Characterization and In Vitro Evaluation of the Complexes of Posaconazole with β- and 2,6-di-O-methyl-β-cyclodextrin.

abstract：:Proanthocyanidins (PAs) have several bioactivities, but they are unstable in the digestive tract and possess low bioavailability. Nanoencapsulation stabilizes these compounds for oral administration. The intestinal absorption of grape seed and skin extracts, and the poly-lactic acid (PLA) nanoparticles loaded with suc...

journal_title：AAPS PharmSciTech

authors： Fernández K,Roeckel M,Canales E,Dumont J

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to develop benzydamine hydrochloride-loaded orodispersible films using the modification of a solvent casting method. An innovative approach was developed when the drying process of a small-scale production was used based on a heated inert base for casting the film. During this process, two ty...

journal_title：AAPS PharmSciTech

authors： Pechová V,Gajdziok J,Muselík J,Vetchý D

更新日期：2018-08-01 00:00:00

abstract：:AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into an...

journal_title：AAPS PharmSciTech

authors： Kushwaha AS,Sharma P,Shivakumar HN,Rappleye C,Zukiwski A,Proniuk S,Murthy SN

更新日期：2017-10-01 00:00:00

abstract：:This investigation aimed to develop nimesulide (NMS)-loaded poly(lactic-co-glycolic acid) (PLGA)-based nanoparticulate formulations as a biodegradable polymeric drug carrier to treat rheumatoid arthritis. Polymeric nanoparticles (NPs) were prepared with two different nonionic surfactants, vitamin E d-α-tocopheryl poly...

journal_title：AAPS PharmSciTech

authors： Turk CT,Oz UC,Serim TM,Hascicek C

更新日期：2014-02-01 00:00:00

abstract：:The main principles of green chemistry and engineering were extended to pharmaceutical formulations to prepare eco-friendly surfactant-free dry emulsion tablets (SFDETs) devoid of solvents or synthetic surfactants. Surfactant-free emulsions were stabilized by in situ cyclodextrins/sweet almond oil inclusion complexes ...

journal_title：AAPS PharmSciTech

authors： Badr-Eldin SM,Labib GS,Aburahma MH

更新日期：2019-07-18 00:00:00

abstract：:A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concent...

journal_title：AAPS PharmSciTech

authors： Mabrouk M,Mulla JA,Kumar P,Chejara DR,Badhe RV,Choonara YE,du Toit LC,Pillay V

更新日期：2016-10-01 00:00:00

abstract：:The paper introduces evaluation methodologies and associated statistical approaches for process validation lifecycle Stage 3A. The assessment tools proposed can be applied to newly developed and launched small molecule as well as bio-pharma products, where substantial process and product knowledge has been gathered. T...

journal_title：AAPS PharmSciTech

authors： Sayeed-Desta N,Pazhayattil AB,Collins J,Chen S,Ingram M,Spes J

更新日期：2017-07-01 00:00:00

abstract：:The purpose of this research was to use our previously validated dynamic injection apparatus as a rapid method for screening pH-adjusted formulations of a new vancomycin analog, Van-An, for their potential to precipitate upon dilution. In 1 vial, Van-An was reconstituted according to the manufacturer's instructions. I...

journal_title：AAPS PharmSciTech

authors： Johnson JL,Yalkowsky SH

更新日期：2006-03-01 00:00:00

abstract：:The aim of this study was to apply quality by design (QbD) for pharmaceutical development of felodipine solid mixture (FSM) containing hydrophilic carriers and/or polymeric surfactants, for easier development of controlled-release tablets of felodipine. The material attributes, the process parameters (CPP), and the cr...

journal_title：AAPS PharmSciTech

authors： Basalious EB,El-Sebaie W,El-Gazayerly O

更新日期：2011-09-01 00:00:00

abstract：:Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability, and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent g...

journal_title：AAPS PharmSciTech

authors： Salústio PJ,Pontes P,Conduto C,Sanches I,Carvalho C,Arrais J,Marques HM

更新日期：2011-12-01 00:00:00

abstract：:Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the ...

journal_title：AAPS PharmSciTech

authors： Wong PM,Chan LW,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:The aim of this work is to improve the understanding of the physicochemical mechanisms involved in the functionality of cross-linked carboxymethyl sodium starch (CCSS) as a tablet super disintegrant (SD). The behavior and properties of this SD (medium uptake, disintegration times, particle size, and rheology) was inve...

journal_title：AAPS PharmSciTech

authors： Delalonde M,Fitouri R,Ruiz E,Bataille B,Sharkawi T

更新日期：2015-04-01 00:00:00

abstract：:Tomographic measurement techniques offer the opportunity to quantify the degree of homogeneity of particulate suspensions and other multiphase mixtures. Electrical resistance tomography is a relatively simple and inexpensive technique for measuring the distribution of electrical conductivity within multiphase systems....

journal_title：AAPS PharmSciTech

authors： Bolton GT,Primrose KM

更新日期：2005-09-30 00:00:00

abstract：:The aim of this research was to design and evaluate a hydrophilic matrix system for sustained release of glipizide, a weakly acidic poor soluble drug. A combination of inclusion complexation and microenvironmental pH modification techniques was utilized to improve the dissolution and pH-independent release of glipizid...

