Terminalia gum as a directly compressible excipient for controlled drug delivery.

abstract：:The purpose of this research was to develop mouth dissolve tablets of nimesulide. Granules containing nimesulide, camphor, crospovidone, and lactose were prepared by wet granulation technique. Camphor was sublimed from the dried granules by exposure to vacuum. The porous granules were then compressed. Alternatively, t...

journal_title：AAPS PharmSciTech

authors： Gohel M,Patel M,Amin A,Agrawal R,Dave R,Bariya N

更新日期：2004-04-26 00:00:00

abstract：:Exogenously supplied alpha-lipoic acid (LA) has proven to be effective as an antioxidant. In an effort to develop a water-soluble formulation for topical administration, LA was formulated in the form of solid lipid nanoparticles (SLN), nanostructure lipid carriers (NLC), and nanoemulsion (NE) and characterized in term...

journal_title：AAPS PharmSciTech

authors： Ruktanonchai U,Bejrapha P,Sakulkhu U,Opanasopit P,Bunyapraphatsara N,Junyaprasert V,Puttipipatkhachorn S

更新日期：2009-01-01 00:00:00

abstract：:Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the ...

journal_title：AAPS PharmSciTech

authors： Wong PM,Chan LW,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:This study investigated the effects of some essential oils on Limantria dispar (Lepidoptera: Lymantridae, gypsy moth) larvae, one of the most serious pests of cork oak forests. The essential oils were first formulated as oil in water (o/w) emulsions and used in laboratory bioassays to assess their lethal concentration...

journal_title：AAPS PharmSciTech

authors： Moretti MD,Sanna-Passino G,Demontis S,Bazzoni E

更新日期：2002-01-01 00:00:00

abstract：:Intra-periodontal pocket drug delivery systems, such as liquid crystalline systems, are widely utilized improving the drug release control and the therapy. Propolis is used in the treatment of periodontal diseases, reducing the inflammatory and infectious conditions. Iron oxide magnetic nanoparticles (MNPs) can improv...

journal_title：AAPS PharmSciTech

authors： de Alcântara Sica de Toledo L,Rosseto HC,Dos Santos RS,Spizzo F,Del Bianco L,Montanha MC,Esposito E,Kimura E,Bonfim-Mendonça PS,Svidzinski TIE,Cortesi R,Bruschi ML

更新日期：2018-10-01 00:00:00

abstract：:The main objective of the present study is the physicochemical characterization of naturally available Terminalia catappa gum (Badam gum [BG]) as a novel pharmaceutical excipient and its suitability in the development of gastroretentive floating drug delivery systems (GRFDDS) to retard the drug for 12 h when the dosag...

journal_title：AAPS PharmSciTech

authors： Meka VS,Nali SR,Songa AS,Kolapalli VR

更新日期：2012-12-01 00:00:00

abstract：:The purpose of the present study was to design mucoadhesive gliadin nanoparticles (GNP) containing amoxicillin and to evaluate their effectiveness in eradicating Helicobacter pylori. GNP-bearing amoxicillin (AGNP) was prepared by desolvation method. The effect of process variables such as gliadin concentration and ini...

journal_title：AAPS PharmSciTech

authors： Umamaheshwari RB,Ramteke S,Jain NK

更新日期：2004-04-07 00:00:00

abstract：:The purpose of this research was to investigate the measurement and in vitro delivery implications of multimodal distributions, occurring near or in the respirable range, emitted from pressurized metered-dose inhalers (pMDIs). Particle size distributions of solution pMDIs containing hydrofluoroalkane-134a (HFA-134a) a...

journal_title：AAPS PharmSciTech

authors： Smyth HD,Hickey AJ

更新日期：2003-01-01 00:00:00

abstract：:Pharmaceutical excipients contain reactive groups and impurities due to manufacturing processes that can cause decomposition of active drug compounds. The aim of this investigation was to determine if commercially available oral disintegrating tablet (ODT) platforms induce active pharmaceutical ingredient (API) degrad...

journal_title：AAPS PharmSciTech

authors： Köllmer M,Popescu C,Manda P,Zhou L,Gemeinhart RA

更新日期：2013-12-01 00:00:00

abstract：:The purpose of this research was to improve the solubility and therefore dissolution and bioavailability of triamterene, a poorly water soluble diuretic, by complexation with beta-cyclodextrin. Triamterene has been reported to show low bioavailability after oral administration, with wide intersubject variation. This s...

