Comparative study of propranolol hydrochloride release from matrix tablets with KollidonSR or hydroxy propyl methyl cellulose.

abstract：:Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticle...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-10-01 00:00:00

abstract：:A simple but novel mixed surfactant system was designed to fabricate a self-nanoemulsifying drug delivery system (SNEDDS) based on hydrophilic-lipophilic balance (HLB) value. The impacts of HLB and molecular structure of surfactants on the formation of SNEDDS were investigated. After screening various oils and surfact...

journal_title：AAPS PharmSciTech

authors： Weerapol Y,Limmatvapirat S,Nunthanid J,Sriamornsak P

更新日期：2014-04-01 00:00:00

abstract：:Enterovirus 71 (EV71) is a pathogenic factor of severe hand, foot, and mouth disease (HFMD). No vaccine or specific treatment is currently available for EV71 infection. Hence, we developed a buccal mucoadhesive gel containing matrine to protect against HFMD. Mucoadhesive gels were prepared by Carbopol 974P and were co...

journal_title：AAPS PharmSciTech

authors： Chen X,Yan J,Yu S,Wang P

更新日期：2018-01-01 00:00:00

abstract：:Curcumin is a naturally occurring constituent of turmeric that is a good substitute for synthetic medicines for the treatment of different diseases, due to its comparatively safer profile. However, there are certain shortcomings that limit its use as an ideal therapeutic agent. In order to overcome these drawbacks, we...

journal_title：AAPS PharmSciTech

authors： Akbar MU,Zia KM,Nazir A,Iqbal J,Ejaz SA,Akash MSH

更新日期：2018-08-01 00:00:00

abstract：:Gliclazide (GLI), a poorly water-soluble antidiabetic, was transformed into a glassy state by melt quench technique in order to improve its physicochemical properties. Chemical stability of GLI during formation of glass was assessed by monitoring thin-layer chromatography, and an existence of amorphous form was confir...

journal_title：AAPS PharmSciTech

authors： Jondhale S,Bhise S,Pore Y

更新日期：2012-06-01 00:00:00

abstract：:The purpose of this research was to evaluate in vitro transnasal sustained-release ability of sorbitan monostearate (SMS) organogels in isopropyl myristate (IM). Organogels were prepared containing SMS (2.5%-20%) and water (5%-25%) in IM and analyzed microscopically for phase behavior. The effect of Tween surfactants ...

journal_title：AAPS PharmSciTech

authors： Pisal S,Shelke V,Mahadik K,Kadam S

更新日期：2004-09-13 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to investigate the feasibility of the inclusion of a water-insoluble drug (diazepam, DZ) into solid lipid nanoparticles (SLNs), which offer combined advantages of rapid onset and prolonged release of the drug. This work also describes a new approach to prepare suppositories containing ...

journal_title：AAPS PharmSciTech

authors： Abdelbary G,Fahmy RH

更新日期：2009-01-01 00:00:00

abstract：:Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study was to identify the most suitable co-processed excipient to use ...

journal_title：AAPS PharmSciTech

authors： Dziemidowicz K,Lopez FL,Bowles BJ,Edwards AJ,Ernest TB,Orlu M,Tuleu C

更新日期：2018-08-01 00:00:00

abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...

journal_title：AAPS PharmSciTech

authors： Hashem FM,Nasr M,Fathy G,Ismail A

更新日期：2016-06-01 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:For the prediction of the air and product temperatures, the product moisture, and the air humidity during a coating process in a Bohle Lab-Coater, a model was developed. The purpose of this work was to determine the limit moisture, the critical moisture, and the constant for the exchange rate between both zones and to...

journal_title：AAPS PharmSciTech

authors： Page S,Baumann KH,Kleinebudde P

更新日期：2006-05-05 00:00:00

abstract：:The purpose of this research was to assess the physicochemical properties of a controlled release formulation of recombinant human growth hormone (rHGH) encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) composite microspheres. rHGH was loaded in poly(acryloyl hydroxyethyl) starch (acHES) microparticles, and then t...

journal_title：AAPS PharmSciTech

authors： Capan Y,Jiang G,Giovagnoli S,Na KH,DeLuca PP

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was to prepare bi-layer tablet of Metoclopramide Hydrochloride (MTH) and Ibuprofen (IB) for the effective treatment of migraine. MTH and IB were formulated as immediate and sustained release layer respectively. MTH was formulated as immediate release layer by using various disintegrants like Ac-D...

journal_title：AAPS PharmSciTech

authors： Shiyani B,Gattani S,Surana S

更新日期：2008-01-01 00:00:00

abstract：:Poly(vinyl alcohol) (PVA)-based formulations are used for pharmaceutical tablet coating with numerous advantages. Our objective is to study the stability of PVA-based coating films in the presence of acidic additives, alkaline additives, and various common impurities typically found in tablet formulations. Opadry® II ...

journal_title：AAPS PharmSciTech

authors： Koo OM,Fiske JD,Yang H,Nikfar F,Thakur A,Scheer B,Adams ML

更新日期：2011-06-01 00:00:00

abstract：:The objective of the study was to investigate in vitro transdermal delivery of venlafaxine hydrochloride across the pigskin by passive diffusion and iontophoresis. For passive diffusion, experiments were carried out in Franz diffusion cell whereas for iontophoretic permeation, the diffusion cell was modified to contai...

