Experimental Aspects of Measuring the Vial Heat Transfer Coefficient in Pharmaceutical Freeze-Drying.

abstract：:Establishing bioequivalence (BE) of drugs indicated to treat cancer poses special challenges. For ethical reasons, often, the studies need to be conducted in cancer patients rather than in healthy volunteers, especially when the drug is cytotoxic. The Biopharmaceutics Classification System (BCS) introduced by Amidon (...

journal_title：AAPS PharmSciTech

authors： Tampal N,Mandula H,Zhang H,Li BV,Nguyen H,Conner DP

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 × 2.5 mm tablets with 15% and 90% infill levels. The prep...

journal_title：AAPS PharmSciTech

authors： Öblom H,Zhang J,Pimparade M,Speer I,Preis M,Repka M,Sandler N

更新日期：2019-01-07 00:00:00

abstract：:The objective of the present study was to develop fast dissolving oral film of the antipsychotic drug, flupentixol dihydrochloride, to enhance its bioavailability, optimize its therapeutic effect when used to treat depression with anxiety, and increase the convenience and compliance by the mentally ill, developmentall...

journal_title：AAPS PharmSciTech

authors： Abdelbary A,Bendas ER,Ramadan AA,Mostafa DA

更新日期：2014-12-01 00:00:00

abstract：:The objective of the present investigation was to reduce the bitterness with improved dissolution, in acidic medium (pH 1.2), of mefloquine hydrochloride (MFL). Microparticles were prepared by coacervation method using Eudragit E (EE) as polymer and sodium hydroxide as precipitant. A 3(2) full factorial design was use...

journal_title：AAPS PharmSciTech

authors： Shah PP,Mashru RC,Rane YM,Thakkar A

更新日期：2008-01-01 00:00:00

abstract：:The reliable in-line monitoring of pharmaceutical processes has been regarded as a key tool toward the full implementation of process analytical technology. In this study, near-infrared (NIR) spectroscopy was examined for use as an in-line monitoring method of the paracetamol cooling crystallization process. The drug ...

journal_title：AAPS PharmSciTech

authors： Wang IC,Lee MJ,Seo DY,Lee HE,Choi Y,Kim WS,Kim CS,Jeong MY,Choi GJ

更新日期：2011-06-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is having many potential pharmacological and physiological actions which reported that therapeutically useful concentration is low (100-160 μM) and a higher concentration could be toxic. Most of its donors produce it on coming into contact with water. All of these problems could be solved by a c...

journal_title：AAPS PharmSciTech

authors： Ali H,Opere C,Singh S

更新日期：2014-08-01 00:00:00

abstract：:While polyethylene oxide (PEO)-based matrix tablets are frequently used as abuse-deterrent dosage forms, there is limited information available regarding how the selection of formulation components and manufacturing processes affect the resulting abuse-deterrent properties. The objective of the current study was to ev...

journal_title：AAPS PharmSciTech

authors： Meruva S,Donovan MD

更新日期：2019-12-19 00:00:00

abstract：:This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200). Critical quality attributes (CQAs) or associated performance indicators of the coated tablets were measured w...

journal_title：AAPS PharmSciTech

authors： Teckoe J,Mascaro T,Farrell TP,Rajabi-Siahboomi AR

更新日期：2013-06-01 00:00:00

abstract：:A folic acid-conjugated paclitaxel (PTX)-doxorubicin (DOX)-loaded nanostructured lipid carrier(s) (FA-PTX-DOX NLCs) were prepared by using emulsion-evaporation method and extensively characterized for particle size, polydispersity index, zeta potential, and % entrapment efficiency which were found to be 196 ± 2.5 nm, ...

journal_title：AAPS PharmSciTech

authors： Raikwar S,Vyas S,Sharma R,Mody N,Dubey S,Vyas SP

更新日期：2018-11-01 00:00:00

abstract：:Co-encapsulation of anticancer drugs paclitaxel and imatinib in nanocarriers is a promising strategy to optimize cancer treatment. Aiming to combine the cytotoxic and antiangiogenic properties of the drugs, a liposome formulation targeted to folate receptor co-encapsulating paclitaxel and imatinib was designed in this...

