Abstract:
:The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporation. The proposed system was evaluated in vitro for particle morphology, lag time and floating time, loading rate, release profile, and the release kinetic of AZT release. AZT's physico-chemical characteristics were evaluated by differential scanning calorimetry (DSC), X-ray diffraction (XDR) and infrared spectroscopy (IR). The particles obtained were sphere-shaped, hollow, and had porous walls. The floating was immediate, and floating time was higher than 12 h. The loading rate was 34.0 ± 9.0%. The system obtained had an extended release. DSC and XDR results showed a modification in AZT's solid state. IR spectroscopy revealed that the chemical structure of the AZT was unchanged. The hollow microballoons presented gastroretentive, floating, and extended-release properties.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Yoshida VM,de Oliveira Junior JM,Gonçalves MM,Vila MM,Chaud MVdoi
10.1208/s12249-011-9627-9subject
Has Abstractpub_date
2011-06-01 00:00:00pages
658-64issue
2issn
1530-9932journal_volume
12pub_type
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