Effect of Different Nail Penetration Enhancers in Solid Lipid Nanoparticles Containing Terbinafine Hydrochloride for Treatment of Onychomycosis.

abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...

journal_title：AAPS PharmSciTech

authors： Hashem FM,Nasr M,Fathy G,Ismail A

更新日期：2016-06-01 00:00:00

abstract：:An innovative and simple methodology has been developed and used for the evaluation of mucoadhesive properties of several polymers by means of sound speed measurements using high-resolution acoustic spectroscopy. In systems made of polymers in water, variations in hydration shell of polymeric chains determine changes ...

journal_title：AAPS PharmSciTech

authors： Cespi M,Bonacucina G,Mencarelli G,Giorgioni G,Palmieri GF

更新日期：2010-09-01 00:00:00

abstract：:Vemurafenib is a poorly soluble, low permeability drug that has a demonstrated need for a solubility-enhanced formulation. However, conventional approaches for amorphous solid dispersion production are challenging due to the physiochemical properties of the compound. A suitable and novel method for creating an amorpho...

journal_title：AAPS PharmSciTech

authors： Ellenberger DJ,Miller DA,Kucera SU,Williams RO 3rd

更新日期：2018-07-01 00:00:00

abstract：:The study was designed to build up a database for the evaluation of the self-emulsifying lipid formulations performance. A standard assessment method was constructed to evaluate the self-emulsifying efficiency of the formulations based on five parameters including excipients miscibility, spontaneity, dispersibility, h...

journal_title：AAPS PharmSciTech

authors： Shahba AA,Mohsin K,Alanazi FK

更新日期：2012-06-01 00:00:00

abstract：:The objective of this study was to develop an efficient tumor vasculature targeted liposome delivery system for combretastatin A4, a novel antivascular agent. Liposomes composed of hydrogenated soybean phosphatidylcholine (HSPC), cholesterol, distearoyl phosphoethanolamine-polyethylene-glycol-2000 conjugate (DSPE-PEG)...

journal_title：AAPS PharmSciTech

authors： Nallamothu R,Wood GC,Pattillo CB,Scott RC,Kiani MF,Moore BM,Thoma LA

更新日期：2006-04-07 00:00:00

abstract：:Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of spironolactone with four disintegrants named as croscarmellose sodium, crospovidone, sodium starch glycolate and microcrystalline cellulose...

journal_title：AAPS PharmSciTech

authors： Rojas J,Guisao S,Ruge V

更新日期：2012-12-01 00:00:00

abstract：:Present investigation deals with formulation and evaluation of tamoxifen (TMX)-loaded liquid crystalline nanoparticles (TMX-LCNPs) for improving oral bioavailability and safety of the existing treatment. Hexagonal Glyceryl monooleate-based TMX-LCNPs (GLCNPs) and Phytantriol-based TMX-LCNPs (PLCNPs) were prepared by di...

journal_title：AAPS PharmSciTech

authors： Jain S,Heeralal B,Swami R,Swarnakar NK,Kushwah V

更新日期：2018-01-01 00:00:00

abstract：:Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interestingly, this errati...

journal_title：AAPS PharmSciTech

authors： Milanowski B,Hejduk A,Bawiec MA,Jakubowska E,Urbańska A,Wiśniewska A,Garbacz G,Lulek J

更新日期：2020-01-27 00:00:00

abstract：:Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the ...

journal_title：AAPS PharmSciTech

authors： Wong PM,Chan LW,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:The reliable in-line monitoring of pharmaceutical processes has been regarded as a key tool toward the full implementation of process analytical technology. In this study, near-infrared (NIR) spectroscopy was examined for use as an in-line monitoring method of the paracetamol cooling crystallization process. The drug ...

journal_title：AAPS PharmSciTech

authors： Wang IC,Lee MJ,Seo DY,Lee HE,Choi Y,Kim WS,Kim CS,Jeong MY,Choi GJ

更新日期：2011-06-01 00:00:00

abstract：:Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was us...

