Pluronic-Based Mixed Polymeric Micelles Enhance the Therapeutic Potential of Curcumin.

abstract：:The effects of solvent [acetonitrile, methanol, and acetonitrile/water mixture (20:80, v/v)], buffer concentration (phosphate buffer, pH 7.5), ionic strength and commonly employed adjuvants on the photodegradation of betamethasone-17 valerate in cream and gel formulations have been studied on exposure to UV light (300...

journal_title：AAPS PharmSciTech

authors： Khattak SU,Shaikh D,Ahmad I,Usmanghani K,Sheraz MA,Ahmed S

更新日期：2013-03-01 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:Hard capsules are made from gelatin, an organic polymer obtained through the hydrolysis of collagen present in animal tissues. Gelatin can be degraded by microorganisms and some strategies can be used to control contaminating micro-organisms. Gamma irradiation is considered as an effective sterilization method; howeve...

journal_title：AAPS PharmSciTech

authors： Rodrigues JT,Neto FNS,Ferreira MF,Naves PLF,Guilherme LR

更新日期：2019-05-20 00:00:00

abstract：:The present study was aimed to optimize, develop, and evaluate microemulsion and microemulsion-based gel as a vehicle for transungual drug delivery of terbinafine hydrochloride for the treatment of onychomycosis. D-optimal mixture experimental design was adopted to optimize the composition of microemulsion having amou...

journal_title：AAPS PharmSciTech

authors： Thatai P,Sapra B

更新日期：2017-08-01 00:00:00

abstract：:A large number of pharmaceuticals exhibit polymorphism; 23% steroids, 60% sulfonamides, and 70% of barbiturates have shown this property. In this study, we have investigated and compared a new technique termed as melt sonocrystallization (MSC) with melt and sonocrystallization (SC) for induction of polymorphism in pro...

journal_title：AAPS PharmSciTech

authors： Tripathi R,Biradar SV,Mishra B,Paradkar AR

更新日期：2010-09-01 00:00:00

abstract：:To investigate the possibility of liquid proliposomes being carriers for oral delivery, nimodipine liquid proliposomes-based soft capsules (NPSC) were prepared. Nimodipine proliposomes were characterized by transmission electron microscopy (TEM), conversion rate from proliposomes to liposomes, entrapment efficiency, p...

journal_title：AAPS PharmSciTech

authors： Sun C,Wang J,Liu J,Qiu L,Zhang W,Zhang L

更新日期：2013-03-01 00:00:00

abstract：:In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced ...

journal_title：AAPS PharmSciTech

authors： Rachid O,Simons KJ,Rawas-Qalaji M

更新日期：2018-11-01 00:00:00

abstract：:The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and Eudragit RS100 as film-forming polymers. Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in firs...

journal_title：AAPS PharmSciTech

authors： Gohel MC,Nagori SA

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to investigate the influence of experimental conditions on levothyroxine sodium release from two immediate-release tablet formulations which narrowly passed the standard requirements for bioequivalence studies. The in vivo study was conducted as randomised, single-dose, two-way cross-over pha...

journal_title：AAPS PharmSciTech

authors： Kocic I,Homsek I,Dacevic M,Parojcic J,Miljkovic B

更新日期：2011-09-01 00:00:00

abstract：:The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro. The delivery system was prepared by a multiple emulsion solvent evaporation method. The n...

journal_title：AAPS PharmSciTech

authors： Trickler WJ,Khurana J,Nagvekar AA,Dash AK

更新日期：2010-03-01 00:00:00

abstract：:Risedronate sodium (RS) is a potent inhibitor of bone resorption, having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions while keeping in an upright posture for at least 30 min to diminish common gastroesophageal injuries. To surmount suc...

journal_title：AAPS PharmSciTech

authors： Elkady OA,Tadros MI,El-Laithy HM

更新日期：2019-12-05 00:00:00

abstract：:Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmona...

journal_title：AAPS PharmSciTech

authors： Chen J,Tang Y,Liu Y,Dou Y

更新日期：2018-11-01 00:00:00

abstract：:The purpose of this present study was to evaluate the antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX). The SSL-PTX was prepared by the thin-film method. The release of paclitaxel from SSL-PTX was analyzed using a dialysis method. The effect of SSL-PTX on endothelial cell prol...

journal_title：AAPS PharmSciTech

authors： Huang Y,Chen XM,Zhao BX,Ke XY,Zhao BJ,Zhao X,Wang Y,Zhang X,Zhang Q

更新日期：2010-06-01 00:00:00

abstract：:Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at ...

journal_title：AAPS PharmSciTech

authors： Terry TL,Givens BE,Rodgers VGJ,Salem AK

更新日期：2019-01-02 00:00:00

abstract：:The current study aimed to develop a prolonged-release pramipexole (PPX) transdermal patch for the treatment of Parkinson's disease. Permeation parameters of PPX were investigated using human cadaver skin. Pramipexole patches were prepared using DURO-TAK® pressure-sensitive-adhesive (PSA) and evaluated for drug stabil...

journal_title：AAPS PharmSciTech

authors： Pu T,Li X,Sun Y,Ding X,Pan Y,Wang Q

更新日期：2017-04-01 00:00:00

abstract：:Nanotechnology is having a significant impact in the drug delivery systems and diagnostic devices. As most of the nanosystems are intended to be administered in vivo, there is a need for stability models, which could simulate the biological environment. Instability issues could lead to particle aggregation and in turn...

