Development and validation of a discriminating in vitro dissolution method for a poorly soluble drug, olmesartan medoxomil: comparison between commercial tablets.

abstract：:This study was performed to prepare and characterize the biotinylated Salmon calcitonin (sCT) for oral delivery and evaluate the hypocalcemic effect of biotinylated-sCTs in rats. Biotinylated sCTs was characterized by using high performance liquid chromatography (HPLC) and MALDITOF-MS. The effect of biotinylation on p...

journal_title：AAPS PharmSciTech

authors： Cetin M,Youn YS,Capan Y,Lee KC

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a type of hydrophobic moiety, extent of N-substitution (ES), and degree of quaternization (DQ) of chitosan (CS) on the transepithelial electrical resistance and permeability of Caco-2 cells monolayer, using fluorescein isothiocyanate dextran 4,400 (FD-4) as the m...

journal_title：AAPS PharmSciTech

authors： Kowapradit J,Opanasopit P,Ngawhirunpat T,Apirakaramwong A,Rojanarata T,Ruktanonchai U,Sajomsang W

更新日期：2010-06-01 00:00:00

abstract：:The hydrophobicity of bioactive molecules poses a considerable problem in the pharmaceutical and the food industry. Using food-based protein nanocarriers is one promising way to deliver hydrophobic molecules. These types of protein possess many functional properties such as surface activity, water-binding capacity, em...

journal_title：AAPS PharmSciTech

authors： Maviah MBJ,Farooq MA,Mavlyanova R,Veroniaina H,Filli MS,Aquib M,Kesse S,Boakye-Yiadom KO,Wang B

更新日期：2020-03-09 00:00:00

abstract：:Bottles and carboys are used for frozen storage and transport of biopharmaceutical formulations under a wide range of conditions. The quality of freezing and thawing in these systems has been questioned due to the formation of heterogeneous ice structures and deformation of containers. This work shows that during free...

journal_title：AAPS PharmSciTech

authors： Duarte A,Rego P,Ferreira A,Dias P,Geraldes V,Rodrigues MA

更新日期：2020-09-01 00:00:00

abstract：:Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study was to identify the most suitable co-processed excipient to use ...

journal_title：AAPS PharmSciTech

authors： Dziemidowicz K,Lopez FL,Bowles BJ,Edwards AJ,Ernest TB,Orlu M,Tuleu C

更新日期：2018-08-01 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:The solubility of five poorly soluble drugs was enhanced by using an effervescence assisted solid dispersion (EASD) technique. EASDs were prepared by using modified fusion method. Drug and hydrophilic carrier were melted, and in this molten mixture, effervescence was generated by adding effervescence couple comprising...

journal_title：AAPS PharmSciTech

authors： Alam MA,Al-Jenoobi FI,Al-Mohizea AM,Ali R

更新日期：2015-12-01 00:00:00

abstract：:The purpose of this work was to measure viscosity of fluids at low microliter volumes by means of quartz crystal impedance analysis. To achieve this, a novel setup was designed that allowed for measurement of viscosity at volumes of 8 to 10 microL. The technique was based on the principle of electromechanical coupling...

journal_title：AAPS PharmSciTech

authors： Saluja A,Kalonia DS

更新日期：2004-08-05 00:00:00

abstract：:A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

journal_title：AAPS PharmSciTech

authors： Bento D,Borchard G,Gonçalves T,Borges O

更新日期：2013-06-01 00:00:00

abstract：:The present study demonstrates a preparative medium-pressure liquid chromatography (MPLC) method for isolation of Morin besides evaluating its efficacy in comparison with its self-nanoemulsifying drug delivery (SNEDD) and nanoemulsion (NE) systems against in-vivo HgCl2-induced lung toxicity in rats. Morin was isolated...

journal_title：AAPS PharmSciTech

authors： El-Haddad AE,Sheta NM,Boshra SA

更新日期：2018-07-01 00:00:00

abstract：:An acid-buffering bioadhesive vaginal tablet was developed for the treatment of genitourinary tract infections. From the bioadhesion experiment and release studies it was found that polycarbophil and sodium carboxymethylcellulose is a good combination for an acid-buffering bioadhesive vaginal tablet. Sodium monocitrat...

