Abstract:
:The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as solution) was compared with the mixture of PVA and gelatin of the same composition. The mechanical properties of the hydrogels were characterized by tensile tests. Swelling behavior and hemocompatibility of the membrane were also evaluated. The diffusion coefficient of salicylic acid (SA), when the receptor compartment contained Ringer's solution, through the membrane was determined. SA was used as a model drug. FTIR spectra of the membranes indicated complete esterification of the free carboxylic groups of gelatin. XRD studies indicated that the crystallinity of the membranes was mainly due to gelatin. The comparison of viscosity indicated an increase in segment density within the molecular coil. The membrane had sufficient strength and water-holding capacity. Hemocompatibility suggested that the hydrogel could be tried as wound dressing and as an implantable drug delivery system. The diffusion coefficient of SA through the membrane was found to be 1.32 x 10(-5) cm(2)/s. The experimental results indicated that the hydrogel could be tried for various biomedical applications.
journal_name
AAPS PharmSciTechjournal_title
AAPS PharmSciTechauthors
Pal K,Banthia AK,Majumdar DKdoi
10.1208/pt080121subject
Has Abstractpub_date
2007-03-16 00:00:00pages
21issue
1issn
1530-9932journal_volume
8pub_type
杂志文章abstract::The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...
journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章,评审
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章
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更新日期:2019-12-26 00:00:00
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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pub_type: 杂志文章,评审
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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journal_title:AAPS PharmSciTech
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更新日期:2017-11-01 00:00:00
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journal_title:AAPS PharmSciTech
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更新日期:2008-01-01 00:00:00
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journal_title:AAPS PharmSciTech
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更新日期:2017-10-01 00:00:00
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journal_title:AAPS PharmSciTech
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更新日期:2012-06-01 00:00:00
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journal_title:AAPS PharmSciTech
pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
abstract::The present study evaluates the antioxidant activity of the flavonol quercetin, and its functional stability as a raw material and when added in formulations. The iron-chelating activity was determined using the bathophenanthroline assay, and the functional stability was evaluated with the antilipoperoxidative assay. ...
journal_title:AAPS PharmSciTech
pub_type: 杂志文章
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更新日期:2006-02-03 00:00:00
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pub_type: 杂志文章,评审
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