Liposome-encapsulated polyethylenimine/oligonucleotide polyplexes prepared by reverse-phase evaporation technique.

abstract：:The objective of this study was to investigate the release behaviour of propranolol hydrochloride from psyllium matrices in the presence hydrophilic polymers. The dissolution test was carried out at pH 1.2 and pH 6.8. Binary mixtures of psyllium and hydroxypropyl methylcellulose (HPMC) used showed that an increase in ...

journal_title：AAPS PharmSciTech

authors： Siahi-Shadbad MR,Asare-Addo K,Azizian K,Hassanzadeh D,Nokhodchi A

更新日期：2011-12-01 00:00:00

abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...

journal_title：AAPS PharmSciTech

authors： Verma S,Rudraraju VS

更新日期：2015-10-01 00:00:00

abstract：:Nanostructured lipid carriers (NLCs) are interesting delivery systems for enhancing the penetration of an active substance through the skin after topical administration. The present paper described the development of a novel NLCs for minoxidil (MXD) topical delivery. Stearic acid and oleic acid that showed the highest...

journal_title：AAPS PharmSciTech

authors： Wang W,Chen L,Huang X,Shao A

更新日期：2017-02-01 00:00:00

abstract：:In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard reaction adducts were monitored in the recommended infusion time. Different physicochemical methods were used to evaluate the Maillard re...

journal_title：AAPS PharmSciTech

authors： Siahi Shadbad MR,Ghaderi F,Hatami L,Monajjemzadeh F

更新日期：2016-12-01 00:00:00

abstract：:The purpose of this study was to compare the effects of denaturation by microwave irradiation on release properties of 2 physically different proteins. Matrices were prepared from water-soluble bovine serum albumin loaded with metoclopramide and sorbed with adequate amount of moisture were thermally denatured in a mic...

journal_title：AAPS PharmSciTech

authors： Qasem RJ

更新日期：2006-03-01 00:00:00

abstract：:A target product profile (TPP) describes how a product will be utilized by the end user. A systematically developed TPP can ensure alignment of objectives across company departments, accelerate development timelines, minimize development risks, and eventually lead to an optimal product. A TPP is particularly important...

journal_title：AAPS PharmSciTech

authors： Lambert WJ

更新日期：2010-09-01 00:00:00

abstract：:The solubility of five poorly soluble drugs was enhanced by using an effervescence assisted solid dispersion (EASD) technique. EASDs were prepared by using modified fusion method. Drug and hydrophilic carrier were melted, and in this molten mixture, effervescence was generated by adding effervescence couple comprising...

journal_title：AAPS PharmSciTech

authors： Alam MA,Al-Jenoobi FI,Al-Mohizea AM,Ali R

更新日期：2015-12-01 00:00:00

abstract：:The present study demonstrates a preparative medium-pressure liquid chromatography (MPLC) method for isolation of Morin besides evaluating its efficacy in comparison with its self-nanoemulsifying drug delivery (SNEDD) and nanoemulsion (NE) systems against in-vivo HgCl2-induced lung toxicity in rats. Morin was isolated...

journal_title：AAPS PharmSciTech

authors： El-Haddad AE,Sheta NM,Boshra SA

更新日期：2018-07-01 00:00:00

abstract：:Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at ...

journal_title：AAPS PharmSciTech

authors： Terry TL,Givens BE,Rodgers VGJ,Salem AK

更新日期：2019-01-02 00:00:00

abstract：:The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose acetate succinate (HPMCAS, Shin-Etsu AQOAT®, medium particle si...

journal_title：AAPS PharmSciTech

authors： Lu J,Obara S,Liu F,Fu W,Zhang W,Kikuchi S

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this research was to compare the viscoelastic properties of several neutral and anionic polysaccharide polymers with their mucociliary transport rates (MTR) across explants of ciliated bovine tracheal tissue to identify rheologic parameters capable of predicting the extent of reduction in mucociliary tr...

journal_title：AAPS PharmSciTech

authors： Shah AJ,Donovan MD

更新日期：2007-04-20 00:00:00

abstract：:Droplet velocity is an important parameter that can be used to characterize nasal spray products. In this study, a phase-Doppler anemometry (PDA) system was used to measure the droplet velocities of nasal sprays. A survey of seven commercial nasal spray products showed a range of droplet velocities from 6.7 to 19.2 m/...

journal_title：AAPS PharmSciTech

authors： Liu X,Doub WH,Guo C

更新日期：2011-03-01 00:00:00

abstract：:Pressurized metered dose inhalers (MDIs) were first introduced in the 1950s and they are currently widely prescribed as portable systems to treat pulmonary conditions. MDIs consist of a formulation containing dissolved or suspended drug and hardware needed to contain the formulation and enable efficient and consistent...

journal_title：AAPS PharmSciTech

authors： Stein SW,Sheth P,Hodson PD,Myrdal PB

更新日期：2014-04-01 00:00:00

abstract：:The study is designed to formulate, optimize, and evaluate astaxanthin (ASTA)-loaded nanostructured lipid carrier (NLC) with an aim to improve its stability, water solubility, skin permeability and retention and reduce drug-related side effects. ASTA was extracted from Haematococcus pluvialis. ASTA-NLC was formulated ...

journal_title：AAPS PharmSciTech

authors： Geng Q,Zhao Y,Wang L,Xu L,Chen X,Han J

更新日期：2020-11-11 00:00:00

abstract：:Use of higher tableting speeds is gaining increasing importance for pharmaceutical industry. There is a profound lack of new studies of mechanical properties of hypromellose, and none of them evaluate different suppliers. Thus, the objective of this study was to investigate flow and compaction properties of different ...

