A Quality by Experimental Design Approach to Assess the Effect of Formulation and Process Variables on the Extrusion and Spheronization of Drug-Loaded Pellets Containing Polyplasdone® XL-10.

abstract：:A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concent...

journal_title：AAPS PharmSciTech

authors： Mabrouk M,Mulla JA,Kumar P,Chejara DR,Badhe RV,Choonara YE,du Toit LC,Pillay V

更新日期：2016-10-01 00:00:00

abstract：:Modifications to the surface chemistry, charge, and hydrophilicity/hydrophobicity of nanoparticles are applicable approaches to the alterations of the in vivo fate of intravenously administered nano-sized drug carriers. The objective of this study is to investigate the in vitro and in vivo antitumor efficacies of curc...

journal_title：AAPS PharmSciTech

authors： Sun L,Xu H,Xu JH,Wang SN,Wang JW,Zhang HF,Jia WR,Li LS

更新日期：2020-06-11 00:00:00

abstract：:The current study aimed to develop a prolonged-release pramipexole (PPX) transdermal patch for the treatment of Parkinson's disease. Permeation parameters of PPX were investigated using human cadaver skin. Pramipexole patches were prepared using DURO-TAK® pressure-sensitive-adhesive (PSA) and evaluated for drug stabil...

journal_title：AAPS PharmSciTech

authors： Pu T,Li X,Sun Y,Ding X,Pan Y,Wang Q

更新日期：2017-04-01 00:00:00

abstract：:The aim of this study was to apply quality by design (QbD) for pharmaceutical development of felodipine solid mixture (FSM) containing hydrophilic carriers and/or polymeric surfactants, for easier development of controlled-release tablets of felodipine. The material attributes, the process parameters (CPP), and the cr...

journal_title：AAPS PharmSciTech

authors： Basalious EB,El-Sebaie W,El-Gazayerly O

更新日期：2011-09-01 00:00:00

abstract：:Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the large armamentarium of drugs available for the management of high blood pressure, low oral availability is an ongoing challenge. Researchers are constantly developing alt...

journal_title：AAPS PharmSciTech

authors： Ita K,Ashong S

更新日期：2020-01-06 00:00:00

abstract：:The physicochemical properties of the optimized microemulsion and the permeating ability of oxyresveratrol in microemulsion were evaluated, and the efficacy of oxyresveratrol microemulsion in cutaneous herpes simplex virus type 1 (HSV-1) infection in mice was examined. The optimized microemulsion was composed of 10% w...

journal_title：AAPS PharmSciTech

authors： Sasivimolphan P,Lipipun V,Ritthidej G,Chitphet K,Yoshida Y,Daikoku T,Sritularak B,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2012-12-01 00:00:00

abstract：:Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC)...

journal_title：AAPS PharmSciTech

authors： Faroongsarng D,Sunpaweravong S,Raksawong A

更新日期：2019-03-18 00:00:00

abstract：:In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard reaction adducts were monitored in the recommended infusion time. Different physicochemical methods were used to evaluate the Maillard re...

journal_title：AAPS PharmSciTech

authors： Siahi Shadbad MR,Ghaderi F,Hatami L,Monajjemzadeh F

更新日期：2016-12-01 00:00:00

abstract：:Emulsions are widely used as topical formulations in the pharmaceutical and cosmetic industries. They are thermodynamically unstable and require emulsifiers for stabilization. Studies have indicated that emulsifiers could affect topical delivery of actives, and this study was therefore designed to investigate the effe...

journal_title：AAPS PharmSciTech

authors： Combrinck J,Otto A,du Plessis J

更新日期：2014-06-01 00:00:00

abstract：:The purpose of the present study was to design mucoadhesive gliadin nanoparticles (GNP) containing amoxicillin and to evaluate their effectiveness in eradicating Helicobacter pylori. GNP-bearing amoxicillin (AGNP) was prepared by desolvation method. The effect of process variables such as gliadin concentration and ini...

journal_title：AAPS PharmSciTech

authors： Umamaheshwari RB,Ramteke S,Jain NK

更新日期：2004-04-07 00:00:00

abstract：:Due to the fact that the number of new poorly soluble active pharmaceutical ingredients is increasing, it is important to investigate the possibilities of improvement of their solubility in order to obtain a final pharmaceutical formulation with enhanced bioavailability. One of the strategies to increase drug solubili...

journal_title：AAPS PharmSciTech

authors： Mihajlovic T,Kachrimanis K,Graovac A,Djuric Z,Ibric S

更新日期：2012-06-01 00:00:00

abstract：:We determined the permeability coefficient of a model hydrophilic drug, calcein, encapsulated within saturated lipid-based nano-sized liposomes of various lipid profiles. We demonstrated that the addition of cholesterol to liposomes containing saturated lipids increased the permeability of the liposomal membrane to ca...

journal_title：AAPS PharmSciTech

authors： Takechi-Haraya Y,Sakai-Kato K,Goda Y

更新日期：2017-07-01 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:The aim of the study is to examine thermal behavior of water within reticulated structure of bacterial cellulose (BC) films by sub-ambient differential scanning calorimetry (DSC). BC films with different carbon source, either manitol (BC (a)) or glycerol (BC (b)), were produced by Acetobacter xylinum using Hestrin and...

journal_title：AAPS PharmSciTech

authors： Kaewnopparat S,Sansernluk K,Faroongsarng D

更新日期：2008-01-01 00:00:00

abstract：:Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generati...

journal_title：AAPS PharmSciTech

authors： Das S,Chaudhury A

更新日期：2011-03-01 00:00:00

abstract：:A melt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (t(g)) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of ...

