The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.

abstract：:An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase...

journal_title：Blood

authors： Cao YA,Wagers AJ,Karsunky H,Zhao H,Reeves R,Wong RJ,Stevenson DK,Weissman IL,Contag CH

更新日期：2008-12-01 00:00:00

abstract：:A common genetic risk factor for venous thrombosis among Caucasoid subpopulations is a polymorphism, nt G1691A, in blood coagulation factor V that replaces Arg506 with Gln and imparts resistance of factor Va to the anticoagulant, activated protein C. Haplotype analyses using six dimorphic sites in the factor V gene fo...

journal_title：Blood

authors： Zivelin A,Griffin JH,Xu X,Pabinger I,Samama M,Conard J,Brenner B,Eldor A,Seligsohn U

更新日期：1997-01-15 00:00:00

abstract：:Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using a sens...

journal_title：Blood

authors： Cozzi MR,Guglielmini G,Battiston M,Momi S,Lombardi E,Miller EC,De Zanet D,Mazzucato M,Gresele P,De Marco L

更新日期：2015-01-22 00:00:00

abstract：:In Burkitt lymphoma/leukemia (BL), achievement of complete remission with first-line chemotherapy remains a challenging issue, as most patients who respond remain disease-free, whereas those refractory have few options of being rescued with salvage therapies. The mechanisms underlying BL chemoresistance and how it can...

journal_title：Blood

authors： Richter-Larrea JA,Robles EF,Fresquet V,Beltran E,Rullan AJ,Agirre X,Calasanz MJ,Panizo C,Richter JA,Hernandez JM,Roman-Gomez J,Prosper F,Martinez-Climent JA

更新日期：2010-10-07 00:00:00

abstract：:Maintenance of myeloid cell homeostasis requires continuous turnover of phagocytes from the bloodstream, yet whether environmental signals influence phagocyte longevity in the absence of inflammation remains unknown. Here, we show that the gut microbiota regulates the steady-state cellular lifespan of neutrophils and ...

journal_title：Blood

authors： Hergott CB,Roche AM,Tamashiro E,Clarke TB,Bailey AG,Laughlin A,Bushman FD,Weiser JN

更新日期：2016-05-19 00:00:00

abstract：:The c-myb proto-oncogene has been implicated in leukemogenesis, but possible mechanisms remain ill defined. To gain further insight to this process, we used transcript profiling in K562 cells expressing a dominant-negative Myb (MERT) protein. A total of 105 potential Myb gene targets were identified. Neuromedin U (NmU...

journal_title：Blood

authors： Shetzline SE,Rallapalli R,Dowd KJ,Zou S,Nakata Y,Swider CR,Kalota A,Choi JK,Gewirtz AM

更新日期：2004-09-15 00:00:00

abstract：:The measurement of platelet-associated IgG (PAIgG) is a potentially useful diagnostic test for idiopathic thrombocytopenia purpura (ITP). However, the restricted application of PAIgG measurements to thrombocytopenic populations primarily comprised of ITP patients will artificially enhance its diagnosis specificity. Fo...

journal_title：Blood

authors： Kelton JG,Powers PJ,Carter CJ

更新日期：1982-10-01 00:00:00

abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

journal_title：Blood

authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

更新日期：2009-12-10 00:00:00

abstract：:The stage of progenitor maturation and factors that determine the fate and clonal acquisition of human natural killer (NK) cell receptors during development are unknown. To study human NK cell receptor ontogeny, umbilical cord blood CD34(+)/Lin(-)/CD38(-) cells were cultured with a murine fetal liver line (AFT024) and...

journal_title：Blood

authors： Miller JS,McCullar V

更新日期：2001-08-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK inhibitor ruxolitinib dampens T-cell activation and lessens inflamm...

