Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride.

abstract：:The purpose of this research was to prepare and evaluate sustained release mucoadhesive tablets of Itraconazole. It is practically insoluble in aqueous fluids hence its solid dispersion with Eudragit E100 was prepared by spray drying. This was formulated in matrix of hydrophilic mucoadhesive polymers Carbopol 934P (CP...

journal_title：AAPS PharmSciTech

authors： Madgulkar A,Kadam S,Pokharkar V

更新日期：2008-01-01 00:00:00

abstract：:Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interestingly, this errati...

journal_title：AAPS PharmSciTech

authors： Milanowski B,Hejduk A,Bawiec MA,Jakubowska E,Urbańska A,Wiśniewska A,Garbacz G,Lulek J

更新日期：2020-01-27 00:00:00

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00

abstract：:Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-release matrix pellets...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Huang Z,Omari-Siaw E,Lu S,Zhu Y,Jiang D,Wang M,Yu J,Xu X,Zhang W

更新日期：2016-04-01 00:00:00

abstract：:The objective of this study was to develop an efficient tumor vasculature targeted liposome delivery system for combretastatin A4, a novel antivascular agent. Liposomes composed of hydrogenated soybean phosphatidylcholine (HSPC), cholesterol, distearoyl phosphoethanolamine-polyethylene-glycol-2000 conjugate (DSPE-PEG)...

journal_title：AAPS PharmSciTech

authors： Nallamothu R,Wood GC,Pattillo CB,Scott RC,Kiani MF,Moore BM,Thoma LA

更新日期：2006-04-07 00:00:00

abstract：:Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child's bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics parameters. If commercial products are unsuitable for administration to children or ...

journal_title：AAPS PharmSciTech

authors： Visser JC,Woerdenbag HJ,Hanff LM,Frijlink HW

更新日期：2017-02-01 00:00:00

abstract：:The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro. The delivery system was prepared by a multiple emulsion solvent evaporation method. The n...

journal_title：AAPS PharmSciTech

authors： Trickler WJ,Khurana J,Nagvekar AA,Dash AK

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to demonstrate acoustic resonance spectrometry (ARS) as an alternative process analytical technology to near infrared (NIR) spectroscopy for the quantification of active pharmaceutical ingredient (API) in semi-solids such as creams, gels, ointments, and lotions. The ARS used for this rese...

journal_title：AAPS PharmSciTech

authors： Medendorp J,Buice RG Jr,Lodder RA

更新日期：2006-07-14 00:00:00

abstract：:The purpose of this research was to explore the utility of beta cyclodextrin (betaCD) and beta cyclodextrin derivatives (hydroxypropyl-beta-cyclodextrin [HPbetaCD], sulfobutylether-beta-CD [SBbetaCD], and a randomly methylated-beta-CD [RMbetaCD]) to form inclusion complexes with the antitumoral drug, beta-lapachone (b...

journal_title：AAPS PharmSciTech

authors： Cunha-Filho MS,Dacunha-Marinho B,Torres-Labandeira JJ,Martínez-Pacheco R,Landín M

更新日期：2007-07-27 00:00:00

abstract：:The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...

journal_title：AAPS PharmSciTech

authors： Kowapradit J,Opanasopit P,Ngawhirunpat T,Apirakaramwong A,Rojanarata T,Ruktanonchai U,Sajomsang W

更新日期：2010-06-01 00:00:00

abstract：:An acid-buffering bioadhesive vaginal tablet was developed for the treatment of genitourinary tract infections. From the bioadhesion experiment and release studies it was found that polycarbophil and sodium carboxymethylcellulose is a good combination for an acid-buffering bioadhesive vaginal tablet. Sodium monocitrat...

journal_title：AAPS PharmSciTech

authors： Alam MA,Ahmad FJ,Khan ZI,Khar RK,Ali M

更新日期：2007-12-14 00:00:00

abstract：:Paclitaxel (PTX) and gemcitabine (GEM) are often used in combination due to the synergistic anticancer effects. PTX and GEM combination showed a synergistic effect to SKOV-3 cells at a molar ratio of 1 to 1 and in PTX ➔ GEM sequence. Liposomes were explored as a carrier of PTX and GEM combination. We optimized the dru...

journal_title：AAPS PharmSciTech

authors： Liu Y,Tamam H,Yeo Y

更新日期：2018-02-01 00:00:00

abstract：:Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the ...

journal_title：AAPS PharmSciTech

authors： Wong PM,Chan LW,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive ...

journal_title：AAPS PharmSciTech

authors： Shah PV,Rajput SJ

更新日期：2018-04-01 00:00:00

abstract：:Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto phthaloyl chitosan (PEG-g-PHCs) was synthesized and then self...

journal_title：AAPS PharmSciTech

authors： Du J,El-Sherbiny IM,Smyth HD

更新日期：2014-12-01 00:00:00

abstract：:The objective of the study was to investigate in vitro transdermal delivery of venlafaxine hydrochloride across the pigskin by passive diffusion and iontophoresis. For passive diffusion, experiments were carried out in Franz diffusion cell whereas for iontophoretic permeation, the diffusion cell was modified to contai...

journal_title：AAPS PharmSciTech

authors： Singh G,Ghosh B,Kaushalkumar D,Somsekhar V

更新日期：2008-01-01 00:00:00

abstract：:Liposome-encapsulated polyplex system represents a promising delivery system for oligonucleotide-based therapeutics such as siRNA and asODN. Here, we report a novel method to prepare liposome-encapsulated cationic polymer/oligonucleotide polyplexes based on the reverse-phase evaporation following organic extraction of...