journal_title：AAPS PharmSciTech

authors： Mukne AP,Nagarsenker MS

更新日期：2004-03-29 00:00:00

abstract：:Pneumocystis carinii pneumonia (PCP) is a major opportunistic infection that affects patients with human immunodeficiency virus. Although orally administered dapsone leads to high hepatic metabolism, decreasing the therapeutic index and causing severe side effects, this drug is an effective alternative for the treatme...

journal_title：AAPS PharmSciTech

authors： Ortiz M,Jornada DS,Pohlmann AR,Guterres SS

更新日期：2015-10-01 00:00:00

abstract：:Risedronate sodium (RS) is a potent inhibitor of bone resorption, having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions while keeping in an upright posture for at least 30 min to diminish common gastroesophageal injuries. To surmount suc...

journal_title：AAPS PharmSciTech

authors： Elkady OA,Tadros MI,El-Laithy HM

更新日期：2019-12-05 00:00:00

abstract：:Development of palatable formulations for pediatric and geriatric patients involves various challenges. However, an innovative development with beneficial characteristics of marketed formulations in a single formulation platform was attempted. The goal of this research was to develop solid oral flexible tablets (OFTs)...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-08-01 00:00:00

abstract：:While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category successfully commercialized to date despite clinical and market demand...

journal_title：AAPS PharmSciTech

authors： Wu F,Jin T

更新日期：2008-01-01 00:00:00

abstract：:The airways are verified as a relevant route to improve antibody therapeutic index with superior lung concentration but limited passage into systemic blood stream. The current research aimed to process spray-dried (SD) powder of Infliximab to assess the feasibility of respiratory delivery of antibody for local suppres...

journal_title：AAPS PharmSciTech

authors： Faghihi H,Najafabadi AR,Daman Z,Ghasemian E,Montazeri H,Vatanara A

更新日期：2019-02-26 00:00:00

abstract：:The aim of this work is to improve the understanding of the physicochemical mechanisms involved in the functionality of cross-linked carboxymethyl sodium starch (CCSS) as a tablet super disintegrant (SD). The behavior and properties of this SD (medium uptake, disintegration times, particle size, and rheology) was inve...

journal_title：AAPS PharmSciTech

authors： Delalonde M,Fitouri R,Ruiz E,Bataille B,Sharkawi T

更新日期：2015-04-01 00:00:00

abstract：:Drug delivery to deep-seated tissues such as bone has been a major complication till date. This preferential drug delivery is further important in targeting anti-tumour agents to bone metastasis owing to its complexity. The present study involves the formulation of PLGA nanoparticles and conjugation with zolendronic a...

journal_title：AAPS PharmSciTech

authors： Raichur V,Vemula KD,Bhadri N,Razdan R

更新日期：2017-08-01 00:00:00

abstract：:The aim of this work was to assess the effect of 2 formulation variables, the pectin type (with different degrees of esterification [DEs]) and the amount of calcium, on drug release from pectin-based matrix tablets. Pectin matrix tablets were prepared by blending indomethacin (a model drug), pectin powder, and various...

journal_title：AAPS PharmSciTech

authors： Sungthongjeen S,Sriamornsak P,Pitaksuteepong T,Somsiri A,Puttipipatkhachorn S

更新日期：2004-02-12 00:00:00

abstract：:The interactions with and effects of five chemically distinct, bioactive phenolic compounds on the lipid bilayers of model dipalmitoylphosphatidylcholine (DPPC) liposomes were investigated. Complementary analytical techniques, including differential scanning calorimetry (DSC) and phosphorus and proton nuclear magnetic...

journal_title：AAPS PharmSciTech

authors： Malekar SA,Sarode AL,Bach AC 2nd,Worthen DR

更新日期：2016-12-01 00:00:00

abstract：:The objective of this paper is to assess the number of drug particles or droplets contained in metered dose inhaler (MDI) aerosols. Equations were developed to estimate this. The number of drug particles was estimated to be as high as about 300 million for QVAR solution MDIs and as low as 670,000 for Beclovent MDIs. T...

