Improved Oral Bioavailability, Therapeutic Efficacy, and Reduced Toxicity of Tamoxifen-Loaded Liquid Crystalline Nanoparticles.

abstract：:In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard reaction adducts were monitored in the recommended infusion time. Different physicochemical methods were used to evaluate the Maillard re...

journal_title：AAPS PharmSciTech

authors： Siahi Shadbad MR,Ghaderi F,Hatami L,Monajjemzadeh F

更新日期：2016-12-01 00:00:00

abstract：:The development of an oral formulation that ensures increased bioavailability of drugs is a great challenge for pharmaceutical scientists. Among many oral formulation systems, a drug delivery system employing superporous networks was developed to provide a prolonged gastro-retention time as well as improved bioavailab...

journal_title：AAPS PharmSciTech

authors： Le TN,Her J,Sim T,Jung CE,Kang JK,Oh KT

更新日期：2020-11-12 00:00:00

abstract：:Poly(vinyl alcohol) (PVA)-based formulations are used for pharmaceutical tablet coating with numerous advantages. Our objective is to study the stability of PVA-based coating films in the presence of acidic additives, alkaline additives, and various common impurities typically found in tablet formulations. Opadry® II ...

journal_title：AAPS PharmSciTech

authors： Koo OM,Fiske JD,Yang H,Nikfar F,Thakur A,Scheer B,Adams ML

更新日期：2011-06-01 00:00:00

abstract：:The effects of solvent [acetonitrile, methanol, and acetonitrile/water mixture (20:80, v/v)], buffer concentration (phosphate buffer, pH 7.5), ionic strength and commonly employed adjuvants on the photodegradation of betamethasone-17 valerate in cream and gel formulations have been studied on exposure to UV light (300...

journal_title：AAPS PharmSciTech

authors： Khattak SU,Shaikh D,Ahmad I,Usmanghani K,Sheraz MA,Ahmed S

更新日期：2013-03-01 00:00:00

abstract：:Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neura...

journal_title：AAPS PharmSciTech

authors： Ahmadi Lakalayeh G,Faridi-Majidi R,Saber R,Partoazar A,Mehr SE,Amani A

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this study was to compare the effects of denaturation by microwave irradiation on release properties of 2 physically different proteins. Matrices were prepared from water-soluble bovine serum albumin loaded with metoclopramide and sorbed with adequate amount of moisture were thermally denatured in a mic...

journal_title：AAPS PharmSciTech

authors： Qasem RJ

更新日期：2006-03-01 00:00:00

abstract：:The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Kiang YH,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:Pluronic F127 (PF-127) shows thermoreversible property, which is of the utmost interest in optimizing drug formulation and delivery. However, its hitherto unresolved drawback of a low phase transition temperature (T (tr)) has limited its application in injectable drug delivery systems. We have ...

journal_title：AAPS PharmSciTech

authors： Ma Y,Zhang C,Chen X,Jiang H,Pan S,Easteal AJ,Sun X

更新日期：2012-06-01 00:00:00

abstract：:A transmission near infrared (NIR) spectroscopic method has been developed for the nondestructive determination of drug content in tablets with less than 1% weight of active ingredient per weight of formulation (m/m) drug content. Tablets were manufactured with drug concentrations of approximately 0.5%, 0.7%, and 1.0%...

journal_title：AAPS PharmSciTech

authors： Meza CP,Santos MA,Romañach RJ

更新日期：2006-03-24 00:00:00

abstract：:The aim of the present study was to develop and evaluate a buccal adhesive tablet containing ondansetron hydrochloride (OH). Special punches and dies were fabricated and used while preparing buccal adhesive tablets. The tablets were prepared using carbopol (CP 934), sodium alginate, sodium carboxymethylcellulose low v...