journal_title：AAPS PharmSciTech

authors： Shaikh MV,Kala M,Nivsarkar M

更新日期：2017-05-01 00:00:00

abstract：:The hydrophobicity of bioactive molecules poses a considerable problem in the pharmaceutical and the food industry. Using food-based protein nanocarriers is one promising way to deliver hydrophobic molecules. These types of protein possess many functional properties such as surface activity, water-binding capacity, em...

journal_title：AAPS PharmSciTech

authors： Maviah MBJ,Farooq MA,Mavlyanova R,Veroniaina H,Filli MS,Aquib M,Kesse S,Boakye-Yiadom KO,Wang B

更新日期：2020-03-09 00:00:00

abstract：:Phase transformations in formulations can lead to instability in physicochemical, biopharmaceutical, and processing properties of products. The influences of formulation design on the optimal dosage forms should be specified. The aim here was to investigate whether excipients with different water sorption behavior aff...

journal_title：AAPS PharmSciTech

authors： Airaksinen S,Karjalainen M,Kivikero N,Westermarck S,Shevchenko A,Rantanen J,Yliruusi J

更新日期：2005-10-06 00:00:00

abstract：:Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good ...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Shang Z,Gao C,Du M,Xu S,Song H,Liu T

更新日期：2014-08-01 00:00:00

abstract：:While polyethylene oxide (PEO)-based matrix tablets are frequently used as abuse-deterrent dosage forms, there is limited information available regarding how the selection of formulation components and manufacturing processes affect the resulting abuse-deterrent properties. The objective of the current study was to ev...

journal_title：AAPS PharmSciTech

authors： Meruva S,Donovan MD

更新日期：2019-12-19 00:00:00

abstract：:Successful pellet production has been reported in literature with cross-linked poly(vinylpyrrolidone), Polyplasdone® XL-10 and INF-10. In the present study, a quality by experimental design approach was used to assess several formulation and process parameter effects on the characteristics of Polyplasdone® XL-10 pelle...

journal_title：AAPS PharmSciTech

authors： Saripella KK,Loka NC,Mallipeddi R,Rane AM,Neau SH

更新日期：2016-04-01 00:00:00

abstract：:Spheroid formation mechanisms were investigated using extrusion-spheronization (ES) and rotary processing (RP). Using ES (cross-hatch), ES (teardrop), and RP (teardrop), spheroids with similar mass median diameter (MMD) and span were produced using equivalent formulation and spheronization conditions. During spheroniz...

journal_title：AAPS PharmSciTech

authors： Liew CV,Chua SM,Heng PW

更新日期：2007-02-09 00:00:00

abstract：:The objective of the present study is to investigate the effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole (MTZ). Twelve formulations (1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol in 4% concentration, 1,2-hexanediol, and 1,2-heptanediol in 1% concentr...

journal_title：AAPS PharmSciTech

authors： Li N,Jia W,Zhang Y,Zhang MC,Tan F,Zhang J

更新日期：2014-04-01 00:00:00

abstract：:This study examined the mechanical (hardness, compressibility, adhesiveness, and cohesiveness) and rheological (zero-rate viscosity and thixotropy) properties of polyethylene glycol (PEG) gels that contain different ratios of Carbopol 934P (CP) and polyvinylpyrrolidone K90 (PVP). Mechanical properties were examined us...

journal_title：AAPS PharmSciTech

authors： Tan YT,Peh KK,Al-Hanbali O

更新日期：2000-08-17 00:00:00

abstract：:A combination of analytical and statistical methods is used to improve a tablet coating process guided by quality by design (QbD) principles. A solid dosage form product was found to intermittently exhibit bad taste. A suspected cause was the variability in coating thickness which could lead to the subject tasting the...

journal_title：AAPS PharmSciTech

authors： Dubey A,Boukouvala F,Keyvan G,Hsia R,Saranteas K,Brone D,Misra T,Ierapetritou MG,Muzzio FJ

更新日期：2012-03-01 00:00:00

abstract：:Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation, where poorly soluble acidic AMG 009 molecule was intimately mixed and compressed together with a basic pH modifier (e.g., sodium carbonate) and nucleation inhibitor hydroxypropyl methylcellulose ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:Pentoxifylline (PTX), an anti-hemorrhage drug used in the treatment of intermittent claudication, is extensively metabolized by the liver resulting in a reduction of the therapeutic levels within a short duration of time. Self-nano-emulsifying drug delivery system (SNEDDS) is well reported to enhance the bio-absorptio...

journal_title：AAPS PharmSciTech

authors： Shailendrakumar AM,Ghate VM,Kinra M,Lewis SA

更新日期：2020-04-21 00:00:00

abstract：:Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...

journal_title：AAPS PharmSciTech

authors： Yu X,Sun L,Tan L,Wang M,Ren X,Pi J,Jiang M,Li N

更新日期：2020-01-29 00:00:00

abstract：:Freeze-dried immunoglobulin G (IgG) incorporating trehalose and human serum albumin (HSA) was statistically evaluated regarding the existence of synergism between additives on the stability profile. The levels of HSA (X1) and trehalose (X2) were independent variables. Aggregation following the process (Y1), after 2 an...

journal_title：AAPS PharmSciTech

authors： Nouraei MS,Faghihi H,Najafabadi AR,Zadeh AHM,Darabi M,Vatanara A

更新日期：2019-10-28 00:00:00

abstract：:Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the drug in the gastrointestinal tract. The study was designed to investigate the lipid formulation digestibility in the simulated gastro intestinal media. Fenofibrate was formulated in representative Type II, ...

journal_title：AAPS PharmSciTech

authors： Mohsin K

更新日期：2012-06-01 00:00:00