Development and characterization of sorbitan monostearate and sesame oil-based organogels for topical delivery of antimicrobials.

abstract：:The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug release and skin retention at molecular level. Formulation factors including oil, emulsifier, and humectant were investigated by in vitro skin retention/permeation study and t...

journal_title：AAPS PharmSciTech

authors： Yang D,Li W,Fang L,Liu C

更新日期：2019-06-20 00:00:00

abstract：:Use of higher tableting speeds is gaining increasing importance for pharmaceutical industry. There is a profound lack of new studies of mechanical properties of hypromellose, and none of them evaluate different suppliers. Thus, the objective of this study was to investigate flow and compaction properties of different ...

journal_title：AAPS PharmSciTech

authors： Grdešič P,Paudel A,German Ilić I

更新日期：2020-07-22 00:00:00

abstract：:In the spectrophotometric assay of multicomponent systems involved in drug degradation studies, some minor or unknown degradation products may be present. These products may interfere in the assay and thus invalidate the results due to their absorption in the range of analytical wavelengths. This interference may be e...

journal_title：AAPS PharmSciTech

authors： Ahmad I,Qadeer K,Iqbal K,Ahmed S,Sheraz MA,Ali SA,Mirza T,Hafeez A

更新日期：2013-09-01 00:00:00

abstract：:Triple-negative breast (TNBC) cancer that is upregulated with epidermal growth factor receptor (EGFR), and devoid of both the hormonal receptors and epidermal growth factor receptor 2 (HER 2), has led to a concept of treating TNBC with EGFR-targeted therapeutics. The combination of paclitaxel (PTX) and piperine (PIP) ...

journal_title：AAPS PharmSciTech

authors： Burande AS,Viswanadh MK,Jha A,Mehata AK,Shaik A,Agrawal N,Poddar S,Mahto SK,Muthu MS

更新日期：2020-05-21 00:00:00

abstract：:This investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated Dapsone (DS) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of Pneumocystis carinii pneumonia (PCP) associated with immunocompromised pat...

journal_title：AAPS PharmSciTech

authors： Chougule M,Padhi B,Misra A

更新日期：2008-01-01 00:00:00

abstract：:A feasibility evaluation of the addition of fumed silica (SiO2) into an agitated dryer to aid spray-dried solid dispersion intermediate (SDSDi) flow during secondary drying and discharge is described. The quantity of SiO2 to enhance the flow character of SDSDi was assessed by measuring particle size distribution, bulk...

journal_title：AAPS PharmSciTech

authors： Lee YC,McNevin M,Ikeda C,Chouzouri G,Moser J,Harris D,Howell L

更新日期：2019-05-03 00:00:00

abstract：:Our aim was to investigate the cellular uptake, in vitro cytotoxicity and bioavailability of ginsenoside-modified nanostructured lipid carrier loaded with curcumin (G-NLC). The formulation was prepared by melt emulsification technique, in which water was added to the melted lipids and homogenized to give a uniform sus...

journal_title：AAPS PharmSciTech

authors： Vijayakumar A,Baskaran R,Baek JH,Sundaramoorthy P,Yoo BK

更新日期：2019-01-23 00:00:00

abstract：:Freeze-dried immunoglobulin G (IgG) incorporating trehalose and human serum albumin (HSA) was statistically evaluated regarding the existence of synergism between additives on the stability profile. The levels of HSA (X1) and trehalose (X2) were independent variables. Aggregation following the process (Y1), after 2 an...

journal_title：AAPS PharmSciTech

authors： Nouraei MS,Faghihi H,Najafabadi AR,Zadeh AHM,Darabi M,Vatanara A

更新日期：2019-10-28 00:00:00

abstract：:The aim of the study is to examine thermal behavior of water within reticulated structure of bacterial cellulose (BC) films by sub-ambient differential scanning calorimetry (DSC). BC films with different carbon source, either manitol (BC (a)) or glycerol (BC (b)), were produced by Acetobacter xylinum using Hestrin and...

journal_title：AAPS PharmSciTech

authors： Kaewnopparat S,Sansernluk K,Faroongsarng D

更新日期：2008-01-01 00:00:00

abstract：:The effect of milled and micronized lactose fines on the fluidization and in vitro aerosolization properties of dry powder inhaler (DPI) formulations was investigated, and the suitability of static and dynamic methods for characterizing general powder flow properties of these blends was assessed. Lactose carrier pre-b...

