Abstract:
:The aim of this research was to advance solid lipid nanoparticle (SLN) preparation methodology by preparing glyceryl monostearate (GMS) nanoparticles using a temperature-modulated solidification process. The technique was reproducible and prepared nanoparticles without the need of organic solvents. An anticancer agent, 5-fluorouracil (5-FU), was incorporated in the SLNs. The SLNs were characterized by particle size analysis, zeta potential analysis, differential scanning calorimetry (DSC), infrared spectroscopy, atomic force microscopy (AFM), transmission electron microscopy (TEM), drug encapsulation efficiency, in vitro drug release, and in vitro cell viability studies. Particle size of the SLN dispersion was below 100 nm, and that of redispersed lyophilizates was ~500 nm. DSC and infrared spectroscopy suggested that the degree of crystallinity did not decrease appreciably when compared to GMS. TEM and AFM images showed well-defined spherical to oval particles. The drug encapsulation efficiency was found to be approximately 46%. In vitro drug release studies showed that 80% of the encapsulated drug was released within 1 h. In vitro cell cultures were biocompatible with blank SLNs but demonstrated concentration-dependent changes in cell viability to 5-FU-loaded SLNs. The 5-FU-loaded SLNs can potentially be utilized in an anticancer drug delivery system.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Patel MN,Lakkadwala S,Majrad MS,Injeti ER,Gollmer SM,Shah ZA,Boddu SH,Nesamony Jdoi
10.1208/s12249-014-0168-xsubject
Has Abstractpub_date
2014-12-01 00:00:00pages
1498-508issue
6issn
1530-9932journal_volume
15pub_type
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:AAPS PharmSciTech
pub_type: 已发布勘误
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更新日期:2019-02-25 00:00:00
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