Development and In Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma.

abstract：:The purpose of this study was to prepare monodisperse gelatin microcapsules containing an active agent using microchannel (MC) emulsification, a novel technique for preparing water-in-oil (W/O) and oil-in-water (O/W) emulsions. As the first step in applying MC emulsification to the preparation of monodisperse gelatin ...

journal_title：AAPS PharmSciTech

authors： Iwamoto S,Nakagawa K,Sugiura S,Nakajima M

更新日期：2002-01-01 00:00:00

abstract：:This study investigated the solubilization of cyclosporin A (CsA), a neutral undecapeptide, by cosolvency, micellization, and complexation. Cosolvents (ethanol, propylene glycol, polyethylene glycol, tetrahydrofurfuryl alcohol polyethyleneglycol ether, and glycerin), surfactants (polyoxyethylene sorbitan monooleate [(...

journal_title：AAPS PharmSciTech

authors： Ran Y,Zhao L,Xu Q,Yalkowsky SH

更新日期：2001-01-18 00:00:00

abstract：:While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category successfully commercialized to date despite clinical and market demand...

journal_title：AAPS PharmSciTech

authors： Wu F,Jin T

更新日期：2008-01-01 00:00:00

abstract：:The present work embarks upon increasing the dissolution rate and the bioavailability of model anti-diabetic drug, gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. The gliquidone nanoparticles were prepared by using anti-solvent precipitation technique in which, gliquidone solution in ...

journal_title：AAPS PharmSciTech

authors： Mohamed MS,Abdelhafez WA,Zayed G,Samy AM

更新日期：2019-12-26 00:00:00

abstract：:The reliable in-line monitoring of pharmaceutical processes has been regarded as a key tool toward the full implementation of process analytical technology. In this study, near-infrared (NIR) spectroscopy was examined for use as an in-line monitoring method of the paracetamol cooling crystallization process. The drug ...

journal_title：AAPS PharmSciTech

authors： Wang IC,Lee MJ,Seo DY,Lee HE,Choi Y,Kim WS,Kim CS,Jeong MY,Choi GJ

更新日期：2011-06-01 00:00:00

abstract：:The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of w/o microemulsion (M) and gel (G) bases for diclofenac sodium (DS). The effect of dimethyl sulfoxide (DMSO) as a penetration enhancer was also examined when it was added to the M formulation. To study the in vitro poten...

journal_title：AAPS PharmSciTech

authors： Sarigüllü Ozgüney I,Yeşim Karasulu H,Kantarci G,Sözer S,Güneri T,Ertan G

更新日期：2006-10-20 00:00:00

abstract：:The purpose of this research was to compare the viscoelastic properties of several neutral and anionic polysaccharide polymers with their mucociliary transport rates (MTR) across explants of ciliated bovine tracheal tissue to identify rheologic parameters capable of predicting the extent of reduction in mucociliary tr...

journal_title：AAPS PharmSciTech

authors： Shah AJ,Donovan MD

更新日期：2007-04-20 00:00:00

abstract：:The present study focuses on the development and characterization of nanosuspension of a poorly soluble drug, silver sulfadiazine (SSD) incorporated in Aloe vera gel (AV-gel) for improving its therapeutic efficacy. The SSD solution in ammonia was subjected to nanoprecipitation in surfactant solution and particle size ...

journal_title：AAPS PharmSciTech

authors： Barkat MA,Harshita,Ahmad I,Ali R,Singh SP,Pottoo FH,Beg S,Ahmad FJ

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to investigate the use of different grades of microcrystalline cellulose (MCC) and lactose in a direct pelletization process in a rotary processor. For this purpose, a mixed 2- and 3-level factorial study was performed to determine the influence of the particle size of microcrystalline...

journal_title：AAPS PharmSciTech

authors： Kristensen J

更新日期：2005-10-24 00:00:00

abstract：:Two different types of derivatives of theophylline (Th-H) incorporating ethyleneoxy groups into the promoiety have been synthesized. One is a soft alkyl type where N-methyl-N-methoxyethyleneoxycarbonylaminomethyl chlorides have been used to alkylate Th-H in the 7 position. The other is in an acyl type where methoxyeth...

