Respiratory Administration of Infliximab Dry Powder for Local Suppression of Inflammation.

abstract：:Polymeric films are safe and effective and can be used for vaginal administration of microbicide drug candidates. Dapivirine (DPV), an investigational and clinically advanced antiretroviral drug, was selected as a model compound for this study. We have previously developed and clinically tested a quick-dissolving DPV ...

journal_title：AAPS PharmSciTech

authors： Regev G,Patel SK,Moncla BJ,Twist J,Devlin B,Rohan LC

更新日期：2019-06-26 00:00:00

abstract：:Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC)...

journal_title：AAPS PharmSciTech

authors： Faroongsarng D,Sunpaweravong S,Raksawong A

更新日期：2019-03-18 00:00:00

abstract：:To ensure consistency of clinical outcomes, orally inhaled therapies must exhibit consistent delivered dose and aerosol properties at the time of manufacturing, throughout storage, and during various patient-use conditions. Achieving consistency across these scenarios has presented a significant challenge, especially ...

journal_title：AAPS PharmSciTech

authors： Doty A,Schroeder J,Vang K,Sommerville M,Taylor M,Flynn B,Lechuga-Ballesteros D,Mack P

更新日期：2018-02-01 00:00:00

abstract：:Droplet velocity is an important parameter that can be used to characterize nasal spray products. In this study, a phase-Doppler anemometry (PDA) system was used to measure the droplet velocities of nasal sprays. A survey of seven commercial nasal spray products showed a range of droplet velocities from 6.7 to 19.2 m/...

journal_title：AAPS PharmSciTech

authors： Liu X,Doub WH,Guo C

更新日期：2011-03-01 00:00:00

abstract：:This proof-of-concept study explores the feasibility of using a drug-loaded hydrophilic polymeric layer sandwiched between two hydrophobic layers for improving film drug load while achieving sustained release of poorly water-soluble drug. Such films having total thickness in range ~ 146-250 μm were prepared by slurry-...

journal_title：AAPS PharmSciTech

authors： Kevadiya BD,Zhang L,Davé RN

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present work was the investigation of robustness and reliability of drug release from 50 to 400 mg quetiapine extended release HPMC matrix tablets towards mechanical stresses of biorelevant intensity. The tests were performed under standard conditions (USP apparatus II) as well as under simulated gastro...

journal_title：AAPS PharmSciTech

authors： Garbacz G,Kandzi A,Koziolek M,Mazgalski J,Weitschies W

更新日期：2014-02-01 00:00:00

abstract：:The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro. The delivery system was prepared by a multiple emulsion solvent evaporation method. The n...

journal_title：AAPS PharmSciTech

authors： Trickler WJ,Khurana J,Nagvekar AA,Dash AK

更新日期：2010-03-01 00:00:00

abstract：:The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment o...

journal_title：AAPS PharmSciTech

authors： Czech T,Lalani R,Oyewumi MO

更新日期：2019-02-15 00:00:00

abstract：:Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug delivery. The objective of this work was to investigate the possibility of encapsulating brinzolamide in PLGA nanoparticles in order to be applied as a su...

journal_title：AAPS PharmSciTech

authors： Salama HA,Ghorab M,Mahmoud AA,Abdel Hady M

更新日期：2017-10-01 00:00:00

abstract：:The objective of the present study is to investigate the confounding effects, if any, of beta-cyclodextrins (βCDs) on corneal permeability coefficients obtained from in vitro transmembrane diffusion studies. Transcorneal permeability studies were carried out with 2-hydroxypropyl-beta-cyclodextrin (HPβCD) and randomly ...

journal_title：AAPS PharmSciTech

authors： Adelli GR,Balguri SP,Majumdar S

更新日期：2015-10-01 00:00:00

abstract：:Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres we...

journal_title：AAPS PharmSciTech

authors： Khare P,Jain SK

更新日期：2009-01-01 00:00:00

abstract：:The potential value of succinylated soy protein (SPS) as a wall material for the encapsulation of ibuprofen (IBU), a model hydrophobic drug, by spray-drying was investigated. A succinylation rate of 93% was obtained for soy protein isolate, with a molar ratio of 1/1.5 (NH2/succinic anhydride). The solubility profile a...

