Proliposome Powders for the Generation of Liposomes: the Influence of Carbohydrate Carrier and Separation Conditions on Crystallinity and Entrapment of a Model Antiasthma Steroid.

abstract：:Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the drug in the gastrointestinal tract. The study was designed to investigate the lipid formulation digestibility in the simulated gastro intestinal media. Fenofibrate was formulated in representative Type II, ...

journal_title：AAPS PharmSciTech

authors： Mohsin K

更新日期：2012-06-01 00:00:00

abstract：:The purpose of the present study was to design mucoadhesive gliadin nanoparticles (GNP) containing amoxicillin and to evaluate their effectiveness in eradicating Helicobacter pylori. GNP-bearing amoxicillin (AGNP) was prepared by desolvation method. The effect of process variables such as gliadin concentration and ini...

journal_title：AAPS PharmSciTech

authors： Umamaheshwari RB,Ramteke S,Jain NK

更新日期：2004-04-07 00:00:00

abstract：:Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the large armamentarium of drugs available for the management of high blood pressure, low oral availability is an ongoing challenge. Researchers are constantly developing alt...

journal_title：AAPS PharmSciTech

authors： Ita K,Ashong S

更新日期：2020-01-06 00:00:00

abstract：:The specific aim of the present study was to investigate the biodegradation and biocompatibility characteristics of rosin, a natural film-forming polymer. Both in vitro as well as in vivo methods were used for assessment of the same. The in vitro degradation of rosin films was followed in pH 7.4 phosphate buffered sal...

journal_title：AAPS PharmSciTech

authors： Satturwar PM,Fulzele SV,Dorle AK

更新日期：2003-10-22 00:00:00

abstract：:Bilayer nicotine mucoadhesive patches were prepared and evaluated to determine the feasibility of the formulation as a nicotine replacement product to aid in smoking cessation. Nicotine patches were prepared using xanthan gum or carbopol 934 as a mucoadhesive polymers and ethyl cellulose as a backing layer. The patche...

journal_title：AAPS PharmSciTech

authors： Abu-Huwaij R,Obaidat RM,Sweidan K,Al-Hiari Y

更新日期：2011-03-01 00:00:00

abstract：:Hypertension shows circadian blood pressure rhythms (day-night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels. Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that immediately releases olmesartan, to give a burst effect, and controls azelnidipine rel...

journal_title：AAPS PharmSciTech

authors： Rashad AA,Nageeb El-Helaly S,Abd El Rehim RT,El-Gazayerly ON

更新日期：2019-12-10 00:00:00

abstract：:As of March 10, 2020, more than 100,000 novel coronavirus pneumonia cases have been confirmed globally. With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. The drugs currently being developed are not adequate to deal ...

journal_title：AAPS PharmSciTech

authors： Yan J,Liu A,Huang J,Wu J,Fan H

更新日期：2020-05-13 00:00:00

abstract：:In this study, the resveratrol spray-dried emulsions were developed using a quality-by-design approach. Further, the product and process factors that affected the quality of the spray-dried emulsions were analyzed and illustrated using an Ishikawa diagram. The product and process risks were prioritized using a risk-ra...

journal_title：AAPS PharmSciTech

authors： Benjasirimongkol P,Piriyaprasarth S,Moribe K,Sriamornsak P

更新日期：2018-12-18 00:00:00

abstract：:The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of w/o microemulsion (M) and gel (G) bases for diclofenac sodium (DS). The effect of dimethyl sulfoxide (DMSO) as a penetration enhancer was also examined when it was added to the M formulation. To study the in vitro poten...

journal_title：AAPS PharmSciTech

authors： Sarigüllü Ozgüney I,Yeşim Karasulu H,Kantarci G,Sözer S,Güneri T,Ertan G

更新日期：2006-10-20 00:00:00

abstract：:This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200). Critical quality attributes (CQAs) or associated performance indicators of the coated tablets were measured w...