journal_title：AAPS PharmSciTech

authors： Majumdar S,Mueller-Spaeth M,Sloan KB

更新日期：2012-09-01 00:00:00

abstract：:The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro. The delivery system was prepared by a multiple emulsion solvent evaporation method. The n...

journal_title：AAPS PharmSciTech

authors： Trickler WJ,Khurana J,Nagvekar AA,Dash AK

更新日期：2010-03-01 00:00:00

abstract：:The current study aimed to develop a prolonged-release pramipexole (PPX) transdermal patch for the treatment of Parkinson's disease. Permeation parameters of PPX were investigated using human cadaver skin. Pramipexole patches were prepared using DURO-TAK® pressure-sensitive-adhesive (PSA) and evaluated for drug stabil...

journal_title：AAPS PharmSciTech

authors： Pu T,Li X,Sun Y,Ding X,Pan Y,Wang Q

更新日期：2017-04-01 00:00:00

abstract：:Loteprednol etabonate (LE) is a soft corticosteroid that maintains therapeutic activity with much reduced adverse effects. Yet, its ocular bioavailability is hindered by its poor aqueous solubility. Early attempts of LE complexation with cyclodextrins (CDs) did not involve the study of the effects of various complexat...

journal_title：AAPS PharmSciTech

authors： Soliman OAE,Mohamed EAM,El-Dahan MS,Khatera NAA

更新日期：2017-05-01 00:00:00

abstract：:Piroxicam is used in the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory diseases. Upon oral administration, it is reported to cause ulcerative colitis, gastrointestinal irritation, edema and peptic ulcer. Hence, an alternative delivery system has been designed in the form of transethosome. T...

journal_title：AAPS PharmSciTech

authors： Garg V,Singh H,Bhatia A,Raza K,Singh SK,Singh B,Beg S

更新日期：2017-01-01 00:00:00

abstract：:The purpose of this research was to evaluate in vitro transnasal sustained-release ability of sorbitan monostearate (SMS) organogels in isopropyl myristate (IM). Organogels were prepared containing SMS (2.5%-20%) and water (5%-25%) in IM and analyzed microscopically for phase behavior. The effect of Tween surfactants ...

journal_title：AAPS PharmSciTech

authors： Pisal S,Shelke V,Mahadik K,Kadam S

更新日期：2004-09-13 00:00:00

abstract：:The present study evaluates the antioxidant activity of the flavonol quercetin, and its functional stability as a raw material and when added in formulations. The iron-chelating activity was determined using the bathophenanthroline assay, and the functional stability was evaluated with the antilipoperoxidative assay. ...

journal_title：AAPS PharmSciTech

authors： Casagrande R,Georgetti SR,Verri WA Jr,Jabor JR,Santos AC,Fonseca MJ

更新日期：2006-02-03 00:00:00

abstract：:Individualized medicines for pediatrics are a useful alternative if there is no correct dosage marketed for this segment (easy to swallow, adequate volume and content, correct composition for pediatrics, good organoleptic properties, etc.). Its validation process must ensure quality testing: its content uniformity, ph...

journal_title：AAPS PharmSciTech

authors： Suárez-González J,Santoveña-Estévez A,Armijo-Ruíz S,Castillo A,Fariña JB

更新日期：2019-06-03 00:00:00

abstract：:The objectives of this study were to formulate, characterize silymarin-loaded Eudragit nanoparticles (SNPs) and evaluate their hepatoprotective and cytotoxic effects after oral administration. SNPs were prepared by nanoprecipitation technique and were evaluated for particle size, entrapment efficiency, TEM, solid-stat...

journal_title：AAPS PharmSciTech

authors： El-Nahas AE,Allam AN,Abdelmonsif DA,El-Kamel AH

更新日期：2017-11-01 00:00:00

abstract：:The objective of the present study is to investigate the effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole (MTZ). Twelve formulations (1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol in 4% concentration, 1,2-hexanediol, and 1,2-heptanediol in 1% concentr...