journal_title：AAPS PharmSciTech

authors： Anaya Castro MA,Alric I,Brouillet F,Peydecastaing J,Fullana SG,Durrieu V

更新日期：2019-01-11 00:00:00

abstract：:The ability to produce submicron particles of monoclonal antibodies of different sizes and shapes would enhance their application to pulmonary delivery. Although non-ionic surfactants are widely used as stabilizers in protein formulations, we hypothesized that non-ionic surfactants will affect the shape and size of su...

journal_title：AAPS PharmSciTech

authors： Srinivasan AR,Shoyele SA

更新日期：2013-03-01 00:00:00

abstract：:The objective of this study was to develop an efficient tumor vasculature targeted liposome delivery system for combretastatin A4, a novel antivascular agent. Liposomes composed of hydrogenated soybean phosphatidylcholine (HSPC), cholesterol, distearoyl phosphoethanolamine-polyethylene-glycol-2000 conjugate (DSPE-PEG)...

journal_title：AAPS PharmSciTech

authors： Nallamothu R,Wood GC,Pattillo CB,Scott RC,Kiani MF,Moore BM,Thoma LA

更新日期：2006-04-07 00:00:00

abstract：:Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the drug in the gastrointestinal tract. The study was designed to investigate the lipid formulation digestibility in the simulated gastro intestinal media. Fenofibrate was formulated in representative Type II, ...

journal_title：AAPS PharmSciTech

authors： Mohsin K

更新日期：2012-06-01 00:00:00

abstract：:The aim of this work was to test innovative approach for enhancing ascorbyl palmitate stability in microemulsions for topical application by addition of newly synthesized co-antioxidant 4-(tridecyloxy)benzaldehyde oxime (TDBO) and to investigate its antioxidant activity and finally to evaluate cytotoxicity of TDBO-loa...

journal_title：AAPS PharmSciTech

authors： Gosenca M,Obreza A,Pečar S,Gašperlin M

更新日期：2010-09-01 00:00:00

abstract：:The objective of this study was to produce microparticles of a new asthma-controlling drug by supercritical assisted atomization (SAA), proposed as an alternative to conventional jet-milling process. SAA is based on the solubilization of supercritical carbon dioxide in a liquid solution containing the drug; the ternar...

journal_title：AAPS PharmSciTech

authors： Della Porta G,De Vittori C,Reverchon E

更新日期：2005-10-22 00:00:00

abstract：:The purpose of this research was to address the utility of rheological study in understanding the influence of oppositely charged polymers on release of naproxen sodium encapsulated in chitosan particles. The interaction between oppositely charged kappa-carrageenan (kappa-Ca) and chitosan leads to relatively higher ge...

journal_title：AAPS PharmSciTech

authors： Bhise KS,Dhumal RS,Shailesh B,Paradkar AR,Kadam SS

更新日期：2010-03-01 00:00:00

abstract：:Transdermal drug delivery is an emerging field in the pharmaceutical remit compared with conventional methods (oral and parenteral). Microneedle (MN)-based devices have gained significant interest as a strategy to overcome the skin's formidable barrier: the stratum corneum. This approach provides a less invasive, more...

journal_title：AAPS PharmSciTech

authors： Ali R,Mehta P,Arshad MS,Kucuk I,Chang MW,Ahmad Z

更新日期：2019-12-05 00:00:00

abstract：:To investigate the possibility of liquid proliposomes being carriers for oral delivery, nimodipine liquid proliposomes-based soft capsules (NPSC) were prepared. Nimodipine proliposomes were characterized by transmission electron microscopy (TEM), conversion rate from proliposomes to liposomes, entrapment efficiency, p...

journal_title：AAPS PharmSciTech

authors： Sun C,Wang J,Liu J,Qiu L,Zhang W,Zhang L

更新日期：2013-03-01 00:00:00

abstract：:An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded ther...

