Evaluation of a new wireless Temperature Remote Interrogation System (TEMPRIS) to measure product temperature during freeze drying.

abstract：:While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category successfully commercialized to date despite clinical and market demand...

journal_title：AAPS PharmSciTech

authors： Wu F,Jin T

更新日期：2008-01-01 00:00:00

abstract：:The present study focuses on the development and characterization of nanosuspension of a poorly soluble drug, silver sulfadiazine (SSD) incorporated in Aloe vera gel (AV-gel) for improving its therapeutic efficacy. The SSD solution in ammonia was subjected to nanoprecipitation in surfactant solution and particle size ...

journal_title：AAPS PharmSciTech

authors： Barkat MA,Harshita,Ahmad I,Ali R,Singh SP,Pottoo FH,Beg S,Ahmad FJ

更新日期：2017-11-01 00:00:00

abstract：:In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro r...

journal_title：AAPS PharmSciTech

authors： Madheswaran T,Baskaran R,Thapa RK,Rhyu JY,Choi HY,Kim JO,Yong CS,Yoo BK

更新日期：2013-03-01 00:00:00

abstract：:Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neura...

journal_title：AAPS PharmSciTech

authors： Ahmadi Lakalayeh G,Faridi-Majidi R,Saber R,Partoazar A,Mehr SE,Amani A

更新日期：2012-12-01 00:00:00

abstract：:Formulation effects on the entrapment of beclometasone dipropionate (BDP) in liposomes generated by hydration of proliposomes were studied, using the high-density dispersion medium deuterium oxide in comparison to deionized water (DW). Proliposomes incorporating BDP (2 mol% of the lipid phase consisting of soya phosph...

journal_title：AAPS PharmSciTech

authors： Khan I,Yousaf S,Subramanian S,Alhnan MA,Ahmed W,Elhissi A

更新日期：2018-01-01 00:00:00

abstract：:Vemurafenib is a poorly soluble, low permeability drug that has a demonstrated need for a solubility-enhanced formulation. However, conventional approaches for amorphous solid dispersion production are challenging due to the physiochemical properties of the compound. A suitable and novel method for creating an amorpho...

journal_title：AAPS PharmSciTech

authors： Ellenberger DJ,Miller DA,Kucera SU,Williams RO 3rd

更新日期：2018-07-01 00:00:00

abstract：:Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmona...

journal_title：AAPS PharmSciTech

authors： Chen J,Tang Y,Liu Y,Dou Y

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 × 2.5 mm tablets with 15% and 90% infill levels. The prep...

journal_title：AAPS PharmSciTech

authors： Öblom H,Zhang J,Pimparade M,Speer I,Preis M,Repka M,Sandler N

更新日期：2019-01-07 00:00:00

abstract：:The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol 934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into...

journal_title：AAPS PharmSciTech

authors： Patel VM,Prajapati BG,Patel MM

更新日期：2007-06-22 00:00:00

abstract：:The purpose of this research was to investigate the measurement and in vitro delivery implications of multimodal distributions, occurring near or in the respirable range, emitted from pressurized metered-dose inhalers (pMDIs). Particle size distributions of solution pMDIs containing hydrofluoroalkane-134a (HFA-134a) a...

journal_title：AAPS PharmSciTech

authors： Smyth HD,Hickey AJ

更新日期：2003-01-01 00:00:00

abstract：:This study investigated the effects of some essential oils on Limantria dispar (Lepidoptera: Lymantridae, gypsy moth) larvae, one of the most serious pests of cork oak forests. The essential oils were first formulated as oil in water (o/w) emulsions and used in laboratory bioassays to assess their lethal concentration...

journal_title：AAPS PharmSciTech

authors： Moretti MD,Sanna-Passino G,Demontis S,Bazzoni E

更新日期：2002-01-01 00:00:00

abstract：:Penetration and distribution of thiocolchicoside from a commercially available foam (Miotens 0.25%, w/v) through human excised full-thickness skin were evaluated using two different in vitro apparatus: a Franz diffusion cell and a Saarbruecken penetration model-based cell. In order to evaluate the intrinsic capability...

journal_title：AAPS PharmSciTech

authors： Aguzzi C,Rossi S,Bagnasco M,Lanata L,Sandri G,Bona F,Ferrari F,Bonferoni MC,Caramella C

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to introduce smectite clay matrices as a drug delivery carrier for the development of amorphous solid dispersions (ASD). Indomethacin (IND) was processed with two different smectite clays, magnesium aluminium and lithium magnesium sodium silicates, using hot melt extrusion (HME) to prepare so...

journal_title：AAPS PharmSciTech

authors： Nandi U,Mithu MSH,Hurt AP,Trivedi V,Douroumis D

更新日期：2020-10-08 00:00:00

abstract：:Due to the fact that the number of new poorly soluble active pharmaceutical ingredients is increasing, it is important to investigate the possibilities of improvement of their solubility in order to obtain a final pharmaceutical formulation with enhanced bioavailability. One of the strategies to increase drug solubili...

journal_title：AAPS PharmSciTech

authors： Mihajlovic T,Kachrimanis K,Graovac A,Djuric Z,Ibric S

更新日期：2012-06-01 00:00:00

abstract：:Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug delivery. The objective of this work was to investigate the possibility of encapsulating brinzolamide in PLGA nanoparticles in order to be applied as a su...

