Characterization of beta-lapachone and methylated beta-cyclodextrin solid-state systems.

abstract：:A transdermal drug delivery system (TDDS) is generally designed to deliver an active pharmaceutical ingredient (API) through the skin for systemic action. Permeation of an API through the skin is controlled by adjusting drug concentration, formulation composition, and patch design. A bilayer, drug-in-adhesive TDDS des...

journal_title：AAPS PharmSciTech

authors： Davis DA,Martins PP,Zamloot MS,Kucera SA,Williams RO 3rd,Smyth HDC,Warnken ZN

更新日期：2020-06-04 00:00:00

abstract：:Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal bioadhesive films of clotrimazole for oral candidiasis. The film was designed to release the drug...

journal_title：AAPS PharmSciTech

authors： Singh S,Jain S,Muthu MS,Tiwari S,Tilak R

更新日期：2008-01-01 00:00:00

abstract：:A melt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (t(g)) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of ...

journal_title：AAPS PharmSciTech

authors： Paradkar A,Maheshwari M,Tyagi AK,Chauhan B,Kadam SS

更新日期：2003-12-16 00:00:00

abstract：:Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good ...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Shang Z,Gao C,Du M,Xu S,Song H,Liu T

更新日期：2014-08-01 00:00:00

abstract：:As of March 10, 2020, more than 100,000 novel coronavirus pneumonia cases have been confirmed globally. With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. The drugs currently being developed are not adequate to deal ...

journal_title：AAPS PharmSciTech

authors： Yan J,Liu A,Huang J,Wu J,Fan H

更新日期：2020-05-13 00:00:00

abstract：:Due to the fact that the number of new poorly soluble active pharmaceutical ingredients is increasing, it is important to investigate the possibilities of improvement of their solubility in order to obtain a final pharmaceutical formulation with enhanced bioavailability. One of the strategies to increase drug solubili...

journal_title：AAPS PharmSciTech

authors： Mihajlovic T,Kachrimanis K,Graovac A,Djuric Z,Ibric S

更新日期：2012-06-01 00:00:00

abstract：:The objective of the present study is to investigate the effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole (MTZ). Twelve formulations (1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol in 4% concentration, 1,2-hexanediol, and 1,2-heptanediol in 1% concentr...

journal_title：AAPS PharmSciTech

authors： Li N,Jia W,Zhang Y,Zhang MC,Tan F,Zhang J

更新日期：2014-04-01 00:00:00

abstract：:Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation, where poorly soluble acidic AMG 009 molecule was intimately mixed and compressed together with a basic pH modifier (e.g., sodium carbonate) and nucleation inhibitor hydroxypropyl methylcellulose ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:The purpose of this study was to investigate physicochemical characteristics and in vitro release of zidovudine from monolithic film of Eudragit RL 100 and ethyl cellulose. Films included 2.5% or 5% (w/w) zidovudine of the dry polymer weight were prepared in various ratios of polymers by solvent evaporation method fro...

journal_title：AAPS PharmSciTech

authors： Takmaz EA,Inal O,Baykara T

更新日期：2009-01-01 00:00:00

abstract：:This research was performed to test the hypothesis that acoustic-resonance spectrometry (ARS) is able to rapidly and accurately differentiate tablets of similar size and shape. The US Food and Drug Administration frequently orders recalls of tablets because of labeling problems (eg, the wrong tablet appears in a bottl...

journal_title：AAPS PharmSciTech

authors： Medendorp J,Lodder RA

更新日期：2006-03-01 00:00:00

abstract：:The aim of this study was to prepare bi-layer tablet of Metoclopramide Hydrochloride (MTH) and Ibuprofen (IB) for the effective treatment of migraine. MTH and IB were formulated as immediate and sustained release layer respectively. MTH was formulated as immediate release layer by using various disintegrants like Ac-D...

journal_title：AAPS PharmSciTech

authors： Shiyani B,Gattani S,Surana S

更新日期：2008-01-01 00:00:00

abstract：:Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generati...

journal_title：AAPS PharmSciTech

authors： Das S,Chaudhury A

更新日期：2011-03-01 00:00:00

abstract：:Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...