journal_title：AAPS PharmSciTech

authors： Teckoe J,Mascaro T,Farrell TP,Rajabi-Siahboomi AR

更新日期：2013-06-01 00:00:00

abstract：:The aim of this research was to design and evaluate a hydrophilic matrix system for sustained release of glipizide, a weakly acidic poor soluble drug. A combination of inclusion complexation and microenvironmental pH modification techniques was utilized to improve the dissolution and pH-independent release of glipizid...

journal_title：AAPS PharmSciTech

authors： Huang J,Lin H,Peng B,Huang Q,Shuai F,Xie Y

更新日期：2018-07-01 00:00:00

abstract：:The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglo...

journal_title：AAPS PharmSciTech

authors： Furukawa R,Kadota K,Noguchi T,Shimosaka A,Shirakawa Y

更新日期：2017-08-01 00:00:00

abstract：:The effects of solvent [acetonitrile, methanol, and acetonitrile/water mixture (20:80, v/v)], buffer concentration (phosphate buffer, pH 7.5), ionic strength and commonly employed adjuvants on the photodegradation of betamethasone-17 valerate in cream and gel formulations have been studied on exposure to UV light (300...

journal_title：AAPS PharmSciTech

authors： Khattak SU,Shaikh D,Ahmad I,Usmanghani K,Sheraz MA,Ahmed S

更新日期：2013-03-01 00:00:00

abstract：:Onychomycosis is a chronic disorder that is difficult to manage and hard to eradicate with perilous trends to relapse. Due to increased prevalence of HIV, use of immunosuppressant drugs and lifestyle-related factors, population affected with fungal infection of nail (Onychomycosis) happens to increase extensively in l...

journal_title：AAPS PharmSciTech

authors： Vikas A,Rashmin P,Mrunali P,Chavan RB,Kaushik T

更新日期：2020-01-14 00:00:00

abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...

journal_title：AAPS PharmSciTech

authors： Hashem FM,Nasr M,Fathy G,Ismail A

更新日期：2016-06-01 00:00:00

abstract：:Gliclazide (GLI), a poorly water-soluble antidiabetic, was transformed into a glassy state by melt quench technique in order to improve its physicochemical properties. Chemical stability of GLI during formation of glass was assessed by monitoring thin-layer chromatography, and an existence of amorphous form was confir...

journal_title：AAPS PharmSciTech

authors： Jondhale S,Bhise S,Pore Y

更新日期：2012-06-01 00:00:00

abstract：:This paper is a continuation of the research published by the Stability Shelf Life Working Group as chartered under the Product Quality Research Institute. The Working Group was formed in 2006 and disbanded in late 2019. Following the philosophy presented by the Working Group on how to characterize the stability shelf...

journal_title：AAPS PharmSciTech

authors： Schwenke J,Quinlan M,Stroup W,Forenzo P

更新日期：2020-10-20 00:00:00

abstract：:Nanoparticles, of the poorly water-soluble drug, itraconazole (ITZ), were produced by the Advanced Evaporative Precipitation into Aqueous Solution process (Advanced EPAS). This process combines emulsion templating and EPAS processing to provide improved control over the size distribution of precipitated particles. Spe...

journal_title：AAPS PharmSciTech

authors： Bosselmann S,Nagao M,Chow KT,Williams RO 3rd

更新日期：2012-09-01 00:00:00

abstract：:Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child's bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics parameters. If commercial products are unsuitable for administration to children or ...

journal_title：AAPS PharmSciTech

authors： Visser JC,Woerdenbag HJ,Hanff LM,Frijlink HW

更新日期：2017-02-01 00:00:00

abstract：:The aim of this work was the formulation and characterization of alginate (ALG)-doxycycline (DOX) hydrogel microparticles (MPs) embedded into Pluronic F127 thermogel for DOX intradermal sustained delivery. ALG-DOX MPs were formed by adding a solution of the drug into a 1.5% polymer solution while stirring. The MPs wer...

journal_title：AAPS PharmSciTech

authors： Giovagnoli S,Tsai T,DeLuca PP

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to prepare ginkgolide B (GB) lyophilized powder for injection with excellent appearance and stable quality through a formulation screening and by optimizing the freeze-drying process. Cremophor EL as a solubilizer, PEG 400 as a latent solvent, and mannitol as an excipient were mixed to in...

