The effect of microwave thermal denaturation on release properties of bovine serum albumin and gluten matrices.

abstract：:In a systematic effort to develop a dual-function intravaginal spermicide as well as a drug delivery vehicle against sexually transmitted pathogens, a submicron particle size (30-80 nm), lipophilic and spermicidal gel-microemulsion (viz GM-144) containing the pharmaceutical excipients propylene glycol, Captex 300, Cre...

journal_title：AAPS PharmSciTech

authors： D'Cruz OJ,Yiv SH,Uckun FM

更新日期：2001-04-09 00:00:00

abstract：:The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and Eudragit RS100 as film-forming polymers. Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in firs...

journal_title：AAPS PharmSciTech

authors： Gohel MC,Nagori SA

更新日期：2009-01-01 00:00:00

abstract：:The main objective of the present study is the physicochemical characterization of naturally available Terminalia catappa gum (Badam gum [BG]) as a novel pharmaceutical excipient and its suitability in the development of gastroretentive floating drug delivery systems (GRFDDS) to retard the drug for 12 h when the dosag...

journal_title：AAPS PharmSciTech

authors： Meka VS,Nali SR,Songa AS,Kolapalli VR

更新日期：2012-12-01 00:00:00

abstract：:In this study, the use of trimethylchitosan (TMC), by higher solubility in comparison with chitosan, in alginate/chitosan nanoparticles containing cationic β-cyclodextrin polymers (CPβCDs) has been studied, with the aim of increasing insulin uptake by nanoparticles. Firstly, TMCs were synthesized by iodomethane, and C...

journal_title：AAPS PharmSciTech

authors： Mansourpour M,Mahjub R,Amini M,Ostad SN,Shamsa ES,Rafiee-Tehrani M,Dorkoosh FA

更新日期：2015-08-01 00:00:00

abstract：:A dissolution test for tablets containing 40 mg of olmesartan medoxomil (OLM) was developed and validated using both LC-UV and UV methods. After evaluation of the sink condition, dissolution medium, and stability of the drug, the method was validated using USP apparatus 2, 50 rpm rotation speed, and 900 ml of deaerate...

journal_title：AAPS PharmSciTech

authors： Bajerski L,Rossi RC,Dias CL,Bergold AM,Fröehlich PE

更新日期：2010-06-01 00:00:00

abstract：:Amylin is a pancreatic hormone that plays important roles in overall metabolism and in glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable for patients with diabetes who need to avoid glucose excursions. Protein conjugation with polyethylene glycol (PEG) has lon...

journal_title：AAPS PharmSciTech

authors： Guerreiro LH,Guterres MF,Melo-Ferreira B,Erthal LC,Rosa Mda S,Lourenço D,Tinoco P,Lima LM

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this research was to develop and evaluate different preparations of sustained delivery systems, using Carbopols as carriers, in the form of matrices and three-layer tablets with isosorbite mononitrate. Matrix tablets were prepared by direct compression whereas three-layer tablets were prepared by compre...

journal_title：AAPS PharmSciTech

authors： Efentakis M,Peponaki C

更新日期：2008-01-01 00:00:00

abstract：:The objective of the present study was to develop a hydrodynamically balanced system for celecoxib as single-unit floating capsules. Various grades of low-density polymers were used for formulation of these capsules. The capsules were prepared by physical blending of celecoxib and the polymer in varying ratios. The fo...

journal_title：AAPS PharmSciTech

authors： Ali J,Arora S,Ahuja A,Babbar AK,Sharma RK,Khar RK

更新日期：2007-12-28 00:00:00

abstract：:One-third of the population of the USA suffers from metabolic syndrome (MetS). Treatment of patients with MetS regularly includes drugs prescribed simultaneously to treat diabetes and cardiovascular diseases. Therefore, the development of novel multidrug formulations is recommended. However, the main problem with thes...

journal_title：AAPS PharmSciTech

authors： Cruz-Angeles J,Videa M,Martínez LM

更新日期：2019-03-18 00:00:00

abstract：:In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the li...

journal_title：AAPS PharmSciTech

authors： Halenius A,Lakio S,Antikainen O,Hatara J,Yliruusi J

更新日期：2014-06-01 00:00:00

abstract：:The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglo...

journal_title：AAPS PharmSciTech

authors： Furukawa R,Kadota K,Noguchi T,Shimosaka A,Shirakawa Y

更新日期：2017-08-01 00:00:00

abstract：:The purpose of this research was to develop and evaluate buccal mucoadhesive controlled release tablets of lercanidipine hydrochloride using polyethylene oxide and different viscosity grades of hydroxypropyl methylcellulose individually and in combination. Effect of polymer type, proportion and combination was studied...

journal_title：AAPS PharmSciTech

authors： Charde S,Mudgal M,Kumar L,Saha R

更新日期：2008-01-01 00:00:00

abstract：:The potential value of succinylated soy protein (SPS) as a wall material for the encapsulation of ibuprofen (IBU), a model hydrophobic drug, by spray-drying was investigated. A succinylation rate of 93% was obtained for soy protein isolate, with a molar ratio of 1/1.5 (NH2/succinic anhydride). The solubility profile a...

journal_title：AAPS PharmSciTech

authors： Anaya Castro MA,Alric I,Brouillet F,Peydecastaing J,Fullana SG,Durrieu V

更新日期：2019-01-11 00:00:00

abstract：:The main principles of green chemistry and engineering were extended to pharmaceutical formulations to prepare eco-friendly surfactant-free dry emulsion tablets (SFDETs) devoid of solvents or synthetic surfactants. Surfactant-free emulsions were stabilized by in situ cyclodextrins/sweet almond oil inclusion complexes ...