journal_title：AAPS PharmSciTech

authors： Alam MA,Ahmad FJ,Khan ZI,Khar RK,Ali M

更新日期：2007-12-14 00:00:00

abstract：:Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticle...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-10-01 00:00:00

abstract：:Piroxicam is used in the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory diseases. Upon oral administration, it is reported to cause ulcerative colitis, gastrointestinal irritation, edema and peptic ulcer. Hence, an alternative delivery system has been designed in the form of transethosome. T...

journal_title：AAPS PharmSciTech

authors： Garg V,Singh H,Bhatia A,Raza K,Singh SK,Singh B,Beg S

更新日期：2017-01-01 00:00:00

abstract：:Nanoparticles, of the poorly water-soluble drug, itraconazole (ITZ), were produced by the Advanced Evaporative Precipitation into Aqueous Solution process (Advanced EPAS). This process combines emulsion templating and EPAS processing to provide improved control over the size distribution of precipitated particles. Spe...

journal_title：AAPS PharmSciTech

authors： Bosselmann S,Nagao M,Chow KT,Williams RO 3rd

更新日期：2012-09-01 00:00:00

abstract：:Freeze-dried immunoglobulin G (IgG) incorporating trehalose and human serum albumin (HSA) was statistically evaluated regarding the existence of synergism between additives on the stability profile. The levels of HSA (X1) and trehalose (X2) were independent variables. Aggregation following the process (Y1), after 2 an...

journal_title：AAPS PharmSciTech

authors： Nouraei MS,Faghihi H,Najafabadi AR,Zadeh AHM,Darabi M,Vatanara A

更新日期：2019-10-28 00:00:00

abstract：:This study examined the mechanical (hardness, compressibility, adhesiveness, and cohesiveness) and rheological (zero-rate viscosity and thixotropy) properties of polyethylene glycol (PEG) gels that contain different ratios of Carbopol 934P (CP) and polyvinylpyrrolidone K90 (PVP). Mechanical properties were examined us...

journal_title：AAPS PharmSciTech

authors： Tan YT,Peh KK,Al-Hanbali O

更新日期：2000-08-17 00:00:00

abstract：:The purpose of this paper is to describe results from the use of a set of Excel macros written to facilitate the comparison of image analysis (IA) and laser diffraction (LD) particle size analysis (psa) data. Measurements were made on particle systems of differing morphological characteristics including differing aver...

journal_title：AAPS PharmSciTech

authors： Kelly RN,DiSante KJ,Stranzl E,Kazanjian JA,Bowen P,Matsuyama T,Gabas N

更新日期：2006-08-18 00:00:00

abstract：:The purpose of this research was to evaluate the relation between preferential direction of pores and mechanical strength of cubic starch compacts. The preferential pore direction was quantified in SEM images of cross sections of starch compacts using a previously described algorithm for determination of the quotient ...

journal_title：AAPS PharmSciTech

authors： Wu YS,van Vliet LJ,Frijlink HW,Stokroos I,van der Voort Maarschalk K

更新日期：2008-01-01 00:00:00

abstract：:In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro r...

journal_title：AAPS PharmSciTech

authors： Madheswaran T,Baskaran R,Thapa RK,Rhyu JY,Choi HY,Kim JO,Yong CS,Yoo BK

更新日期：2013-03-01 00:00:00

abstract：:A number of synthesized chemical molecules suffer from low aqueous solubility problems. Enhancement of aqueous solubility, dissolution rate, and bioavailability of drug is a very challenging task in drug development. In the present study, solubility and dissolution of poorly aqueous soluble drug simvastatin (SIM) was ...

journal_title：AAPS PharmSciTech

authors： Pandya P,Gattani S,Jain P,Khirwal L,Surana S

更新日期：2008-01-01 00:00:00

abstract：:Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neura...

