Estimating the number of droplets and drug particles emitted from MDIs.

abstract：:The addition of polysorbate 20 (T20) is required to achieve "sink" conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml...

journal_title：AAPS PharmSciTech

authors： Hoppe K,Sznitowska M

更新日期：2014-10-01 00:00:00

abstract：:Combined dissolution and permeation systems are designed to simultaneously assess the dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs therefrom. However, there were still some limitations on predicting the possible absorption rate-limiting steps and improving the in vitro-in vivo corr...

journal_title：AAPS PharmSciTech

authors： Li Z,He X,Tian S,Feng G,Huang C,Xun M,Wu Z,Wang Y

更新日期：2019-10-24 00:00:00

abstract：:Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection ...

journal_title：AAPS PharmSciTech

authors： Li L,Li W,Sun J,Zhang H,Gao J,Guo F,Yang X,Zhang X,Li Y,Zheng A

更新日期：2018-04-01 00:00:00

abstract：:Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree of crystallinity and melted at lower temperatures. Melting...

journal_title：AAPS PharmSciTech

authors： Bikiaris DN,Papageorgiou GZ,Papadimitriou SA,Karavas E,Avgoustakis K

更新日期：2009-01-01 00:00:00

abstract：:A dissolution test for tablets containing 40 mg of olmesartan medoxomil (OLM) was developed and validated using both LC-UV and UV methods. After evaluation of the sink condition, dissolution medium, and stability of the drug, the method was validated using USP apparatus 2, 50 rpm rotation speed, and 900 ml of deaerate...

journal_title：AAPS PharmSciTech

authors： Bajerski L,Rossi RC,Dias CL,Bergold AM,Fröehlich PE

更新日期：2010-06-01 00:00:00

abstract：:Due to the fact that the number of new poorly soluble active pharmaceutical ingredients is increasing, it is important to investigate the possibilities of improvement of their solubility in order to obtain a final pharmaceutical formulation with enhanced bioavailability. One of the strategies to increase drug solubili...

journal_title：AAPS PharmSciTech

authors： Mihajlovic T,Kachrimanis K,Graovac A,Djuric Z,Ibric S

更新日期：2012-06-01 00:00:00

abstract：:Present investigation deals with formulation and evaluation of tamoxifen (TMX)-loaded liquid crystalline nanoparticles (TMX-LCNPs) for improving oral bioavailability and safety of the existing treatment. Hexagonal Glyceryl monooleate-based TMX-LCNPs (GLCNPs) and Phytantriol-based TMX-LCNPs (PLCNPs) were prepared by di...

journal_title：AAPS PharmSciTech

authors： Jain S,Heeralal B,Swami R,Swarnakar NK,Kushwah V

更新日期：2018-01-01 00:00:00

abstract：:Helicobacter pylori infection remains challenging as it mainly colonized beneath the deep gastric mucosa and adheres to epithelial cells of the stomach. Concanavalin-A (Con-A)-conjugated gastro-retentive poly (lactic-co-glycolic acid) (PLGA) nanoparticles of acetohydroxamic acid (AHA) and clarithromycin (CLR) were pre...

journal_title：AAPS PharmSciTech

authors： Jain SK,Haider T,Kumar A,Jain A

更新日期：2016-10-01 00:00:00

abstract：:The purpose of this study was to prepare monodisperse gelatin microcapsules containing an active agent using microchannel (MC) emulsification, a novel technique for preparing water-in-oil (W/O) and oil-in-water (O/W) emulsions. As the first step in applying MC emulsification to the preparation of monodisperse gelatin ...

journal_title：AAPS PharmSciTech

authors： Iwamoto S,Nakagawa K,Sugiura S,Nakajima M

更新日期：2002-01-01 00:00:00

abstract：:The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often ter...

journal_title：AAPS PharmSciTech

authors： Patil SS,Venugopal E,Bhat S,Mahadik KR,Paradkar AR

更新日期：2015-10-01 00:00:00

abstract：:The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro. The delivery system was prepared by a multiple emulsion solvent evaporation method. The n...