journal_title：AAPS PharmSciTech

authors： Peres-Filho MJ,Dos Santos AP,Nascimento TL,de Ávila RI,Ferreira FS,Valadares MC,Lima EM

更新日期：2018-01-01 00:00:00

abstract：:Non-invasive administration of insulin is expected for better diabetes mellitus therapy. In this report, we developed intraoral preparation for insulin. Insulin was encapsulated into nanocarrier using self-assembly emulsification process. To increase lipophilicity of insulin, it was dispersed in phospholipid resulted ...

journal_title：AAPS PharmSciTech

authors： Rachmawati H,Haryadi BM,Anggadiredja K,Suendo V

更新日期：2015-06-01 00:00:00

abstract：:The purpose of this study was to investigate physicochemical characteristics and in vitro release of zidovudine from monolithic film of Eudragit RL 100 and ethyl cellulose. Films included 2.5% or 5% (w/w) zidovudine of the dry polymer weight were prepared in various ratios of polymers by solvent evaporation method fro...

journal_title：AAPS PharmSciTech

authors： Takmaz EA,Inal O,Baykara T

更新日期：2009-01-01 00:00:00

abstract：:Pentoxifylline (PTX), an anti-hemorrhage drug used in the treatment of intermittent claudication, is extensively metabolized by the liver resulting in a reduction of the therapeutic levels within a short duration of time. Self-nano-emulsifying drug delivery system (SNEDDS) is well reported to enhance the bio-absorptio...

journal_title：AAPS PharmSciTech

authors： Shailendrakumar AM,Ghate VM,Kinra M,Lewis SA

更新日期：2020-04-21 00:00:00

abstract：:The specific aim of the present study was to investigate the biodegradation and biocompatibility characteristics of rosin, a natural film-forming polymer. Both in vitro as well as in vivo methods were used for assessment of the same. The in vitro degradation of rosin films was followed in pH 7.4 phosphate buffered sal...

journal_title：AAPS PharmSciTech

authors： Satturwar PM,Fulzele SV,Dorle AK

更新日期：2003-10-22 00:00:00

abstract：:The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of ...

journal_title：AAPS PharmSciTech

authors： Mohamed EM,Barakh Ali SF,Rahman Z,Dharani S,Ozkan T,Kuttolamadom MA,Khan MA

更新日期：2020-08-13 00:00:00

abstract：:The stability of the 37-amino acid peptide pramlintide, in aqueous solution, was studied as a function of pH and temperature. Samples of pramlintide formulated as a parenteral product were exposed to elevated temperatures and to realistic storage conditions for as long as 30 months. Pramlintide degradation was monitor...

journal_title：AAPS PharmSciTech

authors： Kenley RA,Tracht S,Stepanenko A,Townsend M,L'Italien J

更新日期：2000-03-18 00:00:00

abstract：:MUC1 gene encodes a transmembrane mucin glycoprotein that is overexpressed in human breast cancer and colon cancer. The objective of this study was to develop an in situ gel delivery system containing paclitaxel (PTX) and mucoadhesives for sustained and targeted delivery of anticancer drugs. The delivery system consis...

journal_title：AAPS PharmSciTech

authors： Jauhari S,Dash AK

更新日期：2006-06-02 00:00:00

abstract：:The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the ...

journal_title：AAPS PharmSciTech

authors： Bi M,Kyad A,Kiang YH,Alvarez-Nunez F,Alvarez F

更新日期：2011-12-01 00:00:00

abstract：:The paper introduces evaluation methodologies and associated statistical approaches for process validation lifecycle Stage 3A. The assessment tools proposed can be applied to newly developed and launched small molecule as well as bio-pharma products, where substantial process and product knowledge has been gathered. T...

journal_title：AAPS PharmSciTech

authors： Sayeed-Desta N,Pazhayattil AB,Collins J,Chen S,Ingram M,Spes J

更新日期：2017-07-01 00:00:00

abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...