journal_title：AAPS PharmSciTech

authors： Yu X,Sun L,Tan L,Wang M,Ren X,Pi J,Jiang M,Li N

更新日期：2020-01-29 00:00:00

abstract：:This proof-of-concept study explores the feasibility of using a drug-loaded hydrophilic polymeric layer sandwiched between two hydrophobic layers for improving film drug load while achieving sustained release of poorly water-soluble drug. Such films having total thickness in range ~ 146-250 μm were prepared by slurry-...

journal_title：AAPS PharmSciTech

authors： Kevadiya BD,Zhang L,Davé RN

更新日期：2018-08-01 00:00:00

abstract：:Celecoxib (CXB) is a poorly aqueous solubility sulfonamide non-steroidal anti-inflammatory drug (NSAID). Hence, the formulation of CXB was selected for solubilization and bioavailability. To find out suitable formulation for microemulsion, the solubility of CXB in triacetin (oil phase), Tween 80 (surfactant), and Tran...

journal_title：AAPS PharmSciTech

authors： Cao M,Ren L,Chen G

更新日期：2017-08-01 00:00:00

abstract：:The objective of this study was to investigate the release behaviour of propranolol hydrochloride from psyllium matrices in the presence hydrophilic polymers. The dissolution test was carried out at pH 1.2 and pH 6.8. Binary mixtures of psyllium and hydroxypropyl methylcellulose (HPMC) used showed that an increase in ...

journal_title：AAPS PharmSciTech

authors： Siahi-Shadbad MR,Asare-Addo K,Azizian K,Hassanzadeh D,Nokhodchi A

更新日期：2011-12-01 00:00:00

abstract：:The purpose of the present investigation is to formulate and evaluate proniosomal transdermal carrier systems for flurbiprofen. Proniosomes were prepared using various non-ionic surfactants, namely span 20 (Sp 20), span 40 (Sp 40), span 60 (Sp 60) and span 80 (Sp 80) without and with cholesterol at percentages ranging...

journal_title：AAPS PharmSciTech

authors： Ibrahim MM,Sammour OA,Hammad MA,Megrab NA

更新日期：2008-01-01 00:00:00

abstract：:Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto phthaloyl chitosan (PEG-g-PHCs) was synthesized and then self...

journal_title：AAPS PharmSciTech

authors： Du J,El-Sherbiny IM,Smyth HD

更新日期：2014-12-01 00:00:00

abstract：:In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced ...

journal_title：AAPS PharmSciTech

authors： Rachid O,Simons KJ,Rawas-Qalaji M

更新日期：2018-11-01 00:00:00

abstract：:Droplet velocity is an important parameter that can be used to characterize nasal spray products. In this study, a phase-Doppler anemometry (PDA) system was used to measure the droplet velocities of nasal sprays. A survey of seven commercial nasal spray products showed a range of droplet velocities from 6.7 to 19.2 m/...

journal_title：AAPS PharmSciTech

authors： Liu X,Doub WH,Guo C

更新日期：2011-03-01 00:00:00

abstract：:The ability to produce submicron particles of monoclonal antibodies of different sizes and shapes would enhance their application to pulmonary delivery. Although non-ionic surfactants are widely used as stabilizers in protein formulations, we hypothesized that non-ionic surfactants will affect the shape and size of su...

journal_title：AAPS PharmSciTech

authors： Srinivasan AR,Shoyele SA

更新日期：2013-03-01 00:00:00

abstract：:The objective of the study was to investigate in vitro transdermal delivery of venlafaxine hydrochloride across the pigskin by passive diffusion and iontophoresis. For passive diffusion, experiments were carried out in Franz diffusion cell whereas for iontophoretic permeation, the diffusion cell was modified to contai...

journal_title：AAPS PharmSciTech

authors： Singh G,Ghosh B,Kaushalkumar D,Somsekhar V

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this study was to compare the effects of denaturation by microwave irradiation on release properties of 2 physically different proteins. Matrices were prepared from water-soluble bovine serum albumin loaded with metoclopramide and sorbed with adequate amount of moisture were thermally denatured in a mic...

