Abstract：
:The present investigation was undertaken with the objective of formulating orodispersible film(s) of the antidepressant drug tianeptine sodium to enhance the convenience and compliance by the elderly and pediatric patients. The novel film former, lycoat NG73 (granular hydroxypropyl starch), along with different film-forming agents (hydroxypropyl methyl cellulose, hydroxyethyl cellulose, and polyvinyl alcohol), in addition to three film modifiers; namely, maltodextrin, polyvinyl pyrrolidone K90 and lycoat RS780 (pregelatinized hydroxypropyl starch) were evaluated. Eight formulae were prepared by the solvent-casting method; and were evaluated for their in vitro dissolution characteristics, in vitro disintegration time, and their physico-mechanical properties. The promising orodispersible film based on lycoat NG73 (F1); showing the greatest drug dissolution, satisfactory in vitro disintegration time and physico-mechanical properties that are suitable for orodispersible films, was evaluated for its bioavailability compared with a reference marketed product (Stablon® tablets) in rabbits. Statistical analysis revealed no significant difference between the bioavailability parameters (C(max) (ng/ml), t(max) (h), AUC(0-t) (ng hml(-1)), and AUC(0-∞) (ng hml(-1))] of the test film (F1) and the reference product. The mean ratio values (test/reference) of C(max) (89.74%), AUC(0-t) (110.9%), and AUC(0-∞) (109.21%) indicated that the two formulae exhibited comparable plasma level-time profiles. These findings suggest that the fast orodispersible film containing tianeptine is likely to become one of choices for acute treatment of depression.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
El-Setouhy DA,Abd El-Malak NSdoi
10.1208/s12249-010-9464-2subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1018-25issue
3issn
1530-9932journal_volume
11pub_type
杂志文章abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...
journal_title：AAPS PharmSciTech
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更新日期：2015-10-01 00:00:00
abstract：:The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro. The delivery system was prepared by a multiple emulsion solvent evaporation method. The n...
journal_title：AAPS PharmSciTech
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doi：10.1208/s12249-010-9393-0
更新日期：2010-03-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2012-12-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2009-01-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2014-02-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章,评审
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更新日期：2019-02-15 00:00:00
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journal_title：AAPS PharmSciTech
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更新日期：2008-01-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2019-10-31 00:00:00
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journal_title：AAPS PharmSciTech
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更新日期：2012-12-01 00:00:00
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journal_title：AAPS PharmSciTech
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更新日期：2017-11-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章,评审
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2008-01-01 00:00:00
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journal_title：AAPS PharmSciTech
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journal_title：AAPS PharmSciTech
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更新日期：2012-09-01 00:00:00
abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...
journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
abstract：:The purpose of this research was to improve the solubility and therefore dissolution and bioavailability of triamterene, a poorly water soluble diuretic, by complexation with beta-cyclodextrin. Triamterene has been reported to show low bioavailability after oral administration, with wide intersubject variation. This s...
journal_title：AAPS PharmSciTech
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更新日期：2004-03-29 00:00:00
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journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
abstract：:A transdermal drug delivery system (TDDS) is generally designed to deliver an active pharmaceutical ingredient (API) through the skin for systemic action. Permeation of an API through the skin is controlled by adjusting drug concentration, formulation composition, and patch design. A bilayer, drug-in-adhesive TDDS des...
journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2020-06-04 00:00:00
abstract：:Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal bioadhesive films of clotrimazole for oral candidiasis. The film was designed to release the drug...
journal_title：AAPS PharmSciTech
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
