Initial characterization of micafungin pulmonary delivery via two different nebulizers and multivariate data analysis of aerosol mass distribution profiles.

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00

abstract：:Colorectal cancer is a global concern, and its treatment is fraught with non-selective effects including adverse side effects requiring hospital visits and palliative care. A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance. Metformin-loaded solid l...

journal_title：AAPS PharmSciTech

authors： Ngwuluka NC,Kotak DJ,Devarajan PV

更新日期：2017-02-01 00:00:00

abstract：:This study examined the effect of rotor speed, amount of water sprayed, and atomizing air pressure on the geometric mean diameter and geometric standard deviation of pellets produced in a fluid-bed rotor granulator using a 23 factorial design and an optimization technique. Pellets were prepared by wet granulation. Equ...

journal_title：AAPS PharmSciTech

authors： Korakianiti ES,Rekkas DM,Dallas PP,Choulis NH

更新日期：2000-12-01 00:00:00

abstract：:The clinical potential of naringenin (NRG) is compromised due to its poor aqueous solubility and low oral bioavailability. The study is aimed at addressing these issues by means of naringenin nanosuspensions (NRG-NS) formulated using polyvinylpyrrolidone (PVP K-90) as stabiliser via antisolvent sonoprecipitation metho...

journal_title：AAPS PharmSciTech

authors： Gera S,Talluri S,Rangaraj N,Sampathi S

更新日期：2017-11-01 00:00:00

abstract：:The current study explains the development of sorbitan monostearate and sesame oil-based organogels for topical drug delivery. The organogels were prepared by dissolving sorbitan monostearate in sesame oil (70°C). Metronidazole was used as a model antimicrobial. The formulations were characterized using phase contrast...

journal_title：AAPS PharmSciTech

authors： Singh VK,Pramanik K,Ray SS,Pal K

更新日期：2015-04-01 00:00:00

abstract：:Successful pellet production has been reported in literature with cross-linked poly(vinylpyrrolidone), Polyplasdone® XL-10 and INF-10. In the present study, a quality by experimental design approach was used to assess several formulation and process parameter effects on the characteristics of Polyplasdone® XL-10 pelle...

journal_title：AAPS PharmSciTech

authors： Saripella KK,Loka NC,Mallipeddi R,Rane AM,Neau SH

更新日期：2016-04-01 00:00:00

abstract：:Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto phthaloyl chitosan (PEG-g-PHCs) was synthesized and then self...

journal_title：AAPS PharmSciTech

authors： Du J,El-Sherbiny IM,Smyth HD

更新日期：2014-12-01 00:00:00

abstract：:The approach documented in this article reviews data from earlier process validation lifecycle stages with a described statistical model to provide the "best estimate" on the number of process performance qualification (PPQ) batches that should generate sufficient information to make a scientific and risk-based decisi...

journal_title：AAPS PharmSciTech

authors： Pazhayattil A,Alsmeyer D,Chen S,Hye M,Ingram M,Sanghvi P

更新日期：2016-08-01 00:00:00

abstract：:This paper reports for the first time the possible formation of a novel room temperature therapeutic deep eutectic solvent (THEDES) of risperidone (RIS) with some fatty acids, namely capric acid (C10; CA), lauric acid (C12; LA), and myristic acid (C14; MA). All mixtures of RIS and MA yielded a solid or pasty-like soli...

journal_title：AAPS PharmSciTech

authors： Al-Akayleh F,Adwan S,Khanfar M,Idkaidek N,Al-Remawi M

更新日期：2020-11-22 00:00:00

abstract：:Polymeric films are safe and effective and can be used for vaginal administration of microbicide drug candidates. Dapivirine (DPV), an investigational and clinically advanced antiretroviral drug, was selected as a model compound for this study. We have previously developed and clinically tested a quick-dissolving DPV ...

journal_title：AAPS PharmSciTech

authors： Regev G,Patel SK,Moncla BJ,Twist J,Devlin B,Rohan LC

更新日期：2019-06-26 00:00:00

abstract：:Gliclazide (GLI), a poorly water-soluble antidiabetic, was transformed into a glassy state by melt quench technique in order to improve its physicochemical properties. Chemical stability of GLI during formation of glass was assessed by monitoring thin-layer chromatography, and an existence of amorphous form was confir...

