Fast tablet tensile strength prediction based on non-invasive analytics.


:In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the literature and our own measurements, various models were made to predict the tensile strength of the tablets. It appeared that only three parameters-surface roughness, upper punch force, and the true density of material-were needed to predict the tensile strength of a tablet. Rather surprising was that the surface roughness alone was capable in the prediction. The used new 3D imaging method (Flash sizer) was roughly a thousand times quicker in determining tablet surface roughness than traditionally used laser profilometer. Both methods gave practically analogous results. It is finally suggested that the rapid 3D imaging can be a potential in-line PAT tool to predict mechanical properties of tablets in production.


AAPS PharmSciTech


AAPS PharmSciTech


Halenius A,Lakio S,Antikainen O,Hatara J,Yliruusi J




Has Abstract


2014-06-01 00:00:00










  • Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects.

    abstract::In our previously studies, we confirmed that ergosterol could ameliorate diabetic nephropathy by suppressing the proliferation of mesangial cells and the accumulation of extracellular matrix (ECM). However, the therapeutic application of ergosterol may be confined due to poor aqueous solubility and low oral bioavailab...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Dong Z,Iqbal S,Zhao Z

    更新日期:2020-01-13 00:00:00

  • Estimating Shelf Life Through Tolerance Intervals.

    abstract::This paper is a continuation of the research published by the Stability Shelf Life Working Group as chartered under the Product Quality Research Institute. The Working Group was formed in 2006 and disbanded in late 2019. Following the philosophy presented by the Working Group on how to characterize the stability shelf...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Schwenke J,Quinlan M,Stroup W,Forenzo P

    更新日期:2020-10-20 00:00:00

  • To Evaluate the Effect of Solvents and Different Relative Humidity Conditions on Thermal and Rheological Properties of Microcrystalline Cellulose 101 Using METHOCEL™ E15LV as a Binder.

    abstract::The solvent used for preparing the binder solution in wet granulation can affect the granulation end point and also impact the thermal, rheological, and flow properties of the granules. The present study investigates the effect of solvents and percentage relative humidity (RH) on the granules of microcrystalline cellu...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Jagia M,Trivedi M,Dave RH

    更新日期:2016-08-01 00:00:00

  • Preparation of gelatin microbeads with a narrow size distribution using microchannel emulsification.

    abstract::The purpose of this study was to prepare monodisperse gelatin microcapsules containing an active agent using microchannel (MC) emulsification, a novel technique for preparing water-in-oil (W/O) and oil-in-water (O/W) emulsions. As the first step in applying MC emulsification to the preparation of monodisperse gelatin ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Iwamoto S,Nakagawa K,Sugiura S,Nakajima M

    更新日期:2002-01-01 00:00:00

  • Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method.

    abstract::The aim of this study was to develop benzydamine hydrochloride-loaded orodispersible films using the modification of a solvent casting method. An innovative approach was developed when the drying process of a small-scale production was used based on a heated inert base for casting the film. During this process, two ty...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Pechová V,Gajdziok J,Muselík J,Vetchý D

    更新日期:2018-08-01 00:00:00

  • Development and evaluation of buccoadhesive controlled release tablets of lercanidipine.

    abstract::The purpose of this research was to develop and evaluate buccal mucoadhesive controlled release tablets of lercanidipine hydrochloride using polyethylene oxide and different viscosity grades of hydroxypropyl methylcellulose individually and in combination. Effect of polymer type, proportion and combination was studied...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Charde S,Mudgal M,Kumar L,Saha R

    更新日期:2008-01-01 00:00:00

  • Optimization, in-vitro Release and in-vivo Evaluation of Gliquidone Nanoparticles.

    abstract::The present work embarks upon increasing the dissolution rate and the bioavailability of model anti-diabetic drug, gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. The gliquidone nanoparticles were prepared by using anti-solvent precipitation technique in which, gliquidone solution in ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Mohamed MS,Abdelhafez WA,Zayed G,Samy AM

    更新日期:2019-12-26 00:00:00

  • Tunable Properties of Poly-DL-Lactide-Monomethoxypolyethylene Glycol Porous Microparticles for Sustained Release of Polyethylenimine-DNA Polyplexes.

    abstract::Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Terry TL,Givens BE,Rodgers VGJ,Salem AK

    更新日期:2019-01-02 00:00:00

  • Release characteristics of quetiapine fumarate extended release tablets under biorelevant stress test conditions.