journal_title：AAPS PharmSciTech

authors： Li N,Jia W,Zhang Y,Zhang MC,Tan F,Zhang J

更新日期：2014-04-01 00:00:00

abstract：:For the prediction of the air and product temperatures, the product moisture, and the air humidity during a coating process in a Bohle Lab-Coater, a model was developed. The purpose of this work was to determine the limit moisture, the critical moisture, and the constant for the exchange rate between both zones and to...

journal_title：AAPS PharmSciTech

authors： Page S,Baumann KH,Kleinebudde P

更新日期：2006-05-05 00:00:00

abstract：:The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as sol...

journal_title：AAPS PharmSciTech

authors： Pal K,Banthia AK,Majumdar DK

更新日期：2007-03-16 00:00:00

abstract：:Establishing bioequivalence (BE) of drugs indicated to treat cancer poses special challenges. For ethical reasons, often, the studies need to be conducted in cancer patients rather than in healthy volunteers, especially when the drug is cytotoxic. The Biopharmaceutics Classification System (BCS) introduced by Amidon (...

journal_title：AAPS PharmSciTech

authors： Tampal N,Mandula H,Zhang H,Li BV,Nguyen H,Conner DP

更新日期：2015-02-01 00:00:00

abstract：:The purpose of this study was to prepare ginkgolide B (GB) lyophilized powder for injection with excellent appearance and stable quality through a formulation screening and by optimizing the freeze-drying process. Cremophor EL as a solubilizer, PEG 400 as a latent solvent, and mannitol as an excipient were mixed to in...

journal_title：AAPS PharmSciTech

authors： Liu D,Galvanin F,Yu Y

更新日期：2018-02-01 00:00:00

abstract：:Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interestingly, this errati...

journal_title：AAPS PharmSciTech

authors： Milanowski B,Hejduk A,Bawiec MA,Jakubowska E,Urbańska A,Wiśniewska A,Garbacz G,Lulek J

更新日期：2020-01-27 00:00:00

abstract：:The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio...

journal_title：AAPS PharmSciTech

authors： Douroumis DD,Gryczke A,Schminke S

更新日期：2011-03-01 00:00:00

abstract：:This paper is a continuation of the research published by the Stability Shelf Life Working Group as chartered under the Product Quality Research Institute. The Working Group was formed in 2006 and disbanded in late 2019. Following the philosophy presented by the Working Group on how to characterize the stability shelf...

journal_title：AAPS PharmSciTech

authors： Schwenke J,Quinlan M,Stroup W,Forenzo P

更新日期：2020-10-20 00:00:00

abstract：:A dissolution test for tablets containing 40 mg of olmesartan medoxomil (OLM) was developed and validated using both LC-UV and UV methods. After evaluation of the sink condition, dissolution medium, and stability of the drug, the method was validated using USP apparatus 2, 50 rpm rotation speed, and 900 ml of deaerate...

journal_title：AAPS PharmSciTech

authors： Bajerski L,Rossi RC,Dias CL,Bergold AM,Fröehlich PE

更新日期：2010-06-01 00:00:00

abstract：:A near-infrared (NIR) spectroscopic method to determine content uniformity of a large, thick tablet using an approach that could facilitate future validations has been developed. A CT ibuprofen 800-mg tablet weighs about 1150 mg and is about 18.6 mm wide and 7.6 mm thick. The FT NIR spectrometer was optimized for tran...

journal_title：AAPS PharmSciTech

authors： Ramirez JL,Bellamy MK,Romañac RJ

更新日期：2001-07-12 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:The purpose of the study was to synthesize and characterize a new form of topical membranes as chitosan-based hydrogel membranes for bacterial skin infections. The polymeric membranes were synthesized by modification in free radical solution polymerization technique. High molecular weight (HMW) chitosan polymer was cr...

journal_title：AAPS PharmSciTech

authors： Ahmad S,Minhas MU,Ahmad M,Sohail M,Abdullah O,Badshah SF

更新日期：2018-10-01 00:00:00