journal_title：AAPS PharmSciTech

authors： Huang J,Lin H,Peng B,Huang Q,Shuai F,Xie Y

更新日期：2018-07-01 00:00:00

abstract：:In this study, the use of trimethylchitosan (TMC), by higher solubility in comparison with chitosan, in alginate/chitosan nanoparticles containing cationic β-cyclodextrin polymers (CPβCDs) has been studied, with the aim of increasing insulin uptake by nanoparticles. Firstly, TMCs were synthesized by iodomethane, and C...

journal_title：AAPS PharmSciTech

authors： Mansourpour M,Mahjub R,Amini M,Ostad SN,Shamsa ES,Rafiee-Tehrani M,Dorkoosh FA

更新日期：2015-08-01 00:00:00

abstract：:Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticle...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporati...

journal_title：AAPS PharmSciTech

authors： Yoshida VM,de Oliveira Junior JM,Gonçalves MM,Vila MM,Chaud MV

更新日期：2011-06-01 00:00:00

abstract：:Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...

journal_title：AAPS PharmSciTech

authors： Yu X,Sun L,Tan L,Wang M,Ren X,Pi J,Jiang M,Li N

更新日期：2020-01-29 00:00:00

abstract：:Combined dissolution and permeation systems are designed to simultaneously assess the dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs therefrom. However, there were still some limitations on predicting the possible absorption rate-limiting steps and improving the in vitro-in vivo corr...

journal_title：AAPS PharmSciTech

authors： Li Z,He X,Tian S,Feng G,Huang C,Xun M,Wu Z,Wang Y

更新日期：2019-10-24 00:00:00

abstract：:In this study, the resveratrol spray-dried emulsions were developed using a quality-by-design approach. Further, the product and process factors that affected the quality of the spray-dried emulsions were analyzed and illustrated using an Ishikawa diagram. The product and process risks were prioritized using a risk-ra...

journal_title：AAPS PharmSciTech

authors： Benjasirimongkol P,Piriyaprasarth S,Moribe K,Sriamornsak P

更新日期：2018-12-18 00:00:00

abstract：:A melt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (t(g)) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of ...

journal_title：AAPS PharmSciTech

authors： Paradkar A,Maheshwari M,Tyagi AK,Chauhan B,Kadam SS

更新日期：2003-12-16 00:00:00

abstract：:Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-release matrix pellets...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Huang Z,Omari-Siaw E,Lu S,Zhu Y,Jiang D,Wang M,Yu J,Xu X,Zhang W

更新日期：2016-04-01 00:00:00

abstract：:The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug release and skin retention at molecular level. Formulation factors including oil, emulsifier, and humectant were investigated by in vitro skin retention/permeation study and t...

journal_title：AAPS PharmSciTech

authors： Yang D,Li W,Fang L,Liu C

更新日期：2019-06-20 00:00:00

abstract：:The purpose of this research was to evaluate a novel fiber-optic photometer for its ability to monitor physical instabilities occurring in concentrated emulsions during storage. For this, the fiber-optic photometer was used to measure transmission of oil-in-water emulsions stabilized with hypromellose (HPMC) as a func...

journal_title：AAPS PharmSciTech

authors： Oliczewski S,Daniels R

更新日期：2007-08-31 00:00:00

abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...

journal_title：AAPS PharmSciTech

authors： Verma S,Rudraraju VS

更新日期：2015-10-01 00:00:00

abstract：:Development of palatable formulations for pediatric and geriatric patients involves various challenges. However, an innovative development with beneficial characteristics of marketed formulations in a single formulation platform was attempted. The goal of this research was to develop solid oral flexible tablets (OFTs)...

journal_title：AAPS PharmSciTech

authors： Chandrasekaran P,Kandasamy R

更新日期：2017-08-01 00:00:00

abstract：: ...

journal_title：AAPS PharmSciTech

authors： Williams ROB 3rd

更新日期：2018-08-01 00:00:00

abstract：:The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose acetate succinate (HPMCAS, Shin-Etsu AQOAT®, medium particle si...

journal_title：AAPS PharmSciTech

authors： Lu J,Obara S,Liu F,Fu W,Zhang W,Kikuchi S

更新日期：2018-01-01 00:00:00

abstract：:In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied. Pure sodium halides (NaF, NaBr, NaCl, and NaI) were chosen as model substances because of their simple and similar structure. Based on the data available in the li...

journal_title：AAPS PharmSciTech

authors： Halenius A,Lakio S,Antikainen O,Hatara J,Yliruusi J

更新日期：2014-06-01 00:00:00

abstract：:The purpose of this research was to evaluate a new wireless and battery-free sensor technology for invasive product temperature measurement during freeze-drying. Product temperature is the most critical process parameter in a freeze-drying process, in particular during primary drying. The product temperature over time...

journal_title：AAPS PharmSciTech

authors： Schneid S,Gieseler H

更新日期：2008-01-01 00:00:00