Abstract:
:A transdermal drug delivery system (TDDS) is generally designed to deliver an active pharmaceutical ingredient (API) through the skin for systemic action. Permeation of an API through the skin is controlled by adjusting drug concentration, formulation composition, and patch design. A bilayer, drug-in-adhesive TDDS design may allow improved modulation of the drug release profile by facilitating varying layer thicknesses and drug spatial distribution across each layer. We hypothesized that the co-release of two fixed-dose APIs from a bilayer TDDS could be controlled by modifying spatial distribution and layer thickness while maintaining the same overall formulation composition. Franz cell diffusion studies demonstrated that three different bilayer patch designs, with different spatial distribution of drug and layer thicknesses, could modulate drug permeation and be compared with a reference single-layer monolith patch design. Compared with the monolith, decreased opioid antagonist permeation while maintaining fentanyl permeation could be achieved using a bilayer design. In addition, modulation of the drug spatial distribution and individual layer thicknesses, control of each drug's permeation could be independently achieved. Bilayer patch performance did not change over an 8-week period in accelerated stability storage conditions. In conclusion, modifying the patch design of a bilayer TDDS achieves an individualized permeation of each API while maintaining constant patch composition.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Davis DA,Martins PP,Zamloot MS,Kucera SA,Williams RO 3rd,Smyth HDC,Warnken ZNdoi
10.1208/s12249-020-01682-4subject
Has Abstractpub_date
2020-06-04 00:00:00pages
165issue
5issn
1530-9932pii
10.1208/s12249-020-01682-4journal_volume
21pub_type
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pub_type: 传,历史文章,新闻
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