journal_title：AAPS PharmSciTech

authors： Ahmadi Lakalayeh G,Faridi-Majidi R,Saber R,Partoazar A,Mehr SE,Amani A

更新日期：2012-12-01 00:00:00

abstract：:Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-release matrix pellets...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Huang Z,Omari-Siaw E,Lu S,Zhu Y,Jiang D,Wang M,Yu J,Xu X,Zhang W

更新日期：2016-04-01 00:00:00

abstract：:The aim of this research was to advance solid lipid nanoparticle (SLN) preparation methodology by preparing glyceryl monostearate (GMS) nanoparticles using a temperature-modulated solidification process. The technique was reproducible and prepared nanoparticles without the need of organic solvents. An anticancer agent...

journal_title：AAPS PharmSciTech

authors： Patel MN,Lakkadwala S,Majrad MS,Injeti ER,Gollmer SM,Shah ZA,Boddu SH,Nesamony J

更新日期：2014-12-01 00:00:00

abstract：:The present investigation was aimed at developing and optimizing a simple aqueous tablet-coating formulation and its process. 5-Fluorouracil (5-FU) was used to ascertain the relative lipophilic/hydrophilic behavior of the coating system. Optimization was performed by evaluating the adhesive force strength and cohesive...

journal_title：AAPS PharmSciTech

authors： Rai PR,Tiwary AK,Rana V

更新日期：2012-06-01 00:00:00

abstract：:Exogenously supplied alpha-lipoic acid (LA) has proven to be effective as an antioxidant. In an effort to develop a water-soluble formulation for topical administration, LA was formulated in the form of solid lipid nanoparticles (SLN), nanostructure lipid carriers (NLC), and nanoemulsion (NE) and characterized in term...

journal_title：AAPS PharmSciTech

authors： Ruktanonchai U,Bejrapha P,Sakulkhu U,Opanasopit P,Bunyapraphatsara N,Junyaprasert V,Puttipipatkhachorn S

更新日期：2009-01-01 00:00:00

abstract：:Chemical penetration enhancers (CPEs) are frequently incorporated into transdermal delivery systems (TDSs) to improve drug delivery and to reduce the required drug load in formulations. However, the minimum detectable effect of formulation changes to CPE-containing TDSs using in vitro permeation tests (IVPT), a widely...

journal_title：AAPS PharmSciTech

authors： Shin SH,Srivilai J,Ibrahim SA,Strasinger C,Hammell DC,Hassan HE,Stinchcomb AL

更新日期：2018-10-01 00:00:00

abstract：:The aim of this work was the formulation and characterization of alginate (ALG)-doxycycline (DOX) hydrogel microparticles (MPs) embedded into Pluronic F127 thermogel for DOX intradermal sustained delivery. ALG-DOX MPs were formed by adding a solution of the drug into a 1.5% polymer solution while stirring. The MPs wer...

journal_title：AAPS PharmSciTech

authors： Giovagnoli S,Tsai T,DeLuca PP

更新日期：2010-03-01 00:00:00

abstract：:This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two diff...

journal_title：AAPS PharmSciTech

authors： Al-Sahaf Z,Raimi-Abraham B,Licciardi M,de Mohac LM

更新日期：2020-10-02 00:00:00

abstract：:To ensure consistency of clinical outcomes, orally inhaled therapies must exhibit consistent delivered dose and aerosol properties at the time of manufacturing, throughout storage, and during various patient-use conditions. Achieving consistency across these scenarios has presented a significant challenge, especially ...

journal_title：AAPS PharmSciTech

authors： Doty A,Schroeder J,Vang K,Sommerville M,Taylor M,Flynn B,Lechuga-Ballesteros D,Mack P

更新日期：2018-02-01 00:00:00

abstract：:The exudates from the incised trunk of Terminalia randii has been evaluated as controlled release excipient in comparison with xanthan gum and hydroxypropylmethylcellulose (HPMC) using carvedilol (water insoluble) and theophylline (water soluble) as model drugs. Matrix tablets were prepared by direct compression and t...

journal_title：AAPS PharmSciTech

authors： Bamiro OA,Odeku OA,Sinha VR,Kumar R

更新日期：2012-03-01 00:00:00