journal_title：AAPS PharmSciTech

authors： Hashem FM,Nasr M,Fathy G,Ismail A

更新日期：2016-06-01 00:00:00

abstract：:The aim of this work was to test innovative approach for enhancing ascorbyl palmitate stability in microemulsions for topical application by addition of newly synthesized co-antioxidant 4-(tridecyloxy)benzaldehyde oxime (TDBO) and to investigate its antioxidant activity and finally to evaluate cytotoxicity of TDBO-loa...

journal_title：AAPS PharmSciTech

authors： Gosenca M,Obreza A,Pečar S,Gašperlin M

更新日期：2010-09-01 00:00:00

abstract：:The aim of this work was to study the effect of the type of substituent of the cellulose ethers and the molecular mass on the state and dynamics of water in the respective hydrogels to specify the quantity of adsorbed water on the polymers or, more explicitly, to calculate the average number of water molecules bound t...

journal_title：AAPS PharmSciTech

authors： Baumgartner S,Lahajnar G,Sepe A,Kristl J

更新日期：2002-01-01 00:00:00

abstract：:Biowaivers are recommended for immediate-release solid oral dosage forms using dissolution testing as a surrogate for in vivo bioequivalence studies. Several guidance are currently available (the World Health Organization (WHO), the US FDA, and the EMEA) where the conditions are described. In this study, definitions, ...

journal_title：AAPS PharmSciTech

authors： Reddy NH,Patnala S,Löbenberg R,Kanfer I

更新日期：2014-10-01 00:00:00

abstract：:Combined dissolution and permeation systems are designed to simultaneously assess the dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs therefrom. However, there were still some limitations on predicting the possible absorption rate-limiting steps and improving the in vitro-in vivo corr...

journal_title：AAPS PharmSciTech

authors： Li Z,He X,Tian S,Feng G,Huang C,Xun M,Wu Z,Wang Y

更新日期：2019-10-24 00:00:00

abstract：:Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-release matrix pellets...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Huang Z,Omari-Siaw E,Lu S,Zhu Y,Jiang D,Wang M,Yu J,Xu X,Zhang W

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this research was to address the utility of rheological study in understanding the influence of oppositely charged polymers on release of naproxen sodium encapsulated in chitosan particles. The interaction between oppositely charged kappa-carrageenan (kappa-Ca) and chitosan leads to relatively higher ge...

journal_title：AAPS PharmSciTech

authors： Bhise KS,Dhumal RS,Shailesh B,Paradkar AR,Kadam SS

更新日期：2010-03-01 00:00:00

abstract：:The aim of this study was to develop benzydamine hydrochloride-loaded orodispersible films using the modification of a solvent casting method. An innovative approach was developed when the drying process of a small-scale production was used based on a heated inert base for casting the film. During this process, two ty...

journal_title：AAPS PharmSciTech

authors： Pechová V,Gajdziok J,Muselík J,Vetchý D

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To develop a novel nanoparticle drug delivery system consisting of chitosan and glyceryl monooleate (GMO) for the delivery of a wide variety of therapeutics including paclitaxel. METHODS:Chitosan/GMO nanoparticles were prepared by multiple emulsion (o/w/o) solvent evaporation methods. Particle size and surface...

journal_title：AAPS PharmSciTech

authors： Trickler WJ,Nagvekar AA,Dash AK

更新日期：2008-01-01 00:00:00

abstract：:Onychomycosis is considered a stubborn nail fungal infection that does not respond to conventional topical antifungal treatments. This study aimed to develop and characterize novel solid lipid nanoparticles (SLNs) formulae containing terbinafine HCl (TFH) and loaded with different nail penetration enhancers (nPEs). Th...

journal_title：AAPS PharmSciTech

authors： Abobakr FE,Fayez SM,Elwazzan VS,Sakran W

更新日期：2021-01-06 00:00:00

abstract：:Topical administration is a preferable choice for local anesthetic delivery. Microemulsions have shown great effectiveness for transdermal transport of lidocaine. However, fabrication of microemulsions containing highly concentrated lidocaine (10%) to provide an extended local anesthetic effect is still a challenge. T...

journal_title：AAPS PharmSciTech

authors： Wang Y,Wang X,Wang X,Song Y,Wang X,Hao J

更新日期：2019-01-09 00:00:00