Study of polymorphs of progesterone by novel melt sonocrystallization technique: a technical note.

abstract：:Ferulic acid is contained in some Chinese herbal medicines such as Ligusticum chuanxiong or Angelica sinensis. Studies have focused on the treatment of inflammatory diseases and pain using ferulic acid. However, little is known about its pharmacokinetics after transdermal administration. The present research investiga...

journal_title：AAPS PharmSciTech

authors： Yan N,Tang Z,Xu Y,Li X,Wang Q

更新日期：2020-06-08 00:00:00

abstract：:In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new microencapsulated formulation of probucol-sodium alginate (PB-SA), with good structural properties and excipient compati...

journal_title：AAPS PharmSciTech

authors： Mooranian A,Negrulj R,Al-Sallami HS,Fang Z,Mikov M,Golocorbin-Kon S,Fakhoury M,Watts GF,Matthews V,Arfuso F,Lambros A,Al-Salami H

更新日期：2015-02-01 00:00:00

abstract：:Gliclazide (GLI), a poorly water-soluble antidiabetic, was transformed into a glassy state by melt quench technique in order to improve its physicochemical properties. Chemical stability of GLI during formation of glass was assessed by monitoring thin-layer chromatography, and an existence of amorphous form was confir...

journal_title：AAPS PharmSciTech

authors： Jondhale S,Bhise S,Pore Y

更新日期：2012-06-01 00:00:00

abstract：:An acid-buffering bioadhesive vaginal tablet was developed for the treatment of genitourinary tract infections. From the bioadhesion experiment and release studies it was found that polycarbophil and sodium carboxymethylcellulose is a good combination for an acid-buffering bioadhesive vaginal tablet. Sodium monocitrat...

journal_title：AAPS PharmSciTech

authors： Alam MA,Ahmad FJ,Khan ZI,Khar RK,Ali M

更新日期：2007-12-14 00:00:00

abstract：:Drying is one of the standard unit operations in the pharmaceutical industry and it is important to become aware of the circumstances that dominate during the process. The purpose of this study was to test microcapsulated thermochromic pigments as heat indicators in a fluid bed drying process. The indicator powders we...

journal_title：AAPS PharmSciTech

authors： Lakio S,Heinämäki J,Yliruusi J

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this present study was to evaluate the antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX). The SSL-PTX was prepared by the thin-film method. The release of paclitaxel from SSL-PTX was analyzed using a dialysis method. The effect of SSL-PTX on endothelial cell prol...

journal_title：AAPS PharmSciTech

authors： Huang Y,Chen XM,Zhao BX,Ke XY,Zhao BJ,Zhao X,Wang Y,Zhang X,Zhang Q

更新日期：2010-06-01 00:00:00

abstract：:The addition of polysorbate 20 (T20) is required to achieve "sink" conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml...

journal_title：AAPS PharmSciTech

authors： Hoppe K,Sznitowska M

更新日期：2014-10-01 00:00:00

abstract：:Itraconazole (ITZ) crystalline nanoparticles were prepared using relatively simple, low-cost sonoprecipitation technique, in which both the solvent and antisolvent were organic in nature. The effect of stabilizer type (hydroxypropyl methylcellulose, hydroxypropyl cellulose, Inutec SP1®, and pluronic F127), drying meth...

journal_title：AAPS PharmSciTech

authors： Badawi AA,El-Nabarawi MA,El-Setouhy DA,Alsammit SA

更新日期：2011-09-01 00:00:00

abstract：:A target product profile (TPP) describes how a product will be utilized by the end user. A systematically developed TPP can ensure alignment of objectives across company departments, accelerate development timelines, minimize development risks, and eventually lead to an optimal product. A TPP is particularly important...