journal_title：AAPS PharmSciTech

authors： Singh G,Ghosh B,Kaushalkumar D,Somsekhar V

更新日期：2008-01-01 00:00:00

abstract：:In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new microencapsulated formulation of probucol-sodium alginate (PB-SA), with good structural properties and excipient compati...

journal_title：AAPS PharmSciTech

authors： Mooranian A,Negrulj R,Al-Sallami HS,Fang Z,Mikov M,Golocorbin-Kon S,Fakhoury M,Watts GF,Matthews V,Arfuso F,Lambros A,Al-Salami H

更新日期：2015-02-01 00:00:00

abstract：:MUC1 gene encodes a transmembrane mucin glycoprotein that is overexpressed in human breast cancer and colon cancer. The objective of this study was to develop an in situ gel delivery system containing paclitaxel (PTX) and mucoadhesives for sustained and targeted delivery of anticancer drugs. The delivery system consis...

journal_title：AAPS PharmSciTech

authors： Jauhari S,Dash AK

更新日期：2006-06-02 00:00:00

abstract：:In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the li...

journal_title：AAPS PharmSciTech

authors： Halenius A,Lakio S,Antikainen O,Hatara J,Yliruusi J

更新日期：2014-06-01 00:00:00

abstract：:While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category successfully commercialized to date despite clinical and market demand...

journal_title：AAPS PharmSciTech

authors： Wu F,Jin T

更新日期：2008-01-01 00:00:00

abstract：:Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generati...

journal_title：AAPS PharmSciTech

authors： Das S,Chaudhury A

更新日期：2011-03-01 00:00:00

abstract：:Curcumin chewing gums could be therapeutically beneficial if used by the head and neck cancer patients. High curcumin loading in chewing gums however is needed to achieve desired therapeutic effect. Preparing gums with high drug load is nonetheless challenging because of the negative impact of solids on their masticat...

journal_title：AAPS PharmSciTech

authors： Al Hagbani T,Altomare C,Kamal MM,Nazzal S

更新日期：2018-11-01 00:00:00

abstract：:An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded ther...

journal_title：AAPS PharmSciTech

authors： Priprem A,Janpim K,Nualkaew S,Mahakunakorn P

更新日期：2016-06-01 00:00:00

abstract：:For polymer-based controlled release drug products (e.g. microspheres and implants), active pharmaceutical ingredient distribution and microporosity inside the polymer matrix are critical for product performance, particularly drug release kinetics. Due to the decreasing domain size and increasing complexity of such pr...

journal_title：AAPS PharmSciTech

authors： Zhang S,Wu D,Zhou L

更新日期：2020-07-14 00:00:00

abstract：:The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol 934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into...

journal_title：AAPS PharmSciTech

authors： Patel VM,Prajapati BG,Patel MM

更新日期：2007-06-22 00:00:00

abstract：:This work was aimed at evaluating the effect of a pharmaceutical cationic exchange resin (Amberlite IRP-69) on the properties of controlled release matrices using Methocel K4M (HPMC) or Ethocel 7cP (EC) as matrix formers. Diphenhydramine hydrochloride (DPH), which was cationic and water soluble, was chosen as a model ...

journal_title：AAPS PharmSciTech

authors： Akkaramongkolporn P,Ngawhirunpat T,Nunthanid J,Opanasopit P

更新日期：2008-01-01 00:00:00

abstract：:Transdermal drug delivery is an emerging field in the pharmaceutical remit compared with conventional methods (oral and parenteral). Microneedle (MN)-based devices have gained significant interest as a strategy to overcome the skin's formidable barrier: the stratum corneum. This approach provides a less invasive, more...

journal_title：AAPS PharmSciTech

authors： Ali R,Mehta P,Arshad MS,Kucuk I,Chang MW,Ahmad Z

更新日期：2019-12-05 00:00:00

abstract：:The aim of this study was to introduce smectite clay matrices as a drug delivery carrier for the development of amorphous solid dispersions (ASD). Indomethacin (IND) was processed with two different smectite clays, magnesium aluminium and lithium magnesium sodium silicates, using hot melt extrusion (HME) to prepare so...

journal_title：AAPS PharmSciTech

authors： Nandi U,Mithu MSH,Hurt AP,Trivedi V,Douroumis D

更新日期：2020-10-08 00:00:00

abstract：:Ambient air humidity and temperature are known to influence the mechanical strength of tablets. The objective of this work is to understand the influence of processing parameters and environmental conditions (humidity and temperature) on the strength of bilayer tablets. As part of this study, bilayer tablets were comp...

journal_title：AAPS PharmSciTech

authors： Kottala N,Abebe A,Sprockel O,Bergum J,Nikfar F,Cuitiño AM

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this present study was to evaluate the antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX). The SSL-PTX was prepared by the thin-film method. The release of paclitaxel from SSL-PTX was analyzed using a dialysis method. The effect of SSL-PTX on endothelial cell prol...

journal_title：AAPS PharmSciTech

authors： Huang Y,Chen XM,Zhao BX,Ke XY,Zhao BJ,Zhao X,Wang Y,Zhang X,Zhang Q

更新日期：2010-06-01 00:00:00