journal_title：AAPS PharmSciTech

authors： Priprem A,Janpim K,Nualkaew S,Mahakunakorn P

更新日期：2016-06-01 00:00:00

abstract：:Triple-negative breast (TNBC) cancer that is upregulated with epidermal growth factor receptor (EGFR), and devoid of both the hormonal receptors and epidermal growth factor receptor 2 (HER 2), has led to a concept of treating TNBC with EGFR-targeted therapeutics. The combination of paclitaxel (PTX) and piperine (PIP) ...

journal_title：AAPS PharmSciTech

authors： Burande AS,Viswanadh MK,Jha A,Mehata AK,Shaik A,Agrawal N,Poddar S,Mahto SK,Muthu MS

更新日期：2020-05-21 00:00:00

abstract：:Griseofulvin, an antifungal agent, is a BCS class II drug slowly, erratically, and incompletely absorbed from the gastrointestinal tract in humans. The clinical failure of the conventional oral therapy of griseofulvin is most likely attributed to its poor solubility and appreciable inter- and intra-subject variation i...

journal_title：AAPS PharmSciTech

authors： Aggarwal N,Goindi S,Mehta SD

更新日期：2012-03-01 00:00:00

abstract：:Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interestingly, this errati...

journal_title：AAPS PharmSciTech

authors： Milanowski B,Hejduk A,Bawiec MA,Jakubowska E,Urbańska A,Wiśniewska A,Garbacz G,Lulek J

更新日期：2020-01-27 00:00:00

abstract：:Individualized medicines for pediatrics are a useful alternative if there is no correct dosage marketed for this segment (easy to swallow, adequate volume and content, correct composition for pediatrics, good organoleptic properties, etc.). Its validation process must ensure quality testing: its content uniformity, ph...

journal_title：AAPS PharmSciTech

authors： Suárez-González J,Santoveña-Estévez A,Armijo-Ruíz S,Castillo A,Fariña JB

更新日期：2019-06-03 00:00:00

abstract：:Rifaximin (RFX), a semi-synthetic antibiotic belonging to BCS class IV category, has been used in the treatment of traveler's diarrhea. An attempt has been made to improve aqueous solubility of RFX in the presence of β-cyclodextrin (β-CD) and hydroxy propyl β-cyclodextrin (HP-β-CD) and control its release in the gut b...

journal_title：AAPS PharmSciTech

authors： Karanje RV,Bhavsar YV,Jahagirdar KH,Bhise KS

更新日期：2013-06-01 00:00:00

abstract：:Nanostructured lipid carriers (NLCs) are interesting delivery systems for enhancing the penetration of an active substance through the skin after topical administration. The present paper described the development of a novel NLCs for minoxidil (MXD) topical delivery. Stearic acid and oleic acid that showed the highest...

journal_title：AAPS PharmSciTech

authors： Wang W,Chen L,Huang X,Shao A

更新日期：2017-02-01 00:00:00

abstract：:Piroxicam is used in the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory diseases. Upon oral administration, it is reported to cause ulcerative colitis, gastrointestinal irritation, edema and peptic ulcer. Hence, an alternative delivery system has been designed in the form of transethosome. T...

journal_title：AAPS PharmSciTech

authors： Garg V,Singh H,Bhatia A,Raza K,Singh SK,Singh B,Beg S

更新日期：2017-01-01 00:00:00

abstract：:Multidrug resistance is the major problem in cancer treatment nowadays. Compounds from plants are the new targets to solve this problem. Quercetin (QCT), quercetrin (QTR), and rutin (RUT) are potential anticancer flavonoids but their poor water solubility leads to less efficacy. In this study, the polymeric micelles o...

journal_title：AAPS PharmSciTech

authors： Khonkarn R,Daowtak K,Okonogi S

更新日期：2020-04-26 00:00:00

abstract：:This study tests the hypothesis that association complexes formed between enoxaparin and cetyltrimethylammonium bromide (CTAB) augment permeation across the gastrointestinal mucosa due to improved encapsulation of this hydrophilic macromolecule within biocompatible poly (lactide-co-glycolide, PLGA RG 503) nanoparticle...

journal_title：AAPS PharmSciTech

authors： Eleraky NE,Swarnakar NK,Mohamed DF,Attia MA,Pauletti GM

更新日期：2020-02-03 00:00:00