journal_title：AAPS PharmSciTech

authors： Hassan N,Khar RK,Ali M,Ali J

更新日期：2009-01-01 00:00:00

abstract：:This study examined the mechanical (hardness, compressibility, adhesiveness, and cohesiveness) and rheological (zero-rate viscosity and thixotropy) properties of polyethylene glycol (PEG) gels that contain different ratios of Carbopol 934P (CP) and polyvinylpyrrolidone K90 (PVP). Mechanical properties were examined us...

journal_title：AAPS PharmSciTech

authors： Tan YT,Peh KK,Al-Hanbali O

更新日期：2000-08-17 00:00:00

abstract：:The purpose of this present study was to evaluate the antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX). The SSL-PTX was prepared by the thin-film method. The release of paclitaxel from SSL-PTX was analyzed using a dialysis method. The effect of SSL-PTX on endothelial cell prol...

journal_title：AAPS PharmSciTech

authors： Huang Y,Chen XM,Zhao BX,Ke XY,Zhao BJ,Zhao X,Wang Y,Zhang X,Zhang Q

更新日期：2010-06-01 00:00:00

abstract：:Risedronate sodium (RS) is a potent inhibitor of bone resorption, having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions while keeping in an upright posture for at least 30 min to diminish common gastroesophageal injuries. To surmount suc...

journal_title：AAPS PharmSciTech

authors： Elkady OA,Tadros MI,El-Laithy HM

更新日期：2019-12-05 00:00:00

abstract：:In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new microencapsulated formulation of probucol-sodium alginate (PB-SA), with good structural properties and excipient compati...

journal_title：AAPS PharmSciTech

authors： Mooranian A,Negrulj R,Al-Sallami HS,Fang Z,Mikov M,Golocorbin-Kon S,Fakhoury M,Watts GF,Matthews V,Arfuso F,Lambros A,Al-Salami H

更新日期：2015-02-01 00:00:00

abstract：:This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200). Critical quality attributes (CQAs) or associated performance indicators of the coated tablets were measured w...

journal_title：AAPS PharmSciTech

authors： Teckoe J,Mascaro T,Farrell TP,Rajabi-Siahboomi AR

更新日期：2013-06-01 00:00:00

abstract：:As a synthetic clay material, laponite RDS (LR) was investigated as an effective drug carrier as a result of the special nanodisk structure together with the negative-charged surface to achieve enhanced cellular uptake and targeted delivery. In this research work, the synthesized oligomeric hyaluronic acid-aminophenyl...

journal_title：AAPS PharmSciTech

authors： Yang Y,Li J,Chen F,Qiao S,Li Y,Pan W

更新日期：2019-11-20 00:00:00

abstract：:The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the extrudates. Differential scanning calorimetry (DSC) was utilized on...

journal_title：AAPS PharmSciTech

authors： Maddineni S,Battu SK,Morott J,Majumdar S,Murthy SN,Repka MA

更新日期：2015-04-01 00:00:00

abstract：:The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug release and skin retention at molecular level. Formulation factors including oil, emulsifier, and humectant were investigated by in vitro skin retention/permeation study and t...

journal_title：AAPS PharmSciTech

authors： Yang D,Li W,Fang L,Liu C

更新日期：2019-06-20 00:00:00

abstract：:The present study was carried out with a view to enhance the dissolution of poorly water-soluble BCS-class II drug aceclofenac by co-grinding with novel porous carrier Neusilin US(2.) (amorphous microporous granules of magnesium aluminosilicate, Fuji Chemical Industry, Toyama, Japan). Neusilin US(2) has been used as a...

journal_title：AAPS PharmSciTech

authors： Vadher AH,Parikh JR,Parikh RH,Solanki AB

更新日期：2009-01-01 00:00:00

abstract：:Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the drug in the gastrointestinal tract. The study was designed to investigate the lipid formulation digestibility in the simulated gastro intestinal media. Fenofibrate was formulated in representative Type II, ...

journal_title：AAPS PharmSciTech

authors： Mohsin K

更新日期：2012-06-01 00:00:00

abstract：:Rheumatoid arthritis is an autoimmune disease that leads to cartilage destruction, synovial joint inflammation, and bacterial joint/bone infections. In the present work, methotrexate and minocycline-loaded nanoparticles (MMNPs) were developed with an aim to provide relief from inflammation and disease progression/join...