journal_title：AAPS PharmSciTech

authors： Liu D,Galvanin F,Yu Y

更新日期：2018-02-01 00:00:00

abstract：:A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

journal_title：AAPS PharmSciTech

authors： Bento D,Borchard G,Gonçalves T,Borges O

更新日期：2013-06-01 00:00:00

abstract：:An innovative and simple methodology has been developed and used for the evaluation of mucoadhesive properties of several polymers by means of sound speed measurements using high-resolution acoustic spectroscopy. In systems made of polymers in water, variations in hydration shell of polymeric chains determine changes ...

journal_title：AAPS PharmSciTech

authors： Cespi M,Bonacucina G,Mencarelli G,Giorgioni G,Palmieri GF

更新日期：2010-09-01 00:00:00

abstract：:This investigation aimed to develop nimesulide (NMS)-loaded poly(lactic-co-glycolic acid) (PLGA)-based nanoparticulate formulations as a biodegradable polymeric drug carrier to treat rheumatoid arthritis. Polymeric nanoparticles (NPs) were prepared with two different nonionic surfactants, vitamin E d-α-tocopheryl poly...

journal_title：AAPS PharmSciTech

authors： Turk CT,Oz UC,Serim TM,Hascicek C

更新日期：2014-02-01 00:00:00

abstract：:This study focused on the chemical stability of the cephalosporin (6R, 7R)-7-(1-pentafluorophenoxyacetamido)-3-[2-(5-methyl-1,3,4-thiodiazolyl)thiomethyl]-Delta(3)-cephem-4-carboxylic acid, sodium salt (cephem 1) formulation after electron beam (e-beam) irradiation. The cephem 1 concentrations of samples irradiated at...

journal_title：AAPS PharmSciTech

authors： Johns PJ,Turberg M,Willard K,Matagne D,Cheesman D

更新日期：2001-11-19 00:00:00

abstract：:The aim of this work is to improve the understanding of the physicochemical mechanisms involved in the functionality of cross-linked carboxymethyl sodium starch (CCSS) as a tablet super disintegrant (SD). The behavior and properties of this SD (medium uptake, disintegration times, particle size, and rheology) was inve...

journal_title：AAPS PharmSciTech

authors： Delalonde M,Fitouri R,Ruiz E,Bataille B,Sharkawi T

更新日期：2015-04-01 00:00:00

abstract：:Ambient air humidity and temperature are known to influence the mechanical strength of tablets. The objective of this work is to understand the influence of processing parameters and environmental conditions (humidity and temperature) on the strength of bilayer tablets. As part of this study, bilayer tablets were comp...

journal_title：AAPS PharmSciTech

authors： Kottala N,Abebe A,Sprockel O,Bergum J,Nikfar F,Cuitiño AM

更新日期：2012-12-01 00:00:00

abstract：:Emulsions are widely used as topical formulations in the pharmaceutical and cosmetic industries. They are thermodynamically unstable and require emulsifiers for stabilization. Studies have indicated that emulsifiers could affect topical delivery of actives, and this study was therefore designed to investigate the effe...

journal_title：AAPS PharmSciTech

authors： Combrinck J,Otto A,du Plessis J

更新日期：2014-06-01 00:00:00

abstract：:To investigate the possibility of liquid proliposomes being carriers for oral delivery, nimodipine liquid proliposomes-based soft capsules (NPSC) were prepared. Nimodipine proliposomes were characterized by transmission electron microscopy (TEM), conversion rate from proliposomes to liposomes, entrapment efficiency, p...

journal_title：AAPS PharmSciTech

authors： Sun C,Wang J,Liu J,Qiu L,Zhang W,Zhang L

更新日期：2013-03-01 00:00:00

abstract：:The purpose of this study was to demonstrate acoustic resonance spectrometry (ARS) as an alternative process analytical technology to near infrared (NIR) spectroscopy for the quantification of active pharmaceutical ingredient (API) in semi-solids such as creams, gels, ointments, and lotions. The ARS used for this rese...

journal_title：AAPS PharmSciTech

authors： Medendorp J,Buice RG Jr,Lodder RA

更新日期：2006-07-14 00:00:00