In vitro-controlled release delivery system for hydrogen sulfide donor.

abstract：:For polymer-based controlled release drug products (e.g. microspheres and implants), active pharmaceutical ingredient distribution and microporosity inside the polymer matrix are critical for product performance, particularly drug release kinetics. Due to the decreasing domain size and increasing complexity of such pr...

journal_title：AAPS PharmSciTech

authors： Zhang S,Wu D,Zhou L

更新日期：2020-07-14 00:00:00

abstract：:Griseofulvin, an antifungal agent, is a BCS class II drug slowly, erratically, and incompletely absorbed from the gastrointestinal tract in humans. The clinical failure of the conventional oral therapy of griseofulvin is most likely attributed to its poor solubility and appreciable inter- and intra-subject variation i...

journal_title：AAPS PharmSciTech

authors： Aggarwal N,Goindi S,Mehta SD

更新日期：2012-03-01 00:00:00

abstract：:The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of ...

journal_title：AAPS PharmSciTech

authors： Mohamed EM,Barakh Ali SF,Rahman Z,Dharani S,Ozkan T,Kuttolamadom MA,Khan MA

更新日期：2020-08-13 00:00:00

abstract：:The aim of this study was to apply quality by design (QbD) for pharmaceutical development of felodipine solid mixture (FSM) containing hydrophilic carriers and/or polymeric surfactants, for easier development of controlled-release tablets of felodipine. The material attributes, the process parameters (CPP), and the cr...

journal_title：AAPS PharmSciTech

authors： Basalious EB,El-Sebaie W,El-Gazayerly O

更新日期：2011-09-01 00:00:00

abstract：:Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the ...

journal_title：AAPS PharmSciTech

authors： Wong PM,Chan LW,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into an...

journal_title：AAPS PharmSciTech

authors： Kushwaha AS,Sharma P,Shivakumar HN,Rappleye C,Zukiwski A,Proniuk S,Murthy SN

更新日期：2017-10-01 00:00:00

abstract：:A simple but novel mixed surfactant system was designed to fabricate a self-nanoemulsifying drug delivery system (SNEDDS) based on hydrophilic-lipophilic balance (HLB) value. The impacts of HLB and molecular structure of surfactants on the formation of SNEDDS were investigated. After screening various oils and surfact...

journal_title：AAPS PharmSciTech

authors： Weerapol Y,Limmatvapirat S,Nunthanid J,Sriamornsak P

更新日期：2014-04-01 00:00:00

abstract：:An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded ther...

journal_title：AAPS PharmSciTech

authors： Priprem A,Janpim K,Nualkaew S,Mahakunakorn P

更新日期：2016-06-01 00:00:00

abstract：:Pellet manufacturing by extrusion/spheronization is quite common in the pharmaceutical field because the obtained product is characterized by a high sphericity as well as a narrow particle size distribution. The established mechanisms only consider deformation of the initially fractured particles but do not account fo...

journal_title：AAPS PharmSciTech

authors： Koester M,Thommes M

更新日期：2010-12-01 00:00:00

abstract：:The objective of this study was to determine the influence of mechanical stresses simulating gastrointestinal contraction forces of 2.0 N (stomach) and 1.2 N (intestine) on the gel properties and drug release characteristics from sustained release swelling and eroding hydrophilic matrices during dissolution studies. T...

journal_title：AAPS PharmSciTech

authors： Takieddin M,Fassihi R

更新日期：2015-04-01 00:00:00

abstract：:The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio...

journal_title：AAPS PharmSciTech

authors： Douroumis DD,Gryczke A,Schminke S

更新日期：2011-03-01 00:00:00

abstract：:To enhance the stability of coenzyme Q10 (CoQ10), Kolliphor® HS 15 (HS15) was employed as a carrier to build up a stable CoQ10-loaded micelle delivery system. The impact of micellar compositions, the preparation condition, and the preparation method on size characteristics, the solubilization efficiency, and micellar ...

journal_title：AAPS PharmSciTech

authors： Liu L,Mao K,Wang W,Pan H,Wang F,Yang M,Liu H

更新日期：2016-06-01 00:00:00

abstract：:In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro r...

journal_title：AAPS PharmSciTech

authors： Madheswaran T,Baskaran R,Thapa RK,Rhyu JY,Choi HY,Kim JO,Yong CS,Yoo BK

更新日期：2013-03-01 00:00:00

abstract：:Nanotechnology is having a significant impact in the drug delivery systems and diagnostic devices. As most of the nanosystems are intended to be administered in vivo, there is a need for stability models, which could simulate the biological environment. Instability issues could lead to particle aggregation and in turn...

journal_title：AAPS PharmSciTech

authors： Shaikh MV,Kala M,Nivsarkar M

更新日期：2017-05-01 00:00:00

abstract：:The exudates from the incised trunk of Terminalia randii has been evaluated as controlled release excipient in comparison with xanthan gum and hydroxypropylmethylcellulose (HPMC) using carvedilol (water insoluble) and theophylline (water soluble) as model drugs. Matrix tablets were prepared by direct compression and t...

journal_title：AAPS PharmSciTech

authors： Bamiro OA,Odeku OA,Sinha VR,Kumar R

更新日期：2012-03-01 00:00:00

abstract：:As of March 10, 2020, more than 100,000 novel coronavirus pneumonia cases have been confirmed globally. With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. The drugs currently being developed are not adequate to deal ...

