In Vitro Cytotoxicity and Bioavailability of Ginsenoside-Modified Nanostructured Lipid Carrier Containing Curcumin.

abstract：:The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug release and skin retention at molecular level. Formulation factors including oil, emulsifier, and humectant were investigated by in vitro skin retention/permeation study and t...

journal_title：AAPS PharmSciTech

authors： Yang D,Li W,Fang L,Liu C

更新日期：2019-06-20 00:00:00

abstract：:Bimatoprost is widely used for the management of glaucoma. Currently, it is delivered via eye drop solution, which is highly inefficient due to low bioavailability. To control the release of ocular drugs, contact lenses are used by scientists. However, the conventional soaking method showed high burst release due to a...

journal_title：AAPS PharmSciTech

authors： Yan F,Liu Y,Han S,Zhao Q,Liu N

更新日期：2020-01-13 00:00:00

abstract：:Onychomycosis is a chronic disorder that is difficult to manage and hard to eradicate with perilous trends to relapse. Due to increased prevalence of HIV, use of immunosuppressant drugs and lifestyle-related factors, population affected with fungal infection of nail (Onychomycosis) happens to increase extensively in l...

journal_title：AAPS PharmSciTech

authors： Vikas A,Rashmin P,Mrunali P,Chavan RB,Kaushik T

更新日期：2020-01-14 00:00:00

abstract：:Polymeric films are safe and effective and can be used for vaginal administration of microbicide drug candidates. Dapivirine (DPV), an investigational and clinically advanced antiretroviral drug, was selected as a model compound for this study. We have previously developed and clinically tested a quick-dissolving DPV ...

journal_title：AAPS PharmSciTech

authors： Regev G,Patel SK,Moncla BJ,Twist J,Devlin B,Rohan LC

更新日期：2019-06-26 00:00:00

abstract：:Particulate drug delivery systems (PDDS) have been broadly explored as platforms for delivery of drugs, enzymes, cells, and vaccines for pharmaceutical applications. Studies suggest that microspheres (MS) can stimulate innate immune cells even without a drug payload; however, less is known regarding how they impact ho...

journal_title：AAPS PharmSciTech

authors： Vaghasiya K,Eram A,Sharma A,Ray E,Adlakha S,Verma RK

更新日期：2019-06-27 00:00:00

abstract：:The purpose of this research was to address the utility of rheological study in understanding the influence of oppositely charged polymers on release of naproxen sodium encapsulated in chitosan particles. The interaction between oppositely charged kappa-carrageenan (kappa-Ca) and chitosan leads to relatively higher ge...

journal_title：AAPS PharmSciTech

authors： Bhise KS,Dhumal RS,Shailesh B,Paradkar AR,Kadam SS

更新日期：2010-03-01 00:00:00

abstract：:Penetration and distribution of thiocolchicoside from a commercially available foam (Miotens 0.25%, w/v) through human excised full-thickness skin were evaluated using two different in vitro apparatus: a Franz diffusion cell and a Saarbruecken penetration model-based cell. In order to evaluate the intrinsic capability...

journal_title：AAPS PharmSciTech

authors： Aguzzi C,Rossi S,Bagnasco M,Lanata L,Sandri G,Bona F,Ferrari F,Bonferoni MC,Caramella C

更新日期：2008-01-01 00:00:00

abstract：:Chemical penetration enhancers are widely used in transdermal drug delivery system. However, few studies have focused on changes of concentration in chemical penetration enhancers. In this study, the effect of concentrations of enhancers on drug release and its mechanism were investigated. Zolmitriptan (ZOL) was used ...

journal_title：AAPS PharmSciTech

authors： Ruan J,Wan X,Quan P,Liu C,Fang L

更新日期：2019-04-25 00:00:00

abstract：:Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interestingly, this errati...

journal_title：AAPS PharmSciTech

authors： Milanowski B,Hejduk A,Bawiec MA,Jakubowska E,Urbańska A,Wiśniewska A,Garbacz G,Lulek J

更新日期：2020-01-27 00:00:00

abstract：:The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...

journal_title：AAPS PharmSciTech

authors： Kowapradit J,Opanasopit P,Ngawhirunpat T,Apirakaramwong A,Rojanarata T,Ruktanonchai U,Sajomsang W