journal_title：AAPS PharmSciTech

authors： Trickler WJ,Khurana J,Nagvekar AA,Dash AK

更新日期：2010-03-01 00:00:00

abstract：:The objectives of this study were to formulate, characterize silymarin-loaded Eudragit nanoparticles (SNPs) and evaluate their hepatoprotective and cytotoxic effects after oral administration. SNPs were prepared by nanoprecipitation technique and were evaluated for particle size, entrapment efficiency, TEM, solid-stat...

journal_title：AAPS PharmSciTech

authors： El-Nahas AE,Allam AN,Abdelmonsif DA,El-Kamel AH

更新日期：2017-11-01 00:00:00

abstract：:The utilization of ferrets as a non-clinical model for disease is rapidly increasing within drug development. Many of these models include respiratory diseases that involve targeted drug delivery via nose-only inhalation. While the deposition patterns within other non-clinical models (mice, rats, canines, and non-huma...

journal_title：AAPS PharmSciTech

authors： Kuehl PJ,Chand R,McDonald JD,Hava DL,DeHaan WH

更新日期：2019-07-01 00:00:00

abstract：:Bilayer nicotine mucoadhesive patches were prepared and evaluated to determine the feasibility of the formulation as a nicotine replacement product to aid in smoking cessation. Nicotine patches were prepared using xanthan gum or carbopol 934 as a mucoadhesive polymers and ethyl cellulose as a backing layer. The patche...

journal_title：AAPS PharmSciTech

authors： Abu-Huwaij R,Obaidat RM,Sweidan K,Al-Hiari Y

更新日期：2011-03-01 00:00:00

abstract：:The specific aim of the present study was to investigate the biodegradation and biocompatibility characteristics of rosin, a natural film-forming polymer. Both in vitro as well as in vivo methods were used for assessment of the same. The in vitro degradation of rosin films was followed in pH 7.4 phosphate buffered sal...

journal_title：AAPS PharmSciTech

authors： Satturwar PM,Fulzele SV,Dorle AK

更新日期：2003-10-22 00:00:00

abstract：:The objective of the study was to investigate in vitro transdermal delivery of venlafaxine hydrochloride across the pigskin by passive diffusion and iontophoresis. For passive diffusion, experiments were carried out in Franz diffusion cell whereas for iontophoretic permeation, the diffusion cell was modified to contai...

journal_title：AAPS PharmSciTech

authors： Singh G,Ghosh B,Kaushalkumar D,Somsekhar V

更新日期：2008-01-01 00:00:00

abstract：:As of March 10, 2020, more than 100,000 novel coronavirus pneumonia cases have been confirmed globally. With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. The drugs currently being developed are not adequate to deal ...

journal_title：AAPS PharmSciTech

authors： Yan J,Liu A,Huang J,Wu J,Fan H

更新日期：2020-05-13 00:00:00

abstract：:The aim of this work was to assess the effect of formulation parameters of a mucoadhesive vaginal gel based on chitosan and lactic acid, and to highlight its release mechanisms. Two molecular weight chitosans were used to prepare gels with 2 lactic acid concentrations. Both chitosan molecular weight and lactic acid co...

journal_title：AAPS PharmSciTech

authors： Bonferoni MC,Giunchedi P,Scalia S,Rossi S,Sandri G,Caramella C

更新日期：2006-01-01 00:00:00

abstract：:Nanotechnology is having a significant impact in the drug delivery systems and diagnostic devices. As most of the nanosystems are intended to be administered in vivo, there is a need for stability models, which could simulate the biological environment. Instability issues could lead to particle aggregation and in turn...

journal_title：AAPS PharmSciTech

authors： Shaikh MV,Kala M,Nivsarkar M

更新日期：2017-05-01 00:00:00

abstract：:Anti-vascular endothelial growth factor agents have been widely used to treat several eye diseases including age-related macular degeneration (AMD). An approach to maximize the local concentration of drug at the target site and minimize systemic exposure is to be sought. Sunitinib malate, a multiple receptor tyrosine ...

journal_title：AAPS PharmSciTech

authors： Bhatt P,Narvekar P,Lalani R,Chougule MB,Pathak Y,Sutariya V

更新日期：2019-08-09 00:00:00

abstract：:The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol 934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into...