journal_title：Blood

authors： Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE

更新日期：2019-07-11 00:00:00

abstract：:The molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome is the presence of a mutation in the iron-responsive element (IRE) of the L ferritin gene, located on chromosome 19q13.3-13.4. Two mutations have been reported so far, altering adjacent nucleotides in the IRE loop, in a regio...

journal_title：Blood

authors： Martin ME,Fargion S,Brissot P,Pellat B,Beaumont C

更新日期：1998-01-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

journal_title：Blood

authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

更新日期：2005-06-15 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is characterized by the continuous proliferation and abnormal circulation of malignant hematopoietic progenitors. This may be related to the unresponsiveness of CML progenitors to beta1 integrin adhesion receptor-mediated inhibition of progenitor proliferation by the marrow microenvi...

journal_title：Blood

authors： Bhatia R,Verfaillie CM

更新日期：1998-05-01 00:00:00

abstract：:Cutaneous T-cell lymphomas (CTCLs) primarily affect skin and are characterized by proliferation of mature CD4(+) T-helper cells. The pattern of cytokine production in the skin and blood is considered to be of major importance for the pathogenesis of CTCLs. Abnormal cytokine expression in CTCLs may be responsible for e...

journal_title：Blood

authors： Geskin LJ,Viragova S,Stolz DB,Fuschiotti P

更新日期：2015-04-30 00:00:00

abstract：:During the inflammatory response, granulocytes and other leukocytes adhere to and emigrate from small venules. Before firm attachment, leukocytes are observed rolling slowly along the endothelium in venules of most tissues accessible to intravital microscopy. The molecular mechanism underlying this early type of leuko...

journal_title：Blood

authors： Ley K,Gaehtgens P,Fennie C,Singer MS,Lasky LA,Rosen SD

更新日期：1991-06-15 00:00:00

abstract：:We have previously described the development of oncoretrovirus vectors for human gamma-globin using a truncated beta-globin promoter, modified gamma-globin cassette, and alpha-globin enhancer. However, one of these vectors is genetically unstable, and both vectors exhibit variable expression patterns in cultured cells...

journal_title：Blood

authors： Emery DW,Yannaki E,Tubb J,Nishino T,Li Q,Stamatoyannopoulos G

更新日期：2002-09-15 00:00:00

abstract：:Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobese diabetic-severe combined immunodeficient (NOD/SCID) mic...

journal_title：Blood

authors： Bair S,Spaulding E,Parkkinen J,Shulman HM,Lesnikov V,Beauchamp M,Canonne-Hergaux F,Kowdley KV,Deeg HJ

更新日期：2009-02-19 00:00:00

abstract：:Conditioned medium (CM) obtained from a human hepatoma cell line, SK-HEP-1, contains colony-stimulating factors (CSFs) active on murine and human bone marrow-derived granulocyte and macrophage colony-forming units (CFU-GM) and a factor capable of inducing granulocyte-macrophage differentiation (GM-DF) of murine myelom...

journal_title：Blood

authors： Gabrilove JL,Welte K,Lu L,Castro-Malaspina H,Moore MA

更新日期：1985-08-01 00:00:00

abstract：:Germline mutations of the CDKN2A (p16(INK4A)) tumor suppressor gene predispose patients to melanoma and pancreatic carcinoma. In contrast, mutations of the murine CDKN2A gene predispose BALB/c mice to pristane-induced plasmacytoma. We describe here a family in which a germline mutation of CDKN2A is present in 4 indivi...

journal_title：Blood

authors： Dilworth D,Liu L,Stewart AK,Berenson JR,Lassam N,Hogg D

更新日期：2000-03-01 00:00:00

abstract：:The CD11b/CD18 leukocyte integrin molecule mediates diverse neutrophil adherence-related functions, including cell:cell and cell:extracellular matrix attachments. To study the individual role of this leukocyte integrin in cell adherence in hematopoietic cells, we expressed the CD11b/CD18 complex on the surface of K562...

journal_title：Blood

authors： Hickstein DD,Grunvald E,Shumaker G,Baker DM,Back AL,Embree LJ,Yee E,Gollahon KA