journal_title：AAPS PharmSciTech

authors： Lambert WJ

更新日期：2010-09-01 00:00:00

abstract：:This work was aimed at evaluating the effect of a pharmaceutical cationic exchange resin (Amberlite IRP-69) on the properties of controlled release matrices using Methocel K4M (HPMC) or Ethocel 7cP (EC) as matrix formers. Diphenhydramine hydrochloride (DPH), which was cationic and water soluble, was chosen as a model ...

journal_title：AAPS PharmSciTech

authors： Akkaramongkolporn P,Ngawhirunpat T,Nunthanid J,Opanasopit P

更新日期：2008-01-01 00:00:00

abstract：:Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray D...

journal_title：AAPS PharmSciTech

authors： Ubale RV,Shastri PN,Oettinger C,D'Souza MJ

更新日期：2018-05-01 00:00:00

abstract：:The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio...

journal_title：AAPS PharmSciTech

authors： Douroumis DD,Gryczke A,Schminke S

更新日期：2011-03-01 00:00:00

abstract：:This investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated Dapsone (DS) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of Pneumocystis carinii pneumonia (PCP) associated with immunocompromised pat...

journal_title：AAPS PharmSciTech

authors： Chougule M,Padhi B,Misra A

更新日期：2008-01-01 00:00:00

abstract：:A transmission near infrared (NIR) spectroscopic method has been developed for the nondestructive determination of drug content in tablets with less than 1% weight of active ingredient per weight of formulation (m/m) drug content. Tablets were manufactured with drug concentrations of approximately 0.5%, 0.7%, and 1.0%...

journal_title：AAPS PharmSciTech

authors： Meza CP,Santos MA,Romañach RJ

更新日期：2006-03-24 00:00:00

abstract：:Biowaivers are recommended for immediate-release solid oral dosage forms using dissolution testing as a surrogate for in vivo bioequivalence studies. Several guidance are currently available (the World Health Organization (WHO), the US FDA, and the EMEA) where the conditions are described. In this study, definitions, ...

journal_title：AAPS PharmSciTech

authors： Reddy NH,Patnala S,Löbenberg R,Kanfer I

更新日期：2014-10-01 00:00:00

abstract：:Droplet velocity is an important parameter that can be used to characterize nasal spray products. In this study, a phase-Doppler anemometry (PDA) system was used to measure the droplet velocities of nasal sprays. A survey of seven commercial nasal spray products showed a range of droplet velocities from 6.7 to 19.2 m/...

journal_title：AAPS PharmSciTech

authors： Liu X,Doub WH,Guo C

更新日期：2011-03-01 00:00:00

abstract：:The main objective of the present study is the physicochemical characterization of naturally available Terminalia catappa gum (Badam gum [BG]) as a novel pharmaceutical excipient and its suitability in the development of gastroretentive floating drug delivery systems (GRFDDS) to retard the drug for 12 h when the dosag...

journal_title：AAPS PharmSciTech

authors： Meka VS,Nali SR,Songa AS,Kolapalli VR

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this research was to address the utility of rheological study in understanding the influence of oppositely charged polymers on release of naproxen sodium encapsulated in chitosan particles. The interaction between oppositely charged kappa-carrageenan (kappa-Ca) and chitosan leads to relatively higher ge...

journal_title：AAPS PharmSciTech

authors： Bhise KS,Dhumal RS,Shailesh B,Paradkar AR,Kadam SS

更新日期：2010-03-01 00:00:00

abstract：:In this study, the resveratrol spray-dried emulsions were developed using a quality-by-design approach. Further, the product and process factors that affected the quality of the spray-dried emulsions were analyzed and illustrated using an Ishikawa diagram. The product and process risks were prioritized using a risk-ra...

journal_title：AAPS PharmSciTech

authors： Benjasirimongkol P,Piriyaprasarth S,Moribe K,Sriamornsak P

更新日期：2018-12-18 00:00:00

abstract：:Low solubility of active pharmaceutical compounds (APIs) remains an important challenge in dosage form development process. In the manuscript, empirical models were developed and analyzed in order to predict dissolution of bicalutamide (BCL) from solid dispersion with various carriers. BCL was chosen as an example of ...

