Understanding the tendency of amorphous solid dispersions to undergo amorphous-amorphous phase separation in the presence of absorbed moisture.

abstract：:The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and Eudragit RS100 as film-forming polymers. Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in firs...

journal_title：AAPS PharmSciTech

authors： Gohel MC,Nagori SA

更新日期：2009-01-01 00:00:00

abstract：:Poly(vinyl alcohol) (PVA)-based formulations are used for pharmaceutical tablet coating with numerous advantages. Our objective is to study the stability of PVA-based coating films in the presence of acidic additives, alkaline additives, and various common impurities typically found in tablet formulations. Opadry® II ...

journal_title：AAPS PharmSciTech

authors： Koo OM,Fiske JD,Yang H,Nikfar F,Thakur A,Scheer B,Adams ML

更新日期：2011-06-01 00:00:00

abstract：:The objective of the present investigation was to reduce the bitterness with improved dissolution, in acidic medium (pH 1.2), of mefloquine hydrochloride (MFL). Microparticles were prepared by coacervation method using Eudragit E (EE) as polymer and sodium hydroxide as precipitant. A 3(2) full factorial design was use...

journal_title：AAPS PharmSciTech

authors： Shah PP,Mashru RC,Rane YM,Thakkar A

更新日期：2008-01-01 00:00:00

abstract：:Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT relea...

journal_title：AAPS PharmSciTech

authors： Pongjanyakul T,Kanjanabat S

更新日期：2012-06-01 00:00:00

abstract：:Pharmaceutical aerosols have been targeted to the lungs for the treatment of asthma and pulmonary infectious diseases successfully. Micafungin (Astellas Pharma US, Deerfield, IL, USA) has been shown to be an effective antifungal agent when administrated intravenously. Pulmonary delivery of micafungin has not previousl...

journal_title：AAPS PharmSciTech

authors： Shi S,Ashley ES,Alexander BD,Hickey AJ

更新日期：2009-01-01 00:00:00

abstract：:The study was designed to build up a database for the evaluation of the self-emulsifying lipid formulations performance. A standard assessment method was constructed to evaluate the self-emulsifying efficiency of the formulations based on five parameters including excipients miscibility, spontaneity, dispersibility, h...

journal_title：AAPS PharmSciTech

authors： Shahba AA,Mohsin K,Alanazi FK

更新日期：2012-06-01 00:00:00

abstract：:Pentoxifylline (PTX), an anti-hemorrhage drug used in the treatment of intermittent claudication, is extensively metabolized by the liver resulting in a reduction of the therapeutic levels within a short duration of time. Self-nano-emulsifying drug delivery system (SNEDDS) is well reported to enhance the bio-absorptio...

journal_title：AAPS PharmSciTech

authors： Shailendrakumar AM,Ghate VM,Kinra M,Lewis SA

更新日期：2020-04-21 00:00:00

abstract：:The objective of this work was the preparation of osmotic tablets using polymer blends of cellulose acetate butyrate (CAB) or ethylcellulose with ammonio methacrylate copolymer (Eudragit® RL). The advantage of these coatings in comparison to the traditionally used cellulose acetate is their solubility in safer organic...

journal_title：AAPS PharmSciTech

authors： Ali R,Walther M,Bodmeier R

更新日期：2018-01-01 00:00:00

abstract：:The objective of the present study is to investigate the confounding effects, if any, of beta-cyclodextrins (βCDs) on corneal permeability coefficients obtained from in vitro transmembrane diffusion studies. Transcorneal permeability studies were carried out with 2-hydroxypropyl-beta-cyclodextrin (HPβCD) and randomly ...

journal_title：AAPS PharmSciTech

authors： Adelli GR,Balguri SP,Majumdar S

更新日期：2015-10-01 00:00:00

abstract：:Although several guidelines do exist for freeze-drying process development and scale-up, there are still a number of issues that require additional attention. The objective of this review article is to discuss some emerging process development and scale-up issue with emphasis on effect of load condition and freeze-dry...