journal_title：AAPS PharmSciTech

authors： Yan J,Liu A,Huang J,Wu J,Fan H

更新日期：2020-05-13 00:00:00

abstract：:The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often ter...

journal_title：AAPS PharmSciTech

authors： Patil SS,Venugopal E,Bhat S,Mahadik KR,Paradkar AR

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this research was to evaluate a new wireless and battery-free sensor technology for invasive product temperature measurement during freeze-drying. Product temperature is the most critical process parameter in a freeze-drying process, in particular during primary drying. The product temperature over time...

journal_title：AAPS PharmSciTech

authors： Schneid S,Gieseler H

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this research was to assess the physicochemical properties of a controlled release formulation of recombinant human growth hormone (rHGH) encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) composite microspheres. rHGH was loaded in poly(acryloyl hydroxyethyl) starch (acHES) microparticles, and then t...

journal_title：AAPS PharmSciTech

authors： Capan Y,Jiang G,Giovagnoli S,Na KH,DeLuca PP

更新日期：2003-01-01 00:00:00

abstract：:The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as sol...

journal_title：AAPS PharmSciTech

authors： Pal K,Banthia AK,Majumdar DK

更新日期：2007-03-16 00:00:00

abstract：:The purpose of this research was to evaluate in vitro transnasal sustained-release ability of sorbitan monostearate (SMS) organogels in isopropyl myristate (IM). Organogels were prepared containing SMS (2.5%-20%) and water (5%-25%) in IM and analyzed microscopically for phase behavior. The effect of Tween surfactants ...

journal_title：AAPS PharmSciTech

authors： Pisal S,Shelke V,Mahadik K,Kadam S

更新日期：2004-09-13 00:00:00

abstract：:Triple-negative breast (TNBC) cancer that is upregulated with epidermal growth factor receptor (EGFR), and devoid of both the hormonal receptors and epidermal growth factor receptor 2 (HER 2), has led to a concept of treating TNBC with EGFR-targeted therapeutics. The combination of paclitaxel (PTX) and piperine (PIP) ...

journal_title：AAPS PharmSciTech

authors： Burande AS,Viswanadh MK,Jha A,Mehata AK,Shaik A,Agrawal N,Poddar S,Mahto SK,Muthu MS

更新日期：2020-05-21 00:00:00

abstract：:This work examines the influence of various process parameters (like sodium alginate concentration, calcium chloride concentration, and hardening time) on papain entrapped in ionotropically cross-linked alginate beads for stability improvement and site-specific delivery to the small intestine using neural network mode...

journal_title：AAPS PharmSciTech

authors： Sankalia MG,Mashru RC,Sankalia JM,Sutariya VB

更新日期：2005-09-30 00:00:00

abstract：:This study assessed the utility of near-infrared (NIR) spectroscopy for the real-time monitoring of content uniformity and critical quality attributes (tensile strength, Young's modulus, and relative density) of ribbed roller compacted flakes made by axially corrugated or ribbed rolls. A custom-built setup was used to...

journal_title：AAPS PharmSciTech

authors： Samanta AK,Karande AD,Ng KY,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose acetate succinate (HPMCAS, Shin-Etsu AQOAT®, medium particle si...

journal_title：AAPS PharmSciTech

authors： Lu J,Obara S,Liu F,Fu W,Zhang W,Kikuchi S

更新日期：2018-01-01 00:00:00

abstract：:Hypertension shows circadian blood pressure rhythms (day-night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels. Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that immediately releases olmesartan, to give a burst effect, and controls azelnidipine rel...

journal_title：AAPS PharmSciTech

authors： Rashad AA,Nageeb El-Helaly S,Abd El Rehim RT,El-Gazayerly ON

更新日期：2019-12-10 00:00:00

abstract：:Our objective was to prepare nanoparticulate system using a simple yet attractive innovated method as an ophthalmic delivery system for fluocinolone acetonide to improve its ocular bioavailability. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by adopting thin film hydration method using PLGA/poloxa...

journal_title：AAPS PharmSciTech

authors： Salama AH,Mahmoud AA,Kamel R

更新日期：2016-10-01 00:00:00

abstract：:Combined dissolution and permeation systems are designed to simultaneously assess the dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs therefrom. However, there were still some limitations on predicting the possible absorption rate-limiting steps and improving the in vitro-in vivo corr...

journal_title：AAPS PharmSciTech

authors： Li Z,He X,Tian S,Feng G,Huang C,Xun M,Wu Z,Wang Y

更新日期：2019-10-24 00:00:00

abstract：:Exogenously supplied alpha-lipoic acid (LA) has proven to be effective as an antioxidant. In an effort to develop a water-soluble formulation for topical administration, LA was formulated in the form of solid lipid nanoparticles (SLN), nanostructure lipid carriers (NLC), and nanoemulsion (NE) and characterized in term...

journal_title：AAPS PharmSciTech

authors： Ruktanonchai U,Bejrapha P,Sakulkhu U,Opanasopit P,Bunyapraphatsara N,Junyaprasert V,Puttipipatkhachorn S

更新日期：2009-01-01 00:00:00

abstract：:In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard reaction adducts were monitored in the recommended infusion time. Different physicochemical methods were used to evaluate the Maillard re...

journal_title：AAPS PharmSciTech

authors： Siahi Shadbad MR,Ghaderi F,Hatami L,Monajjemzadeh F

更新日期：2016-12-01 00:00:00