journal_title：AAPS PharmSciTech

authors： Mendyk A,Pacławski A,Szafraniec-Szczęsny J,Antosik A,Jamróz W,Paluch M,Jachowicz R

更新日期：2020-03-31 00:00:00

abstract：:The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Kiang YH,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:This research was performed to test the hypothesis that acoustic-resonance spectrometry (ARS) is able to rapidly and accurately differentiate tablets of similar size and shape. The US Food and Drug Administration frequently orders recalls of tablets because of labeling problems (eg, the wrong tablet appears in a bottl...

journal_title：AAPS PharmSciTech

authors： Medendorp J,Lodder RA

更新日期：2006-03-01 00:00:00

abstract：:Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug delivery. The objective of this work was to investigate the possibility of encapsulating brinzolamide in PLGA nanoparticles in order to be applied as a su...

journal_title：AAPS PharmSciTech

authors： Salama HA,Ghorab M,Mahmoud AA,Abdel Hady M

更新日期：2017-10-01 00:00:00

abstract：:Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good ...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Shang Z,Gao C,Du M,Xu S,Song H,Liu T

更新日期：2014-08-01 00:00:00

abstract：:The physicochemical properties of the optimized microemulsion and the permeating ability of oxyresveratrol in microemulsion were evaluated, and the efficacy of oxyresveratrol microemulsion in cutaneous herpes simplex virus type 1 (HSV-1) infection in mice was examined. The optimized microemulsion was composed of 10% w...

journal_title：AAPS PharmSciTech

authors： Sasivimolphan P,Lipipun V,Ritthidej G,Chitphet K,Yoshida Y,Daikoku T,Sritularak B,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2012-12-01 00:00:00

abstract：:Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto phthaloyl chitosan (PEG-g-PHCs) was synthesized and then self...

journal_title：AAPS PharmSciTech

authors： Du J,El-Sherbiny IM,Smyth HD

更新日期：2014-12-01 00:00:00

abstract：:The potential value of succinylated soy protein (SPS) as a wall material for the encapsulation of ibuprofen (IBU), a model hydrophobic drug, by spray-drying was investigated. A succinylation rate of 93% was obtained for soy protein isolate, with a molar ratio of 1/1.5 (NH2/succinic anhydride). The solubility profile a...

journal_title：AAPS PharmSciTech

authors： Anaya Castro MA,Alric I,Brouillet F,Peydecastaing J,Fullana SG,Durrieu V

更新日期：2019-01-11 00:00:00

abstract：:The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of ...

journal_title：AAPS PharmSciTech

authors： Mohamed EM,Barakh Ali SF,Rahman Z,Dharani S,Ozkan T,Kuttolamadom MA,Khan MA

更新日期：2020-08-13 00:00:00

abstract：:We have designed a microemulsion (ME) containing Ketoprofen (KET) for anti-inflammatory effect evaluated using the rat paw edema model. The ME was prepared by adding propylene glycol (PG) loaded with 1% KET/water (3:1, w/w), to a mixture of sorbitan monooleate and polysorbate 80 (47.0%) at 3:1 (w/w) and canola oil (38...

journal_title：AAPS PharmSciTech

authors： Aliberti ALM,de Queiroz AC,Praça FSG,Eloy JO,Bentley MVLB,Medina WSG

更新日期：2017-10-01 00:00:00

abstract：:Co-encapsulation of anticancer drugs paclitaxel and imatinib in nanocarriers is a promising strategy to optimize cancer treatment. Aiming to combine the cytotoxic and antiangiogenic properties of the drugs, a liposome formulation targeted to folate receptor co-encapsulating paclitaxel and imatinib was designed in this...

journal_title：AAPS PharmSciTech

authors： Peres-Filho MJ,Dos Santos AP,Nascimento TL,de Ávila RI,Ferreira FS,Valadares MC,Lima EM

更新日期：2018-01-01 00:00:00