    abstract::The aim of the present work was the investigation of robustness and reliability of drug release from 50 to 400 mg quetiapine extended release HPMC matrix tablets towards mechanical stresses of biorelevant intensity. The tests were performed under standard conditions (USP apparatus II) as well as under simulated gastro...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Garbacz G,Kandzi A,Koziolek M,Mazgalski J,Weitschies W

    更新日期:2014-02-01 00:00:00

  • Validation of a new 96-well plate spectrophotometric method for the quantification of compound 48/80 associated with particles.

    abstract::A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Bento D,Borchard G,Gonçalves T,Borges O

    更新日期:2013-06-01 00:00:00

  • Formulation Optimization of Selective Laser Sintering 3D-Printed Tablets of Clindamycin Palmitate Hydrochloride by Response Surface Methodology.

    abstract::The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Mohamed EM,Barakh Ali SF,Rahman Z,Dharani S,Ozkan T,Kuttolamadom MA,Khan MA

    更新日期:2020-08-13 00:00:00

  • A comprehensive development strategy in buccal drug delivery.

    abstract::This work combines several methods in an integrated strategy to develop a matrix for buccal administration. For this purpose, tablets containing selected mucoadhesive polymers loaded with a model drug (omeprazole), free or in a complexed form with cyclodextrins, and in the absence and presence of alkali agents were su...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Figueiras A,Pais AA,Veiga FJ

    更新日期:2010-12-01 00:00:00

  • Respiratory Administration of Infliximab Dry Powder for Local Suppression of Inflammation.

    abstract::The airways are verified as a relevant route to improve antibody therapeutic index with superior lung concentration but limited passage into systemic blood stream. The current research aimed to process spray-dried (SD) powder of Infliximab to assess the feasibility of respiratory delivery of antibody for local suppres...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Faghihi H,Najafabadi AR,Daman Z,Ghasemian E,Montazeri H,Vatanara A

    更新日期:2019-02-26 00:00:00

  • Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films.

    abstract::Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child's bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics parameters. If commercial products are unsuitable for administration to children or ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章,评审


    authors: Visser JC,Woerdenbag HJ,Hanff LM,Frijlink HW

    更新日期:2017-02-01 00:00:00

  • A Novel Eutectic-Based Transdermal Delivery System for Risperidone.

    abstract::This paper reports for the first time the possible formation of a novel room temperature therapeutic deep eutectic solvent (THEDES) of risperidone (RIS) with some fatty acids, namely capric acid (C10; CA), lauric acid (C12; LA), and myristic acid (C14; MA). All mixtures of RIS and MA yielded a solid or pasty-like soli...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Al-Akayleh F,Adwan S,Khanfar M,Idkaidek N,Al-Remawi M

    更新日期:2020-11-22 00:00:00

  • Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules.

    abstract::The effects of electron beam or gamma-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Cilurzo F,Selmin F,Minghetti P,Montanari L,Lenardi C,Orsini F,Poletti G

    更新日期:2005-12-01 00:00:00

  • Considerations in developing a target product profile for parenteral pharmaceutical products.

    abstract::A target product profile (TPP) describes how a product will be utilized by the end user. A systematically developed TPP can ensure alignment of objectives across company departments, accelerate development timelines, minimize development risks, and eventually lead to an optimal product. A TPP is particularly important...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章,评审


    authors: Lambert WJ

    更新日期:2010-09-01 00:00:00

  • Nucleic Acid-Based Therapeutics for Pulmonary Diseases.

    abstract::Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmona...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章,评审


    authors: Chen J,Tang Y,Liu Y,Dou Y

    更新日期:2018-11-01 00:00:00

  • Effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole: toward development of a general vehicle for controlled release.

    abstract::The objective of the present study is to investigate the effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole (MTZ). Twelve formulations (1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol in 4% concentration, 1,2-hexanediol, and 1,2-heptanediol in 1% concentr...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Li N,Jia W,Zhang Y,Zhang MC,Tan F,Zhang J

    更新日期:2014-04-01 00:00:00

  • Preparation and Evaluation of Progesterone Nanocrystals to Decrease Muscle Irritation and Improve Bioavailability.

    abstract::Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Li L,Li W,Sun J,Zhang H,Gao J,Guo F,Yang X,Zhang X,Li Y,Zheng A

    更新日期:2018-04-01 00:00:00

  • Alginate Microspheres Elicit Innate M1-Inflammatory Response in Macrophages Leading to Bacillary Killing.

    abstract::Particulate drug delivery systems (PDDS) have been broadly explored as platforms for delivery of drugs, enzymes, cells, and vaccines for pharmaceutical applications. Studies suggest that microspheres (MS) can stimulate innate immune cells even without a drug payload; however, less is known regarding how they impact ho...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Vaghasiya K,Eram A,Sharma A,Ray E,Adlakha S,Verma RK