journal_title：AAPS PharmSciTech

authors： Badr-Eldin SM,Labib GS,Aburahma MH

更新日期：2019-07-18 00:00:00

abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...

journal_title：AAPS PharmSciTech

authors： Verma S,Rudraraju VS

更新日期：2015-10-01 00:00:00

abstract：:A melt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (t(g)) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of ...

journal_title：AAPS PharmSciTech

authors： Paradkar A,Maheshwari M,Tyagi AK,Chauhan B,Kadam SS

更新日期：2003-12-16 00:00:00

abstract：:The purpose of this research was to prepare and evaluate sustained release mucoadhesive tablets of Itraconazole. It is practically insoluble in aqueous fluids hence its solid dispersion with Eudragit E100 was prepared by spray drying. This was formulated in matrix of hydrophilic mucoadhesive polymers Carbopol 934P (CP...

journal_title：AAPS PharmSciTech

authors： Madgulkar A,Kadam S,Pokharkar V

更新日期：2008-01-01 00:00:00

abstract：:For polymer-based controlled release drug products (e.g. microspheres and implants), active pharmaceutical ingredient distribution and microporosity inside the polymer matrix are critical for product performance, particularly drug release kinetics. Due to the decreasing domain size and increasing complexity of such pr...

journal_title：AAPS PharmSciTech

authors： Zhang S,Wu D,Zhou L

更新日期：2020-07-14 00:00:00

abstract：:In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro r...

journal_title：AAPS PharmSciTech

authors： Madheswaran T,Baskaran R,Thapa RK,Rhyu JY,Choi HY,Kim JO,Yong CS,Yoo BK

更新日期：2013-03-01 00:00:00

abstract：:The addition of polysorbate 20 (T20) is required to achieve "sink" conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml...

journal_title：AAPS PharmSciTech

authors： Hoppe K,Sznitowska M

更新日期：2014-10-01 00:00:00

abstract：:The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporati...

journal_title：AAPS PharmSciTech

authors： Yoshida VM,de Oliveira Junior JM,Gonçalves MM,Vila MM,Chaud MV

更新日期：2011-06-01 00:00:00

abstract：:Bimatoprost is widely used for the management of glaucoma. Currently, it is delivered via eye drop solution, which is highly inefficient due to low bioavailability. To control the release of ocular drugs, contact lenses are used by scientists. However, the conventional soaking method showed high burst release due to a...

journal_title：AAPS PharmSciTech

authors： Yan F,Liu Y,Han S,Zhao Q,Liu N

更新日期：2020-01-13 00:00:00

abstract：:The present investigation concerns with the development and optimization of an in situ forming formulation using 3(3) full factorial design experimentation. Metformin, an antidiabetic drug with upper part of gastrointestinal tract as absorption window was used as a model drug. The formulations were designed with an ob...

journal_title：AAPS PharmSciTech

authors： Nagarwal RC,Srinatha A,Pandit JK

更新日期：2009-01-01 00:00:00

abstract：:This study focused on the chemical stability of the cephalosporin (6R, 7R)-7-(1-pentafluorophenoxyacetamido)-3-[2-(5-methyl-1,3,4-thiodiazolyl)thiomethyl]-Delta(3)-cephem-4-carboxylic acid, sodium salt (cephem 1) formulation after electron beam (e-beam) irradiation. The cephem 1 concentrations of samples irradiated at...

journal_title：AAPS PharmSciTech

authors： Johns PJ,Turberg M,Willard K,Matagne D,Cheesman D

更新日期：2001-11-19 00:00:00

abstract：:Enterovirus 71 (EV71) is a pathogenic factor of severe hand, foot, and mouth disease (HFMD). No vaccine or specific treatment is currently available for EV71 infection. Hence, we developed a buccal mucoadhesive gel containing matrine to protect against HFMD. Mucoadhesive gels were prepared by Carbopol 974P and were co...

journal_title：AAPS PharmSciTech

authors： Chen X,Yan J,Yu S,Wang P

更新日期：2018-01-01 00:00:00

abstract：:The study was designed to build up a database for the evaluation of the self-emulsifying lipid formulations performance. A standard assessment method was constructed to evaluate the self-emulsifying efficiency of the formulations based on five parameters including excipients miscibility, spontaneity, dispersibility, h...

journal_title：AAPS PharmSciTech

authors： Shahba AA,Mohsin K,Alanazi FK

更新日期：2012-06-01 00:00:00

abstract：:Biowaivers are recommended for immediate-release solid oral dosage forms using dissolution testing as a surrogate for in vivo bioequivalence studies. Several guidance are currently available (the World Health Organization (WHO), the US FDA, and the EMEA) where the conditions are described. In this study, definitions, ...

journal_title：AAPS PharmSciTech

authors： Reddy NH,Patnala S,Löbenberg R,Kanfer I

更新日期：2014-10-01 00:00:00

abstract：:The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol 934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into...

journal_title：AAPS PharmSciTech

authors： Patel VM,Prajapati BG,Patel MM

更新日期：2007-06-22 00:00:00

abstract：:Posaconazole is a triazole antifungal drug that with extremely poor aqueous solubility. Up to now, this drug can be administered via intravenous injection and oral suspension. However, its oral bioavailability is greatly limited by the dissolution rate of the drug. This study aimed to improve water solubility and diss...

journal_title：AAPS PharmSciTech

authors： Tang P,Wang L,Ma X,Xu K,Xiong X,Liao X,Li H

更新日期：2017-01-01 00:00:00

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00