Abstract:
:For the prediction of the air and product temperatures, the product moisture, and the air humidity during a coating process in a Bohle Lab-Coater, a model was developed. The purpose of this work was to determine the limit moisture, the critical moisture, and the constant for the exchange rate between both zones and to use these values for other sets of experiments to test the model. The adaptation of the 3 parameters (limit moisture, critical moisture, and exchange rate constant) was done by calculation of the product temperature in both zones for several sets of parameters in order to minimize the sum of square deviation between the calculated and the measured product temperatures. This set of parameters was used to test the validity of the model. By applying the model, the product temperature could be predicted based on the product, process, and equipment-related parameters. Hence, the model can be used to theoretically investigate the influence of different process parameters. The mean difference between the predicted and measured product temperatures in the steady state is approximately 2 up to 3 K using the determined parameter set for the limit moisture, the critical moisture, and the exchange rate constant. The model is useful for the prediction of the air and product temperatures, the product moisture, and air humidity during a coating process in the Bohle Lab-Coater using round, biconvex tablets.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Page S,Baumann KH,Kleinebudde Pdoi
10.1208/pt070243subject
Has Abstractpub_date
2006-05-05 00:00:00pages
E43issue
2issn
1530-9932journal_volume
7pub_type
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