract：:Curcumin is a naturally occurring constituent of turmeric that is a good substitute for synthetic medicines for the treatment of different diseases, due to its comparatively safer profile. However, there are certain shortcomings that limit its use as an ideal therapeutic agent. In order to overcome these drawbacks, we...

journal_title：AAPS PharmSciTech

authors： Akbar MU,Zia KM,Nazir A,Iqbal J,Ejaz SA,Akash MSH

更新日期：2018-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide. Its poor response to current treatment options in advanced stages and the need for efficient diagnosis in early stages call for the development of new therapeutic and diagnostic strategies. Some of them are based on the use of nanometric materials as c...

journal_title：AAPS PharmSciTech

authors： Cabeza L,Perazzoli G,Mesas C,Jiménez-Luna C,Prados J,Rama AR,Melguizo C

更新日期：2020-06-26 00:00:00

abstract：:Bimatoprost is widely used for the management of glaucoma. Currently, it is delivered via eye drop solution, which is highly inefficient due to low bioavailability. To control the release of ocular drugs, contact lenses are used by scientists. However, the conventional soaking method showed high burst release due to a...

journal_title：AAPS PharmSciTech

authors： Yan F,Liu Y,Han S,Zhao Q,Liu N

更新日期：2020-01-13 00:00:00

abstract：:Droplet velocity is an important parameter that can be used to characterize nasal spray products. In this study, a phase-Doppler anemometry (PDA) system was used to measure the droplet velocities of nasal sprays. A survey of seven commercial nasal spray products showed a range of droplet velocities from 6.7 to 19.2 m/...

journal_title：AAPS PharmSciTech

authors： Liu X,Doub WH,Guo C

更新日期：2011-03-01 00:00:00

abstract：:Topical administration is a preferable choice for local anesthetic delivery. Microemulsions have shown great effectiveness for transdermal transport of lidocaine. However, fabrication of microemulsions containing highly concentrated lidocaine (10%) to provide an extended local anesthetic effect is still a challenge. T...

journal_title：AAPS PharmSciTech

authors： Wang Y,Wang X,Wang X,Song Y,Wang X,Hao J

更新日期：2019-01-09 00:00:00

abstract：:Freeze-dried immunoglobulin G (IgG) incorporating trehalose and human serum albumin (HSA) was statistically evaluated regarding the existence of synergism between additives on the stability profile. The levels of HSA (X1) and trehalose (X2) were independent variables. Aggregation following the process (Y1), after 2 an...

journal_title：AAPS PharmSciTech

authors： Nouraei MS,Faghihi H,Najafabadi AR,Zadeh AHM,Darabi M,Vatanara A

更新日期：2019-10-28 00:00:00

abstract：:The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglo...

journal_title：AAPS PharmSciTech

authors： Furukawa R,Kadota K,Noguchi T,Shimosaka A,Shirakawa Y

更新日期：2017-08-01 00:00:00

abstract：:Phase transformations in formulations can lead to instability in physicochemical, biopharmaceutical, and processing properties of products. The influences of formulation design on the optimal dosage forms should be specified. The aim here was to investigate whether excipients with different water sorption behavior aff...

journal_title：AAPS PharmSciTech

authors： Airaksinen S,Karjalainen M,Kivikero N,Westermarck S,Shevchenko A,Rantanen J,Yliruusi J

更新日期：2005-10-06 00:00:00

abstract：:The purpose of this research was to use our previously validated dynamic injection apparatus as a rapid method for screening pH-adjusted formulations of a new vancomycin analog, Van-An, for their potential to precipitate upon dilution. In 1 vial, Van-An was reconstituted according to the manufacturer's instructions. I...

journal_title：AAPS PharmSciTech

authors： Johnson JL,Yalkowsky SH

更新日期：2006-03-01 00:00:00

abstract：:The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment o...

journal_title：AAPS PharmSciTech

authors： Czech T,Lalani R,Oyewumi MO

更新日期：2019-02-15 00:00:00

abstract：:In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard reaction adducts were monitored in the recommended infusion time. Different physicochemical methods were used to evaluate the Maillard re...