journal_title：AAPS PharmSciTech

authors： Patel VM,Prajapati BG,Patel MM

更新日期：2007-06-22 00:00:00

abstract：:The aim of this study was to prepare bi-layer tablet of Metoclopramide Hydrochloride (MTH) and Ibuprofen (IB) for the effective treatment of migraine. MTH and IB were formulated as immediate and sustained release layer respectively. MTH was formulated as immediate release layer by using various disintegrants like Ac-D...

journal_title：AAPS PharmSciTech

authors： Shiyani B,Gattani S,Surana S

更新日期：2008-01-01 00:00:00

abstract：:Pentoxifylline (PTX), an anti-hemorrhage drug used in the treatment of intermittent claudication, is extensively metabolized by the liver resulting in a reduction of the therapeutic levels within a short duration of time. Self-nano-emulsifying drug delivery system (SNEDDS) is well reported to enhance the bio-absorptio...

journal_title：AAPS PharmSciTech

authors： Shailendrakumar AM,Ghate VM,Kinra M,Lewis SA

更新日期：2020-04-21 00:00:00

abstract：:The purpose of the present investigation is to formulate and evaluate proniosomal transdermal carrier systems for flurbiprofen. Proniosomes were prepared using various non-ionic surfactants, namely span 20 (Sp 20), span 40 (Sp 40), span 60 (Sp 60) and span 80 (Sp 80) without and with cholesterol at percentages ranging...

journal_title：AAPS PharmSciTech

authors： Ibrahim MM,Sammour OA,Hammad MA,Megrab NA

更新日期：2008-01-01 00:00:00

abstract：:Cationic liposomes have long been used as non-viral vectors for small interfering RNA (siRNA) delivery but are associated with high toxicity, less transfection efficiency, and in vivo instability. In this investigation, we have developed siRNA targeted to RRM1 that is responsible for development of resistance to gemci...

journal_title：AAPS PharmSciTech

authors： Khatri N,Baradia D,Vhora I,Rathi M,Misra A

更新日期：2014-12-01 00:00:00

abstract：:The purpose of this study was to compare the effects of denaturation by microwave irradiation on release properties of 2 physically different proteins. Matrices were prepared from water-soluble bovine serum albumin loaded with metoclopramide and sorbed with adequate amount of moisture were thermally denatured in a mic...

journal_title：AAPS PharmSciTech

authors： Qasem RJ

更新日期：2006-03-01 00:00:00

abstract：:Penetration and distribution of thiocolchicoside from a commercially available foam (Miotens 0.25%, w/v) through human excised full-thickness skin were evaluated using two different in vitro apparatus: a Franz diffusion cell and a Saarbruecken penetration model-based cell. In order to evaluate the intrinsic capability...

journal_title：AAPS PharmSciTech

authors： Aguzzi C,Rossi S,Bagnasco M,Lanata L,Sandri G,Bona F,Ferrari F,Bonferoni MC,Caramella C

更新日期：2008-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is a pathogenic factor of severe hand, foot, and mouth disease (HFMD). No vaccine or specific treatment is currently available for EV71 infection. Hence, we developed a buccal mucoadhesive gel containing matrine to protect against HFMD. Mucoadhesive gels were prepared by Carbopol 974P and were co...

journal_title：AAPS PharmSciTech

authors： Chen X,Yan J,Yu S,Wang P

更新日期：2018-01-01 00:00:00

abstract：: ...

journal_title：AAPS PharmSciTech

authors： Williams ROB 3rd

更新日期：2018-08-01 00:00:00

abstract：:Nanoparticles, of the poorly water-soluble drug, itraconazole (ITZ), were produced by the Advanced Evaporative Precipitation into Aqueous Solution process (Advanced EPAS). This process combines emulsion templating and EPAS processing to provide improved control over the size distribution of precipitated particles. Spe...

journal_title：AAPS PharmSciTech

authors： Bosselmann S,Nagao M,Chow KT,Williams RO 3rd

更新日期：2012-09-01 00:00:00