journal_title：AAPS PharmSciTech

authors： Grdešič P,Paudel A,German Ilić I

更新日期：2020-07-22 00:00:00

abstract：:In the spectrophotometric assay of multicomponent systems involved in drug degradation studies, some minor or unknown degradation products may be present. These products may interfere in the assay and thus invalidate the results due to their absorption in the range of analytical wavelengths. This interference may be e...

journal_title：AAPS PharmSciTech

authors： Ahmad I,Qadeer K,Iqbal K,Ahmed S,Sheraz MA,Ali SA,Mirza T,Hafeez A

更新日期：2013-09-01 00:00:00

abstract：:The scale up of production processes is a major challenge in pharmaceutical industry. Using a quality by design approach, upscaling can be based on the design space, which can be assessed on a small scale. In a previous study, the critical process parameters were identified by a definitive screening design on cetomacr...

journal_title：AAPS PharmSciTech

authors： van Heugten AJP,Vromans H

更新日期：2018-07-01 00:00:00

abstract：:The purpose of this research was to evaluate a novel fiber-optic photometer for its ability to monitor physical instabilities occurring in concentrated emulsions during storage. For this, the fiber-optic photometer was used to measure transmission of oil-in-water emulsions stabilized with hypromellose (HPMC) as a func...

journal_title：AAPS PharmSciTech

authors： Oliczewski S,Daniels R

更新日期：2007-08-31 00:00:00

abstract：:The aim of the present study was to investigate the feasibility of the inclusion of a water-insoluble drug (diazepam, DZ) into solid lipid nanoparticles (SLNs), which offer combined advantages of rapid onset and prolonged release of the drug. This work also describes a new approach to prepare suppositories containing ...

journal_title：AAPS PharmSciTech

authors： Abdelbary G,Fahmy RH

更新日期：2009-01-01 00:00:00

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00

abstract：:This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two diff...

journal_title：AAPS PharmSciTech

authors： Al-Sahaf Z,Raimi-Abraham B,Licciardi M,de Mohac LM

更新日期：2020-10-02 00:00:00

abstract：:The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglo...

journal_title：AAPS PharmSciTech

authors： Furukawa R,Kadota K,Noguchi T,Shimosaka A,Shirakawa Y

更新日期：2017-08-01 00:00:00

abstract：:Rheumatoid arthritis is an autoimmune disease that leads to cartilage destruction, synovial joint inflammation, and bacterial joint/bone infections. In the present work, methotrexate and minocycline-loaded nanoparticles (MMNPs) were developed with an aim to provide relief from inflammation and disease progression/join...

journal_title：AAPS PharmSciTech

authors： Janakiraman K,Krishnaswami V,Sethuraman V,Natesan S,Rajendran V,Kandasamy R

更新日期：2019-12-23 00:00:00

abstract：:The aim of this research was to advance solid lipid nanoparticle (SLN) preparation methodology by preparing glyceryl monostearate (GMS) nanoparticles using a temperature-modulated solidification process. The technique was reproducible and prepared nanoparticles without the need of organic solvents. An anticancer agent...

journal_title：AAPS PharmSciTech

authors： Patel MN,Lakkadwala S,Majrad MS,Injeti ER,Gollmer SM,Shah ZA,Boddu SH,Nesamony J

更新日期：2014-12-01 00:00:00

abstract：:Onychomycosis is a chronic disorder that is difficult to manage and hard to eradicate with perilous trends to relapse. Due to increased prevalence of HIV, use of immunosuppressant drugs and lifestyle-related factors, population affected with fungal infection of nail (Onychomycosis) happens to increase extensively in l...

journal_title：AAPS PharmSciTech

authors： Vikas A,Rashmin P,Mrunali P,Chavan RB,Kaushik T

更新日期：2020-01-14 00:00:00

abstract：:In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the li...

journal_title：AAPS PharmSciTech

authors： Halenius A,Lakio S,Antikainen O,Hatara J,Yliruusi J

更新日期：2014-06-01 00:00:00

abstract：:The purpose of this study was to investigate physicochemical characteristics and in vitro release of zidovudine from monolithic film of Eudragit RL 100 and ethyl cellulose. Films included 2.5% or 5% (w/w) zidovudine of the dry polymer weight were prepared in various ratios of polymers by solvent evaporation method fro...

journal_title：AAPS PharmSciTech

authors： Takmaz EA,Inal O,Baykara T

更新日期：2009-01-01 00:00:00

abstract：:The effects of electron beam or gamma-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated...

journal_title：AAPS PharmSciTech

authors： Cilurzo F,Selmin F,Minghetti P,Montanari L,Lenardi C,Orsini F,Poletti G

更新日期：2005-12-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of particle size, storage temperature, and duration of storage on the physical stability and morphology of polylactic-co-glycolic acid (PLGA) nanospheres and microspheres. PLGA nanospheres and microspheres containing the fluorescent dye, Bodipy, were prepared in ...

journal_title：AAPS PharmSciTech

authors： De S,Robinson DH

更新日期：2004-09-13 00:00:00

abstract：:The addition of polysorbate 20 (T20) is required to achieve "sink" conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml...

journal_title：AAPS PharmSciTech

authors： Hoppe K,Sznitowska M

更新日期：2014-10-01 00:00:00