更新日期：1993-10-15 00:00:00

abstract：:The calcium, sodium, and magnesium permeability of erythrocytes from blood stored at 4 degrees C in various anticoagulant media has been studied and compared to that of fresh erythrocytes. Passive influx of CA2+ was measured at 37 degrees C in cells pretreated to abolish Ca2+ pumping and was up to fivefold greater for...

journal_title：Blood

authors： Wiley JS,McCulloch KE,Bowden DS

更新日期：1982-07-01 00:00:00

abstract：:Recently, we described a new genetic disorder (the "hereditary hyperferritinemia-cataract syndrome") clinically characterized by the combination of elevated serum ferritin and congenital bilateral nuclear cataract, both cotransmitted as an autosomal dominant trait. In affected subjects, hyperferritinemia (ranging from...

journal_title：Blood

authors： Girelli D,Corrocher R,Bisceglia L,Olivieri O,De Franceschi L,Zelante L,Gasparini P

更新日期：1995-12-01 00:00:00

abstract：:The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or wheth...

journal_title：Blood

authors： Taveirne S,Filtjens J,Van Ammel E,De Colvenaer V,Kerre T,Taghon T,Vandekerckhove B,Plum J,Held W,Leclercq G

更新日期：2011-07-14 00:00:00

abstract：:Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for the main...

journal_title：Blood

authors： Quesniaux VF,Clark SC,Turner K,Fagg B

更新日期：1992-09-01 00:00:00

abstract：:A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at t...

journal_title：Blood

authors： Reuter CW,Morgan MA,Bergmann L

更新日期：2000-09-01 00:00:00

abstract：:Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow ab...

journal_title：Blood

authors： Kessinger A,Bierman PJ,Vose JM,Armitage JO

更新日期：1991-06-01 00:00:00

abstract：:Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in patients with refractory CGVHD a total of 80 patients who failed to respond to prednisone (PSE) or PSE and cyclosporine (CSA) were treated with thalidomide. Sixt...

journal_title：Blood

authors： Parker PM,Chao N,Nademanee A,O'Donnell MR,Schmidt GM,Snyder DS,Stein AS,Smith EP,Molina A,Stepan DE,Kashyap A,Planas I,Spielberger R,Somlo G,Margolin K,Zwingenberger K,Wilsman K,Negrin RS,Long GD,Niland JC,Blume K

更新日期：1995-11-01 00:00:00

abstract：:In this issue of Blood, Doyle et al provide evidence that knockout of the genes encoding the two most abundant eosinophil secondary granule proteins disrupts the normal differentiation of eosinophils from progenitors in the bone marrow, providing a novel strain of mice with a highly specific deficiency in eosinophilop...

journal_title：Blood

authors： Ackerman SJ

更新日期：2013-08-01 00:00:00

abstract：:Sepsis and septic shock remain an important medical problem, emphasizing the need to identify novel therapeutic opportunities. Hypovolemic hypotension, coagulation dysfunction, disturbed microcirculation, and multiorgan failure resulting from vascular leakage are often observed in these severe conditions. In the prese...

journal_title：Blood

authors： Oehmcke S,Shannon O,von Köckritz-Blickwede M,Mörgelin M,Linder A,Olin AI,Björck L,Herwald H

更新日期：2009-07-09 00:00:00

abstract：:Glycoprotein VI (GPVI) is an essential platelet receptor for collagens that is exclusively expressed in the megakaryocytic lineage. Transcription of the human gene GP6 is driven largely by GATA-binding protein 1 (GATA-1), specificity protein 1 (Sp1), and Friend leukemia integration 1 (Fli-1). In this report, we show t...

journal_title：Blood

authors： Kanaji S,Kanaji T,Jacquelin B,Chang M,Nugent DJ,Komatsu N,Moroi M,Izuhara K,Kunicki TJ

更新日期：2005-05-15 00:00:00