journal_title：AAPS PharmSciTech

authors： Paradkar A,Maheshwari M,Tyagi AK,Chauhan B,Kadam SS

更新日期：2003-12-16 00:00:00

abstract：:The aim of this work was to assess the effect of 2 formulation variables, the pectin type (with different degrees of esterification [DEs]) and the amount of calcium, on drug release from pectin-based matrix tablets. Pectin matrix tablets were prepared by blending indomethacin (a model drug), pectin powder, and various...

journal_title：AAPS PharmSciTech

authors： Sungthongjeen S,Sriamornsak P,Pitaksuteepong T,Somsiri A,Puttipipatkhachorn S

更新日期：2004-02-12 00:00:00

abstract：:The aim of the work is to develop a data fusion model using near-infrared (NIR) and process parameters for the predictions of drug dissolution from controlled release multiparticulate beads. Using a design of experiments, ciprofloxacin-coated beads were manufactured and critical process parameters such as air volume, ...

journal_title：AAPS PharmSciTech

authors： Ibrahim A,Kothari BH,Fahmy R,Hoag SW

更新日期：2019-06-18 00:00:00

abstract：:Our aim was to investigate the cellular uptake, in vitro cytotoxicity and bioavailability of ginsenoside-modified nanostructured lipid carrier loaded with curcumin (G-NLC). The formulation was prepared by melt emulsification technique, in which water was added to the melted lipids and homogenized to give a uniform sus...

journal_title：AAPS PharmSciTech

authors： Vijayakumar A,Baskaran R,Baek JH,Sundaramoorthy P,Yoo BK

更新日期：2019-01-23 00:00:00

abstract：:The present investigation was aimed at developing and optimizing a simple aqueous tablet-coating formulation and its process. 5-Fluorouracil (5-FU) was used to ascertain the relative lipophilic/hydrophilic behavior of the coating system. Optimization was performed by evaluating the adhesive force strength and cohesive...

journal_title：AAPS PharmSciTech

authors： Rai PR,Tiwary AK,Rana V

更新日期：2012-06-01 00:00:00

abstract：:The development of an oral formulation that ensures increased bioavailability of drugs is a great challenge for pharmaceutical scientists. Among many oral formulation systems, a drug delivery system employing superporous networks was developed to provide a prolonged gastro-retention time as well as improved bioavailab...

journal_title：AAPS PharmSciTech

authors： Le TN,Her J,Sim T,Jung CE,Kang JK,Oh KT

更新日期：2020-11-12 00:00:00

abstract：:Pentoxifylline (PTX), an anti-hemorrhage drug used in the treatment of intermittent claudication, is extensively metabolized by the liver resulting in a reduction of the therapeutic levels within a short duration of time. Self-nano-emulsifying drug delivery system (SNEDDS) is well reported to enhance the bio-absorptio...

journal_title：AAPS PharmSciTech

authors： Shailendrakumar AM,Ghate VM,Kinra M,Lewis SA

更新日期：2020-04-21 00:00:00

abstract：:AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into an...

journal_title：AAPS PharmSciTech

authors： Kushwaha AS,Sharma P,Shivakumar HN,Rappleye C,Zukiwski A,Proniuk S,Murthy SN

更新日期：2017-10-01 00:00:00

abstract：:Pellet manufacturing by extrusion/spheronization is quite common in the pharmaceutical field because the obtained product is characterized by a high sphericity as well as a narrow particle size distribution. The established mechanisms only consider deformation of the initially fractured particles but do not account fo...

journal_title：AAPS PharmSciTech

authors： Koester M,Thommes M

更新日期：2010-12-01 00:00:00

abstract：:An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive ...

journal_title：AAPS PharmSciTech

authors： Shah PV,Rajput SJ

更新日期：2018-04-01 00:00:00

abstract：:The purpose of this research was to assess the physicochemical properties of a controlled release formulation of recombinant human growth hormone (rHGH) encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) composite microspheres. rHGH was loaded in poly(acryloyl hydroxyethyl) starch (acHES) microparticles, and then t...

journal_title：AAPS PharmSciTech

authors： Capan Y,Jiang G,Giovagnoli S,Na KH,DeLuca PP

更新日期：2003-01-01 00:00:00

abstract：:The present work was undertaken with the objectives of improving the dissolution velocity, related oral bioavailability, and minimizing the fasted/fed state variability of repaglinide, a poorly water-soluble anti-diabetic active by exploring the principles of nanotechnology. Nanocrystal formulations were prepared by b...

journal_title：AAPS PharmSciTech

authors： Gadadare R,Mandpe L,Pokharkar V

更新日期：2015-08-01 00:00:00

abstract：:Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection ...

journal_title：AAPS PharmSciTech

authors： Li L,Li W,Sun J,Zhang H,Gao J,Guo F,Yang X,Zhang X,Li Y,Zheng A

更新日期：2018-04-01 00:00:00

abstract：:Chemical penetration enhancers (CPEs) are frequently incorporated into transdermal delivery systems (TDSs) to improve drug delivery and to reduce the required drug load in formulations. However, the minimum detectable effect of formulation changes to CPE-containing TDSs using in vitro permeation tests (IVPT), a widely...

journal_title：AAPS PharmSciTech

authors： Shin SH,Srivilai J,Ibrahim SA,Strasinger C,Hammell DC,Hassan HE,Stinchcomb AL

更新日期：2018-10-01 00:00:00

abstract：:Drying is one of the standard unit operations in the pharmaceutical industry and it is important to become aware of the circumstances that dominate during the process. The purpose of this study was to test microcapsulated thermochromic pigments as heat indicators in a fluid bed drying process. The indicator powders we...

journal_title：AAPS PharmSciTech

authors： Lakio S,Heinämäki J,Yliruusi J

更新日期：2010-03-01 00:00:00