    更新日期:2019-06-27 00:00:00

  • Investigation of Effect of Isopropyl Palmitate on Drug Release from Transdermal Patch and Molecular Dynamics Study.

    abstract::Chemical penetration enhancers are widely used in transdermal drug delivery system. However, few studies have focused on changes of concentration in chemical penetration enhancers. In this study, the effect of concentrations of enhancers on drug release and its mechanism were investigated. Zolmitriptan (ZOL) was used ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Ruan J,Wan X,Quan P,Liu C,Fang L

    更新日期:2019-04-25 00:00:00

  • Polymorphic and Quantum Chemistry Characterization of Candesartan Cilexetil: Importance for the Correct Drug Classification According to Biopharmaceutics Classification System.

    abstract::The recommended method for the biopharmaceutical evaluation of drug solubility is the shake flask; however, there are discrepancies reported about the solubility of certain compounds measured with this method, one of them is candesartan cilexetil. The present work aimed to elucidate the solubility of candesartan cilex...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: de Campos DP,Silva-Barcellos NM,Lima RR,Savedra RML,Siqueira MF,Yoshida MI,da Nova Mussel W,de Souza J

    更新日期:2018-10-01 00:00:00

  • In Situ Salification in Polar Solvents: a Paradigm for Enabling Drug Delivery of Weakly Ionic Drugs as Amorphous Solid Dispersion.

    abstract::Solubility challenge for a poorly water-soluble drug gets further intensified when it is weakly ionic because the most common solubility enhancement technique, salt formation, becomes less feasible. Salt screening for such drugs often concludes with either a difficult to crystalize salt or an unstable salt, leading th...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Nair R,Lamare I,Tiwari NK,Ravi PR,Pillai R

    更新日期:2018-01-01 00:00:00

  • Investigating the parameters affecting the stability of superparamagnetic iron oxide-loaded nanoemulsion using artificial neural networks.

    abstract::Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neura...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Ahmadi Lakalayeh G,Faridi-Majidi R,Saber R,Partoazar A,Mehr SE,Amani A

    更新日期:2012-12-01 00:00:00

  • Development of spray dried liposomal dry powder inhaler of Dapsone.

    abstract::This investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated Dapsone (DS) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of Pneumocystis carinii pneumonia (PCP) associated with immunocompromised pat...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Chougule M,Padhi B,Misra A

    更新日期:2008-01-01 00:00:00

  • Release behaviour of propranolol HCl from hydrophilic matrix tablets containing psyllium powder in combination with hydrophilic polymers.

    abstract::The objective of this study was to investigate the release behaviour of propranolol hydrochloride from psyllium matrices in the presence hydrophilic polymers. The dissolution test was carried out at pH 1.2 and pH 6.8. Binary mixtures of psyllium and hydroxypropyl methylcellulose (HPMC) used showed that an increase in ...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Siahi-Shadbad MR,Asare-Addo K,Azizian K,Hassanzadeh D,Nokhodchi A

    更新日期:2011-12-01 00:00:00

  • Formulation and in vitro evaluation of xanthan gum or carbopol 934-based mucoadhesive patches, loaded with nicotine.

    abstract::Bilayer nicotine mucoadhesive patches were prepared and evaluated to determine the feasibility of the formulation as a nicotine replacement product to aid in smoking cessation. Nicotine patches were prepared using xanthan gum or carbopol 934 as a mucoadhesive polymers and ethyl cellulose as a backing layer. The patche...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Abu-Huwaij R,Obaidat RM,Sweidan K,Al-Hiari Y

    更新日期:2011-03-01 00:00:00

  • 3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis-Personalized Dosing and Drug Release.

    abstract::The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 × 2.5 mm tablets with 15% and 90% infill levels. The prep...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Öblom H,Zhang J,Pimparade M,Speer I,Preis M,Repka M,Sandler N

    更新日期:2019-01-07 00:00:00

  • Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates.

    abstract::The purpose of this research was to compare the viscoelastic properties of several neutral and anionic polysaccharide polymers with their mucociliary transport rates (MTR) across explants of ciliated bovine tracheal tissue to identify rheologic parameters capable of predicting the extent of reduction in mucociliary tr...

    journal_title:AAPS PharmSciTech

    pub_type: 杂志文章


    authors: Shah AJ,Donovan MD

    更新日期:2007-04-20 00:00:00