journal_title：AAPS PharmSciTech

authors： Yu X,Sun L,Tan L,Wang M,Ren X,Pi J,Jiang M,Li N

更新日期：2020-01-29 00:00:00

abstract：:Spheroid formation mechanisms were investigated using extrusion-spheronization (ES) and rotary processing (RP). Using ES (cross-hatch), ES (teardrop), and RP (teardrop), spheroids with similar mass median diameter (MMD) and span were produced using equivalent formulation and spheronization conditions. During spheroniz...

journal_title：AAPS PharmSciTech

authors： Liew CV,Chua SM,Heng PW

更新日期：2007-02-09 00:00:00

abstract：:The aim of present research work was to design, fabricate, optimize, and evaluate allopurinol (ALLO)-loaded bovine serum albumin nanoparticles (ABNPs) for kidney targeting of the drug and exploring the potential of fabricated ABNPs for management of hyperuricemia-related nephrolithiasis. ABNP formulation was prepared ...

journal_title：AAPS PharmSciTech

authors： Kandav G,Bhatt DC,Jindal DK,Singh SK

更新日期：2020-06-02 00:00:00

abstract：:The present investigation was undertaken with the objective of formulating orodispersible film(s) of the antidepressant drug tianeptine sodium to enhance the convenience and compliance by the elderly and pediatric patients. The novel film former, lycoat NG73 (granular hydroxypropyl starch), along with different film-f...

journal_title：AAPS PharmSciTech

authors： El-Setouhy DA,Abd El-Malak NS

更新日期：2010-09-01 00:00:00

abstract：:Curcumin chewing gums could be therapeutically beneficial if used by the head and neck cancer patients. High curcumin loading in chewing gums however is needed to achieve desired therapeutic effect. Preparing gums with high drug load is nonetheless challenging because of the negative impact of solids on their masticat...

journal_title：AAPS PharmSciTech

authors： Al Hagbani T,Altomare C,Kamal MM,Nazzal S

更新日期：2018-11-01 00:00:00

abstract：:The objective of this study was to evaluate possible usefulness of pectins for direct compression of tablets. The deformation behavior of pectin grades of different degree of methoxylation (DM), namely, 5%, 10%, 25%, 35%, 40%, 50%, and 60% were, examined in terms of yield pressures (YP) derived from Heckel profiles fo...

journal_title：AAPS PharmSciTech

authors： Salbu L,Bauer-Brandl A,Tho I

更新日期：2010-03-01 00:00:00

abstract：:This paper reports for the first time the possible formation of a novel room temperature therapeutic deep eutectic solvent (THEDES) of risperidone (RIS) with some fatty acids, namely capric acid (C10; CA), lauric acid (C12; LA), and myristic acid (C14; MA). All mixtures of RIS and MA yielded a solid or pasty-like soli...

journal_title：AAPS PharmSciTech

authors： Al-Akayleh F,Adwan S,Khanfar M,Idkaidek N,Al-Remawi M

更新日期：2020-11-22 00:00:00

abstract：:Formulation of an amorphous solid dispersion (ASD) is one of the methods commonly considered to increase the bioavailability of a poorly water-soluble small-molecule active pharmaceutical ingredient (API). However, many factors have to be considered in designing an API-polymer system, including any potential changes t...

journal_title：AAPS PharmSciTech

authors： Rumondor AC,Wikström H,Van Eerdenbrugh B,Taylor LS

更新日期：2011-12-01 00:00:00

abstract：:Anti-vascular endothelial growth factor agents have been widely used to treat several eye diseases including age-related macular degeneration (AMD). An approach to maximize the local concentration of drug at the target site and minimize systemic exposure is to be sought. Sunitinib malate, a multiple receptor tyrosine ...

journal_title：AAPS PharmSciTech

authors： Bhatt P,Narvekar P,Lalani R,Chougule MB,Pathak Y,Sutariya V

更新日期：2019-08-09 00:00:00

abstract：:A folic acid-conjugated paclitaxel (PTX)-doxorubicin (DOX)-loaded nanostructured lipid carrier(s) (FA-PTX-DOX NLCs) were prepared by using emulsion-evaporation method and extensively characterized for particle size, polydispersity index, zeta potential, and % entrapment efficiency which were found to be 196 ± 2.5 nm, ...

