Abstract:
:The aim of this work was to assess the effect of formulation parameters of a mucoadhesive vaginal gel based on chitosan and lactic acid, and to highlight its release mechanisms. Two molecular weight chitosans were used to prepare gels with 2 lactic acid concentrations. Both chitosan molecular weight and lactic acid concentration had a significant and mutually dependent influence on mucoadhesion, measured on pig vaginal mucosa. Similarly, the lactate release profiles were found to be dependent on lactic acid content and polymer molecular weight. One gel formulation based on the stoichiometric lactate to chitosan ratio was subjected to release test in media with 2 different counterions and increasing ionic strength. This test demonstrated that the lactate release is mainly due to ionic displacement.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Bonferoni MC,Giunchedi P,Scalia S,Rossi S,Sandri G,Caramella Cdoi
10.1208/pt0704104subject
Has Abstractpub_date
2006-01-01 00:00:00pages
104issue
4issn
1530-9932journal_volume
7pub_type
杂志文章abstract::The purpose of this research was to use inline real-time near-infrared (NIR) to measure the moisture content of granules manufactured using a commercial production scale continuous twin-screw granulator fluid-bed dryer milling process. A central composite response surface statistical design was used to study the effec...
journal_title:AAPS PharmSciTech
pub_type: 杂志文章
doi:10.1208/s12249-011-9669-z
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To develop a novel nanoparticle drug delivery system consisting of chitosan and glyceryl monooleate (GMO) for the delivery of a wide variety of therapeutics including paclitaxel. METHODS:Chitosan/GMO nanoparticles were prepared by multiple emulsion (o/w/o) solvent evaporation methods. Particle size and surface...
journal_title:AAPS PharmSciTech
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abstract::This paper is a continuation of the research published by the Stability Shelf Life Working Group as chartered under the Product Quality Research Institute. The Working Group was formed in 2006 and disbanded in late 2019. Following the philosophy presented by the Working Group on how to characterize the stability shelf...
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更新日期:2020-10-20 00:00:00
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章,随机对照试验
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abstract::Formulation of an amorphous solid dispersion (ASD) is one of the methods commonly considered to increase the bioavailability of a poorly water-soluble small-molecule active pharmaceutical ingredient (API). However, many factors have to be considered in designing an API-polymer system, including any potential changes t...
journal_title:AAPS PharmSciTech
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更新日期:2011-12-01 00:00:00
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journal_title:AAPS PharmSciTech
pub_type: 已发布勘误
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更新日期:2019-02-25 00:00:00
abstract::The purpose of this study was to develop and validate a rapid, sensitive, and specific reversed-phase high-performance liquid chromatography method for the quantitative determination of native tenofovir (TNF) for various applications. Different analytical performance parameters such as linearity, precision, accuracy, ...
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章
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abstract::The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug release and skin retention at molecular level. Formulation factors including oil, emulsifier, and humectant were investigated by in vitro skin retention/permeation study and t...
journal_title:AAPS PharmSciTech
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abstract::Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticle...
journal_title:AAPS PharmSciTech
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更新日期:2017-10-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cancer worldwide. Its poor response to current treatment options in advanced stages and the need for efficient diagnosis in early stages call for the development of new therapeutic and diagnostic strategies. Some of them are based on the use of nanometric materials as c...
journal_title:AAPS PharmSciTech
pub_type: 杂志文章,评审
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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doi:10.1208/s12249-016-0505-3
更新日期:2017-02-01 00:00:00
abstract::We have designed a microemulsion (ME) containing Ketoprofen (KET) for anti-inflammatory effect evaluated using the rat paw edema model. The ME was prepared by adding propylene glycol (PG) loaded with 1% KET/water (3:1, w/w), to a mixture of sorbitan monooleate and polysorbate 80 (47.0%) at 3:1 (w/w) and canola oil (38...
journal_title:AAPS PharmSciTech
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更新日期:2017-10-01 00:00:00
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章,评审
doi:10.1208/s12249-019-1333-z
更新日期:2019-02-15 00:00:00
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journal_title:AAPS PharmSciTech
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doi:10.1208/s12249-016-0597-9
更新日期:2017-05-01 00:00:00
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journal_title:AAPS PharmSciTech
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更新日期:2012-03-01 00:00:00
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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更新日期:2000-12-01 00:00:00
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journal_title:AAPS PharmSciTech
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更新日期:2006-08-18 00:00:00
abstract::Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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更新日期:2018-08-01 00:00:00
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abstract::The effects of electron beam or gamma-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated...
journal_title:AAPS PharmSciTech
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更新日期:2005-12-01 00:00:00
abstract::A large number of pharmaceuticals exhibit polymorphism; 23% steroids, 60% sulfonamides, and 70% of barbiturates have shown this property. In this study, we have investigated and compared a new technique termed as melt sonocrystallization (MSC) with melt and sonocrystallization (SC) for induction of polymorphism in pro...
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