journal_title：AAPS PharmSciTech

authors： Salama HA,Ghorab M,Mahmoud AA,Abdel Hady M

更新日期：2017-10-01 00:00:00

abstract：:The purpose of this study was to prepare monodisperse gelatin microcapsules containing an active agent using microchannel (MC) emulsification, a novel technique for preparing water-in-oil (W/O) and oil-in-water (O/W) emulsions. As the first step in applying MC emulsification to the preparation of monodisperse gelatin ...

journal_title：AAPS PharmSciTech

authors： Iwamoto S,Nakagawa K,Sugiura S,Nakajima M

更新日期：2002-01-01 00:00:00

abstract：:The present work embarks upon increasing the dissolution rate and the bioavailability of model anti-diabetic drug, gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. The gliquidone nanoparticles were prepared by using anti-solvent precipitation technique in which, gliquidone solution in ...

journal_title：AAPS PharmSciTech

authors： Mohamed MS,Abdelhafez WA,Zayed G,Samy AM

更新日期：2019-12-26 00:00:00

abstract：:For polymer-based controlled release drug products (e.g. microspheres and implants), active pharmaceutical ingredient distribution and microporosity inside the polymer matrix are critical for product performance, particularly drug release kinetics. Due to the decreasing domain size and increasing complexity of such pr...

journal_title：AAPS PharmSciTech

authors： Zhang S,Wu D,Zhou L

更新日期：2020-07-14 00:00:00

abstract：:The purpose of this study was to demonstrate acoustic resonance spectrometry (ARS) as an alternative process analytical technology to near infrared (NIR) spectroscopy for the quantification of active pharmaceutical ingredient (API) in semi-solids such as creams, gels, ointments, and lotions. The ARS used for this rese...

journal_title：AAPS PharmSciTech

authors： Medendorp J,Buice RG Jr,Lodder RA

更新日期：2006-07-14 00:00:00

abstract：:Pharmaceutical aerosols have been targeted to the lungs for the treatment of asthma and pulmonary infectious diseases successfully. Micafungin (Astellas Pharma US, Deerfield, IL, USA) has been shown to be an effective antifungal agent when administrated intravenously. Pulmonary delivery of micafungin has not previousl...

journal_title：AAPS PharmSciTech

authors： Shi S,Ashley ES,Alexander BD,Hickey AJ

更新日期：2009-01-01 00:00:00

abstract：:The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of ...

journal_title：AAPS PharmSciTech

authors： Mohamed EM,Barakh Ali SF,Rahman Z,Dharani S,Ozkan T,Kuttolamadom MA,Khan MA

更新日期：2020-08-13 00:00:00

abstract：:The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as sol...

journal_title：AAPS PharmSciTech

authors： Pal K,Banthia AK,Majumdar DK

更新日期：2007-03-16 00:00:00

abstract：:The aim of this work was to study the effect of the type of substituent of the cellulose ethers and the molecular mass on the state and dynamics of water in the respective hydrogels to specify the quantity of adsorbed water on the polymers or, more explicitly, to calculate the average number of water molecules bound t...

journal_title：AAPS PharmSciTech

authors： Baumgartner S,Lahajnar G,Sepe A,Kristl J

更新日期：2002-01-01 00:00:00

abstract：:The stability of the 37-amino acid peptide pramlintide, in aqueous solution, was studied as a function of pH and temperature. Samples of pramlintide formulated as a parenteral product were exposed to elevated temperatures and to realistic storage conditions for as long as 30 months. Pramlintide degradation was monitor...

journal_title：AAPS PharmSciTech

authors： Kenley RA,Tracht S,Stepanenko A,Townsend M,L'Italien J

更新日期：2000-03-18 00:00:00

abstract：:In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced ...

journal_title：AAPS PharmSciTech

authors： Rachid O,Simons KJ,Rawas-Qalaji M

更新日期：2018-11-01 00:00:00

abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...

journal_title：AAPS PharmSciTech

authors： Hashem FM,Nasr M,Fathy G,Ismail A

更新日期：2016-06-01 00:00:00

abstract：:Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability, and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent g...

journal_title：AAPS PharmSciTech

authors： Salústio PJ,Pontes P,Conduto C,Sanches I,Carvalho C,Arrais J,Marques HM

更新日期：2011-12-01 00:00:00

abstract：:The purpose of this research was to develop and evaluate different preparations of sustained delivery systems, using Carbopols as carriers, in the form of matrices and three-layer tablets with isosorbite mononitrate. Matrix tablets were prepared by direct compression whereas three-layer tablets were prepared by compre...

journal_title：AAPS PharmSciTech

authors： Efentakis M,Peponaki C

更新日期：2008-01-01 00:00:00

abstract：:Formulation of an amorphous solid dispersion (ASD) is one of the methods commonly considered to increase the bioavailability of a poorly water-soluble small-molecule active pharmaceutical ingredient (API). However, many factors have to be considered in designing an API-polymer system, including any potential changes t...

journal_title：AAPS PharmSciTech

authors： Rumondor AC,Wikström H,Van Eerdenbrugh B,Taylor LS

更新日期：2011-12-01 00:00:00

abstract：:Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal bioadhesive films of clotrimazole for oral candidiasis. The film was designed to release the drug...

journal_title：AAPS PharmSciTech

authors： Singh S,Jain S,Muthu MS,Tiwari S,Tilak R

更新日期：2008-01-01 00:00:00