journal_title：AAPS PharmSciTech

authors： Stein SW

更新日期：2008-01-01 00:00:00

abstract：:The physicochemical properties of the optimized microemulsion and the permeating ability of oxyresveratrol in microemulsion were evaluated, and the efficacy of oxyresveratrol microemulsion in cutaneous herpes simplex virus type 1 (HSV-1) infection in mice was examined. The optimized microemulsion was composed of 10% w...

journal_title：AAPS PharmSciTech

authors： Sasivimolphan P,Lipipun V,Ritthidej G,Chitphet K,Yoshida Y,Daikoku T,Sritularak B,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2012-12-01 00:00:00

abstract：:This study investigated the solubilization of cyclosporin A (CsA), a neutral undecapeptide, by cosolvency, micellization, and complexation. Cosolvents (ethanol, propylene glycol, polyethylene glycol, tetrahydrofurfuryl alcohol polyethyleneglycol ether, and glycerin), surfactants (polyoxyethylene sorbitan monooleate [(...

journal_title：AAPS PharmSciTech

authors： Ran Y,Zhao L,Xu Q,Yalkowsky SH

更新日期：2001-01-18 00:00:00

abstract：:The present work embarks upon increasing the dissolution rate and the bioavailability of model anti-diabetic drug, gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. The gliquidone nanoparticles were prepared by using anti-solvent precipitation technique in which, gliquidone solution in ...

journal_title：AAPS PharmSciTech

authors： Mohamed MS,Abdelhafez WA,Zayed G,Samy AM

更新日期：2019-12-26 00:00:00

abstract：:Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study was to identify the most suitable co-processed excipient to use ...

journal_title：AAPS PharmSciTech

authors： Dziemidowicz K,Lopez FL,Bowles BJ,Edwards AJ,Ernest TB,Orlu M,Tuleu C

更新日期：2018-08-01 00:00:00

abstract：:Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the large armamentarium of drugs available for the management of high blood pressure, low oral availability is an ongoing challenge. Researchers are constantly developing alt...

journal_title：AAPS PharmSciTech

authors： Ita K,Ashong S

更新日期：2020-01-06 00:00:00

abstract：:The stability of the 37-amino acid peptide pramlintide, in aqueous solution, was studied as a function of pH and temperature. Samples of pramlintide formulated as a parenteral product were exposed to elevated temperatures and to realistic storage conditions for as long as 30 months. Pramlintide degradation was monitor...

journal_title：AAPS PharmSciTech

authors： Kenley RA,Tracht S,Stepanenko A,Townsend M,L'Italien J

更新日期：2000-03-18 00:00:00

abstract：:The objective of this study was to design a time-controlled pulsatile release (TCPR) system containing propranolol (PNH) as an active pharmaceutical ingredient. Here, the developed dosage forms were coated with hydroxypropyl-methylcellulose (HPMC) and other excipients as barrier layer using dry-coated technology. The ...

journal_title：AAPS PharmSciTech

authors： Chen K,Wang Y,Gai X,Wang H,Li Y,Wen H,Pan W,Yang X

更新日期：2017-10-01 00:00:00

abstract：:Due to the fact that the number of new poorly soluble active pharmaceutical ingredients is increasing, it is important to investigate the possibilities of improvement of their solubility in order to obtain a final pharmaceutical formulation with enhanced bioavailability. One of the strategies to increase drug solubili...

journal_title：AAPS PharmSciTech

authors： Mihajlovic T,Kachrimanis K,Graovac A,Djuric Z,Ibric S

更新日期：2012-06-01 00:00:00

abstract：:The oxidation of glucagon by the H2O2/Cu(2+) system and by simulated sunlight was studied using HPLC-MS methodologies. It was found that copper ion-catalyzed oxidation is much faster in the residue 1-12 region than in photo-oxidation, but it is slower than photo-oxidation in the residue 18-29 region. This difference i...

journal_title：AAPS PharmSciTech

authors： Zhang J

更新日期：2016-08-01 00:00:00

abstract：:The purpose of this study was to prepare ginkgolide B (GB) lyophilized powder for injection with excellent appearance and stable quality through a formulation screening and by optimizing the freeze-drying process. Cremophor EL as a solubilizer, PEG 400 as a latent solvent, and mannitol as an excipient were mixed to in...

journal_title：AAPS PharmSciTech

authors： Liu D,Galvanin F,Yu Y

更新日期：2018-02-01 00:00:00