journal_title：AAPS PharmSciTech

authors： Raikwar S,Vyas S,Sharma R,Mody N,Dubey S,Vyas SP

更新日期：2018-11-01 00:00:00

abstract：:The purpose of this article is to report final results of the evaluation of a chi-square ratio test proposed by the US Food and Drug Administration (FDA) for demonstrating equivalence of aerodynamic particle size distribution (APSD) profiles of nasal and orally inhaled drug products. A working group of the Product Qua...

journal_title：AAPS PharmSciTech

authors： Christopher D,Adams W,Amann A,Bertha C,Byron PR,Doub W,Dunbar C,Hauck W,Lyapustina S,Mitchell J,Morgan B,Nichols S,Pan Z,Singh GJ,Tougas T,Tsong Y,Wolff R,Wyka B

更新日期：2007-11-02 00:00:00

abstract：:Onychomycosis is a chronic disorder that is difficult to manage and hard to eradicate with perilous trends to relapse. Due to increased prevalence of HIV, use of immunosuppressant drugs and lifestyle-related factors, population affected with fungal infection of nail (Onychomycosis) happens to increase extensively in l...

journal_title：AAPS PharmSciTech

authors： Vikas A,Rashmin P,Mrunali P,Chavan RB,Kaushik T

更新日期：2020-01-14 00:00:00

abstract：:The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed based on the ternary phase diagram of the MO-PG-water system,...

journal_title：AAPS PharmSciTech

authors： Peng X,Wen X,Pan X,Wang R,Chen B,Wu C

更新日期：2010-09-01 00:00:00

abstract：:A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concent...

journal_title：AAPS PharmSciTech

authors： Mabrouk M,Mulla JA,Kumar P,Chejara DR,Badhe RV,Choonara YE,du Toit LC,Pillay V

更新日期：2016-10-01 00:00:00

abstract：:Non-invasive administration of insulin is expected for better diabetes mellitus therapy. In this report, we developed intraoral preparation for insulin. Insulin was encapsulated into nanocarrier using self-assembly emulsification process. To increase lipophilicity of insulin, it was dispersed in phospholipid resulted ...

journal_title：AAPS PharmSciTech

authors： Rachmawati H,Haryadi BM,Anggadiredja K,Suendo V

更新日期：2015-06-01 00:00:00

abstract：:Pharmaceutical excipients contain reactive groups and impurities due to manufacturing processes that can cause decomposition of active drug compounds. The aim of this investigation was to determine if commercially available oral disintegrating tablet (ODT) platforms induce active pharmaceutical ingredient (API) degrad...

journal_title：AAPS PharmSciTech

authors： Köllmer M,Popescu C,Manda P,Zhou L,Gemeinhart RA

更新日期：2013-12-01 00:00:00

abstract：:The aim of this work was to assess the effect of 2 formulation variables, the pectin type (with different degrees of esterification [DEs]) and the amount of calcium, on drug release from pectin-based matrix tablets. Pectin matrix tablets were prepared by blending indomethacin (a model drug), pectin powder, and various...

journal_title：AAPS PharmSciTech

authors： Sungthongjeen S,Sriamornsak P,Pitaksuteepong T,Somsiri A,Puttipipatkhachorn S

更新日期：2004-02-12 00:00:00

abstract：:The hydrophobicity of bioactive molecules poses a considerable problem in the pharmaceutical and the food industry. Using food-based protein nanocarriers is one promising way to deliver hydrophobic molecules. These types of protein possess many functional properties such as surface activity, water-binding capacity, em...

journal_title：AAPS PharmSciTech

authors： Maviah MBJ,Farooq MA,Mavlyanova R,Veroniaina H,Filli MS,Aquib M,Kesse S,Boakye-Yiadom KO,Wang B

更新日期：2020-03-09 00:00:00