更新日期：2010-06-01 00:00:00

abstract：:The utilization of ferrets as a non-clinical model for disease is rapidly increasing within drug development. Many of these models include respiratory diseases that involve targeted drug delivery via nose-only inhalation. While the deposition patterns within other non-clinical models (mice, rats, canines, and non-huma...

journal_title：AAPS PharmSciTech

authors： Kuehl PJ,Chand R,McDonald JD,Hava DL,DeHaan WH

更新日期：2019-07-01 00:00:00

abstract：:The objective of the study was to investigate in vitro transdermal delivery of venlafaxine hydrochloride across the pigskin by passive diffusion and iontophoresis. For passive diffusion, experiments were carried out in Franz diffusion cell whereas for iontophoretic permeation, the diffusion cell was modified to contai...

journal_title：AAPS PharmSciTech

authors： Singh G,Ghosh B,Kaushalkumar D,Somsekhar V

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this research was to explore the possibility of employing PAT for particle sizing during spray drying with the use of an in-line and at-line laser diffraction system. Microspheres were made using maltodextrin and modified starch as wall material and size results obtained using PAT compared with those de...

journal_title：AAPS PharmSciTech

authors： Chan LW,Tan LH,Heng PW

更新日期：2008-01-01 00:00:00

abstract：:A novel polymer-drug conjugate, polyethylene glycol-N-(acetyl)-glucosamine-doxorubicin (PEG-NAG-DOX) was evaluated in this study for its in vivo potential for treatment of tumours demonstrating improved efficacy and reduced toxicity. The proposed polymer-drug conjugate comprised of polyethylene glycol-maleimide (mPEG-...

journal_title：AAPS PharmSciTech

authors： Pawar S,Mahajan K,Vavia P

更新日期：2017-11-01 00:00:00

abstract：:Rheumatoid arthritis is an autoimmune disease that leads to cartilage destruction, synovial joint inflammation, and bacterial joint/bone infections. In the present work, methotrexate and minocycline-loaded nanoparticles (MMNPs) were developed with an aim to provide relief from inflammation and disease progression/join...

journal_title：AAPS PharmSciTech

authors： Janakiraman K,Krishnaswami V,Sethuraman V,Natesan S,Rajendran V,Kandasamy R

更新日期：2019-12-23 00:00:00

abstract：:To ensure consistency of clinical outcomes, orally inhaled therapies must exhibit consistent delivered dose and aerosol properties at the time of manufacturing, throughout storage, and during various patient-use conditions. Achieving consistency across these scenarios has presented a significant challenge, especially ...

journal_title：AAPS PharmSciTech

authors： Doty A,Schroeder J,Vang K,Sommerville M,Taylor M,Flynn B,Lechuga-Ballesteros D,Mack P

更新日期：2018-02-01 00:00:00

abstract：:This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200). Critical quality attributes (CQAs) or associated performance indicators of the coated tablets were measured w...

journal_title：AAPS PharmSciTech

authors： Teckoe J,Mascaro T,Farrell TP,Rajabi-Siahboomi AR

更新日期：2013-06-01 00:00:00

abstract：:Rifaximin (RFX), a semi-synthetic antibiotic belonging to BCS class IV category, has been used in the treatment of traveler's diarrhea. An attempt has been made to improve aqueous solubility of RFX in the presence of β-cyclodextrin (β-CD) and hydroxy propyl β-cyclodextrin (HP-β-CD) and control its release in the gut b...

journal_title：AAPS PharmSciTech

authors： Karanje RV,Bhavsar YV,Jahagirdar KH,Bhise KS

更新日期：2013-06-01 00:00:00

abstract：:The aim of this work was to assess the effect of 2 formulation variables, the pectin type (with different degrees of esterification [DEs]) and the amount of calcium, on drug release from pectin-based matrix tablets. Pectin matrix tablets were prepared by blending indomethacin (a model drug), pectin powder, and various...

journal_title：AAPS PharmSciTech

authors： Sungthongjeen S,Sriamornsak P,Pitaksuteepong T,Somsiri A,Puttipipatkhachorn S

更新日期：2004-02-12 00:00:00

abstract：:The purpose of the present investigation is to formulate and evaluate proniosomal transdermal carrier systems for flurbiprofen. Proniosomes were prepared using various non-ionic surfactants, namely span 20 (Sp 20), span 40 (Sp 40), span 60 (Sp 60) and span 80 (Sp 80) without and with cholesterol at percentages ranging...