journal_title：AAPS PharmSciTech

authors： Jondhale S,Bhise S,Pore Y

更新日期：2012-06-01 00:00:00

abstract：:Chemical penetration enhancers are widely used in transdermal drug delivery system. However, few studies have focused on changes of concentration in chemical penetration enhancers. In this study, the effect of concentrations of enhancers on drug release and its mechanism were investigated. Zolmitriptan (ZOL) was used ...

journal_title：AAPS PharmSciTech

authors： Ruan J,Wan X,Quan P,Liu C,Fang L

更新日期：2019-04-25 00:00:00

abstract：:Establishing bioequivalence (BE) of drugs indicated to treat cancer poses special challenges. For ethical reasons, often, the studies need to be conducted in cancer patients rather than in healthy volunteers, especially when the drug is cytotoxic. The Biopharmaceutics Classification System (BCS) introduced by Amidon (...

journal_title：AAPS PharmSciTech

authors： Tampal N,Mandula H,Zhang H,Li BV,Nguyen H,Conner DP

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to investigate the feasibility of the inclusion of a water-insoluble drug (diazepam, DZ) into solid lipid nanoparticles (SLNs), which offer combined advantages of rapid onset and prolonged release of the drug. This work also describes a new approach to prepare suppositories containing ...

journal_title：AAPS PharmSciTech

authors： Abdelbary G,Fahmy RH

更新日期：2009-01-01 00:00:00

abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...

journal_title：AAPS PharmSciTech

authors： Verma S,Rudraraju VS

更新日期：2015-10-01 00:00:00

abstract：:Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal bioadhesive films of clotrimazole for oral candidiasis. The film was designed to release the drug...

journal_title：AAPS PharmSciTech

authors： Singh S,Jain S,Muthu MS,Tiwari S,Tilak R

更新日期：2008-01-01 00:00:00

abstract：:The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment o...

journal_title：AAPS PharmSciTech

authors： Czech T,Lalani R,Oyewumi MO

更新日期：2019-02-15 00:00:00

abstract：:Onychomycosis is a chronic disorder that is difficult to manage and hard to eradicate with perilous trends to relapse. Due to increased prevalence of HIV, use of immunosuppressant drugs and lifestyle-related factors, population affected with fungal infection of nail (Onychomycosis) happens to increase extensively in l...

journal_title：AAPS PharmSciTech

authors： Vikas A,Rashmin P,Mrunali P,Chavan RB,Kaushik T

更新日期：2020-01-14 00:00:00

abstract：:The purpose of this study was to develop a lyotropic liquid crystalline formulation using the emulsifier vitamin E TPGS and evaluate its behavior after incorporation of a flavonoid, quercetin. The physical (macro and microscopic), chemical (determination of quercetin content by the HPLC method) and functional (determi...

journal_title：AAPS PharmSciTech

authors： Vicentini FT,Casagrande R,Verri WA Jr,Georgetti SR,Bentley MV,Fonseca MJ

更新日期：2008-01-01 00:00:00

abstract：:Our objective was to prepare nanoparticulate system using a simple yet attractive innovated method as an ophthalmic delivery system for fluocinolone acetonide to improve its ocular bioavailability. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by adopting thin film hydration method using PLGA/poloxa...

journal_title：AAPS PharmSciTech

authors： Salama AH,Mahmoud AA,Kamel R

更新日期：2016-10-01 00:00:00

abstract：:MUC1 gene encodes a transmembrane mucin glycoprotein that is overexpressed in human breast cancer and colon cancer. The objective of this study was to develop an in situ gel delivery system containing paclitaxel (PTX) and mucoadhesives for sustained and targeted delivery of anticancer drugs. The delivery system consis...