journal_title：AAPS PharmSciTech

authors： Kinnunen H,Hebbink G,Peters H,Shur J,Price R

更新日期：2014-08-01 00:00:00

abstract：:Amylin is a pancreatic hormone that plays important roles in overall metabolism and in glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable for patients with diabetes who need to avoid glucose excursions. Protein conjugation with polyethylene glycol (PEG) has lon...

journal_title：AAPS PharmSciTech

authors： Guerreiro LH,Guterres MF,Melo-Ferreira B,Erthal LC,Rosa Mda S,Lourenço D,Tinoco P,Lima LM

更新日期：2013-09-01 00:00:00

abstract：:Piroxicam is used in the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory diseases. Upon oral administration, it is reported to cause ulcerative colitis, gastrointestinal irritation, edema and peptic ulcer. Hence, an alternative delivery system has been designed in the form of transethosome. T...

journal_title：AAPS PharmSciTech

authors： Garg V,Singh H,Bhatia A,Raza K,Singh SK,Singh B,Beg S

更新日期：2017-01-01 00:00:00

abstract：:The purpose of this research was to address the utility of rheological study in understanding the influence of oppositely charged polymers on release of naproxen sodium encapsulated in chitosan particles. The interaction between oppositely charged kappa-carrageenan (kappa-Ca) and chitosan leads to relatively higher ge...

journal_title：AAPS PharmSciTech

authors： Bhise KS,Dhumal RS,Shailesh B,Paradkar AR,Kadam SS

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present study was to develop and evaluate a buccal adhesive tablet containing ondansetron hydrochloride (OH). Special punches and dies were fabricated and used while preparing buccal adhesive tablets. The tablets were prepared using carbopol (CP 934), sodium alginate, sodium carboxymethylcellulose low v...

journal_title：AAPS PharmSciTech

authors： Hassan N,Khar RK,Ali M,Ali J

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporati...

journal_title：AAPS PharmSciTech

authors： Yoshida VM,de Oliveira Junior JM,Gonçalves MM,Vila MM,Chaud MV

更新日期：2011-06-01 00:00:00

abstract：:The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often ter...

journal_title：AAPS PharmSciTech

authors： Patil SS,Venugopal E,Bhat S,Mahadik KR,Paradkar AR

更新日期：2015-10-01 00:00:00

abstract：:In this study, the use of trimethylchitosan (TMC), by higher solubility in comparison with chitosan, in alginate/chitosan nanoparticles containing cationic β-cyclodextrin polymers (CPβCDs) has been studied, with the aim of increasing insulin uptake by nanoparticles. Firstly, TMCs were synthesized by iodomethane, and C...

journal_title：AAPS PharmSciTech

authors： Mansourpour M,Mahjub R,Amini M,Ostad SN,Shamsa ES,Rafiee-Tehrani M,Dorkoosh FA

更新日期：2015-08-01 00:00:00

abstract：:A simple, reliable, highly sensitive and selective spectrofluorimetric method has been developed for determination of certain aminoglycosides namely amikacin sulfate, tobramycin, neomycin sulfate, gentamicin sulfate, kanamycin sulfate and streptomycin sulfate. The method is based on the formation of a charge transfer ...

journal_title：AAPS PharmSciTech

authors： Omar MA,Nagy DM,Hammad MA,Aly AA

更新日期：2013-06-01 00:00:00

abstract：:Development of palatable formulations for pediatric and geriatric patients involves various challenges. However, an innovative development with beneficial characteristics of marketed formulations in a single formulation platform was attempted. The goal of this research was to develop solid oral flexible tablets (OFTs)...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-08-01 00:00:00

abstract：:The present study focuses on the development and characterization of nanosuspension of a poorly soluble drug, silver sulfadiazine (SSD) incorporated in Aloe vera gel (AV-gel) for improving its therapeutic efficacy. The SSD solution in ammonia was subjected to nanoprecipitation in surfactant solution and particle size ...