journal_title：AAPS PharmSciTech

authors： Patel SM,Pikal MJ

更新日期：2011-03-01 00:00:00

abstract：:Triple-negative breast (TNBC) cancer that is upregulated with epidermal growth factor receptor (EGFR), and devoid of both the hormonal receptors and epidermal growth factor receptor 2 (HER 2), has led to a concept of treating TNBC with EGFR-targeted therapeutics. The combination of paclitaxel (PTX) and piperine (PIP) ...

journal_title：AAPS PharmSciTech

authors： Burande AS,Viswanadh MK,Jha A,Mehata AK,Shaik A,Agrawal N,Poddar S,Mahto SK,Muthu MS

更新日期：2020-05-21 00:00:00

abstract：:This research aimed to synthesize and evaluate mucoadhesive catechol-functionalized alginate (Cat-Alg) nanoparticles (NPs) for bladder cancer. Cat-Alg was synthesized using coupling chemistry, and the structure was verified using NMR and FT-IR. Cat-Alg NPs were generated by ionic gelation between the synthesized Cat-A...

journal_title：AAPS PharmSciTech

authors： Sahatsapan N,Ngawhirunpat T,Rojanarata T,Opanasopit P,Patrojanasophon P

更新日期：2020-07-31 00:00:00

abstract：:The purpose of this article is to report final results of the evaluation of a chi-square ratio test proposed by the US Food and Drug Administration (FDA) for demonstrating equivalence of aerodynamic particle size distribution (APSD) profiles of nasal and orally inhaled drug products. A working group of the Product Qua...

journal_title：AAPS PharmSciTech

authors： Christopher D,Adams W,Amann A,Bertha C,Byron PR,Doub W,Dunbar C,Hauck W,Lyapustina S,Mitchell J,Morgan B,Nichols S,Pan Z,Singh GJ,Tougas T,Tsong Y,Wolff R,Wyka B

更新日期：2007-11-02 00:00:00

abstract：:Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree of crystallinity and melted at lower temperatures. Melting...

journal_title：AAPS PharmSciTech

authors： Bikiaris DN,Papageorgiou GZ,Papadimitriou SA,Karavas E,Avgoustakis K

更新日期：2009-01-01 00:00:00

abstract：:Proanthocyanidins (PAs) have several bioactivities, but they are unstable in the digestive tract and possess low bioavailability. Nanoencapsulation stabilizes these compounds for oral administration. The intestinal absorption of grape seed and skin extracts, and the poly-lactic acid (PLA) nanoparticles loaded with suc...

journal_title：AAPS PharmSciTech

authors： Fernández K,Roeckel M,Canales E,Dumont J

更新日期：2017-10-01 00:00:00

abstract：:Solubility challenge for a poorly water-soluble drug gets further intensified when it is weakly ionic because the most common solubility enhancement technique, salt formation, becomes less feasible. Salt screening for such drugs often concludes with either a difficult to crystalize salt or an unstable salt, leading th...

journal_title：AAPS PharmSciTech

authors： Nair R,Lamare I,Tiwari NK,Ravi PR,Pillai R

更新日期：2018-01-01 00:00:00

abstract：:Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC)...

journal_title：AAPS PharmSciTech

authors： Faroongsarng D,Sunpaweravong S,Raksawong A

更新日期：2019-03-18 00:00:00

abstract：:The oxidation of glucagon by the H2O2/Cu(2+) system and by simulated sunlight was studied using HPLC-MS methodologies. It was found that copper ion-catalyzed oxidation is much faster in the residue 1-12 region than in photo-oxidation, but it is slower than photo-oxidation in the residue 18-29 region. This difference i...

journal_title：AAPS PharmSciTech

authors： Zhang J

更新日期：2016-08-01 00:00:00

abstract：:Phase transformations in formulations can lead to instability in physicochemical, biopharmaceutical, and processing properties of products. The influences of formulation design on the optimal dosage forms should be specified. The aim here was to investigate whether excipients with different water sorption behavior aff...

journal_title：AAPS PharmSciTech

authors： Airaksinen S,Karjalainen M,Kivikero N,Westermarck S,Shevchenko A,Rantanen J,Yliruusi J

更新日期：2005-10-06 00:00:00

abstract：:The aim was to develop a liposomal oxymatrine conjugating D-alpha tocopheryl polyethylene glycol 1000 succinate (OMT-LIP) for enhanced therapeutics of hepatic fibrosis. OMT-LIP was prepared using the remote loading method. The influences of formulation compositions on the encapsulation efficiency of OMT-LIP were inves...