journal_title：AAPS PharmSciTech

authors： Jauhari S,Dash AK

更新日期：2006-06-02 00:00:00

abstract：:The airways are verified as a relevant route to improve antibody therapeutic index with superior lung concentration but limited passage into systemic blood stream. The current research aimed to process spray-dried (SD) powder of Infliximab to assess the feasibility of respiratory delivery of antibody for local suppres...

journal_title：AAPS PharmSciTech

authors： Faghihi H,Najafabadi AR,Daman Z,Ghasemian E,Montazeri H,Vatanara A

更新日期：2019-02-26 00:00:00

abstract：:Paclitaxel (PTX) and gemcitabine (GEM) are often used in combination due to the synergistic anticancer effects. PTX and GEM combination showed a synergistic effect to SKOV-3 cells at a molar ratio of 1 to 1 and in PTX ➔ GEM sequence. Liposomes were explored as a carrier of PTX and GEM combination. We optimized the dru...

journal_title：AAPS PharmSciTech

authors： Liu Y,Tamam H,Yeo Y

更新日期：2018-02-01 00:00:00

abstract：:This study examined the mechanical (hardness, compressibility, adhesiveness, and cohesiveness) and rheological (zero-rate viscosity and thixotropy) properties of polyethylene glycol (PEG) gels that contain different ratios of Carbopol 934P (CP) and polyvinylpyrrolidone K90 (PVP). Mechanical properties were examined us...

journal_title：AAPS PharmSciTech

authors： Tan YT,Peh KK,Al-Hanbali O

更新日期：2000-08-17 00:00:00

abstract：:The present study demonstrates a preparative medium-pressure liquid chromatography (MPLC) method for isolation of Morin besides evaluating its efficacy in comparison with its self-nanoemulsifying drug delivery (SNEDD) and nanoemulsion (NE) systems against in-vivo HgCl2-induced lung toxicity in rats. Morin was isolated...

journal_title：AAPS PharmSciTech

authors： El-Haddad AE,Sheta NM,Boshra SA

更新日期：2018-07-01 00:00:00

abstract：:The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio...

journal_title：AAPS PharmSciTech

authors： Douroumis DD,Gryczke A,Schminke S

更新日期：2011-03-01 00:00:00

abstract：:The influence of alkaline and the neutral grade of magnesium aluminometasilicate as a porous solid carrier for the liquid self-emulsifying formulation with ibuprofen is investigated. Ibuprofen is dissolved in Labrasol, then this solution is adsorbed on the silicates. The drug to the silicate ratio is 1:2, 1:4, and 1:6...

journal_title：AAPS PharmSciTech

authors： Krupa A,Szlęk J,Jany BR,Jachowicz R

更新日期：2015-06-01 00:00:00

abstract：:The hydrophobicity of bioactive molecules poses a considerable problem in the pharmaceutical and the food industry. Using food-based protein nanocarriers is one promising way to deliver hydrophobic molecules. These types of protein possess many functional properties such as surface activity, water-binding capacity, em...

journal_title：AAPS PharmSciTech

authors： Maviah MBJ,Farooq MA,Mavlyanova R,Veroniaina H,Filli MS,Aquib M,Kesse S,Boakye-Yiadom KO,Wang B

更新日期：2020-03-09 00:00:00

abstract：:The aim of this study was to introduce smectite clay matrices as a drug delivery carrier for the development of amorphous solid dispersions (ASD). Indomethacin (IND) was processed with two different smectite clays, magnesium aluminium and lithium magnesium sodium silicates, using hot melt extrusion (HME) to prepare so...

journal_title：AAPS PharmSciTech

authors： Nandi U,Mithu MSH,Hurt AP,Trivedi V,Douroumis D

更新日期：2020-10-08 00:00:00

abstract：:Amylin is a pancreatic hormone that plays important roles in overall metabolism and in glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable for patients with diabetes who need to avoid glucose excursions. Protein conjugation with polyethylene glycol (PEG) has lon...

journal_title：AAPS PharmSciTech

authors： Guerreiro LH,Guterres MF,Melo-Ferreira B,Erthal LC,Rosa Mda S,Lourenço D,Tinoco P,Lima LM

更新日期：2013-09-01 00:00:00