Abstract：
:The present study evaluates the antioxidant activity of the flavonol quercetin, and its functional stability as a raw material and when added in formulations. The iron-chelating activity was determined using the bathophenanthroline assay, and the functional stability was evaluated with the antilipoperoxidative assay. Raw material presented concentration-dependent antilipoperoxidative and iron-chelating activities. The initial antilipoperoxidative activity of the raw material, cream and gel-cream were 63%, 78%, and 69%, respectively. There was no detectable loss of activity during 182 days (6 months) of storage at all tested temperatures (4 degrees C, room temperature [RT], 37 degrees C, and 45 degrees C) for the raw material. Considering the method variability of 10%, activity loss greater than 10% for nonionic cream was detected after 126 days at 4 degrees C (20.1%), decreasing thereafter to 22.2% after 182 days. At 45 degrees C, the loss of activity started after 182 days (13.2%). For the anionic gel-cream, activity loss started after 84 days (28.4%, 45 degrees C), decreasing after 182 days to 40.3% at 45 degrees C. At 37 degrees C, activity loss was detected after 182 days (12%). In conclusion, the results suggest that the activity of quercetin depends on iron chelation, and its possible usefulness as a topical antioxidant to prevent oxidative stress-induced skin damage depends on maintaining its antilipoperoxidative activity stored at RT, which avoids special storage conditions.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Casagrande R,Georgetti SR,Verri WA Jr,Jabor JR,Santos AC,Fonseca MJdoi
10.1208/pt070110keywords:
subject
Has Abstractpub_date
2006-02-03 00:00:00pages
E10issue
1issn
1530-9932journal_volume
7pub_type
杂志文章abstract：:The purpose of this research was to assess the physicochemical properties of a controlled release formulation of recombinant human growth hormone (rHGH) encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) composite microspheres. rHGH was loaded in poly(acryloyl hydroxyethyl) starch (acHES) microparticles, and then t...
journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2005-12-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 传,历史文章,新闻
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/pt070105
更新日期：2006-03-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-007-9031-7
更新日期：2008-01-01 00:00:00
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journal_title：AAPS PharmSciTech
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doi：10.1208/s12249-011-9710-2
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-013-0048-9
更新日期：2014-02-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-017-0751-z
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
doi：10.1208/s12249-008-9063-7
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2019-06-03 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
abstract：:The oxidation of glucagon by the H2O2/Cu(2+) system and by simulated sunlight was studied using HPLC-MS methodologies. It was found that copper ion-catalyzed oxidation is much faster in the residue 1-12 region than in photo-oxidation, but it is slower than photo-oxidation in the residue 18-29 region. This difference i...
journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2007-06-22 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2005-10-06 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