journal_title：AAPS PharmSciTech

authors： Zhang S,Wu J,Wang H,Wang T,Jin L,Shu D,Shan W,Xiong S

更新日期：2014-06-01 00:00:00

abstract：:The topical application of all-trans retinoic acid (ATRA) is an effective treatment for several skin disorders, including photo-aging. Unfortunately, ATRA is susceptible to light, heat, and oxidizing agents. Thus, this study aimed to investigate the ability of polymeric micelles prepared from polyethylene glycol conju...

journal_title：AAPS PharmSciTech

authors： Wichit A,Tangsumranjit A,Pitaksuteepong T,Waranuch N

更新日期：2012-03-01 00:00:00

abstract：:A melt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (t(g)) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of ...

journal_title：AAPS PharmSciTech

authors： Paradkar A,Maheshwari M,Tyagi AK,Chauhan B,Kadam SS

更新日期：2003-12-16 00:00:00

abstract：:Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticle...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-10-01 00:00:00

abstract：:This work examines the influence of various process parameters (like sodium alginate concentration, calcium chloride concentration, and hardening time) on papain entrapped in ionotropically cross-linked alginate beads for stability improvement and site-specific delivery to the small intestine using neural network mode...

journal_title：AAPS PharmSciTech

authors： Sankalia MG,Mashru RC,Sankalia JM,Sutariya VB

更新日期：2005-09-30 00:00:00

abstract：:Combined dissolution and permeation systems are designed to simultaneously assess the dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs therefrom. However, there were still some limitations on predicting the possible absorption rate-limiting steps and improving the in vitro-in vivo corr...

journal_title：AAPS PharmSciTech

authors： Li Z,He X,Tian S,Feng G,Huang C,Xun M,Wu Z,Wang Y

更新日期：2019-10-24 00:00:00

abstract：:The aim of this study was to formulate a new delivery system for ecological pesticides by the incorporation of Artemisia arborescens L essential oil into solid lipid nanoparticles (SLN). Two different SLN formulations were prepared following the high-pressure homogenization technique using Compritol 888 ATO as lipid a...

journal_title：AAPS PharmSciTech

authors： Lai F,Wissing SA,Müller RH,Fadda AM

更新日期：2006-01-03 00:00:00

abstract：:The purpose of this research was to improve the solubility and therefore dissolution and bioavailability of triamterene, a poorly water soluble diuretic, by complexation with beta-cyclodextrin. Triamterene has been reported to show low bioavailability after oral administration, with wide intersubject variation. This s...

journal_title：AAPS PharmSciTech

authors： Mukne AP,Nagarsenker MS

更新日期：2004-03-29 00:00:00

abstract：:Multidrug resistance is the major problem in cancer treatment nowadays. Compounds from plants are the new targets to solve this problem. Quercetin (QCT), quercetrin (QTR), and rutin (RUT) are potential anticancer flavonoids but their poor water solubility leads to less efficacy. In this study, the polymeric micelles o...

journal_title：AAPS PharmSciTech

authors： Khonkarn R,Daowtak K,Okonogi S

更新日期：2020-04-26 00:00:00

abstract：:As a synthetic clay material, laponite RDS (LR) was investigated as an effective drug carrier as a result of the special nanodisk structure together with the negative-charged surface to achieve enhanced cellular uptake and targeted delivery. In this research work, the synthesized oligomeric hyaluronic acid-aminophenyl...

journal_title：AAPS PharmSciTech

authors： Yang Y,Li J,Chen F,Qiao S,Li Y,Pan W

更新日期：2019-11-20 00:00:00

abstract：:Objective of the study was to design an injectable microsphere preparation with high drug loading of bupivacaine for prolonged release and local anesthetic. PLA or PLGA was used as the biodegradable matrix material to fabricate microspheres with the o/w emulsification-solvent evaporation method. The characterization o...

journal_title：AAPS PharmSciTech

authors： Xu J,Bai Y,Li X,Wei Z,Sun L,Yu H,Xu H

更新日期：2021-01-06 00:00:00