journal_title：AAPS PharmSciTech

authors： Siahi Shadbad MR,Ghaderi F,Hatami L,Monajjemzadeh F

更新日期：2016-12-01 00:00:00

abstract：:Transcutaneous immunization using a microneedle device presents a promising alternative to syringe-based injection of vaccines. The aim of this study was to investigate the effective immune response elicited after application of tetanus toxoid antigen-loaded dissolvable microneedles (TT-MN) in mice model. Dissolvable ...

journal_title：AAPS PharmSciTech

authors： Pattarabhiran SP,Saju A,Sonawane KR,Manimaran R,Bhatnagar S,Roy G,Kulkarni RB,Venuganti VVK

更新日期：2019-07-22 00:00:00

abstract：:Hydrogen sulfide (H2S) is having many potential pharmacological and physiological actions which reported that therapeutically useful concentration is low (100-160 μM) and a higher concentration could be toxic. Most of its donors produce it on coming into contact with water. All of these problems could be solved by a c...

journal_title：AAPS PharmSciTech

authors： Ali H,Opere C,Singh S

更新日期：2014-08-01 00:00:00

abstract：:The use of amorphous solid dispersions to improve the bioavailability of active ingredients from the BCS II and IV classifications continues to gain interest in the pharmaceutical industry. Over the last decade, methods for generating amorphous solid dispersions have been well established in commercially available pro...

journal_title：AAPS PharmSciTech

authors： Huang S,Williams RO 3rd

更新日期：2018-07-01 00:00:00

abstract：:The influence of alkaline and the neutral grade of magnesium aluminometasilicate as a porous solid carrier for the liquid self-emulsifying formulation with ibuprofen is investigated. Ibuprofen is dissolved in Labrasol, then this solution is adsorbed on the silicates. The drug to the silicate ratio is 1:2, 1:4, and 1:6...

journal_title：AAPS PharmSciTech

authors： Krupa A,Szlęk J,Jany BR,Jachowicz R

更新日期：2015-06-01 00:00:00

abstract：:The purpose of this research was to investigate the measurement and in vitro delivery implications of multimodal distributions, occurring near or in the respirable range, emitted from pressurized metered-dose inhalers (pMDIs). Particle size distributions of solution pMDIs containing hydrofluoroalkane-134a (HFA-134a) a...

journal_title：AAPS PharmSciTech

authors： Smyth HD,Hickey AJ

更新日期：2003-01-01 00:00:00

abstract：:The objective of this study was to investigate the release behaviour of propranolol hydrochloride from psyllium matrices in the presence hydrophilic polymers. The dissolution test was carried out at pH 1.2 and pH 6.8. Binary mixtures of psyllium and hydroxypropyl methylcellulose (HPMC) used showed that an increase in ...

journal_title：AAPS PharmSciTech

authors： Siahi-Shadbad MR,Asare-Addo K,Azizian K,Hassanzadeh D,Nokhodchi A

更新日期：2011-12-01 00:00:00

abstract：:The classically used nontargeted chemotherapeutic approach to pancreatic cancer has a dual drawback of suboptimal drug delivery at the target site and the systemic side effects produced by the unfettered exposure of the drug to healthy tissue. This study has the objective of developing novel poly(2-ethyl-2-oxazoline) ...

journal_title：AAPS PharmSciTech

authors： Deodhar S,Dash AK,North EJ,Hulce M

更新日期：2020-08-10 00:00:00

abstract：:The purpose of this research was to prepare and evaluate sustained release mucoadhesive tablets of Itraconazole. It is practically insoluble in aqueous fluids hence its solid dispersion with Eudragit E100 was prepared by spray drying. This was formulated in matrix of hydrophilic mucoadhesive polymers Carbopol 934P (CP...

journal_title：AAPS PharmSciTech

authors： Madgulkar A,Kadam S,Pokharkar V

更新日期：2008-01-01 00:00:00

abstract：:The objective of this study was to develop an efficient tumor vasculature targeted liposome delivery system for combretastatin A4, a novel antivascular agent. Liposomes composed of hydrogenated soybean phosphatidylcholine (HSPC), cholesterol, distearoyl phosphoethanolamine-polyethylene-glycol-2000 conjugate (DSPE-PEG)...

journal_title：AAPS PharmSciTech

authors： Nallamothu R,Wood GC,Pattillo CB,Scott RC,Kiani MF,Moore BM,Thoma LA

更新日期：2006-04-07 00:00:00