journal_title：AAPS PharmSciTech

authors： Qasem RJ

更新日期：2006-03-01 00:00:00

abstract：:Pneumocystis carinii pneumonia (PCP) is a major opportunistic infection that affects patients with human immunodeficiency virus. Although orally administered dapsone leads to high hepatic metabolism, decreasing the therapeutic index and causing severe side effects, this drug is an effective alternative for the treatme...

journal_title：AAPS PharmSciTech

authors： Ortiz M,Jornada DS,Pohlmann AR,Guterres SS

更新日期：2015-10-01 00:00:00

abstract：:The present study was designed to test the hypothesis that programmed cell death-1 (PD-1) siRNA can downregulate PD-1 expression in macrophages in culture and in tumor tissues in mice and inhibit tumor growth in a mouse model. PD-1 siRNA was encapsulated in solid lipid nanoparticles (SLNs), and the physical properties...

journal_title：AAPS PharmSciTech

authors： Hanafy MS,Hufnagel S,Trementozzi AN,Sakran W,Stachowiak JC,Koleng JJ,Cui Z

更新日期：2021-01-31 00:00:00

abstract：:This paper is a continuation of the research published by the Stability Shelf Life Working Group as chartered under the Product Quality Research Institute. The Working Group was formed in 2006 and disbanded in late 2019. Following the philosophy presented by the Working Group on how to characterize the stability shelf...

journal_title：AAPS PharmSciTech

authors： Schwenke J,Quinlan M,Stroup W,Forenzo P

更新日期：2020-10-20 00:00:00

abstract：:One of the current methods for cycle optimization in primary drying to is develop a graphical design space based on quality by design (QbD). In order to construct the design space, the vial heat transfer coefficient (Kv) is needed. This paper investigated experimental factors that can affect the Kv result, examined th...

journal_title：AAPS PharmSciTech

authors： Wegiel LA,Ferris SJ,Nail SL

更新日期：2018-05-01 00:00:00

abstract：:Two different types of derivatives of theophylline (Th-H) incorporating ethyleneoxy groups into the promoiety have been synthesized. One is a soft alkyl type where N-methyl-N-methoxyethyleneoxycarbonylaminomethyl chlorides have been used to alkylate Th-H in the 7 position. The other is in an acyl type where methoxyeth...

journal_title：AAPS PharmSciTech

authors： Majumdar S,Mueller-Spaeth M,Sloan KB

更新日期：2012-09-01 00:00:00

abstract：:Hypertension shows circadian blood pressure rhythms (day-night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels. Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that immediately releases olmesartan, to give a burst effect, and controls azelnidipine rel...

journal_title：AAPS PharmSciTech

authors： Rashad AA,Nageeb El-Helaly S,Abd El Rehim RT,El-Gazayerly ON

更新日期：2019-12-10 00:00:00

abstract：:Multidrug resistance is the major problem in cancer treatment nowadays. Compounds from plants are the new targets to solve this problem. Quercetin (QCT), quercetrin (QTR), and rutin (RUT) are potential anticancer flavonoids but their poor water solubility leads to less efficacy. In this study, the polymeric micelles o...

journal_title：AAPS PharmSciTech

authors： Khonkarn R,Daowtak K,Okonogi S

更新日期：2020-04-26 00:00:00

abstract：:Itraconazole (ITZ) crystalline nanoparticles were prepared using relatively simple, low-cost sonoprecipitation technique, in which both the solvent and antisolvent were organic in nature. The effect of stabilizer type (hydroxypropyl methylcellulose, hydroxypropyl cellulose, Inutec SP1®, and pluronic F127), drying meth...

journal_title：AAPS PharmSciTech

authors： Badawi AA,El-Nabarawi MA,El-Setouhy DA,Alsammit SA

更新日期：2011-09-01 00:00:00

abstract：:The aim of the work is to develop a data fusion model using near-infrared (NIR) and process parameters for the predictions of drug dissolution from controlled release multiparticulate beads. Using a design of experiments, ciprofloxacin-coated beads were manufactured and critical process parameters such as air volume, ...

journal_title：AAPS PharmSciTech

authors： Ibrahim A,Kothari BH,Fahmy R,Hoag SW

更新日期：2019-06-18 00:00:00