journal_title：AAPS PharmSciTech

authors： Janakiraman K,Krishnaswami V,Sethuraman V,Natesan S,Rajendran V,Kandasamy R

更新日期：2019-12-23 00:00:00

abstract：:This investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated Dapsone (DS) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of Pneumocystis carinii pneumonia (PCP) associated with immunocompromised pat...

journal_title：AAPS PharmSciTech

authors： Chougule M,Padhi B,Misra A

更新日期：2008-01-01 00:00:00

abstract：:This work presents a new user-friendly lyophilization simulation and process optimization tool, freely available under the name LyoPRONTO. This tool comprises freezing and primary drying calculators, a design-space generator, and a primary drying optimizer. The freezing calculator performs 0D lumped capacitance modeli...

journal_title：AAPS PharmSciTech

authors： Shivkumar G,Kazarin PS,Strongrich AD,Alexeenko AA

更新日期：2019-10-31 00:00:00

abstract：:The interactions with and effects of five chemically distinct, bioactive phenolic compounds on the lipid bilayers of model dipalmitoylphosphatidylcholine (DPPC) liposomes were investigated. Complementary analytical techniques, including differential scanning calorimetry (DSC) and phosphorus and proton nuclear magnetic...

journal_title：AAPS PharmSciTech

authors： Malekar SA,Sarode AL,Bach AC 2nd,Worthen DR

更新日期：2016-12-01 00:00:00

abstract：:The objectives of this study were to formulate, characterize silymarin-loaded Eudragit nanoparticles (SNPs) and evaluate their hepatoprotective and cytotoxic effects after oral administration. SNPs were prepared by nanoprecipitation technique and were evaluated for particle size, entrapment efficiency, TEM, solid-stat...

journal_title：AAPS PharmSciTech

authors： El-Nahas AE,Allam AN,Abdelmonsif DA,El-Kamel AH

更新日期：2017-11-01 00:00:00

abstract：:Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree of crystallinity and melted at lower temperatures. Melting...

journal_title：AAPS PharmSciTech

authors： Bikiaris DN,Papageorgiou GZ,Papadimitriou SA,Karavas E,Avgoustakis K

更新日期：2009-01-01 00:00:00

abstract：:Transdermal drug delivery is an emerging field in the pharmaceutical remit compared with conventional methods (oral and parenteral). Microneedle (MN)-based devices have gained significant interest as a strategy to overcome the skin's formidable barrier: the stratum corneum. This approach provides a less invasive, more...

journal_title：AAPS PharmSciTech

authors： Ali R,Mehta P,Arshad MS,Kucuk I,Chang MW,Ahmad Z

更新日期：2019-12-05 00:00:00

abstract：:Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generati...

journal_title：AAPS PharmSciTech

authors： Das S,Chaudhury A

更新日期：2011-03-01 00:00:00

abstract：:Solid dispersion is one of the most effective ways to improve the dissolution of insoluble drugs. When the carrier can highly disperse the drug, it will increase the wettability of the drug and reduce the surface tension, thus improving the solubility, dissolution, and bioavailability. However, amorphous solid dispers...

journal_title：AAPS PharmSciTech

authors： Wang X,Zhang L,Ma D,Tang X,Zhang Y,Yin T,Gou J,Wang Y,He H

更新日期：2020-09-25 00:00:00

abstract：:In our previously studies, we confirmed that ergosterol could ameliorate diabetic nephropathy by suppressing the proliferation of mesangial cells and the accumulation of extracellular matrix (ECM). However, the therapeutic application of ergosterol may be confined due to poor aqueous solubility and low oral bioavailab...

journal_title：AAPS PharmSciTech

authors： Dong Z,Iqbal S,Zhao Z

更新日期：2020-01-13 00:00:00