journal_title：AAPS PharmSciTech

authors： Ibrahim MM,Sammour OA,Hammad MA,Megrab NA

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to prepare bi-layer tablet of Metoclopramide Hydrochloride (MTH) and Ibuprofen (IB) for the effective treatment of migraine. MTH and IB were formulated as immediate and sustained release layer respectively. MTH was formulated as immediate release layer by using various disintegrants like Ac-D...

journal_title：AAPS PharmSciTech

authors： Shiyani B,Gattani S,Surana S

更新日期：2008-01-01 00:00:00

abstract：:Development of palatable formulations for pediatric and geriatric patients involves various challenges. However, an innovative development with beneficial characteristics of marketed formulations in a single formulation platform was attempted. The goal of this research was to develop solid oral flexible tablets (OFTs)...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-08-01 00:00:00

abstract：:Current pharmacopeial methods for in vitro orally inhaled product (OIP) performance testing were developed primarily to support requirements for drug product registration and quality control. In addition, separate clinical studies are undertaken in order to quantify safety and efficacy in the hands of the patient. How...

journal_title：AAPS PharmSciTech

authors： Mitchell JP,Suggett J,Nagel M

更新日期：2016-08-01 00:00:00

abstract：:The oxidation of glucagon by the H2O2/Cu(2+) system and by simulated sunlight was studied using HPLC-MS methodologies. It was found that copper ion-catalyzed oxidation is much faster in the residue 1-12 region than in photo-oxidation, but it is slower than photo-oxidation in the residue 18-29 region. This difference i...

journal_title：AAPS PharmSciTech

authors： Zhang J

更新日期：2016-08-01 00:00:00

abstract：:Onychomycosis is considered a stubborn nail fungal infection that does not respond to conventional topical antifungal treatments. This study aimed to develop and characterize novel solid lipid nanoparticles (SLNs) formulae containing terbinafine HCl (TFH) and loaded with different nail penetration enhancers (nPEs). Th...

journal_title：AAPS PharmSciTech

authors： Abobakr FE,Fayez SM,Elwazzan VS,Sakran W

更新日期：2021-01-06 00:00:00

abstract：:A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

journal_title：AAPS PharmSciTech

authors： Bento D,Borchard G,Gonçalves T,Borges O

更新日期：2013-06-01 00:00:00

abstract：:The exudates from the incised trunk of Terminalia randii has been evaluated as controlled release excipient in comparison with xanthan gum and hydroxypropylmethylcellulose (HPMC) using carvedilol (water insoluble) and theophylline (water soluble) as model drugs. Matrix tablets were prepared by direct compression and t...

journal_title：AAPS PharmSciTech

authors： Bamiro OA,Odeku OA,Sinha VR,Kumar R

更新日期：2012-03-01 00:00:00

abstract：:High inter- and intra-individual variability in the pH of fluids in the human gastrointestinal (GI) tract has been described in the literature. The aim of this study was to assess the influence of physiological variability in fasted pH profiles of media along the GI tract on diclofenac sodium (DF-Na) dissolution from ...

journal_title：AAPS PharmSciTech

authors： Felicijan T,Pišlar M,Vene K,Bogataj M

更新日期：2018-10-01 00:00:00

abstract：:A near-infrared (NIR) spectroscopic method to determine content uniformity of a large, thick tablet using an approach that could facilitate future validations has been developed. A CT ibuprofen 800-mg tablet weighs about 1150 mg and is about 18.6 mm wide and 7.6 mm thick. The FT NIR spectrometer was optimized for tran...

journal_title：AAPS PharmSciTech

authors： Ramirez JL,Bellamy MK,Romañac RJ

更新日期：2001-07-12 00:00:00

abstract：:Kinetic methods for accurate determination of nortriptyline hydrochloride have been described. The methods are based on the oxidation of nortriptyline hydrochloride with KMnO4 in acidic and basic media. In acidic medium, the decrease in absorbance at 525.5 nm and in basic medium, the increase in absorbance at 608.5 nm...

journal_title：AAPS PharmSciTech

authors： Rahman N,Khan S

更新日期：2015-06-01 00:00:00