journal_title：AAPS PharmSciTech

authors： Barkat MA,Harshita,Ahmad I,Ali R,Singh SP,Pottoo FH,Beg S,Ahmad FJ

更新日期：2017-11-01 00:00:00

abstract：:Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the drug in the gastrointestinal tract. The study was designed to investigate the lipid formulation digestibility in the simulated gastro intestinal media. Fenofibrate was formulated in representative Type II, ...

journal_title：AAPS PharmSciTech

authors： Mohsin K

更新日期：2012-06-01 00:00:00

abstract：:The paper introduces evaluation methodologies and associated statistical approaches for process validation lifecycle Stage 3A. The assessment tools proposed can be applied to newly developed and launched small molecule as well as bio-pharma products, where substantial process and product knowledge has been gathered. T...

journal_title：AAPS PharmSciTech

authors： Sayeed-Desta N,Pazhayattil AB,Collins J,Chen S,Ingram M,Spes J

更新日期：2017-07-01 00:00:00

abstract：:The potential value of succinylated soy protein (SPS) as a wall material for the encapsulation of ibuprofen (IBU), a model hydrophobic drug, by spray-drying was investigated. A succinylation rate of 93% was obtained for soy protein isolate, with a molar ratio of 1/1.5 (NH2/succinic anhydride). The solubility profile a...

journal_title：AAPS PharmSciTech

authors： Anaya Castro MA,Alric I,Brouillet F,Peydecastaing J,Fullana SG,Durrieu V

更新日期：2019-01-11 00:00:00

abstract：:This study tests the hypothesis that association complexes formed between enoxaparin and cetyltrimethylammonium bromide (CTAB) augment permeation across the gastrointestinal mucosa due to improved encapsulation of this hydrophilic macromolecule within biocompatible poly (lactide-co-glycolide, PLGA RG 503) nanoparticle...

journal_title：AAPS PharmSciTech

authors： Eleraky NE,Swarnakar NK,Mohamed DF,Attia MA,Pauletti GM

更新日期：2020-02-03 00:00:00

abstract：:The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of ...

journal_title：AAPS PharmSciTech

authors： Mohamed EM,Barakh Ali SF,Rahman Z,Dharani S,Ozkan T,Kuttolamadom MA,Khan MA

更新日期：2020-08-13 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:The aim of this study was to introduce smectite clay matrices as a drug delivery carrier for the development of amorphous solid dispersions (ASD). Indomethacin (IND) was processed with two different smectite clays, magnesium aluminium and lithium magnesium sodium silicates, using hot melt extrusion (HME) to prepare so...

journal_title：AAPS PharmSciTech

authors： Nandi U,Mithu MSH,Hurt AP,Trivedi V,Douroumis D

更新日期：2020-10-08 00:00:00

abstract：:The present study demonstrates a preparative medium-pressure liquid chromatography (MPLC) method for isolation of Morin besides evaluating its efficacy in comparison with its self-nanoemulsifying drug delivery (SNEDD) and nanoemulsion (NE) systems against in-vivo HgCl2-induced lung toxicity in rats. Morin was isolated...

journal_title：AAPS PharmSciTech

authors： El-Haddad AE,Sheta NM,Boshra SA

更新日期：2018-07-01 00:00:00

abstract：:The purpose of this research was to explore the utility of beta cyclodextrin (betaCD) and beta cyclodextrin derivatives (hydroxypropyl-beta-cyclodextrin [HPbetaCD], sulfobutylether-beta-CD [SBbetaCD], and a randomly methylated-beta-CD [RMbetaCD]) to form inclusion complexes with the antitumoral drug, beta-lapachone (b...

journal_title：AAPS PharmSciTech

authors： Cunha-Filho MS,Dacunha-Marinho B,Torres-Labandeira JJ,Martínez-Pacheco R,Landín M

更新日期：2007-07-27 00:00:00

abstract：:The main principles of green chemistry and engineering were extended to pharmaceutical formulations to prepare eco-friendly surfactant-free dry emulsion tablets (SFDETs) devoid of solvents or synthetic surfactants. Surfactant-free emulsions were stabilized by in situ cyclodextrins/sweet almond oil inclusion complexes ...

journal_title：AAPS PharmSciTech

authors： Badr-Eldin SM,Labib GS,Aburahma MH

更新日期：2019-07-18 00:00:00