journal_title：AAPS PharmSciTech

authors： Ko YT,Bickel U

更新日期：2012-06-01 00:00:00

abstract：:Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT relea...

journal_title：AAPS PharmSciTech

authors： Pongjanyakul T,Kanjanabat S

更新日期：2012-06-01 00:00:00

abstract：:The purpose of this study was to develop a lyotropic liquid crystalline formulation using the emulsifier vitamin E TPGS and evaluate its behavior after incorporation of a flavonoid, quercetin. The physical (macro and microscopic), chemical (determination of quercetin content by the HPLC method) and functional (determi...

journal_title：AAPS PharmSciTech

authors： Vicentini FT,Casagrande R,Verri WA Jr,Georgetti SR,Bentley MV,Fonseca MJ

更新日期：2008-01-01 00:00:00

abstract：:Amylin is a pancreatic hormone that plays important roles in overall metabolism and in glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable for patients with diabetes who need to avoid glucose excursions. Protein conjugation with polyethylene glycol (PEG) has lon...

journal_title：AAPS PharmSciTech

authors： Guerreiro LH,Guterres MF,Melo-Ferreira B,Erthal LC,Rosa Mda S,Lourenço D,Tinoco P,Lima LM

更新日期：2013-09-01 00:00:00

abstract：:The approach documented in this article reviews data from earlier process validation lifecycle stages with a described statistical model to provide the "best estimate" on the number of process performance qualification (PPQ) batches that should generate sufficient information to make a scientific and risk-based decisi...

journal_title：AAPS PharmSciTech

authors： Pazhayattil A,Alsmeyer D,Chen S,Hye M,Ingram M,Sanghvi P

更新日期：2016-08-01 00:00:00

abstract：:The topical application of all-trans retinoic acid (ATRA) is an effective treatment for several skin disorders, including photo-aging. Unfortunately, ATRA is susceptible to light, heat, and oxidizing agents. Thus, this study aimed to investigate the ability of polymeric micelles prepared from polyethylene glycol conju...

journal_title：AAPS PharmSciTech

authors： Wichit A,Tangsumranjit A,Pitaksuteepong T,Waranuch N

更新日期：2012-03-01 00:00:00

abstract：:Bottles and carboys are used for frozen storage and transport of biopharmaceutical formulations under a wide range of conditions. The quality of freezing and thawing in these systems has been questioned due to the formation of heterogeneous ice structures and deformation of containers. This work shows that during free...

journal_title：AAPS PharmSciTech

authors： Duarte A,Rego P,Ferreira A,Dias P,Geraldes V,Rodrigues MA

更新日期：2020-09-01 00:00:00

abstract：:This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200). Critical quality attributes (CQAs) or associated performance indicators of the coated tablets were measured w...

journal_title：AAPS PharmSciTech

authors： Teckoe J,Mascaro T,Farrell TP,Rajabi-Siahboomi AR

更新日期：2013-06-01 00:00:00

abstract：:The purpose of this paper is to describe results from the use of a set of Excel macros written to facilitate the comparison of image analysis (IA) and laser diffraction (LD) particle size analysis (psa) data. Measurements were made on particle systems of differing morphological characteristics including differing aver...

journal_title：AAPS PharmSciTech

authors： Kelly RN,DiSante KJ,Stranzl E,Kazanjian JA,Bowen P,Matsuyama T,Gabas N

更新日期：2006-08-18 00:00:00

abstract：:A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

journal_title：AAPS PharmSciTech

authors： Bento D,Borchard G,Gonçalves T,Borges O

更新日期：2013-06-01 00:00:00

abstract：:In this study, the use of trimethylchitosan (TMC), by higher solubility in comparison with chitosan, in alginate/chitosan nanoparticles containing cationic β-cyclodextrin polymers (CPβCDs) has been studied, with the aim of increasing insulin uptake by nanoparticles. Firstly, TMCs were synthesized by iodomethane, and C...

journal_title：AAPS PharmSciTech

authors： Mansourpour M,Mahjub R,Amini M,Ostad SN,Shamsa ES,Rafiee-Tehrani M,Dorkoosh FA

更新日期：2015-08-01 00:00:00

abstract：:Cationic liposomes have long been used as non-viral vectors for small interfering RNA (siRNA) delivery but are associated with high toxicity, less transfection efficiency, and in vivo instability. In this investigation, we have developed siRNA targeted to RRM1 that is responsible for development of resistance to gemci...

journal_title：AAPS PharmSciTech

authors： Khatri N,Baradia D,Vhora I,Rathi M,Misra A

更新日期：2014-12-01 00:00:00

abstract：:The aim of the study is to examine thermal behavior of water within reticulated structure of bacterial cellulose (BC) films by sub-ambient differential scanning calorimetry (DSC). BC films with different carbon source, either manitol (BC (a)) or glycerol (BC (b)), were produced by Acetobacter xylinum using Hestrin and...

journal_title：AAPS PharmSciTech

authors： Kaewnopparat S,Sansernluk K,Faroongsarng D

更新日期：2008-01-01 00:00:00

abstract：:The present investigation was aimed at developing and optimizing a simple aqueous tablet-coating formulation and its process. 5-Fluorouracil (5-FU) was used to ascertain the relative lipophilic/hydrophilic behavior of the coating system. Optimization was performed by evaluating the adhesive force strength and cohesive...

journal_title：AAPS PharmSciTech

authors： Rai PR,Tiwary AK,Rana V

更新日期：2012-06-01 00:00:00